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Q6WRI0 (IGS10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin superfamily member 10

Short name=IgSF10
Alternative name(s):
Calvaria mechanical force protein 608
Short name=CMF608
Gene names
Name:IGSF10
Synonyms:CMF608
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2623 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the maintenance of osteochondroprogenitor cells pool By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Contains 12 Ig-like C2-type (immunoglobulin-like) domains.

Contains 6 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence caution

The sequence BAC05429.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6WRI0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6WRI0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1973: Missing.
     1974-1987: MWRLPSKAVVDQQH → MVESVRLENQPCDL
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6WRI0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2021: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 26232595Immunoglobulin superfamily member 10
PRO_0000286817

Regions

Domain29 – 5628LRRNT
Repeat58 – 7922LRR 1
Repeat82 – 10322LRR 2
Repeat106 – 12722LRR 3
Repeat130 – 15122LRR 4
Repeat154 – 17522LRR 5
Repeat186 – 20722LRR 6
Domain219 – 28163LRRCT
Domain461 – 567107Ig-like C2-type 1
Domain571 – 66191Ig-like C2-type 2
Domain1648 – 173992Ig-like C2-type 3
Domain1745 – 183692Ig-like C2-type 4
Domain1841 – 193393Ig-like C2-type 5
Domain1941 – 203494Ig-like C2-type 6
Domain2037 – 213599Ig-like C2-type 7
Domain2141 – 222989Ig-like C2-type 8
Domain2234 – 233198Ig-like C2-type 9
Domain2337 – 242791Ig-like C2-type 10
Domain2432 – 251887Ig-like C2-type 11
Domain2528 – 262396Ig-like C2-type 12

Amino acid modifications

Modified residue26031Phosphotyrosine By similarity
Glycosylation3191N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential
Glycosylation6271N-linked (GlcNAc...) Potential
Glycosylation7741N-linked (GlcNAc...) Potential
Glycosylation9991N-linked (GlcNAc...) Potential
Glycosylation18991N-linked (GlcNAc...) Potential
Glycosylation19621N-linked (GlcNAc...) Potential
Glycosylation21011N-linked (GlcNAc...) Potential
Disulfide bond497 ↔ 551 By similarity
Disulfide bond595 ↔ 645 By similarity
Disulfide bond1670 ↔ 1723 By similarity
Disulfide bond1767 ↔ 1820 By similarity
Disulfide bond1864 ↔ 1917 By similarity
Disulfide bond1963 ↔ 2016 By similarity
Disulfide bond2060 ↔ 2119 By similarity
Disulfide bond2163 ↔ 2213 By similarity
Disulfide bond2261 ↔ 2313 By similarity
Disulfide bond2359 ↔ 2411 By similarity
Disulfide bond2454 ↔ 2506 By similarity
Disulfide bond2550 ↔ 2605 By similarity

Natural variations

Alternative sequence1 – 20212021Missing in isoform 3.
VSP_025194
Alternative sequence1 – 19731973Missing in isoform 2.
VSP_025195
Alternative sequence1974 – 198714MWRLP…VDQQH → MVESVRLENQPCDL in isoform 2.
VSP_025196
Natural variant1241T → I.
Corresponds to variant rs35953658 [ dbSNP | Ensembl ].
VAR_032179
Natural variant1501Y → D.
Corresponds to variant rs7619322 [ dbSNP | Ensembl ].
VAR_032180
Natural variant5711P → S.
Corresponds to variant rs17204557 [ dbSNP | Ensembl ].
VAR_032181
Natural variant7951D → N.
Corresponds to variant rs58583961 [ dbSNP | Ensembl ].
VAR_061313
Natural variant11991S → A.
Corresponds to variant rs16863403 [ dbSNP | Ensembl ].
VAR_032182
Natural variant13701T → I.
Corresponds to variant rs34933248 [ dbSNP | Ensembl ].
VAR_032183
Natural variant18751Y → H.
Corresponds to variant rs12487205 [ dbSNP | Ensembl ].
VAR_032184
Natural variant24761R → W.
Corresponds to variant rs3732775 [ dbSNP | Ensembl ].
VAR_032185
Natural variant25791H → Y.
Corresponds to variant rs7624011 [ dbSNP | Ensembl ].
VAR_032186

