Reviewed, UniProtKB/Swiss-Prot Q6X1E1 (DMAW_BALOB)

Names and origin

Protein names

Recommended name:
    Tryptophan dimethylallyltransferase
    EC=2.5.1.34
Alternative name(s):
    L-tryptophan dimethylallyl transferase
      Short name=DMATS
    All-trans-hexaprenyl-diphosphate synthase

Gene names

Name:

dmaW

Organism

Balansia obtecta

Taxonomic identifier

40611 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › Balansia

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the first step of ergot alkaloid biosynthesis. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants By similarity.
Catalytic activity	Dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.
Pathway	Alkaloid biosynthesis; ergot alkaloid biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the tryptophan dimethylallyltransferase family.

Ontologies

Keywords
Biological process	Alkaloid metabolism
Molecular function	Transferase
Gene Ontology (GO)
Biological process	alkaloid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	tryptophan dimethylallyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Tryptophan dimethylallyltransferase		PRO_0000181362

Sequences

	Sequence		Length	Mass (Da)
	Q6X1E1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5549517F27EED760	FASTA	465	53,932
	10 20 30 40 50 60 MATENGPDKS VYETLSLIFN FPDDTQRLWW HSTAPMLAEM LQTCEYSVHN QYQQLGIFKK 70 80 90 100 110 120 HIIPYLGVYP TKSKERWLSI LTRYGIPFEL SLNCSDSVVR YTYEPINEAT GTEKDPYNTL 130 140 150 160 170 180 AILDSAQELI RIQAGIDLEW FTYFKDELTV NMTESEYLRS NGLVNCQIKT QNKLALDLKG 190 200 210 220 230 240 DQFTLKVYMY PELKSVATGK SLHELIFGSV RRLSLKYNSI RAPLDMLDDY VTSRNMGANG 250 260 270 280 290 300 EEHLPLEPRL LSCDLMDPHK SRVKIYLHER KVSLSAMEDL WTLGGRRTDS TTMDGLNMVR 310 320 330 340 350 360 ELWDLLEIPT CLQKYPAPFL ELGQIPREQL PSMANYTLHH GDPMPEPQVY FTVFGMNDSK 370 380 390 400 410 420 VISALTEFFK RRVWNGMARK YRAFLQNSYP NDDHESLNYL HTYISFSYRK NKPYLSVYLH 430 440 450 460 TFESGSWPIF PDSSTAFKTY RRCDLSCKDN GLDDKLLSPV CQLRV

References

[1]	"The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass." Wang J., Machado C., Panaccione D.G., Tsai H.-F., Schardl C.L. Fungal Genet. Biol. 41:189-198(2004) [PubMed: 14732265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Mycelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY262013 Genomic DNA. Translation: AAP92451.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.34. 314419.
Family and domain databases
InterPro	IPR017795. Aromatic_prenylTrfase_DMATS. IPR012148. Trp_dimethylallyltransferase. IPR017796. Trp_dimethylallylTrfase_sub. [Graphical view]
PIRSF	PIRSF000509. Trp_DMAT. 1 hit.
TIGRFAMs	TIGR03429. arom_pren_DMATS. 1 hit. TIGR03430. trp_dimet_allyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DMAW_BALOB

Accession

Primary (citable) accession number: Q6X1E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)