Q6XI71 (NDKA_DROYA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoside diphosphate kinase
Short name=NDK
Short name=NDP kinase
EC=2.7.4.6

Alternative name(s):
Abnormal wing disks protein

Gene names

Name:

awd

Organism

Drosophila yakuba (Fruit fly)

Taxonomic identifier

7245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	150 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity. UniProtKB P08879
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. UniProtKB P08879
Cofactor	Magnesium By similarity. UniProtKB P08879
Subunit structure	Homohexamer By similarity. UniProtKB P08879
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	nuclear microtubule Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB magnesium ion binding Inferred from sequence or structural similarity. Source: UniProtKB nucleoside diphosphate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 150	›150	Nucleoside diphosphate kinase		PRO_0000137109
Sites
	Active site	116	1	Pros-phosphohistidine intermediate By similarity UniProtKB P08879
	Binding site	10	1	ATP By similarity UniProtKB P08879
	Binding site	58	1	ATP By similarity UniProtKB P08879
	Binding site	86	1	ATP By similarity UniProtKB P08879
	Binding site	92	1	ATP By similarity UniProtKB P08879
	Binding site	103	1	ATP By similarity UniProtKB P08879
	Binding site	113	1	ATP By similarity UniProtKB P08879
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q6XI71 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 623C4DF0EA047AFA	FASTA	150	16,897
	10 20 30 40 50 60 NKERTFIMVK PDGVQRGLVG KIIERFEQKG FKLVALKFTW ASKELLEKHY ADLSARPFFP 70 80 90 100 110 120 GLVNYMNSGP VVPMVWEGLN VVKTGRQMLG ATNPADSLPG TIRGDFCIQV GRNIIHGSDA 130 140 150 VESAEKEIAL WFNEKELVTW TPAAKDWIYE

References

[1]	"An evolutionary analysis of orphan genes in Drosophila." Domazet-Loso T., Tautz D. Genome Res. 13:2213-2219(2003) [PubMed: 14525923] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY231961 mRNA. Translation: AAR09984.1.
3D structure databases
ProteinModelPortal	Q6XI71.
SMR	Q6XI71. Positions 1-150.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6XI71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0067997. Dyak\awd.
Phylogenomic databases
GeneTree	EMGT00050000005753.
OrthoDB	EOG4XGXG7.
Family and domain databases
InterPro	IPR001564. Nucleoside_diP_kinase. IPR023005. Nucleoside_diP_kinase_AS. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00562. NDK. 1 hit. [Graphical view]
SUPFAM	SSF54919. NDK. 1 hit.
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDKA_DROYA

Accession

Primary (citable) accession number: Q6XI71

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project