Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

One cut domain family member 2

Gene

Onecut2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi325 – 41187CUTPROSITE-ProRule annotationAdd
BLAST
DNA bindingi427 – 48660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • cell fate commitment Source: MGI
  • cilium assembly Source: MGI
  • endocrine pancreas development Source: MGI
  • epithelial cell development Source: MGI
  • liver development Source: MGI
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • pancreas development Source: MGI
  • peripheral nervous system neuron development Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell-matrix adhesion Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 2
Alternative name(s):
One cut homeobox 2
Transcription factor ONECUT-2
Short name:
OC-2
Gene namesi
Name:Onecut2
Synonyms:Oc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1891408. Onecut2.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505One cut domain family member 2PRO_0000202406Add
BLAST

Proteomic databases

PaxDbiQ6XBJ3.
PRIDEiQ6XBJ3.

PTM databases

PhosphoSiteiQ6XBJ3.

Expressioni

Gene expression databases

BgeeiQ6XBJ3.
CleanExiMM_ONECUT2.
ExpressionAtlasiQ6XBJ3. baseline and differential.
GenevisibleiQ6XBJ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110798.

Structurei

3D structure databases

ProteinModelPortaliQ6XBJ3.
SMRiQ6XBJ3. Positions 333-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 5627Gly-richAdd
BLAST
Compositional biasi81 – 844Poly-Pro
Compositional biasi93 – 1008Poly-Ala
Compositional biasi167 – 18519His-richAdd
BLAST
Compositional biasi318 – 3236Poly-Ser

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiQ6XBJ3.
OMAiKEMPGMG.
PhylomeDBiQ6XBJ3.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6XBJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPVGGGS GGGGGGGGGG
60 70 80 90 100
GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPTAHQEL GTAAAAAAAA
110 120 130 140 150
SRSAMVTSMA SILDGSDYRP ELSIPLHHAM SMSCDSSPPG MGMSNTYTTL
160 170 180 190 200
TPLQPLPPIS TVSDKFHHPH PHHHPHHHHH HHHHHQRLSG NVSGSFTLMR
210 220 230 240 250
DERGLPSMNN LYSPYKEMPS MSQSLSPLAA TPLGNGLGGL HNAQQSLPNY
260 270 280 290 300
GPPGHDKMLS PNFDAHHTAM LTRGEQHLSR GLGTPPAAMM SHLNGLHHPG
310 320 330 340 350
HTQSHGPVLA PSRERPPSSS SGSQVATSGQ LEEINTKEVA QRITAELKRY
360 370 380 390 400
SIPQAIFAQR VLCRSQGTLS DLLRNPKPWS KLKSGRETFR RMWKWLQEPE
410 420 430 440 450
FQRMSALRLA ACKRKEQEPN KDRNNSQKKS RLVFTDLQRR TLFAIFKENK
460 470 480 490 500
RPSKEMQITI SQQLGLELTT VSNFFMNARR RSLEKWQDDL GTGGSSSTSS

TCTKA
Length:505
Mass (Da):54,554
Last modified:April 20, 2010 - v2
Checksum:iEACECA422CDCB1A3
GO

Sequence cautioni

The sequence AAP69907.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511T → A in AAP69907 (PubMed:12971999).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY242995 mRNA. Translation: AAP69907.1. Different initiation.
AC102106 Genomic DNA. No translation available.
CCDSiCCDS29302.2.
RefSeqiNP_919244.2. NM_194268.2.
UniGeneiMm.234723.

Genome annotation databases

EnsembliENSMUST00000115145; ENSMUSP00000110798; ENSMUSG00000045991.
GeneIDi225631.
KEGGimmu:225631.
UCSCiuc008fef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY242995 mRNA. Translation: AAP69907.1. Different initiation.
AC102106 Genomic DNA. No translation available.
CCDSiCCDS29302.2.
RefSeqiNP_919244.2. NM_194268.2.
UniGeneiMm.234723.

3D structure databases

ProteinModelPortaliQ6XBJ3.
SMRiQ6XBJ3. Positions 333-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110798.

PTM databases

PhosphoSiteiQ6XBJ3.

Proteomic databases

PaxDbiQ6XBJ3.
PRIDEiQ6XBJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115145; ENSMUSP00000110798; ENSMUSG00000045991.
GeneIDi225631.
KEGGimmu:225631.
UCSCiuc008fef.1. mouse.

Organism-specific databases

CTDi9480.
MGIiMGI:1891408. Onecut2.

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiQ6XBJ3.
OMAiKEMPGMG.
PhylomeDBiQ6XBJ3.
TreeFamiTF318206.

Miscellaneous databases

NextBioi377732.
PROiQ6XBJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6XBJ3.
CleanExiMM_ONECUT2.
ExpressionAtlasiQ6XBJ3. baseline and differential.
GenevisibleiQ6XBJ3. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2."
    Jacquemin P., Pierreux C.E., Fierens S., van Eyll J.M., Lemaigre F.P., Rousseau G.G.
    Gene Expr. Patterns 3:639-644(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiONEC2_MOUSE
AccessioniPrimary (citable) accession number: Q6XBJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 20, 2010
Last modified: May 11, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.