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Protein
Submitted name:

Erythroid spectrin alpha

Gene

Spta1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-375165. NCAM signaling for neurite out-growth.
R-RNO-445095. Interaction between L1 and Ankyrins.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Erythroid spectrin alphaImported
Submitted name:
Protein Spta1Imported
Gene namesi
Name:Spta1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1305194. Spta1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • cytoplasmic side of plasma membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF7FC39.
Q6XDA1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003537.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061853.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini975 – 103460SH3InterPro annotationAdd
BLAST
Domaini2247 – 227226EF-handInterPro annotationAdd
BLAST
Domaini2280 – 231536EF-handInterPro annotationAdd
BLAST
Domaini2336 – 235217EF-handInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili865 – 89228Sequence analysisAdd
BLAST
Coiled coili1427 – 146135Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000246965.
HOVERGENiHBG059266.
KOiK06114.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR014837. EF-hand_Ca_insen.
IPR002048. EF_hand_dom.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR013315. Spectrin_alpha_SH3.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF08726. EFhand_Ca_insen. 1 hit.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 20 hits.
[Graphical view]
PRINTSiPR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00150. SPEC. 20 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XDA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPKETAVE SSGPKVLETA EEIQHRRQEV LDQYQRFKER VAERGQKLEE
60 70 80 90 100
SYHYQVFRRD ADDLEKWIME KLEITKDKTY EPTNIQGKYQ KHESFVSEVQ
110 120 130 140 150
AKSRVLPELE EIREARFAED HFAHEATKTH LKELRHLWDL LLELTQEKSD
160 170 180 190 200
ILLRALKFYQ YCQECEDILE WVKEKEAIVT LVELGDDWER TEVLHKKFEE
210 220 230 240 250
FQEELTARKG KVDRVNQYAN ECAQEQHPKL PEIKAKQDEV NAAWDRLWSL
260 270 280 290 300
ALKRRESLSN AADLQRFKRD VNEAIQWMEE KEPLLTSEDY GKDLVSSEAL
310 320 330 340 350
FHSHKRLERN LAVMDDKVKE LCAKADKLMV SHSADAPQIQ QMKMDLVSNW
360 370 380 390 400
ELIRALATNR YAKLKASYGY HRFLSDYDEL TGWMEEKTAL INADELPTDV
410 420 430 440 450
ASGEALLARH QQHKHEIDSY DDRFQTAEAT GQDLLDGNHE ASDEIREKMT
460 470 480 490 500
ILAHDWAALR ELWNKCQHQY RQSLDFHLFY RDSEQVDSWM SRQEAFLENE
510 520 530 540 550
DLGNSVGSVE ALLQKHDDFE EAFTAQEEKI ITLDETATKL IDNDHYDSEN
560 570 580 590 600
IAAIRDGLLA RRDALRERAA TRRKLLVDSQ LLQQLYQDSD DLKTWINKKK
610 620 630 640 650
KLADDEDYKD VQNLKSRVQK QQDFEEELAA NEIMLNNLER TGQDMIENDH
660 670 680 690 700
YASDAVAARM SEVANLWKEL LEATAQKGTQ LYEANQLLQF ENNAEDLKRW
710 720 730 740 750
LEEVERQVAS EDYGKGLADV QNLLRKHGLL ESAVLARQDQ VDTLTDMAAH
760 770 780 790 800
FEEIGHPDSE NICARQESLL SRFEALKEPL ATRKKKLIDL LKLQQICRDS
810 820 830 840 850
EDEEAWIQET EPSAASTHLG KDLVAAKNLL NRHEVILADI ASHEPRIQTI
860 870 880 890 900
TERGNKMVEE GHFASEDIAS RVESLNKNME SLRARAIRRE NDLKANVQLQ
910 920 930 940 950
QYLADLHEAE AWIKEKEPIV DNKNYGADEE AAGALLKKHE AFLVDLNAFG
960 970 980 990 1000
NSIKALGDQA EACQQQQAAP VDEAGREARV IALYDFEARS RREVSMKKND
1010 1020 1030 1040 1050
VLTLLSSINK DWWKVEADDH QGFVPAVYVR KLAHDELPGF PQQRREEPVN
1060 1070 1080 1090 1100
IPQLQEQIET LYHSLLDRAE ERRRRLLQRY NEFLLAYEAG DMLEWIQEKK
1110 1120 1130 1140 1150
TENTGVELDD VWELQKKFDE FQRDLKSNEP RLKDINKVAD ELLFEDLLTP
1160 1170 1180 1190 1200
EGSHIRQELN TRWSSLKRLA DEQYQLLSSA HAVEMFLREA DDVKEQIDKK
1210 1220 1230 1240 1250
CQALNAADPG SDLLSVQALQ RQHEVFERDI IPLGEKVTTL GETAERLCES
1260 1270 1280 1290 1300
HPDATEDLQK QRTELNEAWD TLQGLTSDRK ESLNEAHKFF LFLSKASDLE
1310 1320 1330 1340 1350
NWIKAIGGVI SSPELAEDLT GTEILLERHQ EHYDDIKRED PTFQALEDFG
1360 1370 1380 1390 1400
RELIDRGHRN SHEIETTLQD IKLKRDDLEK NWENRKKMLD QCLELQLFRG
1410 1420 1430 1440 1450
KCEQVESWMV ARENSLRSDD RDHLNSLQAL MKKRDDLDKA IAAQEGKIAD
1460 1470 1480 1490 1500
LENHATRLMD NDHYAKEEIA ARLQRVLDRW KDLKTQLLAE LGKLGDYADL
1510 1520 1530 1540 1550
KQFYRDLEDL EEWISEMLPV ACDESYKDPT NIQQRKYLKH QAFENEVNGR
1560 1570 1580 1590 1600
AEQVEGVINL GKSLIERRVC DGDEENMQEQ LDKLKENWDY LLERTTDKGQ
1610 1620 1630 1640 1650
KLNEASRQQR FNTSIRDFEF WLSEAEGLLA MKDQARDLTS AGNLLKKHQL
1660 1670 1680 1690 1700
LEAEMLARED PLKDLNGLAK ELISSGTFNI EQIEEKMNGV NERFKNVQSL
1710 1720 1730 1740 1750
AAAHHEKLKE TYALFQFFQD LDDEEAWIEE KLLRVSSQDC GRDLQSVQNL
1760 1770 1780 1790 1800
LKKHRRLEGE LVAHEPAVQN VLDTAESLKD KAAVGKEEIQ ERLAQFVQHW
1810 1820 1830 1840 1850
EKLKELAKTR GVNLEESLQY LQFMENAEEE EAWLGEKDAL VSRGDSGDTL
1860 1870 1880 1890 1900
AATQSLLKKH EALENDFAVH KNRVQDVCAQ GEDILSKEET QNKDKISTKI
1910 1920 1930 1940 1950
EVLNEKTASL TKALAAWKSQ LDEVHAFQQF NWKADVVESW IGEKEASLKT
1960 1970 1980 1990 2000
KSNGADLTAF LTLLAKQDTL DASLQSFQQE RLSEITDLKD ELLAAEHSQS
2010 2020 2030 2040 2050
KAIEERHAAL LRRWEQLLEA CRVHRQKLLE KQLPLQKAEE LFMEFAHKAS
2060 2070 2080 2090 2100
AFNNWCENAE EDLSEPVHCV SLNEIRQLQK EHEAFLASMV GAQEDFNYLL
2110 2120 2130 2140 2150
ALDQQIKALN VSSSPYTWLT VDVLGRIWKH LPEIIKEREQ ELQKEEARQI
2160 2170 2180 2190 2200
KNFEMCQEFE QNASAFLQWI QETRAYFLDG SVFSRKQKEI QAMKRHLTKI
2210 2220 2230 2240 2250
EDLGDSMEEA LILDIKYSTI GLAQQWDQLH QLGMRMQHNL EQQIQAKHFD
2260 2270 2280 2290 2300
ENLTGRLTHK EFRSCLRGLN YYLPMVEEGE PEPKFEKFLN AVDPGRKGYV
2310 2320 2330 2340 2350
SLEDYTSFLI DKESENIKTS DDIESGFQAL AEGKAYITKE DMKQALTPEQ
2360 2370 2380
VSFCTIHMQQ YMDPRGRSQP AGYDYVGFTN SFFGN
Length:2,385
Mass (Da):276,622
Last modified:July 5, 2004 - v1
Checksum:i1D840FAFC8C818F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107095 Genomic DNA. No translation available.
AC117091 Genomic DNA. No translation available.
AY238342 mRNA. Translation: AAQ02378.1.
RefSeqiNP_001011908.2. NM_001011908.3.
UniGeneiRn.44157.

