ID   IGS10_HUMAN             Reviewed;        2623 AA.
AC   Q6WRI0; Q86YJ9; Q8N772; Q8NA84;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Immunoglobulin superfamily member 10;
DE            Short=IgSF10;
DE   AltName: Full=Calvaria mechanical force protein 608;
DE            Short=CMF608;
DE   Flags: Precursor;
GN   Name=IGSF10; Synonyms=CMF608;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14962803; DOI=10.1016/j.bone.2003.10.003;
RA   Segev O., Samach A., Faerman A., Kalinski H., Beiman M., Gelfand A.,
RA   Turam H., Boguslavsky S., Moshayov A., Gottlieb H., Kazanov E., Nevo Z.,
RA   Robinson D., Skaliter R., Einat P., Binderman I., Feinstein E.;
RT   "CMF608 -- a novel mechanical strain-induced bone-specific protein
RT   expressed in early osteochondroprogenitor cells.";
RL   Bone 34:246-260(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 2187-2623 (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   SUBCELLULAR LOCATION, PROBABLE INVOLVEMENT IN SELF-LIMITED DELAYED PUBERTY,
RP   VARIANTS LEU-156; LYS-161; GLY-2264 AND ASN-2614, AND CHARACTERIZATION OF
RP   VARIANTS LEU-156 AND LYS-161.
RX   PubMed=27137492; DOI=10.15252/emmm.201606250;
RA   Howard S.R., Guasti L., Ruiz-Babot G., Mancini A., David A., Storr H.L.,
RA   Metherell L.A., Sternberg M.J., Cabrera C.P., Warren H.R., Barnes M.R.,
RA   Quinton R., de Roux N., Young J., Guiochon-Mantel A., Wehkalampi K.,
RA   Andre V., Gothilf Y., Cariboni A., Dunkel L.;
RT   "IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal
RT   migration resulting in delayed puberty.";
RL   EMBO Mol. Med. 8:626-642(2016).
CC   -!- FUNCTION: Involved in the control of early migration of neurons
CC       expressing gonadotropin-releasing hormone (GNRH neurons) (By
CC       similarity). May be involved in the maintenance of
CC       osteochondroprogenitor cells pool (By similarity).
CC       {ECO:0000250|UniProtKB:Q3V1M1, ECO:0000250|UniProtKB:Q6WRH9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27137492}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6WRI0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6WRI0-2; Sequence=VSP_025195, VSP_025196;
CC       Name=3;
CC         IsoId=Q6WRI0-3; Sequence=VSP_025194;
CC   -!- DISEASE: Note=Mutations in IGSF10 may be a cause of self-limited
CC       delayed puberty. This common condition is defined as the absence of
CC       testicular enlargement in boys or breast development in girls at an age
CC       that is 2-2.5 standard deviations later than the population mean. Self-
CC       limited delayed puberty segregates within families, with the majority
CC       of families displaying an autosomal dominant pattern of inheritance.
CC       {ECO:0000269|PubMed:27137492}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05429.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY273815; AAQ16156.1; -; mRNA.
DR   EMBL; AK093069; BAC04042.1; -; mRNA.
DR   EMBL; AK098838; BAC05429.1; ALT_INIT; mRNA.
DR   EMBL; BC031063; AAH31063.1; -; mRNA.
DR   CCDS; CCDS3160.1; -. [Q6WRI0-1]
DR   RefSeq; NP_001171616.1; NM_001178145.1. [Q6WRI0-3]
DR   RefSeq; NP_001171617.1; NM_001178146.1. [Q6WRI0-3]
DR   RefSeq; NP_849144.2; NM_178822.4. [Q6WRI0-1]
DR   RefSeq; XP_011511011.1; XM_011512709.2. [Q6WRI0-1]
DR   AlphaFoldDB; Q6WRI0; -.
DR   SMR; Q6WRI0; -.
DR   BioGRID; 130074; 7.
DR   IntAct; Q6WRI0; 1.
DR   STRING; 9606.ENSP00000282466; -.
DR   DrugBank; DB00114; Pyridoxal phosphate.
DR   CarbonylDB; Q6WRI0; -.
DR   GlyCosmos; Q6WRI0; 10 sites, 1 glycan.
DR   GlyGen; Q6WRI0; 13 sites, 3 O-linked glycans (5 sites).
DR   iPTMnet; Q6WRI0; -.
DR   PhosphoSitePlus; Q6WRI0; -.
DR   BioMuta; IGSF10; -.
DR   DMDM; 74749492; -.
DR   EPD; Q6WRI0; -.
DR   jPOST; Q6WRI0; -.
DR   MassIVE; Q6WRI0; -.
DR   PaxDb; 9606-ENSP00000282466; -.
DR   PeptideAtlas; Q6WRI0; -.
