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Protein

Kin of IRRE-like protein 1

Gene

Kirrel1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-373753 Nephrin family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Kin of IRRE-like protein 1
Alternative name(s):
Kin of irregular chiasm-like protein 1
Nephrin-like protein 1
Gene namesi
Name:Kirrel1
Synonyms:Kirrel, Neph1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi727883 Kirrel1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini48 – 531ExtracellularSequence analysisAdd BLAST484
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 789CytoplasmicSequence analysisAdd BLAST237

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 47Sequence analysisAdd BLAST47
ChainiPRO_000001509548 – 789Kin of IRRE-like protein 1Add BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi74 ↔ 132PROSITE-ProRule annotation
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi175 ↔ 232PROSITE-ProRule annotation
Disulfide bondi276 ↔ 319PROSITE-ProRule annotation
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi361 ↔ 403PROSITE-ProRule annotation
Disulfide bondi445 ↔ 504PROSITE-ProRule annotation
Glycosylationi503N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei606PhosphoserineBy similarity1
Modified residuei637Phosphotyrosine; by FYN1 Publication1
Modified residuei638Phosphotyrosine; by FYN1 Publication1
Modified residuei654PhosphotyrosineBy similarity1
Modified residuei657PhosphotyrosineBy similarity1
Modified residuei756PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylation probably regulates the interaction with NPHS2 (By similarity). Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding.By similarity1 Publication
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6X936
PRIDEiQ6X936

PTM databases

iPTMnetiQ6X936
PhosphoSitePlusiQ6X936

Expressioni

Gene expression databases

BgeeiENSRNOG00000016408
ExpressionAtlasiQ6X936 baseline and differential
GenevisibleiQ6X936 RN

Interactioni

Subunit structurei

Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL1 glycosylation. Homodimer (via the Ig-like domains) (By similarity). Interacts when tyrosine-phosphorylated with GRB2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6X936, 1 interactor
MINTiQ6X936
STRINGi10116.ENSRNOP00000033900

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 147Ig-like C2-type 1Add BLAST99
Domaini152 – 248Ig-like C2-type 2Add BLAST97
Domaini255 – 335Ig-like C2-type 3Add BLAST81
Domaini340 – 419Ig-like C2-type 4Add BLAST80
Domaini424 – 520Ig-like C2-type 5Add BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi437 – 439Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3510 Eukaryota
ENOG410XPX0 LUCA
GeneTreeiENSGT00550000074545
HOGENOMiHOG000020211
HOVERGENiHBG052260
InParanoidiQ6X936
OMAiHHNTNFT
OrthoDBiEOG091G02BJ

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6X936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLENRSTCL MTCQSSLLPK KPRFLSQKMW APHLVVAYLI FVTLALALPG
60 70 80 90 100
TQTRFSQEPA DQTVVAGHRA VLPCVLLNYS GIVQWTKDGL ALGMGQGLKA
110 120 130 140 150
WPRYRVVGSA DAGQYNLEIT DAELSDDASY ECQATEAALR SRRAKLTVLI
160 170 180 190 200
PPEDTRIDGG PVILLQAGTP YNLTCRAFNA KPAATIIWFR DGTQQEGAVT
210 220 230 240 250
STELLKDGKR ETTISQLLIQ PTDLDIGRVF TCRSMNEAIP NGKETSIELD
260 270 280 290 300
VHHPPTVTLS IEPQTVLEGE RVIFTCQATA NPEILGYRWA KGGFLIEDAH
310 320 330 340 350
ESRYETNVDY SFFTEPVSCE VYNKVGSTNV STLVNVHFAP RIVVYPKPTT
360 370 380 390 400
TDIGSDVTLT CVWVGNPPLT LTWTKKDSNM VLSNSNQLLL KSVTQADAGT
410 420 430 440 450
YTCRAIVPRI GVAEREVPLY VNGPPIISSE AVQFAVRGDG GKVECFIGST
460 470 480 490 500
PPPDRIAWAW KENFLEVGTL ERYTVERTNS GSGVLSTLTI NNVMEADFQT
510 520 530 540 550
HYNCTAWNSF GPGTAIIQLE EREVLPVGII AGATIGAGIL LVFSFAALVF
560 570 580 590 600
FLYRRRKGSR KDVTLRKLDI KVETVNREPL TMHSDREDDT TSISTATRVM
610 620 630 640 650
KAIYSSFKDD VDLKQDLHCD TIETREEYEM KDPTNGYYNV RAHEDRPSSR
660 670 680 690 700
AVLYADYRAP GPTRFDGRPS SRLSHSSGYA QLNTYSRAPA SDYGTEPTPS
710 720 730 740 750
GPSAPGGTDT TSQLSYENYE KFNSHPFPGA AGYPTYRLGY PQAPPSGLER
760 770 780
TPYEAYDPIG KYATATRFSY TSQHSDYGQR FQQRMQTHV
Length:789
Mass (Da):87,241
Last modified:March 19, 2014 - v2
Checksum:iD463901B08FB34BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti322 – 323YN → DS in AAP78673 (Ref. 1) Curated2
Sequence conflicti333L → V in AAP78673 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY249056 mRNA Translation: AAP78673.1
AABR06018737 Genomic DNA No translation available.
AABR06018738 Genomic DNA No translation available.
AY271309 mRNA Translation: AAP12626.1
RefSeqiNP_997489.1, NM_207606.1
XP_006232739.1, XM_006232677.3
UniGeneiRn.211884

Genome annotation databases

EnsembliENSRNOT00000031743; ENSRNOP00000033900; ENSRNOG00000016408
GeneIDi310695
KEGGirno:310695
UCSCiRGD:727883 rat

Similar proteinsi

Entry informationi

Entry nameiKIRR1_RAT
AccessioniPrimary (citable) accession number: Q6X936
Secondary accession number(s): F1M7V1, Q80W67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 19, 2014
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health