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Protein

Immunoglobulin superfamily member 10

Gene

Igsf10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the maintenance of osteochondroprogenitor cells pool.1 Publication

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • ossification Source: MGI
  • tissue regeneration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 10
Short name:
IgSF10
Alternative name(s):
Calvaria mechanical force protein 608
Short name:
CMF608
Gene namesi
Name:Igsf10
Synonyms:Cmf608
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735030. Igsf10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 25972569Immunoglobulin superfamily member 10PRO_0000286819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi497 ↔ 551PROSITE-ProRule annotation
Disulfide bondi595 ↔ 645PROSITE-ProRule annotation
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence analysis
Glycosylationi685 – 6851N-linked (GlcNAc...)Sequence analysis
Glycosylationi1049 – 10491N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1644 ↔ 1697PROSITE-ProRule annotation
Glycosylationi1679 – 16791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1741 ↔ 1794PROSITE-ProRule annotation
Glycosylationi1783 – 17831N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1838 ↔ 1891PROSITE-ProRule annotation
Glycosylationi1873 – 18731N-linked (GlcNAc...)Sequence analysis
Glycosylationi1936 – 19361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1937 ↔ 1990PROSITE-ProRule annotation
Disulfide bondi2034 ↔ 2093PROSITE-ProRule annotation
Glycosylationi2075 – 20751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2137 ↔ 2187PROSITE-ProRule annotation
Disulfide bondi2235 ↔ 2287PROSITE-ProRule annotation
Glycosylationi2269 – 22691N-linked (GlcNAc...)Sequence analysis
Glycosylationi2332 – 23321N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2333 ↔ 2385PROSITE-ProRule annotation
Glycosylationi2367 – 23671N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2428 ↔ 2480PROSITE-ProRule annotation
Disulfide bondi2524 ↔ 2579PROSITE-ProRule annotation
Modified residuei2577 – 25771PhosphotyrosineCombined sources

Post-translational modificationi

N-terminally cleaved to produce a form of around 663 residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6WRH9.
PRIDEiQ6WRH9.

PTM databases

iPTMnetiQ6WRH9.
PhosphoSiteiQ6WRH9.

Expressioni

Tissue specificityi

Bone-specific, main expression is present in mesenchymal osteochondroprogenitors with fibroblast-like morphology abundant in the regions of active bone modeling and remodeling.1 Publication

Inductioni

By estrogen and blood loss.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018629.

Structurei

3D structure databases

ProteinModelPortaliQ6WRH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 5628LRRNTAdd
BLAST
Repeati58 – 7922LRR 1Add
BLAST
Repeati82 – 10322LRR 2Add
BLAST
Repeati106 – 12722LRR 3Add
BLAST
Repeati130 – 15122LRR 4Add
BLAST
Repeati154 – 17522LRR 5Add
BLAST
Repeati186 – 20722LRR 6Add
BLAST
Domaini219 – 28163LRRCTAdd
BLAST
Domaini461 – 567107Ig-like C2-type 1Add
BLAST
Domaini571 – 66191Ig-like C2-type 2Add
BLAST
Domaini1622 – 171392Ig-like C2-type 3Add
BLAST
Domaini1718 – 181093Ig-like C2-type 4Add
BLAST
Domaini1815 – 190793Ig-like C2-type 5Add
BLAST
Domaini1915 – 200894Ig-like C2-type 6Add
BLAST
Domaini2011 – 210999Ig-like C2-type 7Add
BLAST
Domaini2115 – 220389Ig-like C2-type 8Add
BLAST
Domaini2208 – 230598Ig-like C2-type 9Add
BLAST
Domaini2311 – 240191Ig-like C2-type 10Add
BLAST
Domaini2406 – 249287Ig-like C2-type 11Add
BLAST
Domaini2502 – 259796Ig-like C2-type 12Add
BLAST