DR   ProteomicsDB; 67774; -. [Q6WRI0-1]
DR   ProteomicsDB; 67775; -. [Q6WRI0-2]
DR   ProteomicsDB; 67776; -. [Q6WRI0-3]
DR   Pumba; Q6WRI0; -.
DR   Antibodypedia; 2541; 85 antibodies from 15 providers.
DR   DNASU; 285313; -.
DR   Ensembl; ENST00000282466.4; ENSP00000282466.3; ENSG00000152580.9. [Q6WRI0-1]
DR   GeneID; 285313; -.
DR   KEGG; hsa:285313; -.
DR   MANE-Select; ENST00000282466.4; ENSP00000282466.3; NM_178822.5; NP_849144.2.
DR   UCSC; uc011bod.3; human. [Q6WRI0-1]
DR   AGR; HGNC:26384; -.
DR   CTD; 285313; -.
DR   DisGeNET; 285313; -.
DR   GeneCards; IGSF10; -.
DR   HGNC; HGNC:26384; IGSF10.
DR   HPA; ENSG00000152580; Tissue enhanced (gallbladder, ovary).
DR   MIM; 617351; gene.
DR   neXtProt; NX_Q6WRI0; -.
DR   OpenTargets; ENSG00000152580; -.
DR   PharmGKB; PA134900760; -.
DR   VEuPathDB; HostDB:ENSG00000152580; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000158290; -.
DR   HOGENOM; CLU_000580_0_0_1; -.
DR   InParanoid; Q6WRI0; -.
DR   OMA; VTWIMPD; -.
DR   OrthoDB; 2918193at2759; -.
DR   PhylomeDB; Q6WRI0; -.
DR   TreeFam; TF326318; -.
DR   PathwayCommons; Q6WRI0; -.
DR   SignaLink; Q6WRI0; -.
DR   BioGRID-ORCS; 285313; 7 hits in 1143 CRISPR screens.
DR   ChiTaRS; IGSF10; human.
DR   GenomeRNAi; 285313; -.
DR   Pharos; Q6WRI0; Tbio.
DR   PRO; PR:Q6WRI0; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q6WRI0; Protein.
DR   Bgee; ENSG00000152580; Expressed in cardiac muscle of right atrium and 155 other cell types or tissues.
DR   ExpressionAtlas; Q6WRI0; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:2001222; P:regulation of neuron migration; ISS:UniProtKB.
DR   CDD; cd00096; Ig; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR45842:SF2; IMMUNOGLOBULIN SUPERFAMILY MEMBER 10; 1.
DR   PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR   Pfam; PF07679; I-set; 5.
DR   Pfam; PF13927; Ig_3; 7.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00409; IG; 12.
DR   SMART; SM00408; IGc2; 12.
DR   SMART; SM00406; IGv; 7.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 12.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50835; IG_LIKE; 12.
DR   Genevisible; Q6WRI0; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Developmental protein; Differentiation;
KW   Disease variant; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Leucine-rich repeat; Osteogenesis; Phosphoprotein; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..2623
FT                   /note="Immunoglobulin superfamily member 10"
FT                   /id="PRO_0000286817"
FT   DOMAIN          29..56
FT                   /note="LRRNT"
FT   REPEAT          58..79
FT                   /note="LRR 1"
FT   REPEAT          82..103
FT                   /note="LRR 2"
FT   REPEAT          106..127
FT                   /note="LRR 3"
FT   REPEAT          130..151
FT                   /note="LRR 4"
FT   REPEAT          154..175
FT                   /note="LRR 5"
FT   REPEAT          186..207
FT                   /note="LRR 6"
FT   DOMAIN          219..281
FT                   /note="LRRCT"
FT   DOMAIN          461..567
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          571..661
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          1648..1739
FT                   /note="Ig-like C2-type 3"
FT   DOMAIN          1745..1836
FT                   /note="Ig-like C2-type 4"
FT   DOMAIN          1841..1933
FT                   /note="Ig-like C2-type 5"
FT   DOMAIN          1941..2034
FT                   /note="Ig-like C2-type 6"
FT   DOMAIN          2037..2135
FT                   /note="Ig-like C2-type 7"
FT   DOMAIN          2141..2229
FT                   /note="Ig-like C2-type 8"
FT   DOMAIN          2234..2331
FT                   /note="Ig-like C2-type 9"
FT   DOMAIN          2337..2427
FT                   /note="Ig-like C2-type 10"
FT   DOMAIN          2432..2518
FT                   /note="Ig-like C2-type 11"
FT   DOMAIN          2528..2623