Genome annotation databases

EnsembliENSRNOT00000004716; ENSRNOP00000004716; ENSRNOG00000003537.
GeneIDi289257.
KEGGirno:289257.
UCSCiRGD:1305194. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107095 Genomic DNA. No translation available.
AC117091 Genomic DNA. No translation available.
AY238342 mRNA. Translation: AAQ02378.1.
RefSeqiNP_001011908.2. NM_001011908.3.
UniGeneiRn.44157.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061853.

Proteomic databases

PRIDEiF7FC39.
Q6XDA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004716; ENSRNOP00000004716; ENSRNOG00000003537.
GeneIDi289257.
KEGGirno:289257.
UCSCiRGD:1305194. rat.

Organism-specific databases

CTDi6708.
RGDi1305194. Spta1.

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000246965.
HOVERGENiHBG059266.
KOiK06114.

Enzyme and pathway databases

ReactomeiR-RNO-375165. NCAM signaling for neurite out-growth.
R-RNO-445095. Interaction between L1 and Ankyrins.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6807878. COPI-mediated anterograde transport.

Gene expression databases

BgeeiENSRNOG00000003537.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR014837. EF-hand_Ca_insen.
IPR002048. EF_hand_dom.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR013315. Spectrin_alpha_SH3.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF08726. EFhand_Ca_insen. 1 hit.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 20 hits.
[Graphical view]
PRINTSiPR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00150. SPEC. 20 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6XDA1_RAT
AccessioniPrimary (citable) accession number: Q6XDA1
Secondary accession number(s): F7FC39
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.