ID RBMS3_HUMAN Reviewed; 437 AA. AC Q6XE24; B7ZL17; O75876; Q17RI0; Q6XE23; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 19-JAN-2010, entry version 52. DE RecName: Full=RNA-binding motif, single-stranded-interacting protein 3; GN Name=RBMS3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE RP SPECIFICITY, AND SUBCELLULAR LOCATION. RC TISSUE=Fibroblast; RX MEDLINE=20156366; PubMed=10675610; DOI=10.1016/S0378-1119(99)00515-6; RA Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S.; RT "Cloning of a human gene closely related to the genes coding for the RT c-myc single-strand binding proteins."; RL Gene 243:27-36(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). RA Lee Y.-H., Tokraks S., Bogardus C., Permana P.A.; RT "Cloning and characterization of novel alternatively spliced RT transcripts of RBMS3: skeletal muscle mRNA level correlates with whole RT body insulin resistance."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Binds poly(A) and poly(U) oligoribonucleotides. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; Synonyms=DD23-L; CC IsoId=Q6XE24-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6XE24-2; Sequence=VSP_022928, VSP_022930, VSP_022931; CC Name=3; Synonyms=DD23-S; CC IsoId=Q6XE24-3; Sequence=VSP_022927, VSP_022929; CC Name=4; CC IsoId=Q6XE24-4; Sequence=VSP_022930, VSP_022931; CC -!- TISSUE SPECIFICITY: Expressed in fetal brain, fetal lung, fetal CC liver, heart, brain, placenta, lung, liver, muscle, kidney and CC pancreas. CC -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. CC -!- SEQUENCE CAUTION: CC Sequence=AAC63910.1; Type=Frameshift; Positions=1; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF023259; AAC63910.1; ALT_FRAME; mRNA. DR EMBL; AY236871; AAP75555.1; -; mRNA. DR EMBL; AY236872; AAP75556.1; -; mRNA. DR EMBL; BC117315; AAI17316.1; -; mRNA. DR EMBL; BC143521; AAI43522.1; -; mRNA. DR IPI; IPI00298424; -. DR IPI; IPI00456051; -. DR IPI; IPI00472404; -. DR IPI; IPI00827856; -. DR RefSeq; NP_001003792.1; -. DR RefSeq; NP_001003793.1; -. DR RefSeq; NP_055298.2; -. DR UniGene; Hs.696468; -. DR HSSP; Q15434; 1X4E. DR SMR; Q6XE24; 54-224. DR STRING; Q6XE24; -. DR PhosphoSite; Q6XE24; -. DR PRIDE; Q6XE24; -. DR Ensembl; ENST00000383767; ENSP00000373277; ENSG00000144642; Homo sapiens. DR Ensembl; ENST00000396583; ENSP00000379828; ENSG00000144642; Homo sapiens. DR Ensembl; ENST00000456853; ENSP00000400519; ENSG00000144642; Homo sapiens. DR GeneID; 27303; -. DR KEGG; hsa:27303; -. DR UCSC; uc003cek.1; human. DR UCSC; uc003cel.1; human. DR UCSC; uc003cem.1; human. DR UCSC; uc010hfq.1; human. DR CTD; 27303; -. DR GeneCards; GC03P029298; -. DR HGNC; HGNC:13427; RBMS3. DR MIM; 605786; gene. DR PharmGKB; PA34276; -. DR eggNOG; prNOG10638; -. DR HOGENOM; HBG443668; -. DR HOVERGEN; Q6XE24; -. DR InParanoid; Q6XE24; -. DR OMA; LGTTGTX; -. DR NextBio; 50293; -. DR ArrayExpress; Q6XE24; -. DR Bgee; Q6XE24; -. DR CleanEx; HS_RBMS3; -. DR Genevestigator; Q6XE24; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR InterPro; IPR012677; a_b_plait_nuc_bd. DR InterPro; IPR002343; Hud_Sxl_RNA. DR InterPro; IPR000504; RRM_RNP1. DR Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 2. DR Pfam; PF00076; RRM_1; 2. DR PRINTS; PR00961; HUDSXLRNA. DR SMART; SM00360; RRM; 2. DR PROSITE; PS50102; RRM; 2. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Cytoplasm; Repeat; KW RNA-binding. FT CHAIN 1 437 RNA-binding motif, single-stranded- FT interacting protein 3. FT /FTId=PRO_0000274906. FT DOMAIN 61 134 RRM 1. FT DOMAIN 140 225 RRM 2. FT VAR_SEQ 26 26 Missing (in isoform 3). FT /FTId=VSP_022927. FT VAR_SEQ 247 247 G -> GEVLRGRTVPRQNR (in isoform 2). FT /FTId=VSP_022928. FT VAR_SEQ 297 313 Missing (in isoform 3). FT /FTId=VSP_022929. FT VAR_SEQ 351 366 Missing (in isoform 2 and isoform 4). FT /FTId=VSP_022930. FT VAR_SEQ 437 437 Missing (in isoform 2 and isoform 4). FT /FTId=VSP_022931. FT CONFLICT 93 93 I -> L (in Ref. 2; AAP75556). FT CONFLICT 165 165 H -> P (in Ref. 2; AAP75556). SQ SEQUENCE 437 AA; 47840 MW; 7EFC2ECFE24E323C CRC64; MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT IQSQDRIMIL HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS PQTVAPSSQD TSGQQQQIAV DTSNEHAPAY SYQQSKP //