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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Enterobacter aerogenes (Aerobacter aerogenes)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Iron 1Combined sources
Metal bindingi8 – 81Metal cation 1UniRule annotation
Metal bindingi8 – 81Zinc 1Combined sources
Metal bindingi10 – 101Iron 1; via tele nitrogenCombined sources
Metal bindingi10 – 101Metal cation 1UniRule annotation
Metal bindingi10 – 101Zinc 1; via tele nitrogenCombined sources
Binding sitei10 – 101cAMPUniRule annotation
Metal bindingi50 – 501Iron 1Combined sources
Metal bindingi50 – 501Iron 2Combined sources
Metal bindingi50 – 501Metal cation 1UniRule annotation
Metal bindingi50 – 501Metal cation 2UniRule annotation
Metal bindingi50 – 501Zinc 1Combined sources
Metal bindingi50 – 501Zinc 2Combined sources
Binding sitei50 – 501cAMPUniRule annotation
Metal bindingi80 – 801Iron 2Combined sources
Metal bindingi80 – 801Metal cation 2UniRule annotation
Metal bindingi80 – 801Zinc 2Combined sources
Metal bindingi156 – 1561Iron 2; via tele nitrogenCombined sources
Metal bindingi156 – 1561Metal cation 2UniRule annotation
Metal bindingi156 – 1561Zinc 2; via tele nitrogenCombined sources
Metal bindingi195 – 1951Iron 2; via pros nitrogenCombined sources
Metal bindingi195 – 1951Metal cation 2UniRule annotation
Metal bindingi195 – 1951Zinc 2; via pros nitrogenCombined sources
Metal bindingi197 – 1971Iron 1; via tele nitrogenCombined sources
Metal bindingi197 – 1971Metal cation 1UniRule annotation
Metal bindingi197 – 1971Zinc 1; via tele nitrogenCombined sources
Binding sitei197 – 1971cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812cAMPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Ligandi

cAMPUniRule annotation, IronCombined sources, Metal-bindingUniRule annotationCombined sources, Nucleotide-bindingUniRule annotation, ZincCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Synonyms:phImported
OrganismiEnterobacter aerogenes (Aerobacter aerogenes)Imported
Taxonomic identifieri548 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 – 54Interchain (with C-269)Combined sources
Disulfide bondi269 – 269Interchain (with C-54)Combined sources

Interactioni

Protein-protein interaction databases

STRINGi1028307.EAE_09850.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DXLX-ray3.00A/B1-274[»]
2DXNX-ray2.92A/B1-274[»]
2ZO9X-ray2.20B/C1-274[»]
2ZOAX-ray2.40A/B1-274[»]
3D03X-ray1.90A/B/C/D/E/F1-274[»]
ProteinModelPortaliQ6XBH1.
SMRiQ6XBH1. Positions 1-271.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6XBH1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 198196MetallophosInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6XBH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAHISDTH FRSRGEKLYG FIDVNAANAD VVSQLNALRE RPDAVVVSGD
60 70 80 90 100
IVNCGRPEEY QVARQILGSL NYPLYLIPGN HDDKALFLEY LQPLCPQLGS
110 120 130 140 150
DANNMRCAVD DFATRLLFID SSRAGTSKGW LTDETISWLE AQLFEGGDKP
160 170 180 190 200
ATIFMHHPPL PLGNAQMDPI ACENGHRLLA LVERFPSLTR IFCGHNHSLT
210 220 230 240 250
MTQYRQALIS TLPGTVHQVP YCHEDTRPYY DLSPASCLMH RQVGEQWVSY
260 270
QHSLAHYAGP WLYDENISCP TEER
Length:274
Mass (Da):30,840
Last modified:July 5, 2004 - v1
Checksum:iCDAC38387211DE90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243367 Genomic DNA. Translation: AAO83402.1.
RefSeqiWP_048229681.1. NZ_KQ087572.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243367 Genomic DNA. Translation: AAO83402.1.
RefSeqiWP_048229681.1. NZ_KQ087572.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DXLX-ray3.00A/B1-274[»]
2DXNX-ray2.92A/B1-274[»]
2ZO9X-ray2.20B/C1-274[»]
2ZOAX-ray2.40A/B1-274[»]
3D03X-ray1.90A/B/C/D/E/F1-274[»]
ProteinModelPortaliQ6XBH1.
SMRiQ6XBH1. Positions 1-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1028307.EAE_09850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ6XBH1.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6XBH1_ENTAE
AccessioniPrimary (citable) accession number: Q6XBH1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.