FT                   /note="Ig-like C2-type 12"
FT   REGION          668..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          767..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1334..1376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1434..1453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1340..1356
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1357..1376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2603
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6WRH9"
FT   CARBOHYD        319
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        439
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        627
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        774
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        999
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1899
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1962
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        497..551
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        595..645
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        1670..1723
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        1767..1820
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        1864..1917
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        1963..2016
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        2060..2119
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        2163..2213
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        2261..2313
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        2359..2411
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        2454..2506
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        2550..2605
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VAR_SEQ         1..2021
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025194"
FT   VAR_SEQ         1..1973
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_025195"
FT   VAR_SEQ         1974..1987
FT                   /note="MWRLPSKAVVDQQH -> MVESVRLENQPCDL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_025196"
FT   VARIANT         124
FT                   /note="T -> I (in dbSNP:rs35953658)"
FT                   /id="VAR_032179"
FT   VARIANT         150
FT                   /note="Y -> D (in dbSNP:rs7619322)"
FT                   /id="VAR_032180"
FT   VARIANT         156
FT                   /note="R -> L (found in autosomal dominant self-limited
FT                   delayed puberty; likely pathogenic; the mutant protein is
FT                   not secreted; dbSNP:rs138756085)"
FT                   /evidence="ECO:0000269|PubMed:27137492"
FT                   /id="VAR_078550"
FT   VARIANT         161
FT                   /note="E -> K (found in autosomal dominant self-limited
FT                   delayed puberty; likely pathogenic; the mutant protein is
FT                   not secreted; dbSNP:rs114161831)"
FT                   /evidence="ECO:0000269|PubMed:27137492"
FT                   /id="VAR_078551"
FT   VARIANT         571
FT                   /note="P -> S (in dbSNP:rs17204557)"
FT                   /id="VAR_032181"
FT   VARIANT         795
FT                   /note="D -> N (in dbSNP:rs58583961)"
FT                   /id="VAR_061313"
FT   VARIANT         1199
FT                   /note="S -> A (in dbSNP:rs16863403)"
FT                   /id="VAR_032182"
FT   VARIANT         1370
FT                   /note="T -> I (in dbSNP:rs34933248)"
FT                   /id="VAR_032183"
FT   VARIANT         1875
FT                   /note="Y -> H (in dbSNP:rs12487205)"
FT                   /id="VAR_032184"
FT   VARIANT         2264
FT                   /note="E -> G (found in autosomal dominant self-limited
FT                   delayed puberty; uncertain significance;
FT                   dbSNP:rs1204847665)"
