Reviewed, UniProtKB/Swiss-Prot Q6XE38 (SG1D4_HUMAN)

Names and origin

Protein names

Recommended name:
    Secretoglobin family 1D member 4
Alternative name(s):
    IFN-gamma-inducible secretoglobin
      Short name=IIS

Gene names

Name:	SCGB1D4
ORF Names:	UNQ517/PRO812

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	83 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to be involved in the regulation of chemotactic cell migration and invasion.
Subcellular location	Secreted.
Tissue specificity	Expressed in all tissues; the highest level of expression is detectable in lymph nodes, tonsil, cultured lymphoblasts and ovary. Ref.1
Induction	By interferon gamma. Ref.1
Sequence similarities	Belongs to the secretoglobin family. Lipophilin subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.5
	Chain	22 – 83	62	Secretoglobin family 1D member 4		PRO_0000036380

Sequences

	Sequence		Length	Mass (Da)
	Q6XE38-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E6FD7DB7C757A202	FASTA	83	9,201
	10 20 30 40 50 60 MRLSVCLLMV SLALCCYQAH ALVCPAVASE ITVFLFLSDA AVNLQVAKLN PPPEALAAKL 70 80 EVKHCTDQIS FKKRLSLKKS WWK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IFN-gamma stimulates the expression of a novel secretoglobin that regulates chemotactic cell migration and invasion." Choi M.S., Ray R., Zhang Z., Mukherjee A.B. J. Immunol. 172:4245-4252(2004) [PubMed: 15034037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-35.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY236538 mRNA. Translation: AAP69948.1. AY359052 mRNA. Translation: AAQ89411.1. CH471076 Genomic DNA. Translation: EAW74011.1. BC130639 mRNA. Translation: AAI30640.1. BC130645 mRNA. Translation: AAI30646.1.
IPI	IPI00410158.
RefSeq	NP_996881.1.
UniGene	Hs.473247
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000358585; ENSP00000351395; ENSG00000197745; Homo sapiens. [Genome view]
GeneID	404552.
KEGG	hsa:404552.
UCSC	uc001ntd.1. human.
Organism-specific databases
CTD	404552.
GeneCards	GC11M061820.
H-InvDB	HIX0035935.
HGNC	HGNC:31748. SCGB1D4.
PharmGKB	PA142670946.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG099485.
HOVERGEN	Q6XE38.
InParanoid	Q6XE38.
OMA	KHCTDQI.
OrthoDB	EOG9J9QJW.
PhylomeDB	Q6XE38.
Gene expression databases
Bgee	Q6XE38.
CleanEx	HS_SCGB1D4.
Genevestigator	Q6XE38.
Family and domain databases
InterPro	IPR016126. Secretoglobin. IPR006038. Uteroglobin-like_superfam. [Graphical view]
Pfam	PF01099. Uteroglobin. 1 hit. [Graphical view]
PROSITE	PS51311. SCGB. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	107864.

Entry information

Entry name

SG1D4_HUMAN

Accession

Primary (citable) accession number: Q6XE38
Secondary accession number(s): A1L4Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	July 5, 2004
Last modified:	January 19, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.