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Q6XE24

- RBMS3_HUMAN

UniProt

Q6XE24 - RBMS3_HUMAN

Protein

RNA-binding motif, single-stranded-interacting protein 3

Gene

RBMS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Binds poly(A) and poly(U) oligoribonucleotides.1 Publication

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding motif, single-stranded-interacting protein 3
    Gene namesi
    Name:RBMS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:13427. RBMS3.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34276.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437RNA-binding motif, single-stranded-interacting protein 3PRO_0000274906Add
    BLAST

    Proteomic databases

    MaxQBiQ6XE24.
    PaxDbiQ6XE24.
    PRIDEiQ6XE24.

    PTM databases

    PhosphoSiteiQ6XE24.

    Expressioni

    Tissue specificityi

    Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ6XE24.
    BgeeiQ6XE24.
    CleanExiHS_RBMS3.
    GenevestigatoriQ6XE24.

    Organism-specific databases

    HPAiHPA034719.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000373277.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6XE24.
    SMRiQ6XE24. Positions 59-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 13474RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 22586RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG320163.
    HOGENOMiHOG000008467.
    HOVERGENiHBG053108.
    InParanoidiQ6XE24.
    OMAiPMYPQYT.
    PhylomeDBiQ6XE24.
    TreeFamiTF314644.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR002343. Hud_Sxl_RNA.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 2 hits.
    [Graphical view]
    PRINTSiPR00961. HUDSXLRNA.
    SMARTiSM00360. RRM. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6XE24-1) [UniParc]FASTAAdd to Basket

    Also known as: DD23-L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS    50
    NNSSGEQLSK TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ 100
    CKGYGFVDFD SPAAAQKAVA SLKANGVQAQ MAKQQEQDPT NLYISNLPIS 150
    MDEQELENML KPFGHVISTR ILRDANGVSR GVGFARMEST EKCEVVIQHF 200
    NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG RPWPREGEAG 250
    MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST 300
    SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT 350
    IQSQDRIMIL HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS 400
    PQTVAPSSQD TSGQQQQIAV DTSNEHAPAY SYQQSKP 437
    Length:437
    Mass (Da):47,840
    Last modified:July 5, 2004 - v1
    Checksum:i7EFC2ECFE24E323C
    GO
    Isoform 2 (identifier: Q6XE24-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         247-247: G → GEVLRGRTVPRQNR
         351-366: Missing.
         437-437: Missing.

    Show »
    Length:433
    Mass (Da):47,384
    Checksum:i77366F8B4C908862
    GO
    Isoform 3 (identifier: Q6XE24-3) [UniParc]FASTAAdd to Basket

    Also known as: DD23-S

    The sequence of this isoform differs from the canonical sequence as follows:
         26-26: Missing.
         297-313: Missing.

    Show »
    Length:419
    Mass (Da):45,744
    Checksum:iAEC2F5E15BDA4E4D
    GO
    Isoform 4 (identifier: Q6XE24-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-366: Missing.
         437-437: Missing.

    Show »
    Length:420
    Mass (Da):45,822
    Checksum:i2732762E9B9F9043
    GO
    Isoform 5 (identifier: Q6XE24-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-366: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:421
    Mass (Da):45,919
    Checksum:i19F732762E9B9F90
    GO

    Sequence cautioni

    The sequence AAC63910.1 differs from that shown. Reason: Frameshift at position 1.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931I → L in AAP75556. 1 PublicationCurated
    Sequence conflicti165 – 1651H → P in AAP75556. 1 PublicationCurated
    Sequence conflicti418 – 4181I → V in BAF85478. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei26 – 261Missing in isoform 3. 1 PublicationVSP_022927
    Alternative sequencei247 – 2471G → GEVLRGRTVPRQNR in isoform 2. 1 PublicationVSP_022928
    Alternative sequencei297 – 31317Missing in isoform 3. 1 PublicationVSP_022929Add
    BLAST
    Alternative sequencei351 – 36616Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsVSP_022930Add
    BLAST
    Alternative sequencei437 – 4371Missing in isoform 2 and isoform 4. 2 PublicationsVSP_022931

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF023259 mRNA. Translation: AAC63910.1. Frameshift.
    AY236871 mRNA. Translation: AAP75555.1.
    AY236872 mRNA. Translation: AAP75556.1.
    AK292789 mRNA. Translation: BAF85478.1.
    AC012262 Genomic DNA. No translation available.
    AC021068 Genomic DNA. No translation available.
    AC092795 Genomic DNA. No translation available.
    AC092796 Genomic DNA. No translation available.
    AC097633 Genomic DNA. No translation available.
    AC098650 Genomic DNA. No translation available.
    AC099048 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64405.1.
    BC117315 mRNA. Translation: AAI17316.1.
    BC143521 mRNA. Translation: AAI43522.1.
    CCDSiCCDS33724.1. [Q6XE24-1]
    CCDS33725.1. [Q6XE24-3]
    CCDS33726.1. [Q6XE24-4]
    CCDS54557.1. [Q6XE24-2]
    CCDS54558.1. [Q6XE24-5]
    RefSeqiNP_001003792.1. NM_001003792.2. [Q6XE24-3]
    NP_001003793.1. NM_001003793.2. [Q6XE24-1]
    NP_001171182.1. NM_001177711.1. [Q6XE24-5]
    NP_001171183.1. NM_001177712.1. [Q6XE24-2]
    NP_055298.2. NM_014483.3. [Q6XE24-4]
    UniGeneiHs.221436.

