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Protein

Aspartic proteinase CDR1

Gene

CDR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in salicylic acid-dependent inducible resistance responses. May release an endogenous peptide elicitor required for the activation of inducible resistance mechanisms. Possesses protease activity in vitro.1 Publication

Miscellaneous

Gain-of-function mutant CDR1-D (T-DNA tagging) shows a dwarf phenotype with dark and curled leaves, constitutive expression of the pathogenesis-related genes PR1 and PR2, and resistance to virulent Pseudomonas syringae.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108PROSITE-ProRule annotation1
Active sitei319PROSITE-ProRule annotation1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: TAIR

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • protein catabolic process Source: GO_Central
  • regulation of hydrogen peroxide metabolic process Source: TAIR
  • regulation of salicylic acid metabolic process Source: TAIR

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease
Biological processPlant defense

Protein family/group databases

MEROPSiA01.069

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase CDR1 (EC:3.4.23.-)
Alternative name(s):
Protein CONSTITUTIVE DISEASE RESISTANCE 1
Gene namesi
Name:CDR1
Ordered Locus Names:At5g33340
ORF Names:F19N2.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G33340
TAIRilocus:2145954 AT5G33340

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi108D → N: Loss of function. 1 Publication1
Mutagenesisi319D → N: Loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000042063326 – 73Activation peptideSequence analysisAdd BLAST48
ChainiPRO_000042063474 – 437Aspartic proteinase CDR1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ6XBF8

PTM databases

iPTMnetiQ6XBF8

Expressioni

Gene expression databases

ExpressionAtlasiQ6XBF8 baseline and differential
GenevisibleiQ6XBF8 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G33340.1

Structurei

3D structure databases

ProteinModelPortaliQ6XBF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 430Peptidase A1PROSITE-ProRule annotationAdd BLAST341

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
HOGENOMiHOG000237482
InParanoidiQ6XBF8
OMAiCGFAISY
OrthoDBiEOG09360EVH
PhylomeDBiQ6XBF8

Family and domain databases

CDDicd05476 pepsin_A_like_plant, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR034161 Pepsin-like_plant
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR032799 TAXi_C
IPR032861 TAXi_N
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF14541 TAXi_C, 1 hit
PF14543 TAXi_N, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6XBF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLFSSVLL SLCLLSSLFL SNANAKPKLG FTADLIHRDS PKSPFYNPME
60 70 80 90 100
TSSQRLRNAI HRSVNRVFHF TEKDNTPQPQ IDLTSNSGEY LMNVSIGTPP
110 120 130 140 150
FPIMAIADTG SDLLWTQCAP CDDCYTQVDP LFDPKTSSTY KDVSCSSSQC
160 170 180 190 200
TALENQASCS TNDNTCSYSL SYGDNSYTKG NIAVDTLTLG SSDTRPMQLK
210 220 230 240 250
NIIIGCGHNN AGTFNKKGSG IVGLGGGPVS LIKQLGDSID GKFSYCLVPL
260 270 280 290 300
TSKKDQTSKI NFGTNAIVSG SGVVSTPLIA KASQETFYYL TLKSISVGSK
310 320 330 340 350
QIQYSGSDSE SSEGNIIIDS GTTLTLLPTE FYSELEDAVA SSIDAEKKQD
360 370 380 390 400
PQSGLSLCYS ATGDLKVPVI TMHFDGADVK LDSSNAFVQV SEDLVCFAFR
410 420 430
GSPSFSIYGN VAQMNFLVGY DTVSKTVSFK PTDCAKM
Length:437
Mass (Da):46,819
Last modified:July 5, 2004 - v1
Checksum:i67803435746BF3C0
GO

Sequence cautioni

The sequence ABK28718 differs from that shown. Reason: Erroneous termination at position 438. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243479 mRNA Translation: AAP72988.1
AC051625 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED93896.1
DQ446998 mRNA Translation: ABE66189.1
DQ653316 mRNA Translation: ABK28718.1 Sequence problems.
BT026129 mRNA Translation: ABG48485.1
RefSeqiNP_198319.1, NM_122858.3
UniGeneiAt.50488

Genome annotation databases

EnsemblPlantsiAT5G33340.1; AT5G33340.1; AT5G33340
GeneIDi833310
GrameneiAT5G33340.1; AT5G33340.1; AT5G33340
KEGGiath:AT5G33340

Similar proteinsi

Entry informationi

Entry nameiCDR1_ARATH
AccessioniPrimary (citable) accession number: Q6XBF8
Secondary accession number(s): A0MFJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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