Q6XNL5 (RDRP_MRNV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: RNA-directed RNA polymerase Short name=RdRp EC=2.7.7.48 Alternative name(s): RNA replicase
Organism	Macrobrachium rosenbergii nodavirus (MrNV)
Taxonomic identifier	222557 [NCBI]
Taxonomic lineage	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nodaviridae › unclassified Nodaviridae
Virus host	Macrobrachium rosenbergii (Giant fresh water prawn) [TaxID: 79674]

Protein attributes

Sequence length	1045 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2 Potential.
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the nodaviridae RNA polymerase family. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1045	1045	RNA-directed RNA polymerase		PRO_0000223687
Regions
	Domain	593 – 718	126	RdRp catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q6XNL5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 229E7D36C9376032	FASTA	1,045	118,394
	10 20 30 40 50 60 MKCNNLLYGV ELPMCLQSSM GMVVVTGLAI VYLVIYILIY SFTHGPRLSR RLASYVVIGP 70 80 90 100 110 120 YEAIAKSRPA MALQRAMVDL TRRDVRTDWY PLNNLLMNKP HRLSENGHKT SGAVRDAARN 130 140 150 160 170 180 LITSAITSLG MDKYEISPGG HTVDEQLASH RHYAVNDLHR ASADDAVKEN AVIVAIDTDY 190 200 210 220 230 240 YLRDPSIYFS NNNPFILHTF QPITVAGKDG DVRFTISDNQ VDYRVDGGGR WQHKVWNWCD 250 260 270 280 290 300 YGEFLYLKNI LGILSINWWL SFFGIRKVIY QKIQHARPWV DCPNRALVWG LPQFTRYMIT 310 320 330 340 350 360 WLPIEMNARE LSRVNYQCAS RPGWNCLVDH TSTKLVASIG REGNDCHVEL AKEDLDVVLG 370 380 390 400 410 420 LSTMQSVTSR LLQMGYKQPQ TLATVCQFYN SAAYDILSCS IVARPSQPPV HWPLASEIDQ 430 440 450 460 470 480 PTTSFRNYSN NIVTCGNLCP QLKRWEVLSN SLEHRVTMVA NNKVPTPRIA RFAEEYVRLV 490 500 510 520 530 540 VPEANVGVPY SLEDARKELD KPTQVNAVNQ IWETVDMEVR RLIEAFVKNE PTNKSGRIIS 550 560 570 580 590 600 SFADSRFLLK FSTYTLAFRD EVLHAEHNRH WFCPGLTPNE IADKVCDYVR GVATPAEGDF 610 620 630 640 650 660 SNFDGRVSAW CQENVMNAVY HRWFNRKFSK ELQKYTSMLV SCPARAKRFG FQYEPGVGVK 670 680 690 700 710 720 SGSPTTCDLN SVLNNFTQYA AVRLTKPDLS PQEAFEQTGL SFGDDSLFDK QYQLRWNYVV 730 740 750 760 770 780 EQLGMELKVE PFDPSNGVTF LARVFPDPYS TNTSFQDPLR TWRKLNMTSR TCVPVESAAL 790 800 810 820 830 840 DRVSGYLVTD KYSPVTSEYC HMIERCYMNT AESVTRRRQR KDCDREKPYW LVSGGAWPQR 850 860 870 880 890 900 EGDYELMMRV TAARTGFEES KLINLISQFQ SVHDPWDIKP LDYQEPSPYK DTLDIDGQPV 910 920 930 940 950 960 DAVDERQYQN ERNTVNLRAG AAISQMPVPS VPGGEDCNRQ SADMPGPKSS EGSEQLQGLP 970 980 990 1000 1010 1020 EQDGSNRLQC HRQPTFKAKG GSNTKGRSRK SRNGGRSISS KTANPTTHEV GGGNGKTRVT 1030 1040 IAKRSGPKRP HNVVSNAWET LNDNR

References

[1]	"Nucleotide sequence of the MrNV-RNA-1 of Macrobrachium rosenbergii." Bonami J.-R., Sri Widada J., Richard V.R., Vincent A., Durand S.P. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY222839 Genomic RNA. Translation: AAO60068.1.
RefSeq	NP_919036.1. NC_005094.1.
3D structure databases
ProteinModelPortal	Q6XNL5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2943295.
Family and domain databases
InterPro	IPR001205. RNA-dir_pol_C. [Graphical view]
Pfam	PF00680. RdRP_1. 1 hit. [Graphical view]
PROSITE	PS50507. RDRP_SSRNA_POS. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RDRP_MRNV

Accession

Primary (citable) accession number: Q6XNL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program