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Q6XLL7 (KAX68_OPICA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 6.8
Alternative name(s):
OcKTx3
OrganismOpistophthalmus carinatus (African yellow leg scorpion)
Taxonomic identifier190115 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeOpistophthalmus

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Blocker of voltage-gated potassium channels By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 6 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMAmidation
Disulfide bond
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 6037Potassium channel toxin alpha-KTx 6.8
PRO_0000227033

Amino acid modifications

Modified residue601Cysteine amide By similarity
Disulfide bond29 ↔ 50 By similarity
Disulfide bond35 ↔ 55 By similarity
Disulfide bond39 ↔ 57 By similarity
Disulfide bond45 ↔ 60 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6XLL7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D25F4D9774F55D01

FASTA616,747
        10         20         30         40         50         60 
MNAKFILLLL VVTTTILLPD TQGAEVIKCR TPKDCADPCR KQTGCPHAKC MNKTCRCHRC 


G 

« Hide

References

[1]"Evolutionary trace analysis of scorpion toxins specific for K-channels."
Zhu S.-Y., Huys I., Dyason K., Verdonck F., Tytgat J.
Proteins 54:361-370(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY225781 mRNA. Translation: AAP73819.1.

3D structure databases

ProteinModelPortalQ6XLL7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX68_OPICA
AccessionPrimary (citable) accession number: Q6XLL7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries