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Q6XE24 (RBMS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-binding motif, single-stranded-interacting protein 3
Gene names
Name:RBMS3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds poly(A) and poly(U) oligoribonucleotides. Ref.1

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Ref.1

Sequence similarities

Contains 2 RRM (RNA recognition motif) domains.

Sequence caution

The sequence AAC63910.1 differs from that shown. Reason: Frameshift at position 1.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandRNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

intracellular membrane-bounded organelle

Inferred from direct assay. Source: HPA

   Molecular functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6XE24-1)

Also known as: DD23-L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6XE24-2)

The sequence of this isoform differs from the canonical sequence as follows:
     247-247: G → GEVLRGRTVPRQNR
     351-366: Missing.
     437-437: Missing.
Isoform 3 (identifier: Q6XE24-3)

Also known as: DD23-S;

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.
     297-313: Missing.
Isoform 4 (identifier: Q6XE24-4)

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.
     437-437: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437RNA-binding motif, single-stranded-interacting protein 3
PRO_0000274906

Regions

Domain61 – 13474RRM 1
Domain140 – 22586RRM 2

Natural variations

Alternative sequence261Missing in isoform 3.
VSP_022927
Alternative sequence2471G → GEVLRGRTVPRQNR in isoform 2.
VSP_022928
Alternative sequence297 – 31317Missing in isoform 3.
VSP_022929
Alternative sequence351 – 36616Missing in isoform 2 and isoform 4.
VSP_022930
Alternative sequence4371Missing in isoform 2 and isoform 4.
VSP_022931

Experimental info

Sequence conflict931I → L in AAP75556. Ref.2
Sequence conflict1651H → P in AAP75556. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (DD23-L) [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7EFC2ECFE24E323C

FASTA43747,840
        10         20         30         40         50         60 
MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK 

        70         80         90        100        110        120 
TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA 

       130        140        150        160        170        180 
SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR 

       190        200        210        220        230        240 
GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG 

       250        260        270        280        290        300 
RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST 

       310        320        330        340        350        360 
SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT IQSQDRIMIL 

       370        380        390        400        410        420 
HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS PQTVAPSSQD TSGQQQQIAV 

       430 
DTSNEHAPAY SYQQSKP

« Hide

Isoform 2 [UniParc].

Checksum: 77366F8B4C908862
Show »

FASTA43347,384
Isoform 3 (DD23-S) [UniParc].

Checksum: AEC2F5E15BDA4E4D
Show »

FASTA41945,744
Isoform 4 [UniParc].

Checksum: 2732762E9B9F9043
Show »

FASTA42045,822

References

« Hide 'large scale' references
[1]"Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins."
Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S.
Gene 243:27-36(2000) [PubMed: 10675610] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Fibroblast.
[2]"Cloning and characterization of novel alternatively spliced transcripts of RBMS3: skeletal muscle mRNA level correlates with whole body insulin resistance."
Lee Y.-H., Tokraks S., Bogardus C., Permana P.A.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF023259 mRNA. Translation: AAC63910.1. Frameshift.
AY236871 mRNA. Translation: AAP75555.1.
AY236872 mRNA. Translation: AAP75556.1.
BC117315 mRNA. Translation: AAI17316.1.
BC143521 mRNA. Translation: AAI43522.1.
IPIIPI00298424.
IPI00472404.
IPI00827856.
IPI00985081.
RefSeqNP_001003792.1. NM_001003792.2.
NP_001003793.1. NM_001003793.2.
NP_001171183.1. NM_001177712.1.
NP_055298.2. NM_014483.3.
UniGeneHs.221436.

3D structure databases

HSSPHSSP built from PDB template 1X4E based on UniProtKB Q15434.
ProteinModelPortalQ6XE24.
SMRQ6XE24. Positions 59-227.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6XE24.

PTM databases

PhosphoSiteQ6XE24.

Polymorphism databases

DMDM74762382.

Proteomic databases

PRIDEQ6XE24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000383767; ENSP00000373277; ENSG00000144642.
ENST00000396583; ENSP00000379828; ENSG00000144642.
ENST00000456853; ENSP00000400519; ENSG00000144642.
GeneID27303.
KEGGhsa:27303.
UCSCuc003cek.1. human.
uc003cel.1. human.
uc003cem.1. human.
uc010hfq.1. human.

Organism-specific databases

CTD27303.
GeneCardsGC03P029298.
H-InvDBHIX0018061.
HGNCHGNC:13427. RBMS3.
HPAHPA034719.
MIM605786. gene.
neXtProtNX_Q6XE24.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10638.
GeneTreeENSGT00590000082738.
HOGENOMHBG443668.
HOVERGENHBG053108.
InParanoidQ6XE24.
OMALGTTGTX.
OrthoDBEOG4KKZ35.
PhylomeDBQ6XE24.

Gene expression databases

ArrayExpressQ6XE24.
BgeeQ6XE24.
CleanExHS_RBMS3.
GenevestigatorQ6XE24.

Family and domain databases

InterProIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
Gene3DG3DSA:3.30.70.330. a_b_plait_nuc_bd. 2 hits.
PfamPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSPR00961. HUDSXLRNA.
SMARTSM00360. RRM. 2 hits.
[Graphical view]
PROSITEPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio50293.
SOURCESearch...

Entry information

Entry nameRBMS3_HUMAN
AccessionPrimary (citable) accession number: Q6XE24
Secondary accession number(s): B7ZL17 expand/collapse secondary AC list , O75876, Q17RI0, Q6XE23
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents