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Protein

TYRO protein tyrosine kinase-binding protein

Gene

Tyrobp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei56 – 561Important for interaction with transmembrane receptorsBy similarity

GO - Molecular functioni

  • receptor signaling protein activity Source: RGD

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2172127. DAP12 interactions.
R-RNO-2424491. DAP12 signaling.
R-RNO-391160. Signal regulatory protein (SIRP) family interactions.
R-RNO-416700. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
TYRO protein tyrosine kinase-binding protein
Alternative name(s):
DNAX-activation protein 12
Gene namesi
Name:Tyrobp
Synonyms:Dap12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303081. Tyrobp.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 4215ExtracellularSequence analysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Topological domaini64 – 11451CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of membrane Source: RGD
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 11487TYRO protein tyrosine kinase-binding proteinPRO_0000022607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 – 37InterchainBy similarity
Modified residuei92 – 921PhosphotyrosineBy similarity
Modified residuei103 – 1031PhosphotyrosineBy similarity

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ6X9T7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020845.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with CLECSF5. Interacts with SIGLEC14. Interacts with CD300LB, CD300D and CD300E (By similarity). Interacts with KLRC2 and KIR2DS3 (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028284.

Structurei

3D structure databases

ProteinModelPortaliQ6X9T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 10929ITAMAdd
BLAST

Sequence similaritiesi

Belongs to the TYROBP family.Curated
Contains 1 ITAM domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1XS. Eukaryota.
ENOG410Z4TN. LUCA.
GeneTreeiENSGT00390000016786.
HOGENOMiHOG000056440.
HOVERGENiHBG061468.
InParanoidiQ6X9T7.
KOiK07992.
OMAiNCSVVSP.
OrthoDBiEOG091G0X44.
PhylomeDBiQ6X9T7.
TreeFamiTF336898.

Family and domain databases

InterProiIPR026200. Tyrobp.
[Graphical view]
PANTHERiPTHR17554. PTHR17554. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6X9T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPEPSWCF LFLPVLLTVG GLSPVQAQSD NYPGCECSSV SPGVLAGIVL
60 70 80 90 100
GDLVLTLLIA LAVYSLGRLV SRGRGTADGT RKQHMAETES PYQELQGQRP
110
EVYSDLNTQR QYYR
Length:114
Mass (Da):12,361
Last modified:July 5, 2004 - v1
Checksum:iB551352F4FA2760A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247021 mRNA. Translation: AAP79987.1.
RefSeqiNP_997690.1. NM_212525.1.
UniGeneiRn.11534.

Genome annotation databases

EnsembliENSRNOT00000028284; ENSRNOP00000028284; ENSRNOG00000020845.
GeneIDi361537.
KEGGirno:361537.
UCSCiRGD:1303081. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247021 mRNA. Translation: AAP79987.1.
RefSeqiNP_997690.1. NM_212525.1.
UniGeneiRn.11534.

3D structure databases

ProteinModelPortaliQ6X9T7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028284.

Proteomic databases

PaxDbiQ6X9T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028284; ENSRNOP00000028284; ENSRNOG00000020845.
GeneIDi361537.
KEGGirno:361537.
UCSCiRGD:1303081. rat.

Organism-specific databases

CTDi7305.
RGDi1303081. Tyrobp.

Phylogenomic databases

eggNOGiENOG410J1XS. Eukaryota.
ENOG410Z4TN. LUCA.
GeneTreeiENSGT00390000016786.
HOGENOMiHOG000056440.
HOVERGENiHBG061468.
InParanoidiQ6X9T7.
KOiK07992.
OMAiNCSVVSP.
OrthoDBiEOG091G0X44.
PhylomeDBiQ6X9T7.
TreeFamiTF336898.

Enzyme and pathway databases

ReactomeiR-RNO-2172127. DAP12 interactions.
R-RNO-2424491. DAP12 signaling.
R-RNO-391160. Signal regulatory protein (SIRP) family interactions.
R-RNO-416700. Other semaphorin interactions.

Miscellaneous databases

PROiQ6X9T7.

Gene expression databases

BgeeiENSRNOG00000020845.

Family and domain databases

InterProiIPR026200. Tyrobp.
[Graphical view]
PANTHERiPTHR17554. PTHR17554. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTYOBP_RAT
AccessioniPrimary (citable) accession number: Q6X9T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.