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Protein

Anti-tumor lectin

Gene
N/A
Organism
Agrocybe aegerita (Black poplar mushroom) (Agaricus aegerita)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Carbohydrate
Binding sitei72 – 721Carbohydrate
Binding sitei80 – 801Carbohydrate
Binding sitei83 – 831Carbohydrate

GO - Molecular functioni

  • deoxyribonuclease activity Source: UniProtKB
  • polysaccharide binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • positive regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-tumor lectin (EC:3.1.21.-)
Alternative name(s):
AAL
OrganismiAgrocybe aegerita (Black poplar mushroom) (Agaricus aegerita)
Taxonomic identifieri5400 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesBolbitiaceaeAgrocybe

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 158›158Anti-tumor lectinPRO_0000076969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Blocked amino end (Gln)1 Publication

Expressioni

Tissue specificityi

Detected in the fruiting body.1 Publication

Interactioni

Subunit structurei

Homodimer.2 Publications

Structurei

Secondary structure

1
158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Beta strandi12 – 209Combined sources
Beta strandi25 – 317Combined sources
Beta strandi38 – 403Combined sources
Beta strandi45 – 506Combined sources
Beta strandi56 – 638Combined sources
Turni64 – 674Combined sources
Beta strandi68 – 747Combined sources
Beta strandi76 – 783Combined sources
Beta strandi84 – 874Combined sources
Helixi90 – 934Combined sources
Beta strandi96 – 983Combined sources
Beta strandi100 – 1067Combined sources
Beta strandi108 – 1158Combined sources
Beta strandi118 – 1247Combined sources
Beta strandi131 – 1377Combined sources
Turni140 – 1423Combined sources
Beta strandi147 – 1559Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WW4X-ray2.30A/B/C/D3-158[»]
1WW5X-ray2.20A/B/C/D3-158[»]
1WW6X-ray2.20A/B/C/D3-158[»]
1WW7X-ray1.90A/B/C/D3-158[»]
2ZGKX-ray3.00A1-158[»]
2ZGLX-ray1.90A/B1-158[»]
2ZGMX-ray1.90A/B1-158[»]
2ZGNX-ray2.50A/B1-158[»]
2ZGOX-ray2.00A/B1-158[»]
2ZGPX-ray2.70A/B1-158[»]
2ZGQX-ray1.90A/B1-158[»]
2ZGRX-ray1.90A1-158[»]
2ZGSX-ray1.90A/B1-158[»]
2ZGTX-ray2.80A/B1-158[»]
2ZGUX-ray2.40A/B1-158[»]
3AFKX-ray1.95A/B1-158[»]
3M3CX-ray2.00A/B1-158[»]
3M3EX-ray2.10A/B/C/D1-158[»]
3M3OX-ray2.10A1-158[»]
3M3QX-ray2.20A/B1-158[»]
3WG1X-ray1.90A/B3-158[»]
3WG2X-ray2.20A/B3-158[»]
3WG3X-ray1.35A/B3-158[»]
3WG4X-ray1.60A/B3-158[»]
ProteinModelPortaliQ6WY08.
SMRiQ6WY08. Positions 2-158.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6WY08.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 155144GalectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 635Carbohydrate binding

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6WY08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QGVNIYNISA GTSVDLAAPV TTGDIVTFFS SALNLNAGAG NPNNTTLNLF
60 70 80 90 100
AENGAYLLHI AFRLQENVII FNSRQPDGPW LVEQRVSDVA NQFAGIDGKA
110 120 130 140 150
MVTVFDHGDK YQVVINEKTV IQYTKQISGL TLSLSYNATE ETSIFSTVVE

AVTYTGLA
Length:158
Mass (Da):16,995
Last modified:July 5, 2004 - v1
Checksum:iFB977ED58C22EBF0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 111 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264782 mRNA. Translation: AAP93924.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264782 mRNA. Translation: AAP93924.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WW4X-ray2.30A/B/C/D3-158[»]
1WW5X-ray2.20A/B/C/D3-158[»]
1WW6X-ray2.20A/B/C/D3-158[»]
1WW7X-ray1.90A/B/C/D3-158[»]
2ZGKX-ray3.00A1-158[»]
2ZGLX-ray1.90A/B1-158[»]
2ZGMX-ray1.90A/B1-158[»]
2ZGNX-ray2.50A/B1-158[»]
2ZGOX-ray2.00A/B1-158[»]
2ZGPX-ray2.70A/B1-158[»]
2ZGQX-ray1.90A/B1-158[»]
2ZGRX-ray1.90A1-158[»]
2ZGSX-ray1.90A/B1-158[»]
2ZGTX-ray2.80A/B1-158[»]
2ZGUX-ray2.40A/B1-158[»]
3AFKX-ray1.95A/B1-158[»]
3M3CX-ray2.00A/B1-158[»]
3M3EX-ray2.10A/B/C/D1-158[»]
3M3OX-ray2.10A1-158[»]
3M3QX-ray2.20A/B1-158[»]
3WG1X-ray1.90A/B3-158[»]
3WG2X-ray2.20A/B3-158[»]
3WG3X-ray1.35A/B3-158[»]
3WG4X-ray1.60A/B3-158[»]
ProteinModelPortaliQ6WY08.
SMRiQ6WY08. Positions 2-158.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ6WY08.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATLE_AGRAE
AccessioniPrimary (citable) accession number: Q6WY08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.