ID RBMS3_HUMAN Reviewed; 437 AA. AC Q6XE24; A8K9S4; B7ZL17; G5E9J9; O75876; Q17RI0; Q6XE23; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 154. DE RecName: Full=RNA-binding motif, single-stranded-interacting protein 3; GN Name=RBMS3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE RP SPECIFICITY, AND SUBCELLULAR LOCATION. RC TISSUE=Fibroblast; RX PubMed=10675610; DOI=10.1016/s0378-1119(99)00515-6; RA Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S.; RT "Cloning of a human gene closely related to the genes coding for the c-myc RT single-strand binding proteins."; RL Gene 243:27-36(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). RA Lee Y.-H., Tokraks S., Bogardus C., Permana P.A.; RT "Cloning and characterization of novel alternatively spliced transcripts of RT RBMS3: skeletal muscle mRNA level correlates with whole body insulin RT resistance."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). RC TISSUE=Trachea; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Binds poly(A) and poly(U) oligoribonucleotides. CC {ECO:0000269|PubMed:10675610}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10675610}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; Synonyms=DD23-L; CC IsoId=Q6XE24-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6XE24-2; Sequence=VSP_022928, VSP_022930, VSP_022931; CC Name=3; Synonyms=DD23-S; CC IsoId=Q6XE24-3; Sequence=VSP_022927, VSP_022929; CC Name=4; CC IsoId=Q6XE24-4; Sequence=VSP_022930, VSP_022931; CC Name=5; CC IsoId=Q6XE24-5; Sequence=VSP_022930; CC -!- TISSUE SPECIFICITY: Expressed in fetal brain, fetal lung, fetal liver, CC heart, brain, placenta, lung, liver, muscle, kidney and pancreas. CC {ECO:0000269|PubMed:10675610}. CC -!- SEQUENCE CAUTION: CC Sequence=AAC63910.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF023259; AAC63910.1; ALT_FRAME; mRNA. DR EMBL; AY236871; AAP75555.1; -; mRNA. DR EMBL; AY236872; AAP75556.1; -; mRNA. DR EMBL; AK292789; BAF85478.1; -; mRNA. DR EMBL; AC012262; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC021068; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092795; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092796; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC097633; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC098650; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC099048; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471055; EAW64405.1; -; Genomic_DNA. DR EMBL; BC117315; AAI17316.1; -; mRNA. DR EMBL; BC143521; AAI43522.1; -; mRNA. DR CCDS; CCDS33724.1; -. [Q6XE24-1] DR CCDS; CCDS33725.1; -. [Q6XE24-3] DR CCDS; CCDS33726.1; -. [Q6XE24-4] DR CCDS; CCDS54557.1; -. [Q6XE24-2] DR CCDS; CCDS54558.1; -. [Q6XE24-5] DR RefSeq; NP_001003792.1; NM_001003792.2. [Q6XE24-3] DR RefSeq; NP_001003793.1; NM_001003793.2. [Q6XE24-1] DR RefSeq; NP_001171182.1; NM_001177711.1. [Q6XE24-5] DR RefSeq; NP_001171183.1; NM_001177712.1. [Q6XE24-2] DR RefSeq; NP_055298.2; NM_014483.3. [Q6XE24-4] DR AlphaFoldDB; Q6XE24; -. DR SMR; Q6XE24; -. DR BioGRID; 118126; 50. DR IntAct; Q6XE24; 5. DR STRING; 9606.ENSP00000373277; -. DR GlyGen; Q6XE24; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q6XE24; -. DR PhosphoSitePlus; Q6XE24; -. DR BioMuta; RBMS3; -. DR DMDM; 74762382; -. DR EPD; Q6XE24; -. DR jPOST; Q6XE24; -. DR MassIVE; Q6XE24; -. DR MaxQB; Q6XE24; -. DR PaxDb; 9606-ENSP00000373277; -. DR PeptideAtlas; Q6XE24; -. DR ProteomicsDB; 33960; -. DR ProteomicsDB; 67796; -. [Q6XE24-1] DR ProteomicsDB; 67797; -. [Q6XE24-2] DR ProteomicsDB; 67798; -. [Q6XE24-3] DR ProteomicsDB; 67799; -. [Q6XE24-4] DR Antibodypedia; 11544; 218 antibodies from 25 providers. DR DNASU; 27303; -. DR Ensembl; ENST00000273139.13; ENSP00000273139.9; ENSG00000144642.22. [Q6XE24-4] DR Ensembl; ENST00000383766.6; ENSP00000373276.2; ENSG00000144642.22. [Q6XE24-3] DR Ensembl; ENST00000383767.7; ENSP00000373277.2; ENSG00000144642.22. [Q6XE24-1] DR Ensembl; ENST00000452462.5; ENSP00000397926.1; ENSG00000144642.22. [Q6XE24-5] DR Ensembl; ENST00000456853.1; ENSP00000400519.1; ENSG00000144642.22. [Q6XE24-2] DR GeneID; 27303; -. DR KEGG; hsa:27303; -. DR MANE-Select; ENST00000383767.7; ENSP00000373277.2; NM_001003793.3; NP_001003793.1. DR UCSC; uc003cek.4; human. [Q6XE24-1] DR AGR; HGNC:13427; -. DR CTD; 27303; -. DR DisGeNET; 27303; -. DR GeneCards; RBMS3; -. DR HGNC; HGNC:13427; RBMS3. DR HPA; ENSG00000144642; Low tissue specificity. DR MIM; 605786; gene. DR neXtProt; NX_Q6XE24; -. DR OpenTargets; ENSG00000144642; -. DR PharmGKB; PA34276; -. DR VEuPathDB; HostDB:ENSG00000144642; -. DR eggNOG; KOG4733; Eukaryota. DR GeneTree; ENSGT00940000157131; -. DR InParanoid; Q6XE24; -. DR OMA; GTXYMTA; -. DR OrthoDB; 129910at2759; -. DR PhylomeDB; Q6XE24; -. DR TreeFam; TF314644; -. DR PathwayCommons; Q6XE24; -. DR SignaLink; Q6XE24; -. DR BioGRID-ORCS; 27303; 11 hits in 1144 CRISPR screens. DR ChiTaRS; RBMS3; human. DR GenomeRNAi; 27303; -. DR Pharos; Q6XE24; Tbio. DR PRO; PR:Q6XE24; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q6XE24; Protein. DR Bgee; ENSG00000144642; Expressed in trigeminal ganglion and 191 other cell types or tissues. DR ExpressionAtlas; Q6XE24; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central. DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IDA:UniProtKB. DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central. DR GO; GO:0008143; F:poly(A) binding; IDA:UniProtKB. DR GO; GO:0008266; F:poly(U) RNA binding; IDA:UniProtKB. DR GO; GO:0002357; P:defense response to tumor cell; IMP:UniProtKB. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:UniProtKB. DR GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB. DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB. DR CDD; cd12472; RRM1_RBMS3; 1. DR CDD; cd12475; RRM2_RBMS3; 1. DR Gene3D; 3.30.70.330; -; 2. DR InterPro; IPR002343; Hud_Sxl_RNA. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR034406; RBMS3_RRM2. DR InterPro; IPR000504; RRM_dom. DR PANTHER; PTHR48025; OS02G0815200 PROTEIN; 1. DR PANTHER; PTHR48025:SF22; OS02G0815200 PROTEIN; 1. DR Pfam; PF00076; RRM_1; 2. DR PRINTS; PR00961; HUDSXLRNA. DR SMART; SM00360; RRM; 2. DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2. DR PROSITE; PS50102; RRM; 2. DR Genevisible; Q6XE24; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cytoplasm; Reference proteome; Repeat; RNA-binding. FT CHAIN 1..437 FT /note="RNA-binding motif, single-stranded-interacting FT protein 3" FT /id="PRO_0000274906" FT DOMAIN 61..134 FT /note="RRM 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176" FT DOMAIN 140..225 FT /note="RRM 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176" FT REGION 28..57 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 399..437 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 40..57 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 26 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|Ref.2" FT /id="VSP_022927" FT VAR_SEQ 247 FT /note="G -> GEVLRGRTVPRQNR (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_022928" FT VAR_SEQ 297..313 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|Ref.2" FT /id="VSP_022929" FT VAR_SEQ 351..366 FT /note="Missing (in isoform 2, isoform 4 and isoform 5)" FT /evidence="ECO:0000303|PubMed:10675610, FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334" FT /id="VSP_022930" FT VAR_SEQ 437 FT /note="Missing (in isoform 2 and isoform 4)" FT /evidence="ECO:0000303|PubMed:10675610, FT ECO:0000303|PubMed:15489334" FT /id="VSP_022931" FT CONFLICT 93 FT /note="I -> L (in Ref. 2; AAP75556)" FT /evidence="ECO:0000305" FT CONFLICT 165 FT /note="H -> P (in Ref. 2; AAP75556)" FT /evidence="ECO:0000305" FT CONFLICT 418 FT /note="I -> V (in Ref. 3; BAF85478)" FT /evidence="ECO:0000305" SQ SEQUENCE 437 AA; 47840 MW; 7EFC2ECFE24E323C CRC64; MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT IQSQDRIMIL HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS PQTVAPSSQD TSGQQQQIAV DTSNEHAPAY SYQQSKP //