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Protein

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

Gene

TPTE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei320 – 3201Phosphocysteine intermediateCurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-HSA-1660514. Synthesis of PIPs at the Golgi membrane.

Chemistry

SwissLipidsiSLP:000000884. [Q6XPS3-3]

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC:3.1.3.67)
Alternative name(s):
Lipid phosphatase TPIP
TPTE and PTEN homologous inositol lipid phosphatase
Gene namesi
Name:TPTE2
Synonyms:TPIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:17299. TPTE2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi320 – 3201C → S: Loss of activity. 1 Publication

Organism-specific databases

PharmGKBiPA134917664.

Polymorphism and mutation databases

BioMutaiTPTE2.
DMDMi215273973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2PRO_0000224187Add
BLAST

Proteomic databases

MaxQBiQ6XPS3.
PaxDbiQ6XPS3.
PeptideAtlasiQ6XPS3.
PRIDEiQ6XPS3.

PTM databases

DEPODiQ6XPS3.
iPTMnetiQ6XPS3.
PhosphoSiteiQ6XPS3.

Expressioni

Tissue specificityi

Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.1 Publication

Gene expression databases

BgeeiENSG00000132958.
CleanExiHS_TPTE2.
ExpressionAtlasiQ6XPS3. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi125031. 24 interactions.
STRINGi9606.ENSP00000372437.

Structurei

3D structure databases

ProteinModelPortaliQ6XPS3.
SMRiQ6XPS3. Positions 67-188, 206-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 386177Phosphatase tensin-typePROSITE-ProRule annotationAdd
BLAST
Domaini393 – 522130C2 tensin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2283. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000049109.
HOVERGENiHBG084209.
InParanoidiQ6XPS3.
KOiK18079.
OMAiNHYQVYN.
OrthoDBiEOG091G09VG.
PhylomeDBiQ6XPS3.
TreeFamiTF354329.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF10409. PTEN_C2. 1 hit.
[Graphical view]
SMARTiSM01326. PTEN_C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6XPS3-1) [UniParc]FASTAAdd to basket
Also known as: TPIP gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV
60 70 80 90 100
EDAENVASYD SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS
110 120 130 140 150
KLYIPLEYRS ISLAIGLFFL MDVLLRVFVE GRQQYFSDLF NILDTAIIVI
160 170 180 190 200
PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR LIILIRIFHL LHQKRQLEKL
210 220 230 240 250
MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS FYRNPIEEVV
260 270 280 290 300
RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
310 320 330 340 350
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY
360 370 380 390 400
FGERRTNKTH SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR
410 420 430 440 450
FIIYSIRGDV CDLKVQVVME KKVVFSSTSL GNCSILHDIE TDKILINVYD
460 470 480 490 500
GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF NTSFIQNNRL CLPRNELDNP
510 520
HKQKAWKIYP PEFAVEILFG EK
Length:522
Mass (Da):61,112
Last modified:November 25, 2008 - v2
Checksum:i4CC42349355EDA9F
GO
Isoform 2 (identifier: Q6XPS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-171: Missing.

Show »
Length:482
Mass (Da):56,320
Checksum:i7AC9220C5EAA8E7F
GO
Isoform 3 (identifier: Q6XPS3-3) [UniParc]FASTAAdd to basket
Also known as: TPIP alpha

The sequence of this isoform differs from the canonical sequence as follows:
     40-77: SMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFG → R
     132-171: Missing.

Show »
Length:445
Mass (Da):52,231
Checksum:i9808843A147E838D
GO
Isoform 4 (identifier: Q6XPS3-4) [UniParc]FASTAAdd to basket
Also known as: TPIP beta

The sequence of this isoform differs from the canonical sequence as follows:
     40-170: Missing.
     435-522: ILHDIETDKI...FAVEILFGEK → REEGSTLRRANWKGEPSRRPVLD

Show »
Length:326
Mass (Da):38,263
Checksum:iE4E36B37921D7C7F
GO
Isoform 5 (identifier: Q6XPS3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-171: DSKIKKIVHS...DIKLLRNIPR → E

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):48,386
Checksum:iDBC2F0E1B072AFCE
GO
Isoform 6 (identifier: Q6XPS3-6) [UniParc]FASTAAdd to basket
Also known as: TPIP-C2

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Note: Expressed in testis, strongly inhibits cell growth in HeLa cells.
Show »
Length:193
Mass (Da):22,746
Checksum:i9F5DC594BF968538
GO
Isoform 7 (identifier: Q6XPS3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-522: NLPKYYDNCP...FAVEILFGEK → REEGSTLRRANWKGEPSRRPVLD

Note: No experimental confirmation available.
Show »
Length:488
Mass (Da):56,839
Checksum:iEAE72803045303C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti521 – 5211E → K in CAD13144 (PubMed:11716755).Curated
Sequence conflicti521 – 5211E → K in AAP45146 (PubMed:14659893).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti367 – 3671V → I.
Corresponds to variant rs2497218 [ dbSNP | Ensembl ].
VAR_047501
Natural varianti444 – 4441I → V.4 Publications
Corresponds to variant rs2497218 [ dbSNP | Ensembl ].
VAR_057349

