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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Macrobrachium rosenbergii nodavirus (MrNV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
OrganismiMacrobrachium rosenbergii nodavirus (MrNV)
Taxonomic identifieri222557 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeunclassified Nodaviridae
Virus hostiMacrobrachium rosenbergii (Giant fresh water prawn) [TaxID: 79674]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10451045RNA-directed RNA polymerasePRO_0000223687Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6XNL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini593 – 718126RdRp catalyticAdd
BLAST

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.Curated

Family and domain databases

InterProiIPR001205. RNA-dir_pol_C.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XNL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCNNLLYGV ELPMCLQSSM GMVVVTGLAI VYLVIYILIY SFTHGPRLSR
60 70 80 90 100
RLASYVVIGP YEAIAKSRPA MALQRAMVDL TRRDVRTDWY PLNNLLMNKP
110 120 130 140 150
HRLSENGHKT SGAVRDAARN LITSAITSLG MDKYEISPGG HTVDEQLASH
160 170 180 190 200
RHYAVNDLHR ASADDAVKEN AVIVAIDTDY YLRDPSIYFS NNNPFILHTF
210 220 230 240 250
QPITVAGKDG DVRFTISDNQ VDYRVDGGGR WQHKVWNWCD YGEFLYLKNI
260 270 280 290 300
LGILSINWWL SFFGIRKVIY QKIQHARPWV DCPNRALVWG LPQFTRYMIT
310 320 330 340 350
WLPIEMNARE LSRVNYQCAS RPGWNCLVDH TSTKLVASIG REGNDCHVEL
360 370 380 390 400
AKEDLDVVLG LSTMQSVTSR LLQMGYKQPQ TLATVCQFYN SAAYDILSCS
410 420 430 440 450
IVARPSQPPV HWPLASEIDQ PTTSFRNYSN NIVTCGNLCP QLKRWEVLSN
460 470 480 490 500
SLEHRVTMVA NNKVPTPRIA RFAEEYVRLV VPEANVGVPY SLEDARKELD
510 520 530 540 550
KPTQVNAVNQ IWETVDMEVR RLIEAFVKNE PTNKSGRIIS SFADSRFLLK
560 570 580 590 600
FSTYTLAFRD EVLHAEHNRH WFCPGLTPNE IADKVCDYVR GVATPAEGDF
610 620 630 640 650
SNFDGRVSAW CQENVMNAVY HRWFNRKFSK ELQKYTSMLV SCPARAKRFG
660 670 680 690 700
FQYEPGVGVK SGSPTTCDLN SVLNNFTQYA AVRLTKPDLS PQEAFEQTGL
710 720 730 740 750
SFGDDSLFDK QYQLRWNYVV EQLGMELKVE PFDPSNGVTF LARVFPDPYS
760 770 780 790 800
TNTSFQDPLR TWRKLNMTSR TCVPVESAAL DRVSGYLVTD KYSPVTSEYC
810 820 830 840 850
HMIERCYMNT AESVTRRRQR KDCDREKPYW LVSGGAWPQR EGDYELMMRV
860 870 880 890 900
TAARTGFEES KLINLISQFQ SVHDPWDIKP LDYQEPSPYK DTLDIDGQPV
910 920 930 940 950
DAVDERQYQN ERNTVNLRAG AAISQMPVPS VPGGEDCNRQ SADMPGPKSS
960 970 980 990 1000
EGSEQLQGLP EQDGSNRLQC HRQPTFKAKG GSNTKGRSRK SRNGGRSISS
1010 1020 1030 1040
KTANPTTHEV GGGNGKTRVT IAKRSGPKRP HNVVSNAWET LNDNR
Length:1,045
Mass (Da):118,394
Last modified:July 5, 2004 - v1
Checksum:i229E7D36C9376032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY222839 Genomic RNA. Translation: AAO60068.1.
RefSeqiNP_919036.1. NC_005094.1.

Genome annotation databases

GeneIDi2943295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY222839 Genomic RNA. Translation: AAO60068.1.
RefSeqiNP_919036.1. NC_005094.1.

3D structure databases

ProteinModelPortaliQ6XNL5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2943295.

Family and domain databases

InterProiIPR001205. RNA-dir_pol_C.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the MrNV-RNA-1 of Macrobrachium rosenbergii."
    Bonami J.-R., Sri Widada J., Richard V.R., Vincent A., Durand S.P.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiRDRP_MRNV
AccessioniPrimary (citable) accession number: Q6XNL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.