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Protein

Zona pellucida-binding protein 2

Gene

ZPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be implicated in gamete interaction during fertilization.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-binding protein 2
Alternative name(s):
ZPBP-like protein
Gene namesi
Name:ZPBP2
Synonyms:ZPBPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20678. ZPBP2.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: Ensembl
  • cell body Source: Ensembl
  • extracellular region Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
  • zona pellucida receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894503.

Polymorphism and mutation databases

BioMutaiZPBP2.
DMDMi54036632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 338318Zona pellucida-binding protein 2PRO_0000041601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6X784.
PeptideAtlasiQ6X784.
PRIDEiQ6X784.

Expressioni

Gene expression databases

BgeeiENSG00000186075.
CleanExiHS_ZPBP2.
ExpressionAtlasiQ6X784. baseline and differential.
GenevisibleiQ6X784. HS.

Organism-specific databases

HPAiHPA027997.
HPA053070.

Interactioni

Protein-protein interaction databases

BioGridi125879. 13 interactions.
STRINGi9606.ENSP00000335384.

Structurei

3D structure databases

ProteinModelPortaliQ6X784.
SMRiQ6X784. Positions 49-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHHK. Eukaryota.
ENOG410YFNT. LUCA.
GeneTreeiENSGT00520000055647.
HOGENOMiHOG000230972.
HOVERGENiHBG079387.
InParanoidiQ6X784.
OMAiEPSYKCH.
OrthoDBiEOG091G0C7V.
PhylomeDBiQ6X784.
TreeFamiTF335677.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6X784-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMRTCVLLSA VLWCLTGVQC PRFTLFNKKG FIYGKTGQPD KIYVELHQNS
60 70 80 90 100
PVLICMDFKL SKKEIVDPTY LWIGPNEKTL TGNNRINITE TGQLMVKDFL
110 120 130 140 150
EPLSGLYTCT LSYKTVKAET QEEKTVKKRY DFMVFAYREP DYSYQMAVRF
160 170 180 190 200
TTRSCIGRYN DVFFRVLKKI LDSLISDLSC HVIEPSYKCH SVEIPEHGLI
210 220 230 240 250
HELFIAFQVN PFAPGWKGAC NGSVDCEDTT NHNILQARDR IEDFFRSQAY
260 270 280 290 300
IFYHNFNKTL PAMHFVDHSL QVVRLDSCRP GFGKNERLHS NCASCCVVCS
310 320 330
PATFSPDVNV TCQTCVSVLT YGAKSCPQTS NKNQQYED
Length:338
Mass (Da):38,652
Last modified:July 5, 2004 - v1
Checksum:i5D5E271EAB9F3D47
GO
Isoform 2 (identifier: Q6X784-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-39: Missing.

Show »
Length:316
Mass (Da):36,140
Checksum:i63F2D847FA41CE16
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681P → A.
Corresponds to variant rs35591738 [ dbSNP | Ensembl ].
VAR_053747
Natural varianti69 – 691T → I.1 Publication
Corresponds to variant rs189660050 [ dbSNP | Ensembl ].
VAR_067003
Natural varianti118 – 1181A → T.
Corresponds to variant rs35829084 [ dbSNP | Ensembl ].
VAR_053748
Natural varianti173 – 1731S → I.1 Publication
Corresponds to variant rs11557467 [ dbSNP | Ensembl ].
VAR_053749
Natural varianti335 – 3351Q → E.
Corresponds to variant rs35302660 [ dbSNP | Ensembl ].
VAR_053750

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 3922Missing in isoform 2. 2 PublicationsVSP_011683Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251603 mRNA. Translation: AAP83950.1.
AY251604 mRNA. Translation: AAP83951.1.
AK292383 mRNA. Translation: BAF85072.1.
BC043152 mRNA. Translation: AAH43152.3.
CCDSiCCDS11352.1. [Q6X784-1]
CCDS11353.2. [Q6X784-2]
RefSeqiNP_942141.2. NM_198844.2. [Q6X784-2]
NP_955353.1. NM_199321.2. [Q6X784-1]
UniGeneiHs.367245.

Genome annotation databases

EnsembliENST00000348931; ENSP00000335384; ENSG00000186075. [Q6X784-1]
ENST00000377940; ENSP00000367174; ENSG00000186075. [Q6X784-2]
GeneIDi124626.
KEGGihsa:124626.
UCSCiuc002hte.4. human. [Q6X784-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251603 mRNA. Translation: AAP83950.1.
AY251604 mRNA. Translation: AAP83951.1.
AK292383 mRNA. Translation: BAF85072.1.
BC043152 mRNA. Translation: AAH43152.3.
CCDSiCCDS11352.1. [Q6X784-1]
CCDS11353.2. [Q6X784-2]
RefSeqiNP_942141.2. NM_198844.2. [Q6X784-2]
NP_955353.1. NM_199321.2. [Q6X784-1]
UniGeneiHs.367245.

3D structure databases

ProteinModelPortaliQ6X784.
SMRiQ6X784. Positions 49-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125879. 13 interactions.
STRINGi9606.ENSP00000335384.

Polymorphism and mutation databases

BioMutaiZPBP2.
DMDMi54036632.

Proteomic databases

PaxDbiQ6X784.
PeptideAtlasiQ6X784.
PRIDEiQ6X784.

Protocols and materials databases

DNASUi124626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348931; ENSP00000335384; ENSG00000186075. [Q6X784-1]
ENST00000377940; ENSP00000367174; ENSG00000186075. [Q6X784-2]
GeneIDi124626.
KEGGihsa:124626.
UCSCiuc002hte.4. human. [Q6X784-1]

Organism-specific databases

CTDi124626.
GeneCardsiZPBP2.
HGNCiHGNC:20678. ZPBP2.
HPAiHPA027997.
HPA053070.
MIMi608499. gene.
neXtProtiNX_Q6X784.
PharmGKBiPA134894503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHK. Eukaryota.
ENOG410YFNT. LUCA.
GeneTreeiENSGT00520000055647.
HOGENOMiHOG000230972.
HOVERGENiHBG079387.
InParanoidiQ6X784.
OMAiEPSYKCH.
OrthoDBiEOG091G0C7V.
PhylomeDBiQ6X784.
TreeFamiTF335677.

Miscellaneous databases

GenomeRNAii124626.
PROiQ6X784.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186075.
CleanExiHS_ZPBP2.
ExpressionAtlasiQ6X784. baseline and differential.
GenevisibleiQ6X784. HS.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZPBP2_HUMAN
AccessioniPrimary (citable) accession number: Q6X784
Secondary accession number(s): A8K8L8, Q6X783, Q86XL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.