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Protein

Zona pellucida-binding protein 2

Gene

ZPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Is implicated in sperm-oocyte interaction during fertilization.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33508-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-binding protein 2
Alternative name(s):
ZPBP-like protein
Gene namesi
Name:ZPBP2
Synonyms:ZPBPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20678. ZPBP2.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesicleacrosome By similarity
  • Secreted Curated

  • Note: Released after the acrosomal reaction.By similarity

GO - Cellular componenti

  • acrosomal vesicle Source: UniProtKB-SubCell
  • cell body Source: Ensembl
  • extracellular region Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
  • zona pellucida receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi124626.
OpenTargetsiENSG00000186075.
PharmGKBiPA134894503.

Polymorphism and mutation databases

BioMutaiZPBP2.
DMDMi54036632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004160121 – 338Zona pellucida-binding protein 2Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6X784.
PeptideAtlasiQ6X784.
PRIDEiQ6X784.

Expressioni

Tissue specificityi

Expressed specifically in testis.1 Publication

Gene expression databases

BgeeiENSG00000186075.
CleanExiHS_ZPBP2.
ExpressionAtlasiQ6X784. baseline and differential.
GenevisibleiQ6X784. HS.

Organism-specific databases

HPAiHPA027997.
HPA053070.

Interactioni

Protein-protein interaction databases

BioGridi125879. 13 interactors.
STRINGi9606.ENSP00000335384.

Structurei

3D structure databases

ProteinModelPortaliQ6X784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHHK. Eukaryota.
ENOG410YFNT. LUCA.
GeneTreeiENSGT00520000055647.
HOGENOMiHOG000230972.
HOVERGENiHBG079387.
InParanoidiQ6X784.
OMAiEPSYKCH.
OrthoDBiEOG091G0C7V.
PhylomeDBiQ6X784.
TreeFamiTF335677.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6X784-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMRTCVLLSA VLWCLTGVQC PRFTLFNKKG FIYGKTGQPD KIYVELHQNS
60 70 80 90 100
PVLICMDFKL SKKEIVDPTY LWIGPNEKTL TGNNRINITE TGQLMVKDFL
110 120 130 140 150
EPLSGLYTCT LSYKTVKAET QEEKTVKKRY DFMVFAYREP DYSYQMAVRF
160 170 180 190 200
TTRSCIGRYN DVFFRVLKKI LDSLISDLSC HVIEPSYKCH SVEIPEHGLI
210 220 230 240 250
HELFIAFQVN PFAPGWKGAC NGSVDCEDTT NHNILQARDR IEDFFRSQAY
260 270 280 290 300
IFYHNFNKTL PAMHFVDHSL QVVRLDSCRP GFGKNERLHS NCASCCVVCS
310 320 330
PATFSPDVNV TCQTCVSVLT YGAKSCPQTS NKNQQYED
Length:338
Mass (Da):38,652
Last modified:July 5, 2004 - v1
Checksum:i5D5E271EAB9F3D47
GO
Isoform 2 (identifier: Q6X784-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-39: Missing.

Show »
Length:316
Mass (Da):36,140
Checksum:i63F2D847FA41CE16
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05374768P → A.Corresponds to variant rs35591738dbSNPEnsembl.1
Natural variantiVAR_06700369T → I.1 PublicationCorresponds to variant rs189660050dbSNPEnsembl.1
Natural variantiVAR_053748118A → T.Corresponds to variant rs35829084dbSNPEnsembl.1
Natural variantiVAR_053749173S → I.1 PublicationCorresponds to variant rs11557467dbSNPEnsembl.1
Natural variantiVAR_053750335Q → E.Corresponds to variant rs35302660dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01168318 – 39Missing in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251603 mRNA. Translation: AAP83950.1.
AY251604 mRNA. Translation: AAP83951.1.
AK292383 mRNA. Translation: BAF85072.1.
BC043152 mRNA. Translation: AAH43152.3.
CCDSiCCDS11352.1. [Q6X784-1]
CCDS11353.2. [Q6X784-2]
RefSeqiNP_942141.2. NM_198844.2. [Q6X784-2]
NP_955353.1. NM_199321.2. [Q6X784-1]
UniGeneiHs.367245.

Genome annotation databases

EnsembliENST00000348931; ENSP00000335384; ENSG00000186075. [Q6X784-1]
ENST00000377940; ENSP00000367174; ENSG00000186075. [Q6X784-2]
GeneIDi124626.
KEGGihsa:124626.
UCSCiuc002hte.4. human. [Q6X784-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251603 mRNA. Translation: AAP83950.1.
AY251604 mRNA. Translation: AAP83951.1.
AK292383 mRNA. Translation: BAF85072.1.
BC043152 mRNA. Translation: AAH43152.3.
CCDSiCCDS11352.1. [Q6X784-1]
CCDS11353.2. [Q6X784-2]
RefSeqiNP_942141.2. NM_198844.2. [Q6X784-2]
NP_955353.1. NM_199321.2. [Q6X784-1]
UniGeneiHs.367245.

3D structure databases

ProteinModelPortaliQ6X784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125879. 13 interactors.
STRINGi9606.ENSP00000335384.

Polymorphism and mutation databases

BioMutaiZPBP2.
DMDMi54036632.

Proteomic databases

PaxDbiQ6X784.
PeptideAtlasiQ6X784.
PRIDEiQ6X784.

Protocols and materials databases

DNASUi124626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348931; ENSP00000335384; ENSG00000186075. [Q6X784-1]
ENST00000377940; ENSP00000367174; ENSG00000186075. [Q6X784-2]
GeneIDi124626.
KEGGihsa:124626.
UCSCiuc002hte.4. human. [Q6X784-1]

Organism-specific databases

CTDi124626.
DisGeNETi124626.
GeneCardsiZPBP2.
HGNCiHGNC:20678. ZPBP2.
HPAiHPA027997.
HPA053070.
MIMi608499. gene.
neXtProtiNX_Q6X784.
OpenTargetsiENSG00000186075.
PharmGKBiPA134894503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHK. Eukaryota.
ENOG410YFNT. LUCA.
GeneTreeiENSGT00520000055647.
HOGENOMiHOG000230972.
HOVERGENiHBG079387.
InParanoidiQ6X784.
OMAiEPSYKCH.
OrthoDBiEOG091G0C7V.
PhylomeDBiQ6X784.
TreeFamiTF335677.

Enzyme and pathway databases

BioCyciZFISH:G66-33508-MONOMER.

Miscellaneous databases

GenomeRNAii124626.
PROiQ6X784.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186075.
CleanExiHS_ZPBP2.
ExpressionAtlasiQ6X784. baseline and differential.
GenevisibleiQ6X784. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZPBP2_HUMAN
AccessioniPrimary (citable) accession number: Q6X784
Secondary accession number(s): A8K8L8, Q6X783, Q86XL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.