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Protein

RNA-binding motif, single-stranded-interacting protein 3

Gene

RBMS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds poly(A) and poly(U) oligoribonucleotides.1 Publication

GO - Molecular functioni

  • mRNA 3'-UTR AU-rich region binding Source: UniProtKB
  • poly(A) binding Source: UniProtKB
  • poly(U) RNA binding Source: UniProtKB

GO - Biological processi

  • defense response to tumor cell Source: UniProtKB
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of translation Source: Ensembl

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif, single-stranded-interacting protein 3
Gene namesi
Name:RBMS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144642.20.
HGNCiHGNC:13427. RBMS3.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi27303.
OpenTargetsiENSG00000144642.
PharmGKBiPA34276.

Polymorphism and mutation databases

BioMutaiRBMS3.
DMDMi74762382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002749061 – 437RNA-binding motif, single-stranded-interacting protein 3Add BLAST437

Proteomic databases

MaxQBiQ6XE24.
PaxDbiQ6XE24.
PeptideAtlasiQ6XE24.
PRIDEiQ6XE24.

PTM databases

iPTMnetiQ6XE24.
PhosphoSitePlusiQ6XE24.

Expressioni

Tissue specificityi

Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000144642.
CleanExiHS_RBMS3.
ExpressionAtlasiQ6XE24. baseline and differential.
GenevisibleiQ6XE24. HS.

Organism-specific databases

HPAiHPA034719.

Interactioni

Protein-protein interaction databases

BioGridi118126. 9 interactors.
STRINGi9606.ENSP00000373277.

Structurei

3D structure databases

ProteinModelPortaliQ6XE24.
SMRiQ6XE24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 134RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini140 – 225RRM 2PROSITE-ProRule annotationAdd BLAST86

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4733. Eukaryota.
ENOG410XRB5. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000008467.
HOVERGENiHBG053108.
InParanoidiQ6XE24.
OrthoDBiEOG091G0FXS.
PhylomeDBiQ6XE24.
TreeFamiTF314644.

Family and domain databases

CDDicd12475. RRM2_RBMS3. 1 hit.
InterProiView protein in InterPro
IPR002343. Hud_Sxl_RNA.
IPR035979. RBD_domain_sf.
IPR034406. RBMS3_RRM2.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 2 hits.
PRINTSiPR00961. HUDSXLRNA.
SMARTiView protein in SMART
SM00360. RRM. 2 hits.
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 2 hits.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6XE24-1) [UniParc]FASTAAdd to basket
Also known as: DD23-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS
60 70 80 90 100
NNSSGEQLSK TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ
110 120 130 140 150
CKGYGFVDFD SPAAAQKAVA SLKANGVQAQ MAKQQEQDPT NLYISNLPIS
160 170 180 190 200
MDEQELENML KPFGHVISTR ILRDANGVSR GVGFARMEST EKCEVVIQHF
210 220 230 240 250
NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG RPWPREGEAG
260 270 280 290 300
MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST
310 320 330 340 350
SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT
360 370 380 390 400
IQSQDRIMIL HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS
410 420 430
PQTVAPSSQD TSGQQQQIAV DTSNEHAPAY SYQQSKP
Length:437
Mass (Da):47,840
Last modified:July 5, 2004 - v1
Checksum:i7EFC2ECFE24E323C
GO
Isoform 2 (identifier: Q6XE24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-247: G → GEVLRGRTVPRQNR
     351-366: Missing.
     437-437: Missing.

Show »
Length:433
Mass (Da):47,384
Checksum:i77366F8B4C908862
GO
Isoform 3 (identifier: Q6XE24-3) [UniParc]FASTAAdd to basket
Also known as: DD23-S

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.
     297-313: Missing.

Show »
Length:419
Mass (Da):45,744
Checksum:iAEC2F5E15BDA4E4D
GO
Isoform 4 (identifier: Q6XE24-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.
     437-437: Missing.

Show »
Length:420
Mass (Da):45,822
Checksum:i2732762E9B9F9043
GO
Isoform 5 (identifier: Q6XE24-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):45,919
Checksum:i19F732762E9B9F90
GO

Sequence cautioni

The sequence AAC63910 differs from that shown. Reason: Frameshift at position 1.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93I → L in AAP75556 (Ref. 2) Curated1
Sequence conflicti165H → P in AAP75556 (Ref. 2) Curated1
Sequence conflicti418I → V in BAF85478 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02292726Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_022928247G → GEVLRGRTVPRQNR in isoform 2. 1 Publication1
Alternative sequenceiVSP_022929297 – 313Missing in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_022930351 – 366Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_022931437Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023259 mRNA. Translation: AAC63910.1. Frameshift.
AY236871 mRNA. Translation: AAP75555.1.
AY236872 mRNA. Translation: AAP75556.1.
AK292789 mRNA. Translation: BAF85478.1.
AC012262 Genomic DNA. No translation available.
AC021068 Genomic DNA. No translation available.
AC092795 Genomic DNA. No translation available.
AC092796 Genomic DNA. No translation available.
AC097633 Genomic DNA. No translation available.
AC098650 Genomic DNA. No translation available.
AC099048 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64405.1.
BC117315 mRNA. Translation: AAI17316.1.
BC143521 mRNA. Translation: AAI43522.1.
CCDSiCCDS33724.1. [Q6XE24-1]
CCDS33725.1. [Q6XE24-3]
CCDS33726.1. [Q6XE24-4]
CCDS54557.1. [Q6XE24-2]
CCDS54558.1. [Q6XE24-5]
RefSeqiNP_001003792.1. NM_001003792.2. [Q6XE24-3]
NP_001003793.1. NM_001003793.2. [Q6XE24-1]
NP_001171182.1. NM_001177711.1. [Q6XE24-5]
NP_001171183.1. NM_001177712.1. [Q6XE24-2]
NP_055298.2. NM_014483.3. [Q6XE24-4]
UniGeneiHs.221436.

Genome annotation databases

EnsembliENST00000273139; ENSP00000273139; ENSG00000144642. [Q6XE24-4]
ENST00000383766; ENSP00000373276; ENSG00000144642. [Q6XE24-3]
ENST00000383767; ENSP00000373277; ENSG00000144642. [Q6XE24-1]
ENST00000452462; ENSP00000397926; ENSG00000144642. [Q6XE24-5]
ENST00000456853; ENSP00000400519; ENSG00000144642. [Q6XE24-2]
GeneIDi27303.
KEGGihsa:27303.
UCSCiuc003cek.4. human. [Q6XE24-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBMS3_HUMAN
AccessioniPrimary (citable) accession number: Q6XE24
Secondary accession number(s): A8K9S4
, B7ZL17, G5E9J9, O75876, Q17RI0, Q6XE23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot