Reviewed, UniProtKB/Swiss-Prot Q6XLL9 (KAX66_OPICA)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 6.6 Alternative name(s):     OcKTx1
Organism	Opistophthalmus carinatus (African yellow leg scorpion)
Taxonomic identifier	190115 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Opistophthalmus

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Blocker of voltage-gated potassium channels By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 6 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Amidation Disulfide bond
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 60	37	Potassium channel toxin alpha-KTx 6.6		PRO_0000227031
Amino acid modifications
	Modified residue	60	1	Cysteine amide By similarity
	Disulfide bond	29 ↔ 50		By similarity
	Disulfide bond	35 ↔ 55		By similarity
	Disulfide bond	39 ↔ 57		By similarity
	Disulfide bond	45 ↔ 60		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6XLL9-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A5227E8864F78615	FASTA	61	6,668
	10 20 30 40 50 60 MNAKFILLLL VVATTMLLPD TQGAEVIKCR TPKDCAGPCR KQTGCPHGKC MNRTCRCNRC G

References

[1]	"Evolutionary trace analysis of scorpion toxins specific for K-channels." Zhu S.-Y., Huys I., Dyason K., Verdonck F., Tytgat J. Proteins 54:361-370(2004) [PubMed: 14696198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY225779 mRNA. Translation: AAP73817.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001947. Scorpion_toxinS. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX66_OPICA

Accession

Primary (citable) accession number: Q6XLL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)