FT                   /evidence="ECO:0000269|PubMed:27137492"
FT                   /id="VAR_078552"
FT   VARIANT         2476
FT                   /note="R -> W (in dbSNP:rs3732775)"
FT                   /id="VAR_032185"
FT   VARIANT         2579
FT                   /note="H -> Y (in dbSNP:rs7624011)"
FT                   /id="VAR_032186"
FT   VARIANT         2614
FT                   /note="D -> N (found in autosomal dominant self-limited
FT                   delayed puberty; uncertain significance;
FT                   dbSNP:rs112889898)"
FT                   /evidence="ECO:0000269|PubMed:27137492"
FT                   /id="VAR_078553"
FT   CONFLICT        2243
FT                   /note="N -> S (in Ref. 3; AAH31063)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2623 AA;  290838 MW;  CBE7139B0DF16CF8 CRC64;
     MKVKGRGITC LLVSFAVICL VATPGGKACP RRCACYMPTE VHCTFRYLTS IPDSIPPNVE
     RINLGYNSLV RLMETDFSGL TKLELLMLHS NGIHTIPDKT FSDLQALQVL KMSYNKVRKL
     QKDTFYGLRS LTRLHMDHNN IEFINPEVFY GLNFLRLVHL EGNQLTKLHP DTFVSLSYLQ
     IFKISFIKFL YLSDNFLTSL PQEMVSYMPD LDSLYLHGNP WTCDCHLKWL SDWIQEKPDV
     IKCKKDRSPS SAQQCPLCMN PRTSKGKPLA MVSAAAFQCA KPTIDSSLKS KSLTILEDSS
     SAFISPQGFM APFGSLTLNM TDQSGNEANM VCSIQKPSRT SPIAFTEEND YIVLNTSFST
     FLVCNIDYGH IQPVWQILAL YSDSPLILER SHLLSETPQL YYKYKQVAPK PEDIFTNIEA
     DLRADPSWLM QDQISLQLNR TATTFSTLQI QYSSDAQITL PRAEMRPVKH KWTMISRDNN
     TKLEHTVLVG GTVGLNCPGQ GDPTPHVDWL LADGSKVRAP YVSEDGRILI DKSGKLELQM
     ADSFDTGVYH CISSNYDDAD ILTYRITVVE PLVEAYQENG IHHTVFIGET LDLPCHSTGI
     PDASISWVIP GNNVLYQSSR DKKVLNNGTL RILQVTPKDQ GYYRCVAANP SGVDFLIFQV
     SVKMKGQRPL EHDGETEGSG LDESNPIAHL KEPPGAQLRT SALMEAEVGK HTSSTSKRHN
     YRELTLQRRG DSTHRRFREN RRHFPPSARR IDPQHWAALL EKAKKNAMPD KRENTTVSPP
     PVVTQLPNIP GEEDDSSGML ALHEEFMVPA TKALNLPART VTADSRTISD SPMTNINYGT
     EFSPVVNSQI LPPEEPTDFK LSTAIKTTAM SKNINPTMSS QIQGTTNQHS STVFPLLLGA
     TEFQDSDQMG RGREHFQSRP PITVRTMIKD VNVKMLSSTT NKLLLESVNT TNSHQTSVRE
     VSEPRHNHFY SHTTQILSTS TFPSDPHTAA HSQFPIPRNS TVNIPLFRRF GRQRKIGGRG
     RIISPYRTPV LRRHRYSIFR STTRGSSEKS TTAFSATVLN VTCLSCLPRE RLTTATAALS
     FPSAAPITFP KADIARVPSE ESTTLVQNPL LLLENKPSVE KTTPTIKYFR TEISQVTPTG
     AVMTYAPTSI PMEKTHKVNA SYPRVSSTNE AKRDSVITSS LSGAITKPPM TIIAITRFSR
     RKIPWQQNFV NNHNPKGRLR NQHKVSLQKS TAVMLPKTSP ALPRDKVSPF HFTTLSTSVM
     QIPSNTLTTA HHTTTKTHNP GSLPTKKELP FPPLNPMLPS IISKDSSTKS IISTQTAIPA
     TTPTFPASVI TYETQTERSR AQTIQREQEP QKKNRTDPNI SPDQSSGFTT PTAMTPPVLT
     TAETSVKPSV SAFTHSPPEN TTGISSTISF HSRTLNLTDV IEELAQASTQ TLKSTIASET
     TLSSKSHQST TTRKAIIRHS TIPPFLSSSA TLMPVPISPP FTQRAVTDNV ATPISGLMTN
     TVVKLHESSR HNAKPQQLVA EVATSPKVHP NAKFTIGTTH FIYSNLLHST PMPALTTVKS
     QNSKLTPSPW AENQFWHKPY SEIAEKGKKP EVSMLATTGL SEATTLVSDW DGQKNTKKSD
     FDKKPVQEAT TSKLLPFDSL SRYIFEKPRI VGGKAASFTI PANSDAFLPC EAVGNPLPTI
     HWTRVPSGLD LSKRKQNSRV QVLPNGTLSI QRVEIQDRGQ YLCSASNLFG TDHLHVTLSV
     VSYPPRILER RTKEITVHSG STVELKCRAE GRPSPTVTWI LANQTVVSES SQGSRQAVVT
     VDGTLVLHNL SIYDRGFYKC VASNPGGQDS LLVKIQVIAA PPVILEQRRQ VIVGTWGESL
     KLPCTAKGTP QPSVYWVLSD GTEVKPLQFT NSKLFLFSNG TLYIRNLASS DRGTYECIAT
     SSTGSERRVV MLTMEERVTS PRIEAASQKR TEVNFGDKLL LNCSATGEPK PQIMWRLPSK
     AVVDQQHRVG SWIHVYPNGS LFIGSVTEKD SGVYLCVARN KMGDDLILMH VSLRLKPAKI
     DHKQYFRKQV LHGKDFQVDC KASGSPVPEI SWSLPDGTMI NNAMQADDSG HRTRRYTLFN
     NGTLYFNKVG VAEEGDYTCY AQNTLGKDEM KVHLTVITAA PRIRQSNKTN KRIKAGDTAV
     LDCEVTGDPK PKIFWLLPSN DMISFSIDRY TFHANGSLTI NKVKLLDSGE YVCVARNPSG
     DDTKMYKLDV VSKPPLINGL YTNRTVIKAT AVRHSKKHFD CRAEGTPSPE VMWIMPDNIF
     LTAPYYGSRI TVHKNGTLEI RNVRLSDSAD FICVARNEGG ESVLVVQLEV LEMLRRPTFR
     NPFNEKIVAQ LGKSTALNCS VDGNPPPEII WILPNGTRFS NGPQSYQYLI ASNGSFIISK
     TTREDAGKYR CAARNKVGYI EKLVILEIGQ KPVILTYAPG TVKGISGESL SLHCVSDGIP
     KPNIKWTMPS GYVVDRPQIN GKYILHDNGT LVIKEATAYD RGNYICKAQN SVGHTLITVP
     VMIVAYPPRI TNRPPRSIVT RTGAAFQLHC VALGVPKPEI TWEMPDHSLL STASKERTHG
     SEQLHLQGTL VIQNPQTSDS GIYKCTAKNP LGSDYAATYI QVI
//