Q6WRI0 (IGS10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immunoglobulin superfamily member 10
Short name=IgSF10

Alternative name(s):
Calvaria mechanical force protein 608
Short name=CMF608

Gene names

Name:	IGSF10
Synonyms:	CMF608

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2623 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the maintenance of osteochondroprogenitor cells pool By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 12 Ig-like C2-type (immunoglobulin-like) domains. Contains 6 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.
Sequence caution	The sequence BAC05429.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Osteogenesis
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW ossification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6WRI0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6WRI0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1973: Missing.
     1974-1987: MWRLPSKAVVDQQH → MVESVRLENQPCDL

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6WRI0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2021: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 2623	2595	Immunoglobulin superfamily member 10		PRO_0000286817
Regions
	Domain	29 – 56	28	LRRNT
	Repeat	58 – 79	22	LRR 1
	Repeat	82 – 103	22	LRR 2
	Repeat	106 – 127	22	LRR 3
	Repeat	130 – 151	22	LRR 4
	Repeat	154 – 175	22	LRR 5
	Repeat	186 – 207	22	LRR 6
	Domain	219 – 281	63	LRRCT
	Domain	461 – 567	107	Ig-like C2-type 1
	Domain	571 – 661	91	Ig-like C2-type 2
	Domain	1648 – 1739	92	Ig-like C2-type 3
	Domain	1745 – 1836	92	Ig-like C2-type 4
	Domain	1841 – 1933	93	Ig-like C2-type 5
	Domain	1941 – 2034	94	Ig-like C2-type 6
	Domain	2037 – 2135	99	Ig-like C2-type 7
	Domain	2141 – 2229	89	Ig-like C2-type 8
	Domain	2234 – 2331	98	Ig-like C2-type 9
	Domain	2337 – 2427	91	Ig-like C2-type 10
	Domain	2432 – 2518	87	Ig-like C2-type 11
	Domain	2528 – 2623	96	Ig-like C2-type 12
Amino acid modifications
	Glycosylation	319	1	N-linked (GlcNAc...) Potential
	Glycosylation	439	1	N-linked (GlcNAc...) Potential
	Glycosylation	627	1	N-linked (GlcNAc...) Potential
	Glycosylation	774	1	N-linked (GlcNAc...) Potential
	Glycosylation	999	1	N-linked (GlcNAc...) Potential
	Glycosylation	1899	1	N-linked (GlcNAc...) Potential
	Glycosylation	1962	1	N-linked (GlcNAc...) Potential
	Glycosylation	2101	1	N-linked (GlcNAc...) Potential
	Disulfide bond	497 ↔ 551		By similarity
	Disulfide bond	595 ↔ 645		By similarity
	Disulfide bond	1670 ↔ 1723		By similarity
	Disulfide bond	1767 ↔ 1820		By similarity
	Disulfide bond	1864 ↔ 1917		By similarity
