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Protein
Submitted name:

New antigen receptor variable domain

Gene
N/A
Organism
Orectolobus maculatus (spotted wobbegong)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
New antigen receptor variable domainImported
OrganismiOrectolobus maculatus (spotted wobbegong)Imported
Taxonomic identifieri168098 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaOrectolobiformesOrectolobidaeOrectolobus

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 83Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VESX-ray2.18A/B1-113[»]
2Z8VX-ray2.35C/D1-113[»]
2Z8WX-ray2.45C/D1-113[»]
3MOQX-ray2.05A/B/C/D1-87[»]
A/B/C/D102-113[»]
ProteinModelPortaliQ6X1E6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6X1E6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8585Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6X1E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AWVDQTPRTA TKETGESLTI NCVLRDASFE LKDTGWYRTK LGSTNEQSIS
60 70 80 90 100
IGGRYVETVN KGSKSFSLRI SDLRVEDSGT YKCQAFYSLP LGDYNYSLLF
110
RGEKGAGTAL TVK
Length:113
Mass (Da):12,517
Last modified:July 5, 2004 - v1
Checksum:i87813D133624E0F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei113 – 1131Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261682 mRNA. Translation: AAP86762.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261682 mRNA. Translation: AAP86762.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VESX-ray2.18A/B1-113[»]
2Z8VX-ray2.35C/D1-113[»]
2Z8WX-ray2.45C/D1-113[»]
3MOQX-ray2.05A/B/C/D1-87[»]
A/B/C/D102-113[»]
ProteinModelPortaliQ6X1E6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ6X1E6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor."
    Streltsov V.A., Varghese J.N., Carmichael J.A., Irving R.A., Hudson P.J., Nuttall S.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:12444-12449(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS), DISULFIDE BONDS.
  2. "Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1."
    Nuttall S.D., Humberstone K.S., Krishnan U.V., Carmichael J.A., Doughty L., Hattarki M., Coley A.M., Casey J.L., Anders R.F., Foley M., Irving R.A., Hudson P.J.
    Proteins 55:187-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition."
    Henderson K.A., Streltsov V.A., Coley A.M., Dolezal O., Hudson P.J., Batchelor A.H., Gupta A., Bai T., Murphy V.J., Anders R.F., Foley M., Nuttall S.D.
    Structure 15:1452-1466(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS), DISULFIDE BONDS.
  4. "Crystal structure of the amyloid-beta p3 fragment provides a model for oligomer formation in Alzheimer's disease."
    Streltsov V.A., Varghese J.N., Masters C.L., Nuttall S.D.
    J. Neurosci. 31:1419-1426(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1-87 AND 102-113, DISULFIDE BONDS.

Entry informationi

Entry nameiQ6X1E6_9CHON
AccessioniPrimary (citable) accession number: Q6X1E6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.