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Protein

Probable serine/threonine-protein kinase roco4

Gene

roco4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1055ATPPROSITE-ProRule annotation1
Active sitei1154Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi377 – 384GTPPROSITE-ProRule annotation8
Nucleotide bindingi428 – 432GTPPROSITE-ProRule annotation5
Nucleotide bindingi487 – 490GTPPROSITE-ProRule annotation4
Nucleotide bindingi1032 – 1040ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • slug development involved in sorocarp development Source: dictyBase
  • small GTPase mediated signal transduction Source: InterPro
  • sorocarp stalk development Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase roco4 (EC:2.7.11.1)
Alternative name(s):
Ras of complex proteins and C-terminal of roc 4
Gene namesi
Name:roco4
ORF Names:DDB_G0288251
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288251. roco4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003552091 – 1726Probable serine/threonine-protein kinase roco4Add BLAST1726

Proteomic databases

PaxDbiQ6XHB2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0191509.

Structurei

Secondary structure

11726
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni1023 – 1025Combined sources3
Beta strandi1026 – 1034Combined sources9
Beta strandi1036 – 1045Combined sources10
Turni1046 – 1048Combined sources3
Beta strandi1051 – 1056Combined sources6
Turni1061 – 1063Combined sources3
Helixi1067 – 1082Combined sources16
Beta strandi1093 – 1097Combined sources5
Turni1098 – 1101Combined sources4
Beta strandi1102 – 1105Combined sources4
Helixi1113 – 1117Combined sources5
Helixi1126 – 1144Combined sources19
Beta strandi1146 – 1148Combined sources3
Helixi1157 – 1159Combined sources3
Beta strandi1160 – 1163Combined sources4
Beta strandi1173 – 1175Combined sources3
Beta strandi1182 – 1185Combined sources4
Turni1195 – 1197Combined sources3
Helixi1200 – 1203Combined sources4
Beta strandi1204 – 1206Combined sources3
Helixi1207 – 1209Combined sources3
Helixi1213 – 1228Combined sources16
Turni1232 – 1235Combined sources4
Helixi1240 – 1249Combined sources10
Helixi1262 – 1271Combined sources10
Helixi1276 – 1278Combined sources3
Helixi1282 – 1290Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F0FX-ray1.80A1019-1292[»]
4F0GX-ray2.00A1019-1292[»]
4F1MX-ray2.04A1019-1292[»]
4F1OX-ray2.30A1019-1292[»]
4F1TX-ray2.30A1019-1292[»]
4YZMX-ray3.00A/B1019-1292[»]
4YZNX-ray1.55A1019-1292[»]
ProteinModelPortaliQ6XHB2.
SMRiQ6XHB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati256 – 277LRR 1Add BLAST22
Repeati280 – 301LRR 2Add BLAST22
Repeati303 – 324LRR 3Add BLAST22
Repeati326 – 347LRR 4Add BLAST22
Domaini364 – 544RocPROSITE-ProRule annotationAdd BLAST181
Domaini1026 – 1292Protein kinasePROSITE-ProRule annotationAdd BLAST267
Repeati1422 – 1461WD 1Add BLAST40
Repeati1463 – 1502WD 2Add BLAST40
Repeati1506 – 1546WD 3Add BLAST41
Repeati1589 – 1627WD 4Add BLAST39
Repeati1633 – 1670WD 5Add BLAST38
Repeati1674 – 1714WD 6Add BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi394 – 397Poly-Lys4
Compositional biasi802 – 812Poly-GlnAdd BLAST11
Compositional biasi823 – 836Poly-AsnAdd BLAST14
Compositional biasi840 – 845Poly-Ser6
Compositional biasi1332 – 1348Poly-AsnAdd BLAST17
Compositional biasi1365 – 1373Poly-Thr9

