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Q6XLL7

- KAX68_OPICA

UniProt

Q6XLL7 - KAX68_OPICA

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Protein

Potassium channel toxin alpha-KTx 6.8

Gene
N/A
Organism
Opistophthalmus carinatus (African yellow leg scorpion)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Blocker of voltage-gated potassium channels.By similarity

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. defense response Source: InterPro
  2. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 6.8
Alternative name(s):
OcKTx3
OrganismiOpistophthalmus carinatus (African yellow leg scorpion)
Taxonomic identifieri190115 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeOpistophthalmus

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 6037Potassium channel toxin alpha-KTx 6.8PRO_0000227033Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 50By similarity
Disulfide bondi35 ↔ 55By similarity
Disulfide bondi39 ↔ 57By similarity
Disulfide bondi45 ↔ 60By similarity
Modified residuei60 – 601Cysteine amideBy similarity

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ6XLL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
ProDomiPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6XLL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAKFILLLL VVTTTILLPD TQGAEVIKCR TPKDCADPCR KQTGCPHAKC
60
MNKTCRCHRC G
Length:61
Mass (Da):6,747
Last modified:July 5, 2004 - v1
Checksum:iD25F4D9774F55D01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225781 mRNA. Translation: AAP73819.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225781 mRNA. Translation: AAP73819.1 .

3D structure databases

ProteinModelPortali Q6XLL7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view ]
Pfami PF00451. Toxin_2. 1 hit.
[Graphical view ]
ProDomi PD003586. Scorpion_toxinS. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF57095. SSF57095. 1 hit.
PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolutionary trace analysis of scorpion toxins specific for K-channels."
    Zhu S.-Y., Huys I., Dyason K., Verdonck F., Tytgat J.
    Proteins 54:361-370(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiKAX68_OPICA
AccessioniPrimary (citable) accession number: Q6XLL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3