Q6XE24 (RBMS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding motif, single-stranded-interacting protein 3

Gene names

Name:

RBMS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds poly(A) and poly(U) oligoribonucleotides. Ref.1
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Ref.1
Sequence similarities	Contains 2 RRM (RNA recognition motif) domains.
Sequence caution	The sequence AAC63910.1 differs from that shown. Reason: Frameshift at position 1.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6XE24-1)

Also known as: DD23-L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6XE24-2)

The sequence of this isoform differs from the canonical sequence as follows:
     247-247: G → GEVLRGRTVPRQNR
     351-366: Missing.
     437-437: Missing.

Isoform 3 (identifier: Q6XE24-3)

Also known as: DD23-S;

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.
     297-313: Missing.

Isoform 4 (identifier: Q6XE24-4)

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.
     437-437: Missing.

Isoform 5 (identifier: Q6XE24-5)

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	RNA-binding motif, single-stranded-interacting protein 3		PRO_0000274906
Regions
	Domain	61 – 134	74	RRM 1
	Domain	140 – 225	86	RRM 2
Natural variations
	Alternative sequence	26	1	Missing in isoform 3.		VSP_022927
	Alternative sequence	247	1	G → GEVLRGRTVPRQNR in isoform 2.		VSP_022928
	Alternative sequence	297 – 313	17	Missing in isoform 3.		VSP_022929
	Alternative sequence	351 – 366	16	Missing in isoform 2, isoform 4 and isoform 5.		VSP_022930
	Alternative sequence	437	1	Missing in isoform 2 and isoform 4.		VSP_022931
Experimental info
	Sequence conflict	93	1	I → L in AAP75556. Ref.2
	Sequence conflict	165	1	H → P in AAP75556. Ref.2
	Sequence conflict	418	1	I → V in BAF85478. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (DD23-L) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7EFC2ECFE24E323C	FASTA	437	47,840
	10 20 30 40 50 60 MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK 70 80 90 100 110 120 TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA 130 140 150 160 170 180 SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR 190 200 210 220 230 240 GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG 250 260 270 280 290 300 RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST 310 320 330 340 350 360 SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT IQSQDRIMIL 370 380 390 400 410 420 HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS PQTVAPSSQD TSGQQQQIAV 430 DTSNEHAPAY SYQQSKP
	Isoform 2 [UniParc]. Checksum: 77366F8B4C908862	FASTA	433	47,384
	10 20 30 40 50 60 MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK 70 80 90 100 110 120 TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA 130 140 150 160 170 180 SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR 190 200 210 220 230 240 GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG 250 260 270 280 290 300 RPWPREGEVL RGRTVPRQNR EAGMALTYDP TAAIQNGFYS SPYSIATNRM IPQTSITPFI 310 320 330 340 350 360 AASPVSTYQV QSTSWMPHPP YVMQPTGAVI TPTMDHPMSM QPANMMGPLT QQMNHLSLGT 370 380 390 400 410 420 TGTYMTAAAP MQGTYIPQYT PVPPTAVSIE GVVADTSPQT VAPSSQDTSG QQQQIAVDTS 430 NEHAPAYSYQ QSK
	Isoform 3 (DD23-S) [UniParc]. Checksum: AEC2F5E15BDA4E4D	FASTA	419	45,744
	10 20 30 40 50 60 MGKRLDQPQM YPQYTYYYPH YLQTKSYAPA PHPMAPPSPS TNSSSNNSSN NSSGEQLSKT 70 80 90 100 110 120 NLYIRGLPPG TTDQDLIKLC QPYGKIVSTK AILDKNTNQC KGYGFVDFDS PAAAQKAVAS 130 140 150 160 170 180 LKANGVQAQM AKQQEQDPTN LYISNLPISM DEQELENMLK PFGHVISTRI LRDANGVSRG 190 200 210 220 230 240 VGFARMESTE KCEVVIQHFN GKYLKTPPGI PAPSEPLLCK FADGGQKKRQ NQSKYTQNGR 250 260 270 280 290 300 PWPREGEAGM ALTYDPTAAI QNGFYSSPYS IATNRMIPQT SITPFIAASP VSTYQGAVIT 310 320 330 340 350 360 PTMDHPMSMQ PANMMGPLTQ QMNHLSLGTT GTIQSQDRIM ILHQLLCQYM TAAAPMQGTY 370 380 390 400 410 IPQYTPVPPT AVSIEGVVAD TSPQTVAPSS QDTSGQQQQI AVDTSNEHAP AYSYQQSKP
	Isoform 4 [UniParc]. Checksum: 2732762E9B9F9043	FASTA	420	45,822
