Q6X0L5 (Q6X0L5_9MYCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta HAMAP-Rule MF_01321
Short name=RNAP subunit beta HAMAP-Rule MF_01321
EC=2.7.7.6 HAMAP-Rule MF_01321

Alternative name(s):
RNA polymerase subunit beta HAMAP-Rule MF_01321
Transcriptase subunit beta HAMAP-Rule MF_01321

Gene names

Name:

rpoB HAMAP-Rule MF_01321

Organism

Mycobacterium immunogenum EMBL AAQ76598.1

Taxonomic identifier

83262 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium chelonae group

Protein attributes

Sequence length	1171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity. HAMAP-Rule MF_01321 RuleBase RU000432
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_01321
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity. HAMAP-Rule MF_01321 RuleBase RU000433
Sequence similarities	Belongs to the RNA polymerase beta chain family. HAMAP-Rule MF_01321 RuleBase RU000434

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase HAMAP-Rule MF_01321
Molecular function	Nucleotidyltransferase HAMAP-Rule MF_01321 Transferase
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: HAMAP ribonucleoside binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6X0L5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 83CD60F9484469A3	FASTA	1,171	128,989
	10 20 30 40 50 60 MRGNTGGPIL AVSRQTKTDN ATTNSVPGAP NRLSFAKLRE PLAVPGLLDV QTDSFEWLVG 70 80 90 100 110 120 SPRWREVATA RGEVNPTGGL EEILTELSPI EDFSGSMSLS FSDPRFDEVK APVDECKDKD 130 140 150 160 170 180 MTYAAPLFVT AEFINNNTGE IKSQTVFMGD FPMMTDMGTF IINGTERVVV SQLVRSPGVY 190 200 210 220 230 240 FDENIDKSTE KTLHSVKVIP GRGAWLEFDV DKRDTVGVRI DRKRRQPVTV LLKALGWTNE 250 260 270 280 290 300 QIVERFGFSE IMMGTLEKDN IAGPDEALLD IYRKLRPGEP PTKESAQALL ENLFFKEKRY 310 320 330 340 350 360 DLARVGRYKV NKKLGLGGTN PAQVTTTTLT EEDVVATIEY LVRLHEGQTT MTAPGGVEVP 370 380 390 400 410 420 VDVDDIDHFG NRRLRTVGEL IQNQIRVGLS RMERVVRERM TTQDVEAITP QTLINIRPVV 430 440 450 460 470 480 AAIKEFFGTS QLSQFMDQNN PLSGLTHKRR LSALGPGGLT RDRAGLEVRD VHPSHYGRMC 490 500 510 520 530 540 PIETPEGPNI GLIGSLSVYA RVNPFGFIET PYRKVSDGVV TDEIHYLTAD EEDRHVVAQA 550 560 570 580 590 600 NSPVDANGRF TEEKILVRRK GGEVEFVSAT EVDYMDVSPR QMVSVATAMI PFLEHDDANR 610 620 630 640 650 660 ALMGANMQRQ AVPLVRSEAP LVGTGMELRA AIDAGDVVVA EKAGVIEEVS ADYVTVMADD 670 680 690 700 710 720 GTRQSYRLRK FARSNHGTCA NQKPIVDEGQ RVEVGQVLAD GPCTENGEMA LGKNLLVAVM 730 740 750 760 770 780 PWEGHNYEDA IILSNRLVEE DVLTSIHIEE HEIDARDTKL GAEEITRDIP NVSDEVLADL 790 800 810 820 830 840 DERGIVRIGA EVRDGDILVG KVTPKGETEL TPEERLLRAI FGEKAREVRD TSLKVPHGES 850 860 870 880 890 900 GKVIGIRVFS RDDDDDLPAG VNELVRVYVA QKRKISDGDK LAGRHGNKGV IGKILPVEDM 910 920 930 940 950 960 PFLPDGTPVD IILNTHGVPR RMNIGQILET HLGWIAKTGW NIEGDPEWAQ NLPEDLQSAP 970 980 990 1000 1010 1020 ADTRTATPVF DGAREEELTG LLSSTLPNRD GEVMVDGDGK ARLFDGRSGE PFPYPVTVGY 1030 1040 1050 1060 1070 1080 MYILKLHHLV DDKIHARSTG PYSMITQQPL GGKAQFGGQR FGEMECWAMQ AYGAAYTLQE 1090 1100 1110 1120 1130 1140 LLTIKSDDTV GRVKVYEAIV KGENIPEPGI PESFKVLLKE LQSLCLNVEV LSKDGAAIEM 1150 1160 1170 RDGDDEDLER AAANLGINLS RNESASIEDF A

References

[1]	"rpoB-based identification of nonpigmented and late-pigmenting rapidly growing mycobacteria." Adekambi T., Colson P., Drancourt M. J. Clin. Microbiol. 41:5699-5708(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CIP 106684 EMBL AAQ76598.1.
[2]	Adekambi T.D., Drancourt M., Raoult D. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CIP 106684 EMBL AAQ76598.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY262739 Genomic DNA. Translation: AAQ76598.1.
3D structure databases
ProteinModelPortal	Q6X0L5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.30.150.10. 1 hit. 2.40.270.10. 2 hits. 2.40.50.150. 1 hit.
HAMAP	MF_01321. RNApol_bact_RpoB.
InterPro	IPR010243. DNA-dir_RNA_pol_bsu. IPR019462. DNA-dir_RNA_pol_bsu_external_1. IPR015712. DNA-dir_RNA_pol_su2. IPR007120. DNA-dir_RNA_pol_su2_6. IPR007121. RNA_pol_bsu_CS. IPR007644. RNA_pol_bsu_protrusion. IPR007642. RNA_pol_Rpb2_2. IPR007645. RNA_pol_Rpb2_3. IPR007641. RNA_pol_Rpb2_7. IPR014724. RNA_pol_RPB2_OB-fold. [Graphical view]
PANTHER	PTHR20856. PTHR20856. 1 hit. PTHR20856:SF3. PTHR20856:SF3. 1 hit.
Pfam	PF04563. RNA_pol_Rpb2_1. 1 hit. PF04561. RNA_pol_Rpb2_2. 1 hit. PF04565. RNA_pol_Rpb2_3. 1 hit. PF10385. RNA_pol_Rpb2_45. 1 hit. PF00562. RNA_pol_Rpb2_6. 1 hit. PF04560. RNA_pol_Rpb2_7. 1 hit. [Graphical view]
TIGRFAMs	TIGR02013. rpoB. 1 hit.
PROSITE	PS01166. RNA_POL_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6X0L5_9MYCO

Accession

Primary (citable) accession number: Q6X0L5

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	March 6, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)