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Protein

RNA-binding motif, single-stranded-interacting protein 3

Gene

RBMS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds poly(A) and poly(U) oligoribonucleotides.1 Publication

GO - Molecular functioni

  1. mRNA 3'-UTR binding Source: Ensembl
  2. nucleotide binding Source: InterPro

GO - Biological processi

  1. positive regulation of translation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif, single-stranded-interacting protein 3
Gene namesi
Name:RBMS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:13427. RBMS3.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437RNA-binding motif, single-stranded-interacting protein 3PRO_0000274906Add
BLAST

Proteomic databases

MaxQBiQ6XE24.
PaxDbiQ6XE24.
PRIDEiQ6XE24.

PTM databases

PhosphoSiteiQ6XE24.

Expressioni

Tissue specificityi

Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ6XE24.
CleanExiHS_RBMS3.
ExpressionAtlasiQ6XE24. baseline and differential.
GenevestigatoriQ6XE24.

Organism-specific databases

HPAiHPA034719.

Interactioni

Protein-protein interaction databases

BioGridi118126. 9 interactions.
STRINGi9606.ENSP00000373277.

Structurei

3D structure databases

ProteinModelPortaliQ6XE24.
SMRiQ6XE24. Positions 59-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 13474RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini140 – 22586RRM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG320163.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000008467.
HOVERGENiHBG053108.
InParanoidiQ6XE24.
OMAiTGTYMTA.
PhylomeDBiQ6XE24.
TreeFamiTF314644.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6XE24-1) [UniParc]FASTAAdd to Basket

Also known as: DD23-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS
60 70 80 90 100
NNSSGEQLSK TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ
110 120 130 140 150
CKGYGFVDFD SPAAAQKAVA SLKANGVQAQ MAKQQEQDPT NLYISNLPIS
160 170 180 190 200
MDEQELENML KPFGHVISTR ILRDANGVSR GVGFARMEST EKCEVVIQHF
210 220 230 240 250
NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG RPWPREGEAG
260 270 280 290 300
MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST
310 320 330 340 350
SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT
360 370 380 390 400
IQSQDRIMIL HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS
410 420 430
PQTVAPSSQD TSGQQQQIAV DTSNEHAPAY SYQQSKP
Length:437
Mass (Da):47,840
Last modified:July 5, 2004 - v1
Checksum:i7EFC2ECFE24E323C
GO
Isoform 2 (identifier: Q6XE24-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-247: G → GEVLRGRTVPRQNR
     351-366: Missing.
     437-437: Missing.

Show »
Length:433
Mass (Da):47,384
Checksum:i77366F8B4C908862
GO
Isoform 3 (identifier: Q6XE24-3) [UniParc]FASTAAdd to Basket

Also known as: DD23-S

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.
     297-313: Missing.

Show »
Length:419
Mass (Da):45,744
Checksum:iAEC2F5E15BDA4E4D
GO
Isoform 4 (identifier: Q6XE24-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.
     437-437: Missing.

Show »
Length:420
Mass (Da):45,822
Checksum:i2732762E9B9F9043
GO
Isoform 5 (identifier: Q6XE24-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.

Note: No experimental confirmation available.

Show »
Length:421
Mass (Da):45,919
Checksum:i19F732762E9B9F90
GO

Sequence cautioni

The sequence AAC63910.1 differs from that shown. Reason: Frameshift at position 1. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931I → L in AAP75556. 1 PublicationCurated
Sequence conflicti165 – 1651H → P in AAP75556. 1 PublicationCurated
Sequence conflicti418 – 4181I → V in BAF85478. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 261Missing in isoform 3. 1 PublicationVSP_022927
Alternative sequencei247 – 2471G → GEVLRGRTVPRQNR in isoform 2. 1 PublicationVSP_022928
Alternative sequencei297 – 31317Missing in isoform 3. 1 PublicationVSP_022929Add
BLAST
Alternative sequencei351 – 36616Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsVSP_022930Add
BLAST
Alternative sequencei437 – 4371Missing in isoform 2 and isoform 4. 2 PublicationsVSP_022931

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023259 mRNA. Translation: AAC63910.1. Frameshift.
AY236871 mRNA. Translation: AAP75555.1.
AY236872 mRNA. Translation: AAP75556.1.
AK292789 mRNA. Translation: BAF85478.1.
AC012262 Genomic DNA. No translation available.
AC021068 Genomic DNA. No translation available.
AC092795 Genomic DNA. No translation available.
AC092796 Genomic DNA. No translation available.
AC097633 Genomic DNA. No translation available.
AC098650 Genomic DNA. No translation available.
AC099048 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64405.1.
BC117315 mRNA. Translation: AAI17316.1.
BC143521 mRNA. Translation: AAI43522.1.
CCDSiCCDS33724.1. [Q6XE24-1]
CCDS33725.1. [Q6XE24-3]
CCDS33726.1. [Q6XE24-4]
CCDS54557.1. [Q6XE24-2]
CCDS54558.1. [Q6XE24-5]
RefSeqiNP_001003792.1. NM_001003792.2. [Q6XE24-3]
NP_001003793.1. NM_001003793.2. [Q6XE24-1]
NP_001171182.1. NM_001177711.1. [Q6XE24-5]
NP_001171183.1. NM_001177712.1. [Q6XE24-2]
NP_055298.2. NM_014483.3. [Q6XE24-4]
UniGeneiHs.221436.