    Genome annotation databases

    EnsembliENST00000273139; ENSP00000273139; ENSG00000144642. [Q6XE24-4]
    ENST00000383766; ENSP00000373276; ENSG00000144642. [Q6XE24-3]
    ENST00000383767; ENSP00000373277; ENSG00000144642. [Q6XE24-1]
    ENST00000452462; ENSP00000397926; ENSG00000144642. [Q6XE24-5]
    ENST00000456853; ENSP00000400519; ENSG00000144642. [Q6XE24-2]
    GeneIDi27303.
    KEGGihsa:27303.
    UCSCiuc003cek.3. human. [Q6XE24-4]
    uc003cel.3. human. [Q6XE24-1]
    uc003cem.3. human. [Q6XE24-3]
    uc010hfq.3. human. [Q6XE24-2]
    uc010hfr.3. human.

    Polymorphism databases

    DMDMi74762382.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF023259 mRNA. Translation: AAC63910.1 . Frameshift.
    AY236871 mRNA. Translation: AAP75555.1 .
    AY236872 mRNA. Translation: AAP75556.1 .
    AK292789 mRNA. Translation: BAF85478.1 .
    AC012262 Genomic DNA. No translation available.
    AC021068 Genomic DNA. No translation available.
    AC092795 Genomic DNA. No translation available.
    AC092796 Genomic DNA. No translation available.
    AC097633 Genomic DNA. No translation available.
    AC098650 Genomic DNA. No translation available.
    AC099048 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64405.1 .
    BC117315 mRNA. Translation: AAI17316.1 .
    BC143521 mRNA. Translation: AAI43522.1 .
    CCDSi CCDS33724.1. [Q6XE24-1 ]
    CCDS33725.1. [Q6XE24-3 ]
    CCDS33726.1. [Q6XE24-4 ]
    CCDS54557.1. [Q6XE24-2 ]
    CCDS54558.1. [Q6XE24-5 ]
    RefSeqi NP_001003792.1. NM_001003792.2. [Q6XE24-3 ]
    NP_001003793.1. NM_001003793.2. [Q6XE24-1 ]
    NP_001171182.1. NM_001177711.1. [Q6XE24-5 ]
    NP_001171183.1. NM_001177712.1. [Q6XE24-2 ]
    NP_055298.2. NM_014483.3. [Q6XE24-4 ]
    UniGenei Hs.221436.

    3D structure databases

    ProteinModelPortali Q6XE24.
    SMRi Q6XE24. Positions 59-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000373277.

    PTM databases

    PhosphoSitei Q6XE24.

    Polymorphism databases

    DMDMi 74762382.

    Proteomic databases

    MaxQBi Q6XE24.
    PaxDbi Q6XE24.
    PRIDEi Q6XE24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273139 ; ENSP00000273139 ; ENSG00000144642 . [Q6XE24-4 ]
    ENST00000383766 ; ENSP00000373276 ; ENSG00000144642 . [Q6XE24-3 ]
    ENST00000383767 ; ENSP00000373277 ; ENSG00000144642 . [Q6XE24-1 ]
    ENST00000452462 ; ENSP00000397926 ; ENSG00000144642 . [Q6XE24-5 ]
    ENST00000456853 ; ENSP00000400519 ; ENSG00000144642 . [Q6XE24-2 ]
    GeneIDi 27303.
    KEGGi hsa:27303.
    UCSCi uc003cek.3. human. [Q6XE24-4 ]
    uc003cel.3. human. [Q6XE24-1 ]
    uc003cem.3. human. [Q6XE24-3 ]
    uc010hfq.3. human. [Q6XE24-2 ]
    uc010hfr.3. human.

    Organism-specific databases

    CTDi 27303.
    GeneCardsi GC03P029298.
    HGNCi HGNC:13427. RBMS3.
    HPAi HPA034719.
    MIMi 605786. gene.
    neXtProti NX_Q6XE24.
    PharmGKBi PA34276.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320163.
    HOGENOMi HOG000008467.
    HOVERGENi HBG053108.
    InParanoidi Q6XE24.
    OMAi PMYPQYT.
    PhylomeDBi Q6XE24.
    TreeFami TF314644.

    Miscellaneous databases

    ChiTaRSi RBMS3. human.
    GenomeRNAii 27303.
    NextBioi 50293.
    PROi Q6XE24.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6XE24.
    Bgeei Q6XE24.
    CleanExi HS_RBMS3.
    Genevestigatori Q6XE24.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR002343. Hud_Sxl_RNA.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 2 hits.
    [Graphical view ]
    PRINTSi PR00961. HUDSXLRNA.
    SMARTi SM00360. RRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins."
      Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S.
      Gene 243:27-36(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Fibroblast.
    2. "Cloning and characterization of novel alternatively spliced transcripts of RBMS3: skeletal muscle mRNA level correlates with whole body insulin resistance."
      Lee Y.-H., Tokraks S., Bogardus C., Permana P.A.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Trachea.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiRBMS3_HUMAN
    AccessioniPrimary (citable) accession number: Q6XE24
    Secondary accession number(s): A8K9S4
    , B7ZL17, G5E9J9, O75876, Q17RI0, Q6XE23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3