	Disulfide bond	1963 ↔ 2016		By similarity
	Disulfide bond	2060 ↔ 2119		By similarity
	Disulfide bond	2163 ↔ 2213		By similarity
	Disulfide bond	2261 ↔ 2313		By similarity
	Disulfide bond	2359 ↔ 2411		By similarity
	Disulfide bond	2454 ↔ 2506		By similarity
	Disulfide bond	2550 ↔ 2605		By similarity
Natural variations
	Alternative sequence	1 – 2021	2021	Missing in isoform 3.		VSP_025194
	Alternative sequence	1 – 1973	1973	Missing in isoform 2.		VSP_025195
	Alternative sequence	1974 – 1987	14	MWRLP…VDQQH → MVESVRLENQPCDL in isoform 2.		VSP_025196
	Natural variant	124	1	T → I. Corresponds to variant rs35953658 [ dbSNP | Ensembl ].		VAR_032179
	Natural variant	150	1	Y → D. Corresponds to variant rs7619322 [ dbSNP | Ensembl ].		VAR_032180
	Natural variant	571	1	P → S. Corresponds to variant rs17204557 [ dbSNP | Ensembl ].		VAR_032181
	Natural variant	795	1	D → N. Corresponds to variant rs58583961 [ dbSNP | Ensembl ].		VAR_061313
	Natural variant	1199	1	S → A. Corresponds to variant rs16863403 [ dbSNP | Ensembl ].		VAR_032182
	Natural variant	1370	1	T → I. Corresponds to variant rs34933248 [ dbSNP | Ensembl ].		VAR_032183
	Natural variant	1875	1	Y → H. Corresponds to variant rs12487205 [ dbSNP | Ensembl ].		VAR_032184
	Natural variant	2476	1	R → W. Corresponds to variant rs3732775 [ dbSNP | Ensembl ].		VAR_032185
	Natural variant	2579	1	H → Y. Corresponds to variant rs7624011 [ dbSNP | Ensembl ].		VAR_032186
Experimental info
	Sequence conflict	2243	1	N → S in AAH31063. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: CBE7139B0DF16CF8	FASTA	2,623	290,838
	10 20 30 40 50 60 MKVKGRGITC LLVSFAVICL VATPGGKACP RRCACYMPTE VHCTFRYLTS IPDSIPPNVE 70 80 90 100 110 120 RINLGYNSLV RLMETDFSGL TKLELLMLHS NGIHTIPDKT FSDLQALQVL KMSYNKVRKL 130 140 150 160 170 180 QKDTFYGLRS LTRLHMDHNN IEFINPEVFY GLNFLRLVHL EGNQLTKLHP DTFVSLSYLQ 190 200 210 220 230 240 IFKISFIKFL YLSDNFLTSL PQEMVSYMPD LDSLYLHGNP WTCDCHLKWL SDWIQEKPDV 250 260 270 280 290 300 IKCKKDRSPS SAQQCPLCMN PRTSKGKPLA MVSAAAFQCA KPTIDSSLKS KSLTILEDSS 310 320 330 340 350 360 SAFISPQGFM APFGSLTLNM TDQSGNEANM VCSIQKPSRT SPIAFTEEND YIVLNTSFST 370 380 390 400 410 420 FLVCNIDYGH IQPVWQILAL YSDSPLILER SHLLSETPQL YYKYKQVAPK PEDIFTNIEA 430 440 450 460 470 480 DLRADPSWLM QDQISLQLNR TATTFSTLQI QYSSDAQITL PRAEMRPVKH KWTMISRDNN 490 500 510 520 530 540 TKLEHTVLVG GTVGLNCPGQ GDPTPHVDWL LADGSKVRAP YVSEDGRILI DKSGKLELQM 550 560 570 580 590 600 ADSFDTGVYH CISSNYDDAD ILTYRITVVE PLVEAYQENG IHHTVFIGET LDLPCHSTGI 610 620 630 640 650 660 PDASISWVIP GNNVLYQSSR DKKVLNNGTL RILQVTPKDQ GYYRCVAANP SGVDFLIFQV 670 680 690 700 710 720 SVKMKGQRPL EHDGETEGSG LDESNPIAHL KEPPGAQLRT SALMEAEVGK HTSSTSKRHN 730 740 750 760 770 780 YRELTLQRRG DSTHRRFREN RRHFPPSARR IDPQHWAALL EKAKKNAMPD KRENTTVSPP 790 800 810 820 830 840 PVVTQLPNIP GEEDDSSGML ALHEEFMVPA TKALNLPART VTADSRTISD SPMTNINYGT 850 860 870 880 890 900 EFSPVVNSQI LPPEEPTDFK LSTAIKTTAM SKNINPTMSS QIQGTTNQHS STVFPLLLGA 910 920 930 940 950 960 TEFQDSDQMG RGREHFQSRP PITVRTMIKD VNVKMLSSTT NKLLLESVNT TNSHQTSVRE 970 980 990 1000 1010 1020 VSEPRHNHFY SHTTQILSTS TFPSDPHTAA HSQFPIPRNS TVNIPLFRRF GRQRKIGGRG 1030 1040 1050 1060 1070 1080 RIISPYRTPV LRRHRYSIFR STTRGSSEKS TTAFSATVLN VTCLSCLPRE RLTTATAALS 1090 1100 1110 1120 1130 1140 FPSAAPITFP KADIARVPSE ESTTLVQNPL LLLENKPSVE KTTPTIKYFR TEISQVTPTG 1150 1160 1170 1180 1190 1200 AVMTYAPTSI PMEKTHKVNA SYPRVSSTNE AKRDSVITSS LSGAITKPPM TIIAITRFSR 1210 1220 1230 1240 1250 1260 RKIPWQQNFV NNHNPKGRLR NQHKVSLQKS TAVMLPKTSP ALPRDKVSPF HFTTLSTSVM 1270 1280 1290 1300 1310 1320 QIPSNTLTTA HHTTTKTHNP GSLPTKKELP FPPLNPMLPS IISKDSSTKS IISTQTAIPA 1330 1340 1350 1360 1370 1380 TTPTFPASVI TYETQTERSR AQTIQREQEP QKKNRTDPNI SPDQSSGFTT PTAMTPPVLT 1390 1400 1410 1420 1430 1440 TAETSVKPSV SAFTHSPPEN TTGISSTISF HSRTLNLTDV IEELAQASTQ TLKSTIASET 1450 1460 1470 1480 1490 1500 TLSSKSHQST TTRKAIIRHS TIPPFLSSSA TLMPVPISPP FTQRAVTDNV ATPISGLMTN 1510 1520 1530 1540 1550 1560 TVVKLHESSR HNAKPQQLVA EVATSPKVHP NAKFTIGTTH FIYSNLLHST PMPALTTVKS 1570 1580 1590 1600 1610 1620 QNSKLTPSPW AENQFWHKPY SEIAEKGKKP EVSMLATTGL SEATTLVSDW DGQKNTKKSD 1630 1640 1650 1660 1670 1680 FDKKPVQEAT TSKLLPFDSL SRYIFEKPRI VGGKAASFTI PANSDAFLPC EAVGNPLPTI 1690 1700 1710 1720 1730 1740 HWTRVPSGLD LSKRKQNSRV QVLPNGTLSI QRVEIQDRGQ YLCSASNLFG TDHLHVTLSV 1750 1760 1770 1780 1790 1800 VSYPPRILER RTKEITVHSG STVELKCRAE GRPSPTVTWI LANQTVVSES SQGSRQAVVT 1810 1820 1830 1840 1850 1860 VDGTLVLHNL SIYDRGFYKC VASNPGGQDS LLVKIQVIAA PPVILEQRRQ VIVGTWGESL 1870 1880 1890 1900 1910 1920 KLPCTAKGTP QPSVYWVLSD GTEVKPLQFT NSKLFLFSNG TLYIRNLASS DRGTYECIAT 1930 1940 1950 1960 1970 1980 SSTGSERRVV MLTMEERVTS PRIEAASQKR TEVNFGDKLL LNCSATGEPK PQIMWRLPSK 1990 2000 2010 2020 2030 2040 AVVDQQHRVG SWIHVYPNGS LFIGSVTEKD SGVYLCVARN KMGDDLILMH VSLRLKPAKI 2050 2060 2070 2080 2090 2100 DHKQYFRKQV LHGKDFQVDC KASGSPVPEI SWSLPDGTMI NNAMQADDSG HRTRRYTLFN 2110 2120 2130 2140 2150 2160 NGTLYFNKVG VAEEGDYTCY AQNTLGKDEM KVHLTVITAA PRIRQSNKTN KRIKAGDTAV 2170 2180 2190 2200 2210 2220 LDCEVTGDPK PKIFWLLPSN DMISFSIDRY TFHANGSLTI NKVKLLDSGE YVCVARNPSG 2230 2240 2250 2260 2270 2280 DDTKMYKLDV VSKPPLINGL YTNRTVIKAT AVRHSKKHFD CRAEGTPSPE VMWIMPDNIF 2290 2300 2310 2320 2330 2340 LTAPYYGSRI TVHKNGTLEI RNVRLSDSAD FICVARNEGG ESVLVVQLEV LEMLRRPTFR 2350 2360 2370 2380 2390 2400 NPFNEKIVAQ LGKSTALNCS VDGNPPPEII WILPNGTRFS NGPQSYQYLI ASNGSFIISK 2410 2420 2430 2440 2450 2460 TTREDAGKYR CAARNKVGYI EKLVILEIGQ KPVILTYAPG TVKGISGESL SLHCVSDGIP 2470 2480 2490 2500 2510 2520 KPNIKWTMPS GYVVDRPQIN GKYILHDNGT LVIKEATAYD RGNYICKAQN SVGHTLITVP 2530 2540 2550 2560 2570 2580 VMIVAYPPRI TNRPPRSIVT RTGAAFQLHC VALGVPKPEI TWEMPDHSLL STASKERTHG 2590 2600 2610 2620 SEQLHLQGTL VIQNPQTSDS GIYKCTAKNP LGSDYAATYI QVI
	Isoform 2 [UniParc]. Checksum: 8DA678726D7AF644	FASTA	650	72,091
	10 20 30 40 50 60 MVESVRLENQ PCDLRVGSWI HVYPNGSLFI GSVTEKDSGV YLCVARNKMG DDLILMHVSL 70 80 90 100 110 120 RLKPAKIDHK QYFRKQVLHG KDFQVDCKAS GSPVPEISWS LPDGTMINNA MQADDSGHRT 130 140 150 160 170 180 RRYTLFNNGT LYFNKVGVAE EGDYTCYAQN TLGKDEMKVH LTVITAAPRI RQSNKTNKRI 190 200 210 220 230 240 KAGDTAVLDC EVTGDPKPKI FWLLPSNDMI SFSIDRYTFH ANGSLTINKV KLLDSGEYVC 250 260 270 280 290 300 VARNPSGDDT KMYKLDVVSK PPLINGLYTN RTVIKATAVR HSKKHFDCRA EGTPSPEVMW 310 320 330 340 350 360 IMPDNIFLTA PYYGSRITVH KNGTLEIRNV RLSDSADFIC VARNEGGESV LVVQLEVLEM 370 380 390 400 410 420 LRRPTFRNPF NEKIVAQLGK STALNCSVDG NPPPEIIWIL PNGTRFSNGP QSYQYLIASN 430 440 450 460 470 480 GSFIISKTTR EDAGKYRCAA RNKVGYIEKL VILEIGQKPV ILTYAPGTVK GISGESLSLH 490 500 510 520 530 540 CVSDGIPKPN IKWTMPSGYV VDRPQINGKY ILHDNGTLVI KEATAYDRGN YICKAQNSVG 550 560 570 580 590 600 HTLITVPVMI VAYPPRITNR PPRSIVTRTG AAFQLHCVAL GVPKPEITWE MPDHSLLSTA 610 620 630 640 650 SKERTHGSEQ LHLQGTLVIQ NPQTSDSGIY KCTAKNPLGS DYAATYIQVI
	Isoform 3 [UniParc]. Checksum: 6BA060C56FBE460B	FASTA	602	66,741
	10 20 30 40 50 60 MGDDLILMHV SLRLKPAKID HKQYFRKQVL HGKDFQVDCK ASGSPVPEIS WSLPDGTMIN 70 80 90 100 110 120 NAMQADDSGH RTRRYTLFNN GTLYFNKVGV AEEGDYTCYA QNTLGKDEMK VHLTVITAAP 130 140 150 160 170 180 RIRQSNKTNK RIKAGDTAVL DCEVTGDPKP KIFWLLPSND MISFSIDRYT FHANGSLTIN 190 200 210 220 230 240 KVKLLDSGEY VCVARNPSGD DTKMYKLDVV SKPPLINGLY TNRTVIKATA VRHSKKHFDC 250 260 270 280 290 300 RAEGTPSPEV MWIMPDNIFL TAPYYGSRIT VHKNGTLEIR NVRLSDSADF ICVARNEGGE 310 320 330 340 350 360 SVLVVQLEVL EMLRRPTFRN PFNEKIVAQL GKSTALNCSV DGNPPPEIIW ILPNGTRFSN 370 380 390 400 410 420 GPQSYQYLIA SNGSFIISKT TREDAGKYRC AARNKVGYIE KLVILEIGQK PVILTYAPGT 430 440 450 460 470 480 VKGISGESLS LHCVSDGIPK PNIKWTMPSG YVVDRPQING KYILHDNGTL VIKEATAYDR 490 500 510 520 530 540 GNYICKAQNS VGHTLITVPV MIVAYPPRIT NRPPRSIVTR TGAAFQLHCV ALGVPKPEIT 550 560 570 580 590 600 WEMPDHSLLS TASKERTHGS EQLHLQGTLV IQNPQTSDSG IYKCTAKNPL GSDYAATYIQ VI