	10 20 30 40 50 60 MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK 70 80 90 100 110 120 TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA 130 140 150 160 170 180 SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR 190 200 210 220 230 240 GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG 250 260 270 280 290 300 RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST 310 320 330 340 350 360 SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT YMTAAAPMQG 370 380 390 400 410 420 TYIPQYTPVP PTAVSIEGVV ADTSPQTVAP SSQDTSGQQQ QIAVDTSNEH APAYSYQQSK
	Isoform 5 [UniParc]. Checksum: 19F732762E9B9F90	FASTA	421	45,919
	10 20 30 40 50 60 MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK 70 80 90 100 110 120 TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA 130 140 150 160 170 180 SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR 190 200 210 220 230 240 GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG 250 260 270 280 290 300 RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST 310 320 330 340 350 360 SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT YMTAAAPMQG 370 380 390 400 410 420 TYIPQYTPVP PTAVSIEGVV ADTSPQTVAP SSQDTSGQQQ QIAVDTSNEH APAYSYQQSK P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins." Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S. Gene 243:27-36(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Fibroblast.
[2]	"Cloning and characterization of novel alternatively spliced transcripts of RBMS3: skeletal muscle mRNA level correlates with whole body insulin resistance." Lee Y.-H., Tokraks S., Bogardus C., Permana P.A. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Trachea.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF023259 mRNA. Translation: AAC63910.1. Frameshift. AY236871 mRNA. Translation: AAP75555.1. AY236872 mRNA. Translation: AAP75556.1. AK292789 mRNA. Translation: BAF85478.1. AC012262 Genomic DNA. No translation available. AC021068 Genomic DNA. No translation available. AC092795 Genomic DNA. No translation available. AC092796 Genomic DNA. No translation available. AC097633 Genomic DNA. No translation available. AC098650 Genomic DNA. No translation available. AC099048 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW64405.1. BC117315 mRNA. Translation: AAI17316.1. BC143521 mRNA. Translation: AAI43522.1.
IPI	IPI00298424. IPI00472404. IPI00827856. IPI00985081.
RefSeq	NP_001003792.1. NM_001003792.2. NP_001003793.1. NM_001003793.2. NP_001171182.1. NM_001177711.1. NP_001171183.1. NM_001177712.1. NP_055298.2. NM_014483.3.
UniGene	Hs.221436.
3D structure databases
HSSP	HSSP built from PDB template 1X4E based on UniProtKB Q15434.
ProteinModelPortal	Q6XE24.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000373277.
PTM databases
PhosphoSite	Q6XE24.
Polymorphism databases
DMDM	74762382.
Proteomic databases
PaxDb	Q6XE24.
PRIDE	Q6XE24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273139; ENSP00000273139; ENSG00000144642. ENST00000383766; ENSP00000373276; ENSG00000144642. ENST00000383767; ENSP00000373277; ENSG00000144642. ENST00000452462; ENSP00000397926; ENSG00000144642. ENST00000456853; ENSP00000400519; ENSG00000144642.
GeneID	27303.
KEGG	hsa:27303.
UCSC	uc003cek.3. human. uc003cel.3. human. uc003cem.3. human. uc010hfq.3. human.
Organism-specific databases
CTD	27303.
GeneCards	GC03P029298.
HGNC	HGNC:13427. RBMS3.
HPA	HPA034719.
MIM	605786. gene.
neXtProt	NX_Q6XE24.
PharmGKB	PA34276.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320163.
HOGENOM	HOG000008467.
HOVERGEN	HBG053108.
InParanoid	Q6XE24.
OMA	QQMTVET.
OrthoDB	EOG4KKZ35.
Gene expression databases
ArrayExpress	Q6XE24.
Bgee	Q6XE24.
CleanEx	HS_RBMS3.
Genevestigator	Q6XE24.
Family and domain databases
Gene3D	3.30.70.330. 2 hits.
InterPro	IPR002343. Hud_Sxl_RNA. IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Pfam	PF00076. RRM_1. 2 hits. [Graphical view]
PRINTS	PR00961. HUDSXLRNA.
SMART	SM00360. RRM. 2 hits. [Graphical view]
PROSITE	PS50102. RRM. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RBMS3. human.
GenomeRNAi	27303.
NextBio	50293.
SOURCE	Search...

Entry information

Entry name

RBMS3_HUMAN

Accession

Primary (citable) accession number: Q6XE24
Secondary accession number(s): A8K9S4 , B7ZL17, G5E9J9, O75876, Q17RI0, Q6XE23

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.