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Protein

Kin of IRRE-like protein 1

Gene

Kirrel

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-373753. Nephrin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Kin of IRRE-like protein 1
Alternative name(s):
Kin of irregular chiasm-like protein 1
Nephrin-like protein 1
Gene namesi
Name:Kirrel
Synonyms:Kirrel1, Neph1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi727883. Kirrel.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini48 – 531484ExtracellularSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST
Topological domaini553 – 789237CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell-cell junction Source: RGD
  • cell projection membrane Source: RGD
  • dendritic shaft Source: Ensembl
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: UniProtKB
  • perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4747Sequence analysisAdd
BLAST
Chaini48 – 789742Kin of IRRE-like protein 1PRO_0000015095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi74 ↔ 132PROSITE-ProRule annotation
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi175 ↔ 232PROSITE-ProRule annotation
Disulfide bondi276 ↔ 319PROSITE-ProRule annotation
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi361 ↔ 403PROSITE-ProRule annotation
Disulfide bondi445 ↔ 504PROSITE-ProRule annotation
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence analysis
Modified residuei606 – 6061PhosphoserineBy similarity
Modified residuei637 – 6371Phosphotyrosine; by FYN1 Publication
Modified residuei638 – 6381Phosphotyrosine; by FYN1 Publication
Modified residuei654 – 6541PhosphotyrosineBy similarity
Modified residuei657 – 6571PhosphotyrosineBy similarity
Modified residuei756 – 7561PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylation probably regulates the interaction with NPHS2 (By similarity). Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding.By similarity1 Publication
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6X936.
PRIDEiQ6X936.

PTM databases

iPTMnetiQ6X936.
PhosphoSiteiQ6X936.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016408.
ExpressionAtlasiQ6X936. baseline and differential.
GenevisibleiQ6X936. RN.

Interactioni

Subunit structurei

Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains) (By similarity). Interacts when tyrosine-phosphorylated with GRB2.By similarity1 Publication

Protein-protein interaction databases

IntActiQ6X936. 1 interaction.
MINTiMINT-8013671.
STRINGi10116.ENSRNOP00000033900.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 14799Ig-like C2-type 1Add
BLAST
Domaini152 – 24897Ig-like C2-type 2Add
BLAST
Domaini255 – 33581Ig-like C2-type 3Add
BLAST
Domaini340 – 41980Ig-like C2-type 4Add
BLAST
Domaini424 – 52097Ig-like C2-type 5Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi437 – 4393Cell attachment siteSequence analysis

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
ENOG410XPX0. LUCA.
GeneTreeiENSGT00550000074545.
HOGENOMiHOG000020211.
HOVERGENiHBG052260.
InParanoidiQ6X936.
OMAiWILTLSD.
OrthoDBiEOG091G02BJ.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6X936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLENRSTCL MTCQSSLLPK KPRFLSQKMW APHLVVAYLI FVTLALALPG
60 70 80 90 100
TQTRFSQEPA DQTVVAGHRA VLPCVLLNYS GIVQWTKDGL ALGMGQGLKA
110 120 130 140 150
WPRYRVVGSA DAGQYNLEIT DAELSDDASY ECQATEAALR SRRAKLTVLI
160 170 180 190 200
PPEDTRIDGG PVILLQAGTP YNLTCRAFNA KPAATIIWFR DGTQQEGAVT
210 220 230 240 250
STELLKDGKR ETTISQLLIQ PTDLDIGRVF TCRSMNEAIP NGKETSIELD
260 270 280 290 300
VHHPPTVTLS IEPQTVLEGE RVIFTCQATA NPEILGYRWA KGGFLIEDAH
310 320 330 340 350
ESRYETNVDY SFFTEPVSCE VYNKVGSTNV STLVNVHFAP RIVVYPKPTT
360 370 380 390 400
TDIGSDVTLT CVWVGNPPLT LTWTKKDSNM VLSNSNQLLL KSVTQADAGT
410 420 430 440 450
YTCRAIVPRI GVAEREVPLY VNGPPIISSE AVQFAVRGDG GKVECFIGST
460 470 480 490 500
PPPDRIAWAW KENFLEVGTL ERYTVERTNS GSGVLSTLTI NNVMEADFQT
510 520 530 540 550
HYNCTAWNSF GPGTAIIQLE EREVLPVGII AGATIGAGIL LVFSFAALVF
560 570 580 590 600
FLYRRRKGSR KDVTLRKLDI KVETVNREPL TMHSDREDDT TSISTATRVM
610 620 630 640 650
KAIYSSFKDD VDLKQDLHCD TIETREEYEM KDPTNGYYNV RAHEDRPSSR
660 670 680 690 700
AVLYADYRAP GPTRFDGRPS SRLSHSSGYA QLNTYSRAPA SDYGTEPTPS
710 720 730 740 750
GPSAPGGTDT TSQLSYENYE KFNSHPFPGA AGYPTYRLGY PQAPPSGLER
760 770 780
TPYEAYDPIG KYATATRFSY TSQHSDYGQR FQQRMQTHV
Length:789
Mass (Da):87,241
Last modified:March 19, 2014 - v2
Checksum:iD463901B08FB34BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti322 – 3232YN → DS in AAP78673 (Ref. 1) Curated
Sequence conflicti333 – 3331L → V in AAP78673 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY249056 mRNA. Translation: AAP78673.1.
AABR06018737 Genomic DNA. No translation available.
AABR06018738 Genomic DNA. No translation available.
AY271309 mRNA. Translation: AAP12626.1.
RefSeqiNP_997489.1. NM_207606.1.
XP_006232739.1. XM_006232677.2.
UniGeneiRn.211884.

Genome annotation databases

EnsembliENSRNOT00000031743; ENSRNOP00000033900; ENSRNOG00000016408.
GeneIDi310695.
KEGGirno:310695.
UCSCiRGD:727883. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY249056 mRNA. Translation: AAP78673.1.
AABR06018737 Genomic DNA. No translation available.
AABR06018738 Genomic DNA. No translation available.
AY271309 mRNA. Translation: AAP12626.1.
RefSeqiNP_997489.1. NM_207606.1.
XP_006232739.1. XM_006232677.2.
UniGeneiRn.211884.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6X936. 1 interaction.
MINTiMINT-8013671.
STRINGi10116.ENSRNOP00000033900.

PTM databases

iPTMnetiQ6X936.
PhosphoSiteiQ6X936.

Proteomic databases

PaxDbiQ6X936.
PRIDEiQ6X936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031743; ENSRNOP00000033900; ENSRNOG00000016408.
GeneIDi310695.
KEGGirno:310695.
UCSCiRGD:727883. rat.

Organism-specific databases

CTDi55243.
RGDi727883. Kirrel.

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
ENOG410XPX0. LUCA.
GeneTreeiENSGT00550000074545.
HOGENOMiHOG000020211.
HOVERGENiHBG052260.
InParanoidiQ6X936.
OMAiWILTLSD.
OrthoDBiEOG091G02BJ.

Enzyme and pathway databases

ReactomeiR-RNO-373753. Nephrin interactions.

Miscellaneous databases

PROiQ6X936.

Gene expression databases

BgeeiENSRNOG00000016408.
ExpressionAtlasiQ6X936. baseline and differential.
GenevisibleiQ6X936. RN.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIRR1_RAT
AccessioniPrimary (citable) accession number: Q6X936
Secondary accession number(s): F1M7V1, Q80W67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 19, 2014
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.