Experimental info

Sequence conflict22431N → S in AAH31063. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CBE7139B0DF16CF8

FASTA2,623290,838
        10         20         30         40         50         60 
MKVKGRGITC LLVSFAVICL VATPGGKACP RRCACYMPTE VHCTFRYLTS IPDSIPPNVE 

        70         80         90        100        110        120 
RINLGYNSLV RLMETDFSGL TKLELLMLHS NGIHTIPDKT FSDLQALQVL KMSYNKVRKL 

       130        140        150        160        170        180 
QKDTFYGLRS LTRLHMDHNN IEFINPEVFY GLNFLRLVHL EGNQLTKLHP DTFVSLSYLQ 

       190        200        210        220        230        240 
IFKISFIKFL YLSDNFLTSL PQEMVSYMPD LDSLYLHGNP WTCDCHLKWL SDWIQEKPDV 

       250        260        270        280        290        300 
IKCKKDRSPS SAQQCPLCMN PRTSKGKPLA MVSAAAFQCA KPTIDSSLKS KSLTILEDSS 

       310        320        330        340        350        360 
SAFISPQGFM APFGSLTLNM TDQSGNEANM VCSIQKPSRT SPIAFTEEND YIVLNTSFST 

       370        380        390        400        410        420 
FLVCNIDYGH IQPVWQILAL YSDSPLILER SHLLSETPQL YYKYKQVAPK PEDIFTNIEA 

       430        440        450        460        470        480 
DLRADPSWLM QDQISLQLNR TATTFSTLQI QYSSDAQITL PRAEMRPVKH KWTMISRDNN 

       490        500        510        520        530        540 
TKLEHTVLVG GTVGLNCPGQ GDPTPHVDWL LADGSKVRAP YVSEDGRILI DKSGKLELQM 

       550        560        570        580        590        600 
ADSFDTGVYH CISSNYDDAD ILTYRITVVE PLVEAYQENG IHHTVFIGET LDLPCHSTGI 

       610        620        630        640        650        660 
PDASISWVIP GNNVLYQSSR DKKVLNNGTL RILQVTPKDQ GYYRCVAANP SGVDFLIFQV 

       670        680        690        700        710        720 
SVKMKGQRPL EHDGETEGSG LDESNPIAHL KEPPGAQLRT SALMEAEVGK HTSSTSKRHN 

       730        740        750        760        770        780 
YRELTLQRRG DSTHRRFREN RRHFPPSARR IDPQHWAALL EKAKKNAMPD KRENTTVSPP 

       790        800        810        820        830        840 
PVVTQLPNIP GEEDDSSGML ALHEEFMVPA TKALNLPART VTADSRTISD SPMTNINYGT 

       850        860        870        880        890        900 
EFSPVVNSQI LPPEEPTDFK LSTAIKTTAM SKNINPTMSS QIQGTTNQHS STVFPLLLGA 

       910        920        930        940        950        960 
TEFQDSDQMG RGREHFQSRP PITVRTMIKD VNVKMLSSTT NKLLLESVNT TNSHQTSVRE 

       970        980        990       1000       1010       1020 
VSEPRHNHFY SHTTQILSTS TFPSDPHTAA HSQFPIPRNS TVNIPLFRRF GRQRKIGGRG 

      1030       1040       1050       1060       1070       1080 
RIISPYRTPV LRRHRYSIFR STTRGSSEKS TTAFSATVLN VTCLSCLPRE RLTTATAALS 

      1090       1100       1110       1120       1130       1140 
FPSAAPITFP KADIARVPSE ESTTLVQNPL LLLENKPSVE KTTPTIKYFR TEISQVTPTG 

