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Q6XLL5

- KAX6A_OPICA

UniProt

Q6XLL5 - KAX6A_OPICA

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Protein
Potassium channel toxin alpha-KTx 6.10
Gene
N/A
Organism
Opistophthalmus carinatus (African yellow leg scorpion)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Blocker of voltage-gated potassium channels By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei48 – 481Basic residue of the functional dyad By similarity
Sitei57 – 571Aromatic residue of the functional dyad By similarity

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. defense response Source: InterPro
  2. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 6.10
Alternative name(s):
OcKTx5
OrganismiOpistophthalmus carinatus (African yellow leg scorpion)
Taxonomic identifieri190115 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeOpistophthalmus

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 5936Potassium channel toxin alpha-KTx 6.10
PRO_0000227035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 49 By similarity
Disulfide bondi34 ↔ 54 By similarity
Disulfide bondi38 ↔ 56 By similarity
Disulfide bondi44 ↔ 59 By similarity
Modified residuei59 – 591Cysteine amide By similarity

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ6XLL5.
SMRiQ6XLL5. Positions 24-60.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSiPR00286. CHARYBDTOXIN.
ProDomiPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6XLL5-1 [UniParc]FASTAAdd to Basket

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MNAKFILLLV LTTMMLLPDT KGAEVIRCSG SKQCYGPCKQ QTGCTNSKCM   50
NKVCKCYGCG 60
Length:60
Mass (Da):6,514
Last modified:July 5, 2004 - v1
Checksum:iD672EAC08057143D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225783 mRNA. Translation: AAP73821.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225783 mRNA. Translation: AAP73821.1 .

3D structure databases

ProteinModelPortali Q6XLL5.
SMRi Q6XLL5. Positions 24-60.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view ]
Pfami PF00451. Toxin_2. 1 hit.
[Graphical view ]
PRINTSi PR00286. CHARYBDTOXIN.
ProDomi PD003586. Scorpion_toxinS. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF57095. SSF57095. 1 hit.
PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolutionary trace analysis of scorpion toxins specific for K-channels."
    Zhu S.-Y., Huys I., Dyason K., Verdonck F., Tytgat J.
    Proteins 54:361-370(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiKAX6A_OPICA
AccessioniPrimary (citable) accession number: Q6XLL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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