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Protein

Anti-tumor lectin

Gene
N/A
Organism
Agrocybe aegerita (Black poplar mushroom) (Agaricus aegerita)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43Carbohydrate1
Binding sitei72Carbohydrate1
Binding sitei80Carbohydrate1
Binding sitei83Carbohydrate1

GO - Molecular functioni

  • deoxyribonuclease activity Source: UniProtKB
  • polysaccharide binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • positive regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-tumor lectin (EC:3.1.21.-)
Alternative name(s):
AAL
OrganismiAgrocybe aegerita (Black poplar mushroom) (Agaricus aegerita)
Taxonomic identifieri5400 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesBolbitiaceaeAgrocybe

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000076969‹1 – 158Anti-tumor lectinAdd BLAST›158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Blocked amino end (Gln)1 Publication1

Expressioni

Tissue specificityi

Detected in the fruiting body.1 Publication

Interactioni

Subunit structurei

Homodimer.2 Publications

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Beta strandi12 – 20Combined sources9
Beta strandi25 – 31Combined sources7
Beta strandi38 – 40Combined sources3
Beta strandi45 – 50Combined sources6
Beta strandi56 – 63Combined sources8
Turni64 – 67Combined sources4
Beta strandi68 – 74Combined sources7
Beta strandi76 – 78Combined sources3
Beta strandi84 – 87Combined sources4
Helixi90 – 93Combined sources4
Beta strandi96 – 98Combined sources3
Beta strandi100 – 106Combined sources7
Beta strandi108 – 115Combined sources8
Beta strandi118 – 124Combined sources7
Beta strandi131 – 137Combined sources7
Turni140 – 142Combined sources3
Beta strandi147 – 155Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WW4X-ray2.30A/B/C/D3-158[»]
1WW5X-ray2.20A/B/C/D3-158[»]
1WW6X-ray2.20A/B/C/D3-158[»]
1WW7X-ray1.90A/B/C/D3-158[»]
2ZGKX-ray3.00A1-158[»]
2ZGLX-ray1.90A/B1-158[»]
2ZGMX-ray1.90A/B1-158[»]
2ZGNX-ray2.50A/B1-158[»]
2ZGOX-ray2.00A/B1-158[»]
2ZGPX-ray2.70A/B1-158[»]
2ZGQX-ray1.90A/B1-158[»]
2ZGRX-ray1.90A1-158[»]
2ZGSX-ray1.90A/B1-158[»]
2ZGTX-ray2.80A/B1-158[»]
2ZGUX-ray2.40A/B1-158[»]
3AFKX-ray1.95A/B1-158[»]
3M3CX-ray2.00A/B1-158[»]
3M3EX-ray2.10A/B/C/D1-158[»]
3M3OX-ray2.10A1-158[»]
3M3QX-ray2.20A/B1-158[»]
3WG1X-ray1.90A/B3-158[»]
3WG2X-ray2.20A/B3-158[»]
3WG3X-ray1.35A/B3-158[»]
3WG4X-ray1.60A/B3-158[»]
ProteinModelPortaliQ6WY08.
SMRiQ6WY08.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6WY08.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 155GalectinPROSITE-ProRule annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 63Carbohydrate binding5

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6WY08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QGVNIYNISA GTSVDLAAPV TTGDIVTFFS SALNLNAGAG NPNNTTLNLF
60 70 80 90 100
AENGAYLLHI AFRLQENVII FNSRQPDGPW LVEQRVSDVA NQFAGIDGKA
110 120 130 140 150
MVTVFDHGDK YQVVINEKTV IQYTKQISGL TLSLSYNATE ETSIFSTVVE

AVTYTGLA
Length:158
Mass (Da):16,995
Last modified:July 5, 2004 - v1
Checksum:iFB977ED58C22EBF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264782 mRNA. Translation: AAP93924.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264782 mRNA. Translation: AAP93924.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WW4X-ray2.30A/B/C/D3-158[»]
1WW5X-ray2.20A/B/C/D3-158[»]
1WW6X-ray2.20A/B/C/D3-158[»]
1WW7X-ray1.90A/B/C/D3-158[»]
2ZGKX-ray3.00A1-158[»]
2ZGLX-ray1.90A/B1-158[»]
2ZGMX-ray1.90A/B1-158[»]
2ZGNX-ray2.50A/B1-158[»]
2ZGOX-ray2.00A/B1-158[»]
2ZGPX-ray2.70A/B1-158[»]
2ZGQX-ray1.90A/B1-158[»]
2ZGRX-ray1.90A1-158[»]
2ZGSX-ray1.90A/B1-158[»]
2ZGTX-ray2.80A/B1-158[»]
2ZGUX-ray2.40A/B1-158[»]
3AFKX-ray1.95A/B1-158[»]
3M3CX-ray2.00A/B1-158[»]
3M3EX-ray2.10A/B/C/D1-158[»]
3M3OX-ray2.10A1-158[»]
3M3QX-ray2.20A/B1-158[»]
3WG1X-ray1.90A/B3-158[»]
3WG2X-ray2.20A/B3-158[»]
3WG3X-ray1.35A/B3-158[»]
3WG4X-ray1.60A/B3-158[»]
ProteinModelPortaliQ6WY08.
SMRiQ6WY08.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ6WY08.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATLE_AGRAE
AccessioniPrimary (citable) accession number: Q6WY08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.