Reviewed,
UniProtKB/Swiss-Prot Q6XE24 (RBMS3_HUMAN)
Last modified
November 3, 2009.
Version 49.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: RNA-binding motif, single-stranded-interacting protein 3 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 437 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds poly(A) and poly(U) oligoribonucleotides. Ref.1 |
| Subcellular location | |
| Tissue specificity | Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Ref.1 |
| Sequence similarities | Contains 2 RRM (RNA recognition motif) domains. |
| Sequence caution | The sequence AAC63910.1 differs from that shown. Reason: Frameshift at position 1. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative splicing |
| Domain | Repeat |
| Ligand | RNA-binding |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q6XE24-1) Also known as: DD23-L; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q6XE24-2) The sequence of this isoform differs from the canonical sequence as follows: 247-247: G → GEVLRGRTVPRQNR 351-366: Missing. 437-437: Missing. | ||||||
| Isoform 3 (identifier: Q6XE24-3) Also known as: DD23-S; The sequence of this isoform differs from the canonical sequence as follows: 26-26: Missing. 297-313: Missing. | ||||||
| Isoform 4 (identifier: Q6XE24-4) The sequence of this isoform differs from the canonical sequence as follows: 351-366: Missing. 437-437: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 437 | 437 | RNA-binding motif, single-stranded-interacting protein 3 | PRO_0000274906 | |||||
Regions | |||||||||
| Domain | 61 – 134 | 74 | RRM 1 | ||||||
| Domain | 140 – 225 | 86 | RRM 2 | ||||||
Natural variations | |||||||||
| Alternative sequence | 26 | 1 | Missing in isoform 3. | VSP_022927 | |||||
| Alternative sequence | 247 | 1 | G → GEVLRGRTVPRQNR in isoform 2. | VSP_022928 | |||||
| Alternative sequence | 297 – 313 | 17 | Missing in isoform 3. | VSP_022929 | |||||
| Alternative sequence | 351 – 366 | 16 | Missing in isoform 2 and isoform 4. | VSP_022930 | |||||
| Alternative sequence | 437 | 1 | Missing in isoform 2 and isoform 4. | VSP_022931 | |||||
Experimental info | |||||||||
| Sequence conflict | 93 | 1 | I → L in AAP75556. Ref.2 | ||||||
| Sequence conflict | 165 | 1 | H → P in AAP75556. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins." Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S. Gene 243:27-36(2000) [PubMed: 10675610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Fibroblast. |
| [2] | "Cloning and characterization of novel alternatively spliced transcripts of RBMS3: skeletal muscle mRNA level correlates with whole body insulin resistance." Lee Y.-H., Tokraks S., Bogardus C., Permana P.A. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF023259 mRNA. Translation: AAC63910.1. Frameshift. AY236871 mRNA. Translation: AAP75555.1. AY236872 mRNA. Translation: AAP75556.1. BC117315 mRNA. Translation: AAI17316.1. BC143521 mRNA. Translation: AAI43522.1. | |
| IPI | IPI00298424. IPI00456051. IPI00472404. IPI00827856. |
| RefSeq | NP_001003792.1. NP_001003793.1. NP_055298.2. |
| UniGene | Hs.696468 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B7F based on UniProtKB P19339. |
| SMR | Q6XE24. Positions 61-134, 120-223. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6XE24. |
PTM databases | |
| PhosphoSite | Q6XE24. |
Proteomic databases | |
| PRIDE | Q6XE24. |
Genome annotation databases | |
| Ensembl | ENST00000273139; ENSP00000273139; ENSG00000144642; Homo sapiens. [Genome view] ENST00000383766; ENSP00000373276; ENSG00000144642; Homo sapiens. [Genome view] ENST00000383767; ENSP00000373277; ENSG00000144642; Homo sapiens. [Genome view] ENST00000396583; ENSP00000379828; ENSG00000144642; Homo sapiens. [Genome view] ENST00000434693; ENSP00000395592; ENSG00000144642; Homo sapiens. [Genome view] ENST00000445033; ENSP00000391934; ENSG00000144642; Homo sapiens. [Genome view] ENST00000452462; ENSP00000397926; ENSG00000144642; Homo sapiens. [Genome view] ENST00000456853; ENSP00000400519; ENSG00000144642; Homo sapiens. [Genome view] |
| GeneID | 27303. |
| KEGG | hsa:27303. |
| UCSC | uc003cek.1. human. uc003cel.1. human. uc003cem.1. human. uc010hfq.1. human. |
Organism-specific databases | |
| CTD | 27303. |
| GeneCards | GC03P029298. |
| HGNC | HGNC:13427. RBMS3. |
| MIM | 605786. gene. |
| PharmGKB | PA34276. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q6XE24. |
| OMA | XAGMALT. |
Gene expression databases | |
| ArrayExpress | Q6XE24. |
| Bgee | Q6XE24. |
| CleanEx | HS_RBMS3. |
| Genevestigator | Q6XE24. |
Family and domain databases | |
| InterPro | IPR012677. a_b_plait_nuc_bd. IPR002343. Hud_Sxl_RNA. IPR000504. RRM_RNP1. [Graphical view] |
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 2 hits. |
| Pfam | PF00076. RRM_1. 2 hits. [Graphical view] |
| PRINTS | PR00961. HUDSXLRNA. |
| SMART | SM00360. RRM. 2 hits. [Graphical view] |
| PROSITE | PS50102. RRM. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 50293. |
| SOURCE | Search... |
Entry information
| Entry name | RBMS3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6XE24 Secondary accession number(s): B7ZL17 Q6XE23 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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