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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Enterobacter aerogenes (Aerobacter aerogenes)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Iron 1Combined sources1
Metal bindingi8Metal cation 1UniRule annotation1
Metal bindingi8Zinc 1Combined sources1
Metal bindingi10Iron 1; via tele nitrogenCombined sources1
Metal bindingi10Metal cation 1UniRule annotation1
Metal bindingi10Zinc 1; via tele nitrogenCombined sources1
Binding sitei10cAMPUniRule annotation1
Metal bindingi50Iron 1Combined sources1
Metal bindingi50Iron 2Combined sources1
Metal bindingi50Metal cation 1UniRule annotation1
Metal bindingi50Metal cation 2UniRule annotation1
Metal bindingi50Zinc 1Combined sources1
Metal bindingi50Zinc 2Combined sources1
Binding sitei50cAMPUniRule annotation1
Metal bindingi80Iron 2Combined sources1
Metal bindingi80Metal cation 2UniRule annotation1
Metal bindingi80Zinc 2Combined sources1
Metal bindingi156Iron 2; via tele nitrogenCombined sources1
Metal bindingi156Metal cation 2UniRule annotation1
Metal bindingi156Zinc 2; via tele nitrogenCombined sources1
Metal bindingi195Iron 2; via pros nitrogenCombined sources1
Metal bindingi195Metal cation 2UniRule annotation1
Metal bindingi195Zinc 2; via pros nitrogenCombined sources1
Metal bindingi197Iron 1; via tele nitrogenCombined sources1
Metal bindingi197Metal cation 1UniRule annotation1
Metal bindingi197Zinc 1; via tele nitrogenCombined sources1
Binding sitei197cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 81cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Ligandi

cAMPUniRule annotation, IronCombined sources, Metal-bindingUniRule annotationCombined sources, Nucleotide-bindingUniRule annotation, ZincCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Synonyms:phImported
OrganismiEnterobacter aerogenes (Aerobacter aerogenes)Imported
Taxonomic identifieri548 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54Interchain (with C-269)Combined sources
Disulfide bondi269Interchain (with C-54)Combined sources

Interactioni

Protein-protein interaction databases

STRINGi1028307.EAE_09850.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DXLX-ray3.00A/B1-274[»]
2DXNX-ray2.92A/B1-274[»]
2ZO9X-ray2.20B/C1-274[»]
2ZOAX-ray2.40A/B1-274[»]
3D03X-ray1.90A/B/C/D/E/F1-274[»]
ProteinModelPortaliQ6XBH1.
SMRiQ6XBH1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6XBH1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 198MetallophosInterPro annotationAdd BLAST196

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.

Family and domain databases

CDDicd07402. MPP_GpdQ. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 2 hits.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6XBH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAHISDTH FRSRGEKLYG FIDVNAANAD VVSQLNALRE RPDAVVVSGD
60 70 80 90 100
IVNCGRPEEY QVARQILGSL NYPLYLIPGN HDDKALFLEY LQPLCPQLGS
110 120 130 140 150
DANNMRCAVD DFATRLLFID SSRAGTSKGW LTDETISWLE AQLFEGGDKP
160 170 180 190 200
ATIFMHHPPL PLGNAQMDPI ACENGHRLLA LVERFPSLTR IFCGHNHSLT
210 220 230 240 250
MTQYRQALIS TLPGTVHQVP YCHEDTRPYY DLSPASCLMH RQVGEQWVSY
260 270
QHSLAHYAGP WLYDENISCP TEER
Length:274
Mass (Da):30,840
Last modified:July 5, 2004 - v1
Checksum:iCDAC38387211DE90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243367 Genomic DNA. Translation: AAO83402.1.
RefSeqiWP_048229681.1. NZ_KQ087572.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243367 Genomic DNA. Translation: AAO83402.1.
RefSeqiWP_048229681.1. NZ_KQ087572.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DXLX-ray3.00A/B1-274[»]
2DXNX-ray2.92A/B1-274[»]
2ZO9X-ray2.20B/C1-274[»]
2ZOAX-ray2.40A/B1-274[»]
3D03X-ray1.90A/B/C/D/E/F1-274[»]
ProteinModelPortaliQ6XBH1.
SMRiQ6XBH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1028307.EAE_09850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ6XBH1.

Family and domain databases

CDDicd07402. MPP_GpdQ. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 2 hits.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6XBH1_ENTAE
AccessioniPrimary (citable) accession number: Q6XBH1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.