Reviewed, UniProtKB/Swiss-Prot Q6X2E2 (DMAW1_ACRCO)

Names and origin

Protein names

Recommended name:
    Tryptophan dimethylallyltransferase 1
    EC=2.5.1.34
Alternative name(s):
    L-tryptophan dimethylallyl transferase 1
      Short name=DMATS 1
    All-trans-hexaprenyl-diphosphate synthase 1

Gene names

Name:

dmaW1

Organism

Acremonium coenophialum (Tall fescue endophyte fungus)

Taxonomic identifier

5047 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › mitosporic Clavicipitaceae › Neotyphodium

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the first step of ergot alkaloid biosynthesis. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants By similarity.
Catalytic activity	Dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.
Pathway	Alkaloid biosynthesis; ergot alkaloid biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the tryptophan dimethylallyltransferase family.

Ontologies

Keywords
Biological process	Alkaloid metabolism
Molecular function	Transferase
Gene Ontology (GO)
Biological process	alkaloid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	tryptophan dimethylallyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Tryptophan dimethylallyltransferase 1		PRO_0000181360

Sequences

	Sequence		Length	Mass (Da)
	Q6X2E2-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 205474D3B7EFA10C	FASTA	448	52,010
	10 20 30 40 50 60 MVMAKTLHQE VYHTLSETFD FANNDQRLWW HSTAPMFEKM LQTANYSIDA QYRHLGIYKS 70 80 90 100 110 120 HVIPFLGVYP TRSGERWLSI LTRYGTPFEL SLNCSDSVVR YTYEPINAAT GSHLDPFNTF 130 140 150 160 170 180 AIWEALKKHI ESQPGIDLEW FSYFKQELTL DANESTYLHS QNLVKEQIKT QNKLALDLKG 190 200 210 220 230 240 DKFVLKTYIY PELKSVATGK SVQELVFGSV RKLAQKHKSI RPAFEMLEDY VQSRNKFSTT 250 260 270 280 290 300 DDSHNTLLSS RLLSCDLISP TKSRVKIYLL ERMVSLPAME DLWTLGGRRE DQSTIEGLEM 310 320 330 340 350 360 IRELWGLLNM SPGLRAYPEP YLPLGAIPNE QLPSMANYTL HHNDPIPEPQ VYFTVFGMND 370 380 390 400 410 420 MEVTNALTTF FMRHEWSDMA SKYKACLRES FPHHDYEALN YIHSYISFSY RKNKPYLSVY 430 440 LHSFETGKWP VFPEGLIAFD ACRRDLTC

References

[1]	"The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass." Wang J., Machado C., Panaccione D.G., Tsai H.-F., Schardl C.L. Fungal Genet. Biol. 41:189-198(2004) [PubMed: 14732265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY259838 Genomic DNA. Translation: AAP81207.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR017795. Aromatic_prenylTrfase_DMATS. IPR012148. Trp_dimethylallyltransferase. IPR017796. Trp_dimethylallylTrfase_sub. [Graphical view]
PIRSF	PIRSF000509. Trp_DMAT. 1 hit.
TIGRFAMs	TIGR03429. arom_pren_DMATS. 1 hit. TIGR03430. trp_dimet_allyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DMAW1_ACRCO

Accession

Primary (citable) accession number: Q6X2E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)