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Protein

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

Gene

TPTE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei320Phosphocysteine intermediateCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane

Chemistry databases

SwissLipidsiSLP:000000884 [Q6XPS3-3]

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC:3.1.3.67)
Alternative name(s):
Lipid phosphatase TPIP
TPTE and PTEN homologous inositol lipid phosphatase
Gene namesi
Name:TPTE2
Synonyms:TPIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000132958.17
HGNCiHGNC:17299 TPTE2
MIMi606791 gene
neXtProtiNX_Q6XPS3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi320C → S: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi93492
OpenTargetsiENSG00000132958
PharmGKBiPA134917664

Polymorphism and mutation databases

BioMutaiTPTE2
DMDMi215273973

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002241871 – 522Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2Add BLAST522

Proteomic databases

MaxQBiQ6XPS3
PaxDbiQ6XPS3
PeptideAtlasiQ6XPS3
PRIDEiQ6XPS3

PTM databases

DEPODiQ6XPS3
iPTMnetiQ6XPS3
PhosphoSitePlusiQ6XPS3

Expressioni

Tissue specificityi

Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.1 Publication

Gene expression databases

BgeeiENSG00000132958
CleanExiHS_TPTE2
ExpressionAtlasiQ6XPS3 baseline and differential

Organism-specific databases

HPAiHPA068342

Interactioni

Protein-protein interaction databases

BioGridi125031, 59 interactors
STRINGi9606.ENSP00000372437

Structurei

3D structure databases

ProteinModelPortaliQ6XPS3
SMRiQ6XPS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 386Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST177
Domaini393 – 522C2 tensin-typePROSITE-ProRule annotationAdd BLAST130

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000049109
HOVERGENiHBG084209
InParanoidiQ6XPS3
KOiK18079
OMAiYFWFNTS
OrthoDBiEOG091G09VG
PhylomeDBiQ6XPS3
TreeFamiTF354329

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6XPS3-1) [UniParc]FASTAAdd to basket
Also known as: TPIP gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV
60 70 80 90 100
EDAENVASYD SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS
110 120 130 140 150
KLYIPLEYRS ISLAIGLFFL MDVLLRVFVE GRQQYFSDLF NILDTAIIVI
160 170 180 190 200
PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR LIILIRIFHL LHQKRQLEKL
210 220 230 240 250
MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS FYRNPIEEVV
260 270 280 290 300
RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
310 320 330 340 350
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY
360 370 380 390 400
FGERRTNKTH SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR
410 420 430 440 450
FIIYSIRGDV CDLKVQVVME KKVVFSSTSL GNCSILHDIE TDKILINVYD
460 470 480 490 500
GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF NTSFIQNNRL CLPRNELDNP
510 520
HKQKAWKIYP PEFAVEILFG EK
Length:522
Mass (Da):61,112
Last modified:November 25, 2008 - v2
Checksum:i4CC42349355EDA9F
GO
Isoform 2 (identifier: Q6XPS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-171: Missing.

Show »
Length:482
Mass (Da):56,320
Checksum:i7AC9220C5EAA8E7F
GO
Isoform 3 (identifier: Q6XPS3-3) [UniParc]FASTAAdd to basket
Also known as: TPIP alpha

The sequence of this isoform differs from the canonical sequence as follows:
     40-77: SMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFG → R
     132-171: Missing.

Show »
Length:445
Mass (Da):52,231
Checksum:i9808843A147E838D
GO
Isoform 4 (identifier: Q6XPS3-4) [UniParc]FASTAAdd to basket
Also known as: TPIP beta

The sequence of this isoform differs from the canonical sequence as follows:
     40-170: Missing.
     435-522: ILHDIETDKI...FAVEILFGEK → REEGSTLRRANWKGEPSRRPVLD

Show »
Length:326
Mass (Da):38,263
Checksum:iE4E36B37921D7C7F
GO
Isoform 5 (identifier: Q6XPS3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-171: DSKIKKIVHS...DIKLLRNIPR → E

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):48,386
Checksum:iDBC2F0E1B072AFCE
GO
Isoform 6 (identifier: Q6XPS3-6) [UniParc]FASTAAdd to basket
Also known as: TPIP-C2

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Note: Expressed in testis, strongly inhibits cell growth in HeLa cells.
Show »
Length:193
Mass (Da):22,746
Checksum:i9F5DC594BF968538
GO
Isoform 7 (identifier: Q6XPS3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-522: NLPKYYDNCP...FAVEILFGEK → REEGSTLRRANWKGEPSRRPVLD

Note: No experimental confirmation available.
Show »
Length:488
Mass (Da):56,839
Checksum:iEAE72803045303C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti521E → K in CAD13144 (PubMed:11716755).Curated1
Sequence conflicti521E → K in AAP45146 (PubMed:14659893).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047501367V → I. Corresponds to variant dbSNP:rs2497218Ensembl.1
Natural variantiVAR_057349444I → V4 PublicationsCorresponds to variant dbSNP:rs2497218Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0475691 – 329Missing in isoform 6. 2 PublicationsAdd BLAST329
Alternative sequenceiVSP_01732240 – 170Missing in isoform 4. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_01732340 – 77SMLER…SFAFG → R in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_04450660 – 171DSKIK…RNIPR → E in isoform 5. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_017324132 – 171Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_017325435 – 522ILHDI…LFGEK → REEGSTLRRANWKGEPSRRP VLD in isoform 4. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_053978466 – 522NLPKY…LFGEK → REEGSTLRRANWKGEPSRRP VLD in isoform 7. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421032 mRNA Translation: CAD13144.1
AJ421033 mRNA Translation: CAD13145.1
AY219890 mRNA Translation: AAP45146.1
FJ969729 mRNA Translation: ACT21090.1
AK301741 mRNA Translation: BAG63204.1
AL590076 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08219.1
BC128146 mRNA Translation: AAI28147.1
BC128147 mRNA Translation: AAI28148.1
CCDSiCCDS45013.1 [Q6XPS3-5]
CCDS45014.1 [Q6XPS3-1]
CCDS9285.1 [Q6XPS3-3]
RefSeqiNP_001135440.1, NM_001141968.1 [Q6XPS3-5]
NP_001258779.1, NM_001271850.1 [Q6XPS3-6]
NP_570141.3, NM_130785.3 [Q6XPS3-3]
NP_954863.2, NM_199254.2 [Q6XPS3-1]
UniGeneiHs.377488

Genome annotation databases

EnsembliENST00000255310; ENSP00000255310; ENSG00000132958 [Q6XPS3-3]
ENST00000382978; ENSP00000372438; ENSG00000132958 [Q6XPS3-2]
ENST00000390680; ENSP00000375098; ENSG00000132958 [Q6XPS3-3]
ENST00000400103; ENSP00000382974; ENSG00000132958 [Q6XPS3-5]
ENST00000400230; ENSP00000383089; ENSG00000132958 [Q6XPS3-1]
GeneIDi93492
KEGGihsa:93492
UCSCiuc001ume.4 human [Q6XPS3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTPTE2_HUMAN
AccessioniPrimary (citable) accession number: Q6XPS3
Secondary accession number(s): A1A4X0
, A1A4X1, A8MX64, B1AQ16, B4DWZ2, Q5VUH2, Q8WWL4, Q8WWL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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