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Protein

Prostaglandin D2 receptor 2

Gene

Ptgdr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor 2
Alternative name(s):
G protein-coupled receptor 44
Gene namesi
Name:Ptgdr2
Synonyms:Crth2, Gpr44
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311986. Ptgdr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 71CytoplasmicSequence analysisAdd BLAST16
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 104ExtracellularSequence analysisAdd BLAST12
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 147CytoplasmicSequence analysisAdd BLAST22
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 209ExtracellularSequence analysisAdd BLAST41
Transmembranei210 – 230Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini231 – 245CytoplasmicSequence analysisAdd BLAST15
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 284ExtracellularSequence analysisAdd BLAST18
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 403CytoplasmicSequence analysisAdd BLAST98

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075112.
GuidetoPHARMACOLOGYi339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004159261 – 403Prostaglandin D2 receptor 2Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi103 ↔ 198PROSITE-ProRule annotation
Modified residuei330PhosphoserineCombined sources1
Modified residuei349PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6XKD3.

PTM databases

iPTMnetiQ6XKD3.
PhosphoSitePlusiQ6XKD3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000036631.
GenevisibleiQ6XKD3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066082.

Chemistry databases

BindingDBiQ6XKD3.

Structurei

3D structure databases

ProteinModelPortaliQ6XKD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 332Involved in the recycling of CRTH2By similarity4

Domaini

The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-351 is a major site for PKC-induced internalization of the receptor (By similarity).By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV6V. Eukaryota.
ENOG410YAX7. LUCA.
GeneTreeiENSGT00760000118990.
HOVERGENiHBG099857.
InParanoidiQ6XKD3.
KOiK06715.
OMAiGCRMRQT.
OrthoDBiEOG091G0FTA.
PhylomeDBiQ6XKD3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XKD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANITLKPLC PLLEEMVQLP NHSNSSLRYI DHVSVLLHGL ASLLGLVENG
60 70 80 90 100
LILFVVGCRM RQTVVTTWVL HLALSDLLAA ASLPFFTYFL AVGHSWELGT
110 120 130 140 150
TFCKLHSSVF FLNMFASGFL LSAISLDRCL QVVRPVWAQN HRTVAAAHRV
160 170 180 190 200
CLMLWALAVL NTVPYFVFRD TIPRRDGRIM CYYNMLLLNP GSDRDTTCDY
210 220 230 240 250
RQKALAVSKF LLAFMVPLAI IASSHVAVSL QLHHRGRQRT GRFVRLVAAI
260 270 280 290 300
VVAFILCWGP YHIFSLLEAR AHSVTTLRQL ASRGLPFVTS LAFFNSVVNP
310 320 330 340 350
LLYVLTCPDM LHKLRRSLLT VLESVLVEDS DLSTGPGKRC RRRHRRRASS
360 370 380 390 400
TTTPASTLLL ADRFPQLRPA RLIGWMRRGS AELPRRVREQ SQEKQGSLSC

TLD
Length:403
Mass (Da):45,316
Last modified:July 5, 2004 - v1
Checksum:iA89A0125DCB29885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228550 mRNA. Translation: AAP57088.1.
CH473953 Genomic DNA. Translation: EDM12854.1.
RefSeqiNP_001012070.1. NM_001012070.1.
XP_006231102.1. XM_006231040.3.
XP_008758453.1. XM_008760231.2.
XP_017444751.1. XM_017589262.1.
XP_017444752.1. XM_017589263.1.
XP_017444753.1. XM_017589264.1.
UniGeneiRn.198542.

Genome annotation databases

EnsembliENSRNOT00000054808; ENSRNOP00000066082; ENSRNOG00000036631.
GeneIDi309212.
KEGGirno:309212.
UCSCiRGD:1311986. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228550 mRNA. Translation: AAP57088.1.
CH473953 Genomic DNA. Translation: EDM12854.1.
RefSeqiNP_001012070.1. NM_001012070.1.
XP_006231102.1. XM_006231040.3.
XP_008758453.1. XM_008760231.2.
XP_017444751.1. XM_017589262.1.
XP_017444752.1. XM_017589263.1.
XP_017444753.1. XM_017589264.1.
UniGeneiRn.198542.

3D structure databases

ProteinModelPortaliQ6XKD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066082.

Chemistry databases

BindingDBiQ6XKD3.
ChEMBLiCHEMBL1075112.
GuidetoPHARMACOLOGYi339.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6XKD3.
PhosphoSitePlusiQ6XKD3.

Proteomic databases

PaxDbiQ6XKD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054808; ENSRNOP00000066082; ENSRNOG00000036631.
GeneIDi309212.
KEGGirno:309212.
UCSCiRGD:1311986. rat.

Organism-specific databases

CTDi11251.
RGDi1311986. Ptgdr2.

Phylogenomic databases

eggNOGiENOG410IV6V. Eukaryota.
ENOG410YAX7. LUCA.
GeneTreeiENSGT00760000118990.
HOVERGENiHBG099857.
InParanoidiQ6XKD3.
KOiK06715.
OMAiGCRMRQT.
OrthoDBiEOG091G0FTA.
PhylomeDBiQ6XKD3.

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ6XKD3.

Gene expression databases

BgeeiENSRNOG00000036631.
GenevisibleiQ6XKD3. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPD2R2_RAT
AccessioniPrimary (citable) accession number: Q6XKD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.