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Protein

Glycophorin-C

Gene

Gypc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-C
Alternative name(s):
CD_antigen: CD236
Gene namesi
Name:Gypc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1310295. Gypc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini47 – 9549CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9595Glycophorin-CPRO_0000378455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711PhosphoserineBy similarity
Modified residuei78 – 781PhosphoserineCombined sources
Modified residuei89 – 891PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6XFR6.
PRIDEiQ6XFR6.

Expressioni

Gene expression databases

GenevisibleiQ6XFR6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049537.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2G2. Eukaryota.
ENOG410YT9G. LUCA.
GeneTreeiENSGT00510000049102.
HOGENOMiHOG000112742.
InParanoidiQ6XFR6.
KOiK06576.
OMAiHTNEDKG.
OrthoDBiEOG7VDXSF.
PhylomeDBiQ6XFR6.
TreeFamiTF337016.

Family and domain databases

InterProiIPR003585. Neurexin-like.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XFR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPVRTPPP ERLEPNPGMS YAVMEIAIIA AVITAVALVL VCLLFLMLRY
60 70 80 90
LYRHKGTYYT NEAKGTEFAE SADAALQSDP ALQDAGDTSK KEYFI
Length:95
Mass (Da):10,443
Last modified:July 5, 2004 - v1
Checksum:i6917EF24507EC340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234182 mRNA. Translation: AAP70023.1.
CH473974 Genomic DNA. Translation: EDL76190.1.
BC103641 mRNA. Translation: AAI03642.1.
RefSeqiNP_001013251.1. NM_001013233.1.
UniGeneiRn.7693.

Genome annotation databases

EnsembliENSRNOT00000046369; ENSRNOP00000049537; ENSRNOG00000029939.
GeneIDi364837.
KEGGirno:364837.
UCSCiRGD:1310295. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234182 mRNA. Translation: AAP70023.1.
CH473974 Genomic DNA. Translation: EDL76190.1.
BC103641 mRNA. Translation: AAI03642.1.
RefSeqiNP_001013251.1. NM_001013233.1.
UniGeneiRn.7693.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049537.

Proteomic databases

PaxDbiQ6XFR6.
PRIDEiQ6XFR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046369; ENSRNOP00000049537; ENSRNOG00000029939.
GeneIDi364837.
KEGGirno:364837.
UCSCiRGD:1310295. rat.

Organism-specific databases

CTDi2995.
RGDi1310295. Gypc.

Phylogenomic databases

eggNOGiENOG410J2G2. Eukaryota.
ENOG410YT9G. LUCA.
GeneTreeiENSGT00510000049102.
HOGENOMiHOG000112742.
InParanoidiQ6XFR6.
KOiK06576.
OMAiHTNEDKG.
OrthoDBiEOG7VDXSF.
PhylomeDBiQ6XFR6.
TreeFamiTF337016.

Miscellaneous databases

NextBioi686150.
PROiQ6XFR6.

Gene expression databases

GenevisibleiQ6XFR6. RN.

Family and domain databases

InterProiIPR003585. Neurexin-like.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and evolution of glycophorin C (GPC) proteins."
    Chen Y., Peng J., Huang C.-H.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGLPC_RAT
AccessioniPrimary (citable) accession number: Q6XFR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.