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Protein

Sclerostin domain-containing protein 1

Gene

SOSTDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

SIGNORiQ6X4U4.

Names & Taxonomyi

Protein namesi
Recommended name:
Sclerostin domain-containing protein 1
Alternative name(s):
Ectodermal BMP inhibitor
Short name:
Ectodin
Uterine sensitization-associated gene 1 protein
Short name:
USAG-1
Gene namesi
Name:SOSTDC1
Synonyms:USAG1
ORF Names:CDA019
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21748. SOSTDC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937603.

Polymorphism and mutation databases

BioMutaiSOSTDC1.
DMDMi62287504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 206183Sclerostin domain-containing protein 1PRO_0000033180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi75 ↔ 133PROSITE-ProRule annotation
Disulfide bondi89 ↔ 147PROSITE-ProRule annotation
Disulfide bondi100 ↔ 163PROSITE-ProRule annotation
Disulfide bondi104 ↔ 165PROSITE-ProRule annotation
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6X4U4.
PRIDEiQ6X4U4.

PTM databases

PhosphoSiteiQ6X4U4.

Expressioni

Tissue specificityi

Highly expressed in kidney and weakly in lung.1 Publication

Gene expression databases

BgeeiQ6X4U4.
CleanExiHS_SOSTDC1.
ExpressionAtlasiQ6X4U4. baseline and differential.
GenevisibleiQ6X4U4. HS.

Interactioni

Subunit structurei

Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity.1 Publication

Protein-protein interaction databases

BioGridi117428. 3 interactions.
STRINGi9606.ENSP00000304930.

Structurei

3D structure databases

ProteinModelPortaliQ6X4U4.
SMRiQ6X4U4. Positions 72-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 17096CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sclerostin family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIVA. Eukaryota.
ENOG410YEMP. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ6X4U4.
OMAiAKPAQHH.
OrthoDBiEOG7CVPZN.
PhylomeDBiQ6X4U4.
TreeFamiTF353019.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR008835. Sclerostin/SOSTDC1.
[Graphical view]
PANTHERiPTHR14903. PTHR14903. 1 hit.
PfamiPF05463. Sclerostin. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6X4U4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPPAIHFYL LPLACILMKS CLAFKNDATE ILYSHVVKPV PAHPSSNSTL
60 70 80 90 100
NQARNGGRHF SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC
110 120 130 140 150
AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG
160 170 180 190 200
STRTYKITVV TACKCKRYTR QHNESSHNFE SMSPAKPVQH HRERKRASKS

SKHSMS
Length:206
Mass (Da):23,307
Last modified:March 29, 2005 - v2
Checksum:i9FB3CC41E4B53834
GO
Isoform 2 (identifier: Q6X4U4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-69: NT → NRTESLTRQNYFWLFPGAFLRQLQEA

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):26,260
Checksum:iBFF4B250E7D07775
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 147FYLLPLA → LSLIPLL in AAQ83296 (Ref. 3) Curated
Sequence conflicti20 – 201S → N in AAQ83296 (Ref. 3) Curated
Sequence conflicti41 – 411P → S in AAQ83296 (Ref. 3) Curated
Sequence conflicti62 – 621N → S in AAQ83296 (Ref. 3) Curated
Sequence conflicti69 – 691T → S in AAQ83296 (Ref. 3) Curated
Sequence conflicti106 – 1061P → L in CAB43243 (PubMed:17974005).Curated
Sequence conflicti127 – 1271S → G in AAQ83296 (Ref. 3) Curated
Sequence conflicti182 – 1821M → V in AAQ83296 (Ref. 3) Curated
Sequence conflicti188 – 1881V → A in AAQ83296 (Ref. 3) Curated
Sequence conflicti205 – 2051M → L in AAQ83296 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891Q → H.
Corresponds to variant rs34016012 [ dbSNP | Ensembl ].
VAR_053682

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 692NT → NRTESLTRQNYFWLFPGAFL RQLQEA in isoform 2. 1 PublicationVSP_054240

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059270 mRNA. Translation: BAC20331.1.
AF361494 mRNA. Translation: AAL57219.1.
AY255634 mRNA. Translation: AAQ83296.1.
AK093408 mRNA. Translation: BAG52710.1.
AC005014 Genomic DNA. No translation available.
AC079155 Genomic DNA. Translation: AAQ96855.1.
BC008484 mRNA. Translation: AAH08484.1.
AL050024 mRNA. Translation: CAB43243.2.
CCDSiCCDS5360.1. [Q6X4U4-1]
PIRiT08710.
RefSeqiNP_056279.1. NM_015464.2. [Q6X4U4-1]
UniGeneiHs.648106.

Genome annotation databases

EnsembliENST00000307068; ENSP00000304930; ENSG00000171243. [Q6X4U4-1]
ENST00000396652; ENSP00000379889; ENSG00000171243. [Q6X4U4-2]
GeneIDi25928.
KEGGihsa:25928.
UCSCiuc003stg.4. human. [Q6X4U4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059270 mRNA. Translation: BAC20331.1.
AF361494 mRNA. Translation: AAL57219.1.
AY255634 mRNA. Translation: AAQ83296.1.
AK093408 mRNA. Translation: BAG52710.1.
AC005014 Genomic DNA. No translation available.
AC079155 Genomic DNA. Translation: AAQ96855.1.
BC008484 mRNA. Translation: AAH08484.1.
AL050024 mRNA. Translation: CAB43243.2.
CCDSiCCDS5360.1. [Q6X4U4-1]
PIRiT08710.
RefSeqiNP_056279.1. NM_015464.2. [Q6X4U4-1]
UniGeneiHs.648106.

3D structure databases

ProteinModelPortaliQ6X4U4.
SMRiQ6X4U4. Positions 72-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117428. 3 interactions.
STRINGi9606.ENSP00000304930.

PTM databases

PhosphoSiteiQ6X4U4.

Polymorphism and mutation databases

BioMutaiSOSTDC1.
DMDMi62287504.

Proteomic databases

PaxDbiQ6X4U4.
PRIDEiQ6X4U4.

Protocols and materials databases

DNASUi25928.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307068; ENSP00000304930; ENSG00000171243. [Q6X4U4-1]
ENST00000396652; ENSP00000379889; ENSG00000171243. [Q6X4U4-2]
GeneIDi25928.
KEGGihsa:25928.
UCSCiuc003stg.4. human. [Q6X4U4-1]

Organism-specific databases

CTDi25928.
GeneCardsiSOSTDC1.
HGNCiHGNC:21748. SOSTDC1.
MIMi609675. gene.
neXtProtiNX_Q6X4U4.
PharmGKBiPA134937603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVA. Eukaryota.
ENOG410YEMP. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ6X4U4.
OMAiAKPAQHH.
OrthoDBiEOG7CVPZN.
PhylomeDBiQ6X4U4.
TreeFamiTF353019.

Enzyme and pathway databases

SIGNORiQ6X4U4.

Miscellaneous databases

ChiTaRSiSOSTDC1. human.
GeneWikiiSOSTDC1.
GenomeRNAii25928.
NextBioi35464887.
PROiQ6X4U4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6X4U4.
CleanExiHS_SOSTDC1.
ExpressionAtlasiQ6X4U4. baseline and differential.
GenevisibleiQ6X4U4. HS.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR008835. Sclerostin/SOSTDC1.
[Graphical view]
PANTHERiPTHR14903. PTHR14903. 1 hit.
PfamiPF05463. Sclerostin. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
    Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
    Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A novel gene expressed in human pheochromocytoma."
    Liu F., Xu X.R., Qian B.Z., Xiao H., Chen Z., Han Z.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pheochromocytoma.
  3. "A novel secreted WNT agonist is a requirement for epithelial-mesenchymal interactions."
    O'Shaughnessy R.F.L., Yeo W., Gautier J., Jahoda C.A.B., Christiano A.M.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-206 (ISOFORM 1).
    Tissue: Brain.
  9. Cited for: FUNCTION, INTERACTION WITH BMP2; BMP4 AND BMP7, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSOSD1_HUMAN
AccessioniPrimary (citable) accession number: Q6X4U4
Secondary accession number(s): A8MUA6, Q96HJ7, Q9Y3U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: May 11, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.