Genome annotation databases

EnsembliENST00000273139; ENSP00000273139; ENSG00000144642. [Q6XE24-4]
ENST00000383766; ENSP00000373276; ENSG00000144642. [Q6XE24-3]
ENST00000383767; ENSP00000373277; ENSG00000144642. [Q6XE24-1]
ENST00000452462; ENSP00000397926; ENSG00000144642. [Q6XE24-5]
ENST00000456853; ENSP00000400519; ENSG00000144642. [Q6XE24-2]
GeneIDi27303.
KEGGihsa:27303.
UCSCiuc003cek.3. human. [Q6XE24-4]
uc003cel.3. human. [Q6XE24-1]
uc003cem.3. human. [Q6XE24-3]
uc010hfq.3. human. [Q6XE24-2]
uc010hfr.3. human.

Polymorphism databases

DMDMi74762382.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023259 mRNA. Translation: AAC63910.1. Frameshift.
AY236871 mRNA. Translation: AAP75555.1.
AY236872 mRNA. Translation: AAP75556.1.
AK292789 mRNA. Translation: BAF85478.1.
AC012262 Genomic DNA. No translation available.
AC021068 Genomic DNA. No translation available.
AC092795 Genomic DNA. No translation available.
AC092796 Genomic DNA. No translation available.
AC097633 Genomic DNA. No translation available.
AC098650 Genomic DNA. No translation available.
AC099048 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64405.1.
BC117315 mRNA. Translation: AAI17316.1.
BC143521 mRNA. Translation: AAI43522.1.
CCDSiCCDS33724.1. [Q6XE24-1]
CCDS33725.1. [Q6XE24-3]
CCDS33726.1. [Q6XE24-4]
CCDS54557.1. [Q6XE24-2]
CCDS54558.1. [Q6XE24-5]
RefSeqiNP_001003792.1. NM_001003792.2. [Q6XE24-3]
NP_001003793.1. NM_001003793.2. [Q6XE24-1]
NP_001171182.1. NM_001177711.1. [Q6XE24-5]
NP_001171183.1. NM_001177712.1. [Q6XE24-2]
NP_055298.2. NM_014483.3. [Q6XE24-4]
UniGeneiHs.221436.

3D structure databases

ProteinModelPortaliQ6XE24.
SMRiQ6XE24. Positions 59-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118126. 9 interactions.
STRINGi9606.ENSP00000373277.

PTM databases

PhosphoSiteiQ6XE24.

Polymorphism databases

DMDMi74762382.

Proteomic databases

MaxQBiQ6XE24.
PaxDbiQ6XE24.
PRIDEiQ6XE24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273139; ENSP00000273139; ENSG00000144642. [Q6XE24-4]
ENST00000383766; ENSP00000373276; ENSG00000144642. [Q6XE24-3]
ENST00000383767; ENSP00000373277; ENSG00000144642. [Q6XE24-1]
ENST00000452462; ENSP00000397926; ENSG00000144642. [Q6XE24-5]
ENST00000456853; ENSP00000400519; ENSG00000144642. [Q6XE24-2]
GeneIDi27303.
KEGGihsa:27303.
UCSCiuc003cek.3. human. [Q6XE24-4]
uc003cel.3. human. [Q6XE24-1]
uc003cem.3. human. [Q6XE24-3]
uc010hfq.3. human. [Q6XE24-2]
uc010hfr.3. human.

Organism-specific databases

CTDi27303.
GeneCardsiGC03P029298.
HGNCiHGNC:13427. RBMS3.
HPAiHPA034719.
MIMi605786. gene.
neXtProtiNX_Q6XE24.
PharmGKBiPA34276.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320163.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000008467.
HOVERGENiHBG053108.
InParanoidiQ6XE24.
OMAiTGTYMTA.
PhylomeDBiQ6XE24.
TreeFamiTF314644.

Miscellaneous databases

ChiTaRSiRBMS3. human.
GenomeRNAii27303.
NextBioi50293.
PROiQ6XE24.
SOURCEiSearch...

Gene expression databases

BgeeiQ6XE24.
CleanExiHS_RBMS3.
ExpressionAtlasiQ6XE24. baseline and differential.
GenevestigatoriQ6XE24.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins."
    Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S.
    Gene 243:27-36(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Fibroblast.
  2. "Cloning and characterization of novel alternatively spliced transcripts of RBMS3: skeletal muscle mRNA level correlates with whole body insulin resistance."
    Lee Y.-H., Tokraks S., Bogardus C., Permana P.A.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Trachea.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiRBMS3_HUMAN
AccessioniPrimary (citable) accession number: Q6XE24
Secondary accession number(s): A8K9S4
, B7ZL17, G5E9J9, O75876, Q17RI0, Q6XE23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.