Q6X2E1 (DMAW2_ACRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan dimethylallyltransferase 2
EC=2.5.1.34

Alternative name(s):
4-dimethylallyltryptophan synthase 2
All-trans-hexaprenyl-diphosphate synthase 2
L-tryptophan dimethylallyl transferase 2
Short name=DMATS 2

Gene names

Name:

dmaW2

Organism

Acremonium coenophialum (Tall fescue endophyte fungus)

Taxonomic identifier

5047 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › mitosporic Clavicipitaceae › Neotyphodium

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the first step of ergot alkaloid biosynthesis. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants By similarity.
Catalytic activity	Dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.
Pathway	Alkaloid biosynthesis; ergot alkaloid biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the tryptophan dimethylallyltransferase family.

Ontologies

Keywords
Biological process	Alkaloid metabolism
Molecular function	Transferase
Gene Ontology (GO)
Biological process	alkaloid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	tryptophan dimethylallyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Tryptophan dimethylallyltransferase 2		PRO_0000181361

Sequences

	Sequence		Length	Mass (Da)
	Q6X2E1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4BA1D1F6C1E0BEC0	FASTA	450	52,226
	10 20 30 40 50 60 MVLAKTLHQE VYQTLSETFD FANNDQRLWW HSTAPMFQKI LQTANYSIYA QYQHLSIYKS 70 80 90 100 110 120 HIIPFLGVYP TRSGERWLSI LTRYGTPFEL SLNCSDSIVR YTYEPINAAT GSHLDPFNTF 130 140 150 160 170 180 AIWEALKKLI DSQPGIDLQW FSYFKQELTL DANESTYLHS QNLVKEQIKT QNKLALDLKG 190 200 210 220 230 240 DKFVLKTYIY PELKSVATGK SVQELVFGSV RKLAQKHKSI RPAFEMLEDY VQSRNKVPTT 250 260 270 280 290 300 DDSHNTPLSS RLLSCDLVSP TKSRVKIYLL ERMVSLPAME DLWTLGGRRE DQSTIEGLEM 310 320 330 340 350 360 IRELWGLLNM SPGLRAYPEP YLPLGAIPNE QLPSMANYTL HHNDPIPEPQ VYFTVFGMND 370 380 390 400 410 420 MEVTNALTKF FMRHEWSDMA SKYKACLRES FPHHNYEALN YIHSYISFSY RNNKPYLSVY 430 440 450 LHSFETGEWP VFPEGLIAFD GCRRDLTCYK

References

[1]	"The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass." Wang J., Machado C., Panaccione D.G., Tsai H.-F., Schardl C.L. Fungal Genet. Biol. 41:189-198(2004) [PubMed: 14732265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY259839 Genomic DNA. Translation: AAP81208.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR017795. Aromatic_prenylTrfase_DMATS. IPR012148. Trp_dimethylallyltransferase. IPR017796. Trp_dimethylallylTrfase_sub. [Graphical view]
Pfam	PF11991. Trp_DMAT. 1 hit. [Graphical view]
PIRSF	PIRSF000509. Trp_DMAT. 1 hit.
TIGRFAMs	TIGR03429. Arom_pren_DMATS. 1 hit. TIGR03430. Trp_dimet_allyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DMAW2_ACRCO

Accession

Primary (citable) accession number: Q6X2E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	July 5, 2004
Last modified:	October 19, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program