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 329329Missing in isoform 6. 2 PublicationsVSP_047569Add
BLAST
Alternative sequencei40 – 170131Missing in isoform 4. 1 PublicationVSP_017322Add
BLAST
Alternative sequencei40 – 7738SMLER…SFAFG → R in isoform 3. 1 PublicationVSP_017323Add
BLAST
Alternative sequencei60 – 171112DSKIK…RNIPR → E in isoform 5. 1 PublicationVSP_044506Add
BLAST
Alternative sequencei132 – 17140Missing in isoform 2 and isoform 3. 1 PublicationVSP_017324Add
BLAST
Alternative sequencei435 – 52288ILHDI…LFGEK → REEGSTLRRANWKGEPSRRP VLD in isoform 4. 1 PublicationVSP_017325Add
BLAST
Alternative sequencei466 – 52257NLPKY…LFGEK → REEGSTLRRANWKGEPSRRP VLD in isoform 7. 1 PublicationVSP_053978Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421032 mRNA. Translation: CAD13144.1.
AJ421033 mRNA. Translation: CAD13145.1.
AY219890 mRNA. Translation: AAP45146.1.
FJ969729 mRNA. Translation: ACT21090.1.
AK301741 mRNA. Translation: BAG63204.1.
AL590076 Genomic DNA. Translation: CAH73538.1.
AL590076 Genomic DNA. Translation: CAH73539.1.
CH471075 Genomic DNA. Translation: EAX08219.1.
BC128146 mRNA. Translation: AAI28147.1.
BC128147 mRNA. Translation: AAI28148.1.
CCDSiCCDS45013.1. [Q6XPS3-5]
CCDS45014.1. [Q6XPS3-1]
CCDS9285.1. [Q6XPS3-3]
RefSeqiNP_001135440.1. NM_001141968.1. [Q6XPS3-5]
NP_001258779.1. NM_001271850.1. [Q6XPS3-6]
NP_570141.3. NM_130785.3. [Q6XPS3-3]
NP_954863.2. NM_199254.2. [Q6XPS3-1]
UniGeneiHs.377488.

Genome annotation databases

EnsembliENST00000255310; ENSP00000255310; ENSG00000132958. [Q6XPS3-3]
ENST00000382978; ENSP00000372438; ENSG00000132958. [Q6XPS3-2]
ENST00000390680; ENSP00000375098; ENSG00000132958. [Q6XPS3-3]
ENST00000400103; ENSP00000382974; ENSG00000132958. [Q6XPS3-5]
ENST00000400230; ENSP00000383089; ENSG00000132958. [Q6XPS3-1]
GeneIDi93492.
KEGGihsa:93492.
UCSCiuc001ume.4. human. [Q6XPS3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421032 mRNA. Translation: CAD13144.1.
AJ421033 mRNA. Translation: CAD13145.1.
AY219890 mRNA. Translation: AAP45146.1.
FJ969729 mRNA. Translation: ACT21090.1.
AK301741 mRNA. Translation: BAG63204.1.
AL590076 Genomic DNA. Translation: CAH73538.1.
AL590076 Genomic DNA. Translation: CAH73539.1.
CH471075 Genomic DNA. Translation: EAX08219.1.
BC128146 mRNA. Translation: AAI28147.1.
BC128147 mRNA. Translation: AAI28148.1.
CCDSiCCDS45013.1. [Q6XPS3-5]
CCDS45014.1. [Q6XPS3-1]
CCDS9285.1. [Q6XPS3-3]
RefSeqiNP_001135440.1. NM_001141968.1. [Q6XPS3-5]
NP_001258779.1. NM_001271850.1. [Q6XPS3-6]
NP_570141.3. NM_130785.3. [Q6XPS3-3]
NP_954863.2. NM_199254.2. [Q6XPS3-1]
UniGeneiHs.377488.

3D structure databases

ProteinModelPortaliQ6XPS3.
SMRiQ6XPS3. Positions 67-188, 206-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125031. 24 interactions.
STRINGi9606.ENSP00000372437.

Chemistry

SwissLipidsiSLP:000000884. [Q6XPS3-3]

PTM databases

DEPODiQ6XPS3.
iPTMnetiQ6XPS3.
PhosphoSiteiQ6XPS3.

Polymorphism and mutation databases

BioMutaiTPTE2.
DMDMi215273973.

Proteomic databases

MaxQBiQ6XPS3.
PaxDbiQ6XPS3.
PeptideAtlasiQ6XPS3.
PRIDEiQ6XPS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255310; ENSP00000255310; ENSG00000132958. [Q6XPS3-3]
ENST00000382978; ENSP00000372438; ENSG00000132958. [Q6XPS3-2]
ENST00000390680; ENSP00000375098; ENSG00000132958. [Q6XPS3-3]
ENST00000400103; ENSP00000382974; ENSG00000132958. [Q6XPS3-5]
ENST00000400230; ENSP00000383089; ENSG00000132958. [Q6XPS3-1]
GeneIDi93492.
KEGGihsa:93492.
UCSCiuc001ume.4. human. [Q6XPS3-1]

Organism-specific databases

CTDi93492.
GeneCardsiTPTE2.
H-InvDBHIX0016023.
HIX0020751.
HIX0037315.
HIX0037502.
HGNCiHGNC:17299. TPTE2.
MIMi606791. gene.
neXtProtiNX_Q6XPS3.
PharmGKBiPA134917664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2283. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000049109.
HOVERGENiHBG084209.
InParanoidiQ6XPS3.
KOiK18079.
OMAiNHYQVYN.
OrthoDBiEOG091G09VG.
PhylomeDBiQ6XPS3.
TreeFamiTF354329.

Enzyme and pathway databases

ReactomeiR-HSA-1660514. Synthesis of PIPs at the Golgi membrane.

Miscellaneous databases

GenomeRNAii93492.
PROiQ6XPS3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132958.
CleanExiHS_TPTE2.
ExpressionAtlasiQ6XPS3. baseline and differential.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF10409. PTEN_C2. 1 hit.
[Graphical view]
SMARTiSM01326. PTEN_C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPTE2_HUMAN
AccessioniPrimary (citable) accession number: Q6XPS3
Secondary accession number(s): A1A4X0
, A1A4X1, A8MX64, B1AQ16, B4DWZ2, Q5VUH2, Q8WWL4, Q8WWL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.