Reviewed, UniProtKB/Swiss-Prot Q6XLL5 (KAX6A_OPICA)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 6.10 Alternative name(s):     OcKTx5
Organism	Opistophthalmus carinatus (African yellow leg scorpion)
Taxonomic identifier	190115 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Opistophthalmus

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Blocker of voltage-gated potassium channels By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 6 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Amidation Disulfide bond
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 59	36	Potassium channel toxin alpha-KTx 6.10		PRO_0000227035
Amino acid modifications
	Modified residue	59	1	Cysteine amide By similarity
	Disulfide bond	28 ↔ 49		By similarity
	Disulfide bond	34 ↔ 54		By similarity
	Disulfide bond	38 ↔ 56		By similarity
	Disulfide bond	44 ↔ 59		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6XLL5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D672EAC08057143D	FASTA	60	6,514
	10 20 30 40 50 60 MNAKFILLLV LTTMMLLPDT KGAEVIRCSG SKQCYGPCKQ QTGCTNSKCM NKVCKCYGCG

References

[1]	"Evolutionary trace analysis of scorpion toxins specific for K-channels." Zhu S.-Y., Huys I., Dyason K., Verdonck F., Tytgat J. Proteins 54:361-370(2004) [PubMed: 14696198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY225783 mRNA. Translation: AAP73821.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001947. Scorpion_toxinS. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
PRINTS	PR00286. CHARYBDTOXIN.
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX6A_OPICA

Accession

Primary (citable) accession number: Q6XLL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2004
Last modified:	November 24, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)