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Protein

Probable G-protein coupled receptor 75

Gene

Gpr75

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.1 Publication1 Publication

GO - Molecular functioni

  • C-C chemokine receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • chemokine-mediated signaling pathway Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • regulation of neuron death Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 75
Gene namesi
Name:Gpr75
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2441843. Gpr75.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 86CytoplasmicSequence analysisAdd BLAST19
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 120ExtracellularSequence analysisAdd BLAST13
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 160CytoplasmicSequence analysisAdd BLAST19
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 205ExtracellularSequence analysisAdd BLAST24
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 318CytoplasmicSequence analysisAdd BLAST92
Transmembranei319 – 339Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini340 – 350ExtracellularSequence analysisAdd BLAST11
Transmembranei351 – 371Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini372 – 540CytoplasmicSequence analysisAdd BLAST169

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695841 – 540Probable G-protein coupled receptor 75Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6X632.
PRIDEiQ6X632.

Expressioni

Tissue specificityi

Highly expressed in brain and heart. Also detected in skeletal muscle, liver and kidney. Also expressed by islet cells (at protein level).2 Publications

Developmental stagei

Expressed at E7 and E11. Also detected at E17.1 Publication

Gene expression databases

BgeeiENSMUSG00000043999.
CleanExiMM_GPR75.
ExpressionAtlasiQ6X632. baseline and differential.
GenevisibleiQ6X632. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105057.

Structurei

3D structure databases

ProteinModelPortaliQ6X632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 121Phe-richAdd BLAST61

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVJ. Eukaryota.
ENOG410ZQWK. LUCA.
GeneTreeiENSGT00390000007723.
HOGENOMiHOG000059632.
HOVERGENiHBG051818.
InParanoidiQ6X632.
KOiK08417.
OMAiKAVVTCV.
OrthoDBiEOG091G07SG.
PhylomeDBiQ6X632.
TreeFamiTF331523.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6X632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSAPLQNV PNATLLNMPP LHGGNSTSLQ EGLRDFIHTA TLVTCTFLLA
60 70 80 90 100
IIFCLGSYGN FIVFLSFFDP SFRKFRTNFD FMILNLSFCD LFICGVTAPM
110 120 130 140 150
FTFVLFFSSA SSIPDSFCFT FHLTSSGFVI MSLKMVAVIA LHRLRMVMGK
160 170 180 190 200
QPNCTASFSC ILLLTLLLWA TSFTLATLAT LRTNKSHLCL PMSSLMDGEG
210 220 230 240 250
KAILSLYVVD FTFCVAVVSV SYIMIAQTLR KNAQVKKCPP VITVDASRPQ
260 270 280 290 300
PFMGASVKGN GDPIQCTMPA LYRNQNYNKL QHSQTHGYTK NINQMPIPSA
310 320 330 340 350
SRLQLVSAIN FSTAKDSKAV VTCVVIVLSV LVCCLPLGIS LVQMVLSDNG
360 370 380 390 400
SFILYQFELF GFTLIFFKSG LNPFIYSRNS AGLRRKVLWC LRYTGLGFLC
410 420 430 440 450
CKQKTRLRAM GKGNLEINRN KSSHHETNSA YMLSPKPQRK FVDQACGPSH
460 470 480 490 500
SKESAASPKV SAGHQPCGQS SSTPINTRIE PYYSIYNSSP SQQESGPANL
510 520 530 540
PPVNSFGFAS SYIAMHYYTT NDLMQEYDST SAKQIPIPSV
Length:540
Mass (Da):59,531
Last modified:July 5, 2004 - v1
Checksum:iE8704067FCC70E69
GO

Sequence cautioni

The sequence BAC31978 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti476N → D in BAC31978 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253852 mRNA. Translation: AAP83130.1.
AK044553 mRNA. Translation: BAC31978.1. Different initiation.
AK141614 mRNA. Translation: BAE24767.1.
AL662891 Genomic DNA. Translation: CAI24534.1.
CCDSiCCDS24508.1.
RefSeqiNP_780699.2. NM_175490.4.
XP_006514759.1. XM_006514696.3.
UniGeneiMm.338361.
Mm.491657.

Genome annotation databases

EnsembliENSMUST00000109430; ENSMUSP00000105057; ENSMUSG00000043999.
GeneIDi237716.
KEGGimmu:237716.
UCSCiuc007iib.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253852 mRNA. Translation: AAP83130.1.
AK044553 mRNA. Translation: BAC31978.1. Different initiation.
AK141614 mRNA. Translation: BAE24767.1.
AL662891 Genomic DNA. Translation: CAI24534.1.
CCDSiCCDS24508.1.
RefSeqiNP_780699.2. NM_175490.4.
XP_006514759.1. XM_006514696.3.
UniGeneiMm.338361.
Mm.491657.

3D structure databases

ProteinModelPortaliQ6X632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105057.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ6X632.
PRIDEiQ6X632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109430; ENSMUSP00000105057; ENSMUSG00000043999.
GeneIDi237716.
KEGGimmu:237716.
UCSCiuc007iib.2. mouse.

Organism-specific databases

CTDi10936.
MGIiMGI:2441843. Gpr75.

Phylogenomic databases

eggNOGiENOG410IJVJ. Eukaryota.
ENOG410ZQWK. LUCA.
GeneTreeiENSGT00390000007723.
HOGENOMiHOG000059632.
HOVERGENiHBG051818.
InParanoidiQ6X632.
KOiK08417.
OMAiKAVVTCV.
OrthoDBiEOG091G07SG.
PhylomeDBiQ6X632.
TreeFamiTF331523.

Miscellaneous databases

PROiQ6X632.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043999.
CleanExiMM_GPR75.
ExpressionAtlasiQ6X632. baseline and differential.
GenevisibleiQ6X632. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR75_MOUSE
AccessioniPrimary (citable) accession number: Q6X632
Secondary accession number(s): Q3URC1, Q8BXP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.