      1150       1160       1170       1180       1190       1200 
AVMTYAPTSI PMEKTHKVNA SYPRVSSTNE AKRDSVITSS LSGAITKPPM TIIAITRFSR 

      1210       1220       1230       1240       1250       1260 
RKIPWQQNFV NNHNPKGRLR NQHKVSLQKS TAVMLPKTSP ALPRDKVSPF HFTTLSTSVM 

      1270       1280       1290       1300       1310       1320 
QIPSNTLTTA HHTTTKTHNP GSLPTKKELP FPPLNPMLPS IISKDSSTKS IISTQTAIPA 

      1330       1340       1350       1360       1370       1380 
TTPTFPASVI TYETQTERSR AQTIQREQEP QKKNRTDPNI SPDQSSGFTT PTAMTPPVLT 

      1390       1400       1410       1420       1430       1440 
TAETSVKPSV SAFTHSPPEN TTGISSTISF HSRTLNLTDV IEELAQASTQ TLKSTIASET 

      1450       1460       1470       1480       1490       1500 
TLSSKSHQST TTRKAIIRHS TIPPFLSSSA TLMPVPISPP FTQRAVTDNV ATPISGLMTN 

      1510       1520       1530       1540       1550       1560 
TVVKLHESSR HNAKPQQLVA EVATSPKVHP NAKFTIGTTH FIYSNLLHST PMPALTTVKS 

      1570       1580       1590       1600       1610       1620 
QNSKLTPSPW AENQFWHKPY SEIAEKGKKP EVSMLATTGL SEATTLVSDW DGQKNTKKSD 

      1630       1640       1650       1660       1670       1680 
FDKKPVQEAT TSKLLPFDSL SRYIFEKPRI VGGKAASFTI PANSDAFLPC EAVGNPLPTI 

      1690       1700       1710       1720       1730       1740 
HWTRVPSGLD LSKRKQNSRV QVLPNGTLSI QRVEIQDRGQ YLCSASNLFG TDHLHVTLSV 

      1750       1760       1770       1780       1790       1800 
VSYPPRILER RTKEITVHSG STVELKCRAE GRPSPTVTWI LANQTVVSES SQGSRQAVVT 

      1810       1820       1830       1840       1850       1860 
VDGTLVLHNL SIYDRGFYKC VASNPGGQDS LLVKIQVIAA PPVILEQRRQ VIVGTWGESL 

      1870       1880       1890       1900       1910       1920 
KLPCTAKGTP QPSVYWVLSD GTEVKPLQFT NSKLFLFSNG TLYIRNLASS DRGTYECIAT 

      1930       1940       1950       1960       1970       1980 
SSTGSERRVV MLTMEERVTS PRIEAASQKR TEVNFGDKLL LNCSATGEPK PQIMWRLPSK 

      1990       2000       2010       2020       2030       2040 
AVVDQQHRVG SWIHVYPNGS LFIGSVTEKD SGVYLCVARN KMGDDLILMH VSLRLKPAKI 

      2050       2060       2070       2080       2090       2100 
DHKQYFRKQV LHGKDFQVDC KASGSPVPEI SWSLPDGTMI NNAMQADDSG HRTRRYTLFN 

      2110       2120       2130       2140       2150       2160 
NGTLYFNKVG VAEEGDYTCY AQNTLGKDEM KVHLTVITAA PRIRQSNKTN KRIKAGDTAV 

      2170       2180       2190       2200       2210       2220 
LDCEVTGDPK PKIFWLLPSN DMISFSIDRY TFHANGSLTI NKVKLLDSGE YVCVARNPSG 

      2230       2240       2250       2260       2270       2280 
DDTKMYKLDV VSKPPLINGL YTNRTVIKAT AVRHSKKHFD CRAEGTPSPE VMWIMPDNIF 

      2290       2300       2310       2320       2330       2340 
LTAPYYGSRI TVHKNGTLEI RNVRLSDSAD FICVARNEGG ESVLVVQLEV LEMLRRPTFR 

