Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein KCTD12

Gene

Kctd12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein homooligomerization Source: InterPro
  • regulation of G-protein coupled receptor protein signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD12
Alternative name(s):
Pfetin
Predominantly fetal expressed T1 domain
Gene namesi
Name:Kctd12
Synonyms:Pfet1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2145823. Kctd12.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • postsynaptic membrane Source: MGI
  • presynaptic membrane Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 327326BTB/POZ domain-containing protein KCTD12PRO_0000191296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei119 – 1191PhosphotyrosineCombined sources
Modified residuei153 – 1531PhosphoserineCombined sources
Modified residuei173 – 1731PhosphoserineCombined sources
Modified residuei187 – 1871PhosphoserineBy similarity
Modified residuei198 – 1981PhosphothreonineCombined sources
Modified residuei202 – 2021PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6WVG3.
MaxQBiQ6WVG3.
PeptideAtlasiQ6WVG3.
PRIDEiQ6WVG3.

PTM databases

iPTMnetiQ6WVG3.
PhosphoSiteiQ6WVG3.

Expressioni

Tissue specificityi

Expressed in the brain, mainly in the hippocampus and cerebellum.1 Publication

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6WVG3.
SMRiQ6WVG3. Positions 36-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG052218.
InParanoidiQ6WVG3.
PhylomeDBiQ6WVG3.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6WVG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALADSARGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC
60 70 80 90 100
TVVSVPDSLL WRMFTQQQPQ ELARDSKGRF FLDRDGFFFR YILDYLRDLQ
110 120 130 140 150
LVLPDYFPER SRLQREAEYF ELPELVRRLG APQQPGPGPP PPHSRRGVHK
160 170 180 190 200
EGSLGDELLP LGYAEPEPQE GASAGAPSPT LELASRSPSG GAAGPLLTPS
210 220 230 240 250
QSLDGSRRSG YITIGYRGSY TIGRDAQADA KFRRVARITV CGKTSLAKEV
260 270 280 290 300
FGDTLNESRD PDRPPERYTS RYYLKFNFLE QAFDKLSESG FHMVACSSTG
310 320
TCAFASSTDQ SEDKIWTSYT EYVFCRE
Length:327
Mass (Da):35,892
Last modified:July 5, 2004 - v1
Checksum:i0C84A1AB0CDFEAF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71A → T in BAE43079 (PubMed:16141072).Curated
Sequence conflicti88 – 881F → L in BAE43079 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY267461 Genomic DNA. Translation: AAP92150.1.
AK172581 mRNA. Translation: BAE43079.1.
CCDSiCCDS70611.1.
RefSeqiNP_808383.3. NM_177715.4.
UniGeneiMm.246466.

Genome annotation databases

GeneIDi239217.
KEGGimmu:239217.
UCSCiuc007uwe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY267461 Genomic DNA. Translation: AAP92150.1.
AK172581 mRNA. Translation: BAE43079.1.
CCDSiCCDS70611.1.
RefSeqiNP_808383.3. NM_177715.4.
UniGeneiMm.246466.

3D structure databases

ProteinModelPortaliQ6WVG3.
SMRiQ6WVG3. Positions 36-126.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6WVG3.
PhosphoSiteiQ6WVG3.

Proteomic databases

EPDiQ6WVG3.
MaxQBiQ6WVG3.
PeptideAtlasiQ6WVG3.
PRIDEiQ6WVG3.

Protocols and materials databases

DNASUi239217.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi239217.
KEGGimmu:239217.
UCSCiuc007uwe.1. mouse.

Organism-specific databases

CTDi115207.
MGIiMGI:2145823. Kctd12.

Phylogenomic databases

HOVERGENiHBG052218.
InParanoidiQ6WVG3.
PhylomeDBiQ6WVG3.

Miscellaneous databases

ChiTaRSiKctd12. mouse.
PROiQ6WVG3.
SOURCEiSearch...

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCD12_MOUSE
AccessioniPrimary (citable) accession number: Q6WVG3
Secondary accession number(s): Q3T9E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.