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Protein

Prostaglandin D2 receptor 2

Gene

Ptgdr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor 2
Alternative name(s):
G protein-coupled receptor 44
Gene namesi
Name:Ptgdr2
Synonyms:Crth2, Gpr44
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311986. Ptgdr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini56 – 7116CytoplasmicSequence analysisAdd
BLAST
Transmembranei72 – 9221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini93 – 10412ExtracellularSequence analysisAdd
BLAST
Transmembranei105 – 12521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini126 – 14722CytoplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 20941ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini231 – 24515CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 28418ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini306 – 40398CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075112.
GuidetoPHARMACOLOGYi339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Prostaglandin D2 receptor 2PRO_0000415926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi103 ↔ 198PROSITE-ProRule annotation
Modified residuei330 – 3301PhosphoserineCombined sources
Modified residuei349 – 3491PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6XKD3.

Expressioni

Gene expression databases

GenevisibleiQ6XKD3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066082.

Chemistry

BindingDBiQ6XKD3.

Structurei

3D structure databases

ProteinModelPortaliQ6XKD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi329 – 3324Involved in the recycling of CRTH2By similarity

Domaini

The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for ADRBK1/GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-351 is a major site for PKC-induced internalization of the receptor (By similarity).By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV6V. Eukaryota.
ENOG410YAX7. LUCA.
GeneTreeiENSGT00760000118990.
HOVERGENiHBG099857.
InParanoidiQ6XKD3.
KOiK06715.
OMAiGCRMRQT.
OrthoDBiEOG71RXKP.
PhylomeDBiQ6XKD3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XKD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANITLKPLC PLLEEMVQLP NHSNSSLRYI DHVSVLLHGL ASLLGLVENG
60 70 80 90 100
LILFVVGCRM RQTVVTTWVL HLALSDLLAA ASLPFFTYFL AVGHSWELGT
110 120 130 140 150
TFCKLHSSVF FLNMFASGFL LSAISLDRCL QVVRPVWAQN HRTVAAAHRV
160 170 180 190 200
CLMLWALAVL NTVPYFVFRD TIPRRDGRIM CYYNMLLLNP GSDRDTTCDY
210 220 230 240 250
RQKALAVSKF LLAFMVPLAI IASSHVAVSL QLHHRGRQRT GRFVRLVAAI
260 270 280 290 300
VVAFILCWGP YHIFSLLEAR AHSVTTLRQL ASRGLPFVTS LAFFNSVVNP
310 320 330 340 350
LLYVLTCPDM LHKLRRSLLT VLESVLVEDS DLSTGPGKRC RRRHRRRASS
360 370 380 390 400
TTTPASTLLL ADRFPQLRPA RLIGWMRRGS AELPRRVREQ SQEKQGSLSC

TLD
Length:403
Mass (Da):45,316
Last modified:July 5, 2004 - v1
Checksum:iA89A0125DCB29885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228550 mRNA. Translation: AAP57088.1.
CH473953 Genomic DNA. Translation: EDM12854.1.
RefSeqiNP_001012070.1. NM_001012070.1.
XP_006231102.1. XM_006231040.2.
XP_008758453.1. XM_008760231.1.
UniGeneiRn.198542.

Genome annotation databases

EnsembliENSRNOT00000054808; ENSRNOP00000066082; ENSRNOG00000036631.
GeneIDi309212.
KEGGirno:309212.
UCSCiRGD:1311986. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228550 mRNA. Translation: AAP57088.1.
CH473953 Genomic DNA. Translation: EDM12854.1.
RefSeqiNP_001012070.1. NM_001012070.1.
XP_006231102.1. XM_006231040.2.
XP_008758453.1. XM_008760231.1.
UniGeneiRn.198542.

3D structure databases

ProteinModelPortaliQ6XKD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066082.

Chemistry

BindingDBiQ6XKD3.
ChEMBLiCHEMBL1075112.
GuidetoPHARMACOLOGYi339.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ6XKD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054808; ENSRNOP00000066082; ENSRNOG00000036631.
GeneIDi309212.
KEGGirno:309212.
UCSCiRGD:1311986. rat.

Organism-specific databases

CTDi11251.
RGDi1311986. Ptgdr2.

Phylogenomic databases

eggNOGiENOG410IV6V. Eukaryota.
ENOG410YAX7. LUCA.
GeneTreeiENSGT00760000118990.
HOVERGENiHBG099857.
InParanoidiQ6XKD3.
KOiK06715.
OMAiGCRMRQT.
OrthoDBiEOG71RXKP.
PhylomeDBiQ6XKD3.

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi660444.
PROiQ6XKD3.

Gene expression databases

GenevisibleiQ6XKD3. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of rat CRTH2."
    Encinas J.A., Inbe H., Sugimoto H., Bacon K.B.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPD2R2_RAT
AccessioniPrimary (citable) accession number: Q6XKD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.