      2350       2360       2370       2380       2390       2400 
NPFNEKIVAQ LGKSTALNCS VDGNPPPEII WILPNGTRFS NGPQSYQYLI ASNGSFIISK 

      2410       2420       2430       2440       2450       2460 
TTREDAGKYR CAARNKVGYI EKLVILEIGQ KPVILTYAPG TVKGISGESL SLHCVSDGIP 

      2470       2480       2490       2500       2510       2520 
KPNIKWTMPS GYVVDRPQIN GKYILHDNGT LVIKEATAYD RGNYICKAQN SVGHTLITVP 

      2530       2540       2550       2560       2570       2580 
VMIVAYPPRI TNRPPRSIVT RTGAAFQLHC VALGVPKPEI TWEMPDHSLL STASKERTHG 

      2590       2600       2610       2620 
SEQLHLQGTL VIQNPQTSDS GIYKCTAKNP LGSDYAATYI QVI 

« Hide

Isoform 2 [UniParc].

Checksum: 8DA678726D7AF644
Show »

FASTA65072,091
Isoform 3 [UniParc].

Checksum: 6BA060C56FBE460B
Show »

FASTA60266,741

References

[1]"CMF608 -- a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells."
Segev O., Samach A., Faerman A., Kalinski H., Beiman M., Gelfand A., Turam H., Boguslavsky S., Moshayov A., Gottlieb H., Kazanov E., Nevo Z., Robinson D., Skaliter R., Einat P., Binderman I., Feinstein E.
Bone 34:246-260(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2187-2623 (ISOFORM 1).
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY273815 mRNA. Translation: AAQ16156.1.
AK093069 mRNA. Translation: BAC04042.1.
AK098838 mRNA. Translation: BAC05429.1. Different initiation.
BC031063 mRNA. Translation: AAH31063.1.
RefSeqNP_001171616.1. NM_001178145.1.
NP_001171617.1. NM_001178146.1.
NP_849144.2. NM_178822.4.
XP_005247434.1. XM_005247377.1.
UniGeneHs.58561.

3D structure databases

ProteinModelPortalQ6WRI0.
SMRQ6WRI0. Positions 26-321, 490-651, 1629-2623.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130074. 1 interaction.
STRING9606.ENSP00000282466.

PTM databases

PhosphoSiteQ6WRI0.

Polymorphism databases

DMDM74749492.

Proteomic databases

PaxDbQ6WRI0.
PRIDEQ6WRI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282466; ENSP00000282466; ENSG00000152580. [Q6WRI0-1]
GeneID285313.
KEGGhsa:285313.
UCSCuc011bob.2. human. [Q6WRI0-2]
uc011boc.2. human. [Q6WRI0-3]
uc011bod.2. human. [Q6WRI0-1]

Organism-specific databases

CTD285313.
GeneCardsGC03M151143.
HGNCHGNC:26384. IGSF10.
HPAHPA012921.
neXtProtNX_Q6WRI0.
PharmGKBPA134900760.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG239806.
HOGENOMHOG000113014.
HOVERGENHBG107995.
InParanoidQ6WRI0.
OMARGTYECI.
OrthoDBEOG7HHWR7.
PhylomeDBQ6WRI0.
TreeFamTF326318.

Gene expression databases

ArrayExpressQ6WRI0.
BgeeQ6WRI0.
CleanExHS_IGSF10.
GenevestigatorQ6WRI0.

Family and domain databases

Gene3D2.60.40.10. 12 hits.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF07679. I-set. 12 hits.
[Graphical view]
SMARTSM00409. IG. 2 hits.
SM00408. IGc2. 10 hits.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi285313.
NextBio95425.
PROQ6WRI0.

Entry information

Entry nameIGS10_HUMAN
AccessionPrimary (citable) accession number: Q6WRI0
Secondary accession number(s): Q86YJ9, Q8N772, Q8NA84
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: March 19, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM