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Protein

Probable serine/threonine-protein kinase roco4

Gene

roco4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1055 – 10551ATPPROSITE-ProRule annotation
Active sitei1154 – 11541Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi377 – 3848GTPPROSITE-ProRule annotation
Nucleotide bindingi428 – 4325GTPPROSITE-ProRule annotation
Nucleotide bindingi487 – 4904GTPPROSITE-ProRule annotation
Nucleotide bindingi1032 – 10409ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • slug development involved in sorocarp development Source: dictyBase
  • small GTPase mediated signal transduction Source: InterPro
  • sorocarp stalk development Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase roco4 (EC:2.7.11.1)
Alternative name(s):
Ras of complex proteins and C-terminal of roc 4
Gene namesi
Name:roco4
ORF Names:DDB_G0288251
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288251. roco4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17261726Probable serine/threonine-protein kinase roco4PRO_0000355209Add
BLAST

Proteomic databases

PaxDbiQ6XHB2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0191509.

Structurei

Secondary structure

1
1726
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni1023 – 10253Combined sources
Beta strandi1026 – 10349Combined sources
Beta strandi1036 – 104510Combined sources
Turni1046 – 10483Combined sources
Beta strandi1051 – 10566Combined sources
Turni1061 – 10633Combined sources
Helixi1067 – 108216Combined sources
Beta strandi1093 – 10975Combined sources
Turni1098 – 11014Combined sources
Beta strandi1102 – 11054Combined sources
Helixi1113 – 11175Combined sources
Helixi1126 – 114419Combined sources
Beta strandi1146 – 11483Combined sources
Helixi1157 – 11593Combined sources
Beta strandi1160 – 11634Combined sources
Beta strandi1173 – 11753Combined sources
Beta strandi1182 – 11854Combined sources
Turni1195 – 11973Combined sources
Helixi1200 – 12034Combined sources
Beta strandi1204 – 12063Combined sources
Helixi1207 – 12093Combined sources
Helixi1213 – 122816Combined sources
Turni1232 – 12354Combined sources
Helixi1240 – 124910Combined sources
Helixi1262 – 127110Combined sources
Helixi1276 – 12783Combined sources
Helixi1282 – 12909Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F0FX-ray1.80A1019-1292[»]
4F0GX-ray2.00A1019-1292[»]
4F1MX-ray2.04A1019-1292[»]
4F1OX-ray2.30A1019-1292[»]
4F1TX-ray2.30A1019-1292[»]
4YZMX-ray3.00A/B1019-1292[»]
4YZNX-ray1.55A1019-1292[»]
ProteinModelPortaliQ6XHB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati256 – 27722LRR 1Add
BLAST
Repeati280 – 30122LRR 2Add
BLAST
Repeati303 – 32422LRR 3Add
BLAST
Repeati326 – 34722LRR 4Add
BLAST
Domaini364 – 544181RocPROSITE-ProRule annotationAdd
BLAST
Domaini1026 – 1292267Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati1422 – 146140WD 1Add
BLAST
Repeati1463 – 150240WD 2Add
BLAST
Repeati1506 – 154641WD 3Add
BLAST
Repeati1589 – 162739WD 4Add
BLAST
Repeati1633 – 167038WD 5Add
BLAST
Repeati1674 – 171441WD 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi394 – 3974Poly-Lys
Compositional biasi802 – 81211Poly-GlnAdd
BLAST
Compositional biasi823 – 83614Poly-AsnAdd
BLAST
Compositional biasi840 – 8456Poly-Ser
Compositional biasi1332 – 134817Poly-AsnAdd
BLAST
Compositional biasi1365 – 13739Poly-Thr

Sequence similaritiesi

Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Roc domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IT5J. Eukaryota.
COG1100. LUCA.
InParanoidiQ6XHB2.
OMAiINMIREE.
PhylomeDBiQ6XHB2.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032171. COR.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020635. Tyr_kinase_cat_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16095. COR. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF08477. Roc. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00219. TyrKc. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS51424. ROC. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XHB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSQQLQES QQLQQQYTRV GIDVIGPMKD LIISVMNSLD TTFKIINETY
60 70 80 90 100
RIVYFDTDET KLTSSNLDSD DEEFESDDDA DEEADLQIQA SCNLYTFDGK
110 120 130 140 150
NRQSVDEIKR IVQHLNETQS QQNDNQAVPV IPTFFVVVNI GVGPSFVSEI
160 170 180 190 200
KSAAGTTQFI EWIVNDQASK EVFKVSTNLL SHHKKQIELT HACTVGDVNY
210 220 230 240 250
LDQIILSGVS TDQLKEAHKA GHAIVFDSLL THNSNSLVVT GTMALLGAIV
260 270 280 290 300
ENGDRKGKRL SLSRSNLSRF PMSITQMCTH LVELDLSDNK ITELPKDIQL
310 320 330 340 350
LKSLRILILR GNLLEDIPLE ICYLGDLKIL ELQENPLNNF PLSVVQSGTK
360 370 380 390 400
NLLLFCKNIL ERKKSETWNK VKLMFVGQEG VGKTSLCQAL KGSKKKKAEL
410 420 430 440 450
QVTGDTVSTE GVKIQNIKNK KVEFHAWDFG GQQVFYPTHQ FFLTTHALYL
460 470 480 490 500
VVFKLTDPNF AERVNYWVRQ VKSNSSGAVP AIFLVGTHSD VCTPEQLQEA
510 520 530 540 550
ESILKANFVK YSRVKENTIN FVCCATGKGI KELKKRLIHE AEKSHLIKKD
560 570 580 590 600
IPGNYMVLEA RLTNRGANPG RMAVSGSPIG GGSSAQLSSN AINSQKERYI
610 620 630 640 650
DYDDYMNECK LSHLQPEEIK GATDFLHNLG IILHFDTPTL KNLVVLDPQW
660 670 680 690 700
LADVMSSLIT FSHNWIKRGI LNHSELVAVW GGKYDQSLWP LLLKLLEKFE
710 720 730 740 750
VSYELPNIAK SLIPSLLPED AEGEISTIKD REWVTLPQAI ESGRCQVFGC
760 770 780 790 800
DYNFDFMPLG FFARLLLRIL LISGVEVRTY WRNGVLLDIL TPEQVKLQQS
810 820 830 840 850
KQQQLQQQQQ QQNNNESNDS SVNNNNNNNN NNNNNNIINS SSSSSLNLTQ
860 870 880 890 900
TSTSTSPSKL SLNNSQINNS NSTLNSQQLI NPSVSPLSST TPRHQALITF
910 920 930 940 950
IKKKSFESKD KDSYKLNIEV RSFNTTIEKD HSASLFFQQI LFTIDTLLAS
960 970 980 990 1000
SYVGLEITRM IPCIHCVQKN PRADPYYFDF SSCISALQDG KPHLFCRNDP
1010 1020 1030 1040 1050
SIPVRIDYIA PDLCLKKVPT LADNEIEYEK QIGKGGFGLV HKGRLVKDKS
1060 1070 1080 1090 1100
VVAIKSLILG DSEGETEMIE KFQEFQREVF IMSNLNHPNI VKLYGLMHNP
1110 1120 1130 1140 1150
PRMVMEFVPC GDLYHRLLDK AHPIKWSVKL RLMLDIALGI EYMQNQNPPI
1160 1170 1180 1190 1200
VHRDLRSPNI FLQSLDENAP VCAKVADFGL SQQSVHSVSG LLGNFQWMAP
1210 1220 1230 1240 1250
ETIGAEEESY TEKADTYSFA MILYTILTGE GPFDEYSYGK IKFINMIREE
1260 1270 1280 1290 1300
GLRPTIPEDC PPRLRNVIEL CWSGDPKKRP HFSYIVKELS ELRNGNTTST
1310 1320 1330 1340 1350
TTNTSSTTNN LNSANVSIAS TSSNADDGSQ TNNNNNNNNN NNNNNNNNSG
1360 1370 1380 1390 1400
SSIALSPSRS FEQQTTTTTT TTTSPSSPST SFINSSGSYN TESYSVASSS
1410 1420 1430 1440 1450
TTNLLNTLNN ANQPVNFIGT ASVHKKMEVL AGVEAGETVW TKSADSSLCF
1460 1470 1480 1490 1500
WSTKKGHLIN ELKCPHTVAT TMMIKVGKYI WEATNSNGIY IWDMGTMTIV
1510 1520 1530 1540 1550
QQLTTPHKGD VCLHFVEYGD NNGVWSGGSE GTVCLWDMQT FEKKHSFSLE
1560 1570 1580 1590 1600
SAITAMSYFG NNTLYIASGS HIVVFKTKTL LMNVNQNWKH STGSITSILA
1610 1620 1630 1640 1650
MKDEVWSGGS DGRIYIWKVK NEFELQKVQS LEAHHEKITS LIHLEDNVLS
1660 1670 1680 1690 1700
GSTDKCISLF KISDPKKPFT TQEHHKQGVT SIVKVQSHIV WAITSDTTTP
1710 1720
LVLWNIPQKW EKKTANGILP RLKFFR
Length:1,726
Mass (Da):193,282
Last modified:July 5, 2004 - v1
Checksum:i4F757B2BF814FC4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY232266 Genomic DNA. Translation: AAO83649.1.
AAFI02000109 Genomic DNA. Translation: EAL63307.1.
RefSeqiXP_636808.1. XM_631716.1.

Genome annotation databases

EnsemblProtistsiDDB0191509; DDB0191509; DDB_G0288251.
GeneIDi8626525.
KEGGiddi:DDB_G0288251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY232266 Genomic DNA. Translation: AAO83649.1.
AAFI02000109 Genomic DNA. Translation: EAL63307.1.
RefSeqiXP_636808.1. XM_631716.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F0FX-ray1.80A1019-1292[»]
4F0GX-ray2.00A1019-1292[»]
4F1MX-ray2.04A1019-1292[»]
4F1OX-ray2.30A1019-1292[»]
4F1TX-ray2.30A1019-1292[»]
4YZMX-ray3.00A/B1019-1292[»]
4YZNX-ray1.55A1019-1292[»]
ProteinModelPortaliQ6XHB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191509.

Proteomic databases

PaxDbiQ6XHB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0191509; DDB0191509; DDB_G0288251.
GeneIDi8626525.
KEGGiddi:DDB_G0288251.

Organism-specific databases

dictyBaseiDDB_G0288251. roco4.

Phylogenomic databases

eggNOGiENOG410IT5J. Eukaryota.
COG1100. LUCA.
InParanoidiQ6XHB2.
OMAiINMIREE.
PhylomeDBiQ6XHB2.

Miscellaneous databases

PROiQ6XHB2.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032171. COR.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020635. Tyr_kinase_cat_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16095. COR. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF08477. Roc. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00219. TyrKc. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS51424. ROC. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiROCO4_DICDI
AccessioniPrimary (citable) accession number: Q6XHB2
Secondary accession number(s): Q54J79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.