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Q6WUX8 (CYC_GORGO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c
Gene names
Name:CYCS
Synonyms:CYC
OrganismGorilla gorilla gorilla (Lowland gorilla) [Reference proteome]
Taxonomic identifier9595 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla

Protein attributes

Sequence length105 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases By similarity.

Subcellular location

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Post-translational modification

Binds 1 heme group per subunit.

Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration By similarity.

Sequence similarities

Belongs to the cytochrome c family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 105104Cytochrome c
PRO_0000108215

Sites

Metal binding191Iron (heme axial ligand) By similarity
Metal binding811Iron (heme axial ligand) By similarity
Binding site151Heme (covalent) By similarity
Binding site181Heme (covalent) By similarity

Amino acid modifications

Modified residue21N-acetylglycine By similarity
Modified residue491Phosphotyrosine By similarity
Modified residue981Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6WUX8 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 8EE9689E0102506B

FASTA10511,749
        10         20         30         40         50         60 
MGDVEKGKKI FIMKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGYSYT AANKNKGIIW 

        70         80         90        100 
GEDTLMEYLE NPKKYIPGTK MIFVGIKKKE ERADLIAYLK KATNE 

« Hide

References

[1]"Implications of natural selection in shaping 99.4% nonsynonymous DNA identity between humans and chimpanzees: enlarging genus Homo."
Wildman D.E., Uddin M., Liu G., Grossman L.I., Goodman M.
Proc. Natl. Acad. Sci. U.S.A. 100:7181-7188(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY268593 Genomic DNA. Translation: AAP49488.1.
RefSeqXP_004045243.1. XM_004045195.1.

3D structure databases

ProteinModelPortalQ6WUX8.
SMRQ6WUX8. Positions 2-105.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6WUX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGGOT00000026693; ENSGGOP00000028382; ENSGGOG00000024588.
GeneID101135431.
KEGGggo:101135431.

Organism-specific databases

CTD54205.

Phylogenomic databases

GeneTreeENSGT00390000009405.
HOVERGENHBG003023.
KOK08738.
OMAWNEETLM.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYC_GORGO
AccessionPrimary (citable) accession number: Q6WUX8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries