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Protein

Probable sodium-coupled neutral amino acid transporter 6

Gene

Slc38a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sodium-coupled neutral amino acid transporter 6
Alternative name(s):
N-system amino acid transporter 1
Short name:
NAT-1
Na(+)-coupled neutral amino acid transporter 6
Solute carrier family 38 member 6
Gene namesi
Name:Slc38a6
Synonyms:Nat1, Snat6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310330. Slc38a6.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Colocalizes with synaptotagmins and SNAP25.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence analysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence analysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Probable sodium-coupled neutral amino acid transporter 6PRO_0000311422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei7 – 71PhosphoserineBy similarity
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence analysis
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6WWW3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035818.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ6WWW3.
KOiK14993.
PhylomeDBiQ6WWW3.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6WWW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQASRYSIEA EPGWYVSVQQ PEEAVAAEEW SPLLSNEPRR QGSSGASFGL
60 70 80 90 100
SVFNVMNAIM GSGILGLAYV MANTGILGFS FLLLLVALLA SYSVHLLLAM
110 120 130 140 150
CIHTAVTSYE DLGLFAFGLP GKVVVAGTII IQNIGAMSSY LLIIKTELPA
160 170 180 190 200
AISEVLPSDH SGAWYLDGQM LLIIICVGIV FPLSLLPKIG FLGYTSSLSF
210 220 230 240 250
FFMVFFALVV VIKKWAVPCP LTLNCINAVF QISNATDDCK PKLFHFSKES
260 270 280 290 300
VYAIPTMAFS FLCHTSVLPI YCELRSPSKK RMQNVTNTAI ALSFLVYFVS
310 320 330 340 350
ALFGYLTFYD KVESELLQGY SKYLPHDAAV MAVKLCILFA VLLTVPLIHF
360 370 380 390 400
PARKALMMIL FSNYPFSWIR HSLTTLALNI IIVLLAIYVP DIRNVFGVVG
410 420 430 440 450
ASTSTCLIFV FPGLFYLKLS REDFLSWKKL GALSLLSTGT VVGSFSLVLI

ILDWVNK
Length:457
Mass (Da):50,192
Last modified:July 19, 2004 - v1
Checksum:iE226D4FD03585151
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266018 mRNA. Translation: AAP91872.1.
RefSeqiNP_001013117.1. NM_001013099.1.
UniGeneiRn.55589.

Genome annotation databases

GeneIDi299139.
KEGGirno:299139.
UCSCiRGD:1310330. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266018 mRNA. Translation: AAP91872.1.
RefSeqiNP_001013117.1. NM_001013099.1.
UniGeneiRn.55589.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035818.

Proteomic databases

PaxDbiQ6WWW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi299139.
KEGGirno:299139.
UCSCiRGD:1310330. rat.

Organism-specific databases

CTDi145389.
RGDi1310330. Slc38a6.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ6WWW3.
KOiK14993.
PhylomeDBiQ6WWW3.

Miscellaneous databases

PROiQ6WWW3.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A new member of the SLC38 family of neutral amino acid transporters."
    Varoqui H., Mackenzie B., Morris M., Schafer M.K., Weihe E., Erickson J.D.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiS38A6_RAT
AccessioniPrimary (citable) accession number: Q6WWW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 19, 2004
Last modified: July 6, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.