Sequence similaritiesi

Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Roc domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IT5J. Eukaryota.
COG1100. LUCA.
InParanoidiQ6XHB2.
OMAiINMIREE.
PhylomeDBiQ6XHB2.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032171. COR.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020635. Tyr_kinase_cat_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16095. COR. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF08477. Roc. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00219. TyrKc. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS51424. ROC. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XHB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSQQLQES QQLQQQYTRV GIDVIGPMKD LIISVMNSLD TTFKIINETY
60 70 80 90 100
RIVYFDTDET KLTSSNLDSD DEEFESDDDA DEEADLQIQA SCNLYTFDGK
110 120 130 140 150
NRQSVDEIKR IVQHLNETQS QQNDNQAVPV IPTFFVVVNI GVGPSFVSEI
160 170 180 190 200
KSAAGTTQFI EWIVNDQASK EVFKVSTNLL SHHKKQIELT HACTVGDVNY
210 220 230 240 250
LDQIILSGVS TDQLKEAHKA GHAIVFDSLL THNSNSLVVT GTMALLGAIV
260 270 280 290 300
ENGDRKGKRL SLSRSNLSRF PMSITQMCTH LVELDLSDNK ITELPKDIQL
310 320 330 340 350
LKSLRILILR GNLLEDIPLE ICYLGDLKIL ELQENPLNNF PLSVVQSGTK
360 370 380 390 400
NLLLFCKNIL ERKKSETWNK VKLMFVGQEG VGKTSLCQAL KGSKKKKAEL
410 420 430 440 450
QVTGDTVSTE GVKIQNIKNK KVEFHAWDFG GQQVFYPTHQ FFLTTHALYL
460 470 480 490 500
VVFKLTDPNF AERVNYWVRQ VKSNSSGAVP AIFLVGTHSD VCTPEQLQEA
510 520 530 540 550
ESILKANFVK YSRVKENTIN FVCCATGKGI KELKKRLIHE AEKSHLIKKD
560 570 580 590 600
IPGNYMVLEA RLTNRGANPG RMAVSGSPIG GGSSAQLSSN AINSQKERYI
610 620 630 640 650
DYDDYMNECK LSHLQPEEIK GATDFLHNLG IILHFDTPTL KNLVVLDPQW
660 670 680 690 700
LADVMSSLIT FSHNWIKRGI LNHSELVAVW GGKYDQSLWP LLLKLLEKFE
710 720 730 740 750
VSYELPNIAK SLIPSLLPED AEGEISTIKD REWVTLPQAI ESGRCQVFGC
760 770 780 790 800
DYNFDFMPLG FFARLLLRIL LISGVEVRTY WRNGVLLDIL TPEQVKLQQS
810 820 830 840 850
KQQQLQQQQQ QQNNNESNDS SVNNNNNNNN NNNNNNIINS SSSSSLNLTQ
860 870 880 890 900
TSTSTSPSKL SLNNSQINNS NSTLNSQQLI NPSVSPLSST TPRHQALITF
910 920 930 940 950
IKKKSFESKD KDSYKLNIEV RSFNTTIEKD HSASLFFQQI LFTIDTLLAS
960 970 980 990 1000
SYVGLEITRM IPCIHCVQKN PRADPYYFDF SSCISALQDG KPHLFCRNDP
1010 1020 1030 1040 1050
SIPVRIDYIA PDLCLKKVPT LADNEIEYEK QIGKGGFGLV HKGRLVKDKS
1060 1070 1080 1090 1100
VVAIKSLILG DSEGETEMIE KFQEFQREVF IMSNLNHPNI VKLYGLMHNP
1110 1120 1130 1140 1150
PRMVMEFVPC GDLYHRLLDK AHPIKWSVKL RLMLDIALGI EYMQNQNPPI
1160 1170 1180 1190 1200
VHRDLRSPNI FLQSLDENAP VCAKVADFGL SQQSVHSVSG LLGNFQWMAP
1210 1220 1230 1240 1250
ETIGAEEESY TEKADTYSFA MILYTILTGE GPFDEYSYGK IKFINMIREE
1260 1270 1280 1290 1300
GLRPTIPEDC PPRLRNVIEL CWSGDPKKRP HFSYIVKELS ELRNGNTTST
1310 1320 1330 1340 1350
TTNTSSTTNN LNSANVSIAS TSSNADDGSQ TNNNNNNNNN NNNNNNNNSG
1360 1370 1380 1390 1400
SSIALSPSRS FEQQTTTTTT TTTSPSSPST SFINSSGSYN TESYSVASSS
1410 1420 1430 1440 1450
TTNLLNTLNN ANQPVNFIGT ASVHKKMEVL AGVEAGETVW TKSADSSLCF
1460 1470 1480 1490 1500
WSTKKGHLIN ELKCPHTVAT TMMIKVGKYI WEATNSNGIY IWDMGTMTIV
1510 1520 1530 1540 1550
QQLTTPHKGD VCLHFVEYGD NNGVWSGGSE GTVCLWDMQT FEKKHSFSLE
1560 1570 1580 1590 1600
SAITAMSYFG NNTLYIASGS HIVVFKTKTL LMNVNQNWKH STGSITSILA
1610 1620 1630 1640 1650
MKDEVWSGGS DGRIYIWKVK NEFELQKVQS LEAHHEKITS LIHLEDNVLS
1660 1670 1680 1690 1700
GSTDKCISLF KISDPKKPFT TQEHHKQGVT SIVKVQSHIV WAITSDTTTP
1710 1720
LVLWNIPQKW EKKTANGILP RLKFFR
Length:1,726
Mass (Da):193,282
Last modified:July 5, 2004 - v1
Checksum:i4F757B2BF814FC4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY232266 Genomic DNA. Translation: AAO83649.1.
AAFI02000109 Genomic DNA. Translation: EAL63307.1.
RefSeqiXP_636808.1. XM_631716.1.

Genome annotation databases

EnsemblProtistsiEAL63307; EAL63307; DDB_G0288251.
GeneIDi8626525.
KEGGiddi:DDB_G0288251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY232266 Genomic DNA. Translation: AAO83649.1.
AAFI02000109 Genomic DNA. Translation: EAL63307.1.
RefSeqiXP_636808.1. XM_631716.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F0FX-ray1.80A1019-1292[»]
4F0GX-ray2.00A1019-1292[»]
4F1MX-ray2.04A1019-1292[»]
4F1OX-ray2.30A1019-1292[»]
4F1TX-ray2.30A1019-1292[»]
4YZMX-ray3.00A/B1019-1292[»]
4YZNX-ray1.55A1019-1292[»]
ProteinModelPortaliQ6XHB2.
SMRiQ6XHB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191509.

Proteomic databases

PaxDbiQ6XHB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL63307; EAL63307; DDB_G0288251.
GeneIDi8626525.
KEGGiddi:DDB_G0288251.

Organism-specific databases

dictyBaseiDDB_G0288251. roco4.

Phylogenomic databases

eggNOGiENOG410IT5J. Eukaryota.
COG1100. LUCA.
InParanoidiQ6XHB2.
OMAiINMIREE.
PhylomeDBiQ6XHB2.

Miscellaneous databases

PROiQ6XHB2.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032171. COR.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020635. Tyr_kinase_cat_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16095. COR. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF08477. Roc. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00219. TyrKc. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS51424. ROC. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROCO4_DICDI
AccessioniPrimary (citable) accession number: Q6XHB2
Secondary accession number(s): Q54J79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.