References

[1]	"CMF608 -- a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells." Segev O., Samach A., Faerman A., Kalinski H., Beiman M., Gelfand A., Turam H., Boguslavsky S., Moshayov A., Gottlieb H., Kazanov E., Nevo Z., Robinson D., Skaliter R., Einat P., Binderman I., Feinstein E. Bone 34:246-260(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2187-2623 (ISOFORM 1). Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY273815 mRNA. Translation: AAQ16156.1. AK093069 mRNA. Translation: BAC04042.1. AK098838 mRNA. Translation: BAC05429.1. Different initiation. BC031063 mRNA. Translation: AAH31063.1.
IPI	IPI00183913. IPI00478293. IPI00795608.
RefSeq	NP_001171616.1. NM_001178145.1. NP_001171617.1. NM_001178146.1. NP_849144.2. NM_178822.4.
UniGene	Hs.741587.
3D structure databases
HSSP	HSSP built from PDB template 1OZN based on UniProtKB Q9BZR6.
ProteinModelPortal	Q6WRI0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000282466.
PTM databases
PhosphoSite	Q6WRI0.
Polymorphism databases
DMDM	74749492.
Proteomic databases
PaxDb	Q6WRI0.
PRIDE	Q6WRI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282466; ENSP00000282466; ENSG00000152580.
GeneID	285313.
KEGG	hsa:285313.
UCSC	uc011bob.2. human. uc011boc.2. human. uc011bod.2. human.
Organism-specific databases
CTD	285313.
GeneCards	GC03M151143.
HGNC	HGNC:26384. IGSF10.
HPA	HPA012921.
neXtProt	NX_Q6WRI0.
PharmGKB	PA134900760.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG239806.
HOGENOM	HOG000113014.
HOVERGEN	HBG107995.
InParanoid	Q6WRI0.
OMA	PYVSEDG.
OrthoDB	EOG45MN4F.
PhylomeDB	Q6WRI0.
Gene expression databases
ArrayExpress	Q6WRI0.
Bgee	Q6WRI0.
CleanEx	HS_IGSF10.
Genevestigator	Q6WRI0.
Family and domain databases
Gene3D	2.60.40.10. 12 hits.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF07679. I-set. 12 hits. [Graphical view]
SMART	SM00409. IG. 2 hits. SM00408. IGc2. 10 hits. SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 12 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	285313.
NextBio	95425.

Entry information

Entry name

IGS10_HUMAN

Accession

Primary (citable) accession number: Q6WRI0
Secondary accession number(s): Q86YJ9, Q8N772, Q8NA84

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.