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
ENOG4111N04. LUCA.
HOGENOMiHOG000113014.
HOVERGENiHBG107995.
InParanoidiQ6WRH9.
PhylomeDBiQ6WRH9.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 8 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 12 hits.
SM00408. IGc2. 12 hits.
SM00406. IGv. 5 hits.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6WRH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVRGREVSG LLISLTAVCL VVTPGSRACP RRCACYVPTE VHCTFRYLTS
60 70 80 90 100
IPDGIPANVE RINLGYNSLT RLTENDFDGL SKLELLMLHS NGIHRVSDKT
110 120 130 140 150
FSGLQSLQVL KMSYNKVQII RKDTFYGLGS LVRLHLDHNN IEFINPEAFY
160 170 180 190 200
GLTSLRLVHL EGNRLTKLHP DTFVSLSYLQ IFKTSFIKYL FLSDNFLTSL
210 220 230 240 250
PKEMVSYMPN LESLYLHGNP WTCDCHLKWL SEWMQGNPDI IKCKKDRSSS
260 270 280 290 300
SPQQCPLCMN PRISKGRPFA MVPSGAFLCT KPTIDPSLKS KSLVTQEDNG
310 320 330 340 350
SASTSPQDFI EPFGSLSLNM TDLSGNKADM VCSIQKPSRT SPTAFTEEND
360 370 380 390 400
YIMLNASFST NLVCSVDYNH IQPVWQLLAL YSDSPLILER KPQLTETPSL
410 420 430 440 450
SSRYKQVALR PEDIFTSIEA DVRADPFWFQ QEKIVLQLNR TATTLSTLQI
460 470 480 490 500
QFSTDAQIAL PRAEMRAERL KWTMILMMNN PKLERTVLVG GTIALSCPGK
510 520 530 540 550
GDPSPHLEWL LADGSKVRAP YVSEDGRILI DKNGKLELQM ADSFDAGLYH
560 570 580 590 600
CISTNDADAD VLTYRITVVE PYGESTHDSG VQHTVVTGET LDLPCLSTGV
610 620 630 640 650
PDASISWILP GNTVFSQPSR DRQILNNGTL RILQVTPKDQ GHYQCVAANP
660 670 680 690 700
SGADFSSFKV SVQKKGQRMV EHDREAGGSG LGEPNSSVSL KQPASLKLSA
710 720 730 740 750
SALTGSEAGK QVSGVHRKNK HRDLIHRRRG DSTLRRFREH RRQLPLSARR
760 770 780 790 800
IDPQRWAALL EKAKKNSVPK KQENTTVKPV PLAVPLVELT DEEKDASGMI
810 820 830 840 850
PPDEEFMVLK TKASGVPGRS PTADSGPVNH GFMTSIASGT EVSTVNPQTL
860 870 880 890 900
QSEHLPDFKL FSVTNGTAVT KSMNPSIASK IEDTTNQNPI IIFPSVAEIR
910 920 930 940 950
DSAQAGRASS QSAHPVTGGN MATYGHTNTY SSFTSKASTV LQPINPTESY
960 970 980 990 1000
GPQIPITGVS RPSSSDISSH TTADPSFSSH PSGSHTTASS LFHIPRNNNT
1010 1020 1030 1040 1050
GNFPLSRHLG RERTIWSRGR VKNPHRTPVL RRHRHRTVRP AIKGPANKNV
1060 1070 1080 1090 1100
SQVPATEYPG MCHTCPSAEG LTVATAALSV PSSSHSALPK TNNVGVIAEE
1110 1120 1130 1140 1150
STTVVKKPLL LFKDKQNVDI EIITTTTKYS GGESNHVIPT EASMTSAPTS
1160 1170 1180 1190 1200
VSLGKSPVDN SGHLSMPGTI QTGKDSVETT PLPSPLSTPS IPTSTKFSKR
1210 1220 1230 1240 1250
KTPLHQIFVN NQKKEGMLKN PYQFGLQKNP AAKLPKIAPL LPTGQSSPSD
1260 1270 1280 1290 1300
STTLLTSPPP ALSTTMAATQ NKGTEVVSGA RSLSAGKKQP FTNSSPVLPS
1310 1320 1330 1340 1350
TISKRSNTLN FLSTETPTVT SPTATASVIM SETQRTRSKE AKDQIKGPRK
1360 1370 1380 1390 1400
NRNNANTTPR QVSGYSAYSA LTTADTPLAF SHSPRQDDGG NVSAVAYHST
1410 1420 1430 1440 1450
TSLLAITELF EKYTQTLGNT TALETTLLSK SQESTTVKRA SDTPPPLLSS
1460 1470 1480 1490 1500
GAPPVPTPSP PPFTKGVVTD SKVTSAFQMT SNRVVTIYES SRHNTDLQQP
1510 1520 1530 1540 1550
SAEASPNPEI ITGTTDSPSN LFPSTSVPAL RVDKPQNSKW KPSPWPEHKY
1560 1570 1580 1590 1600
QLKSYSETIE KGKRPAVSMS PHLSLPEAST HASHWNTQKH AEKSVFDKKP
1610 1620 1630 1640 1650
GQNPTSKHLP YVSLPKTLLK KPRIIGGKAA SFTVPANSDV FLPCEAVGDP
1660 1670 1680 1690 1700
LPIIHWTRVS SGLEISQGTQ KSRFHVLPNG TLSIQRVSIQ DRGQYLCSAF
1710 1720 1730 1740 1750
NPLGVDHFHV SLSVVFYPAR ILDRHVKEIT VHFGSTVELK CRVEGMPRPT
1760 1770 1780 1790 1800
VSWILANQTV VSETAKGSRK VWVTPDGTLI IYNLSLYDRG FYKCVASNPS
1810 1820 1830 1840 1850
GQDSLLVKIQ VITAPPVIIE QKRQAIVGVL GGSLKLPCTA KGTPQPSVHW
1860 1870 1880 1890 1900
VLYDGTELKP LQLTHSRFFL YPNGTLYIRS IAPSVRGTYE CIATSSSGSE
1910 1920 1930 1940 1950
RRVVILTVEE GETIPRIETA SQKWTEVNLG EKLLLNCSAT GDPKPRIIWR
1960 1970 1980 1990 2000
LPSKAVIDQW HRMGSRIHVY PNGSLVVGSV TEKDAGDYLC VARNKMGDDL
2010 2020 2030 2040 2050
VLMHVRLRLT PAKIEQKQYF KKQVLHGKDF QVDCKASGSP VPEVSWSLPD
2060 2070 2080 2090 2100
GTVLNNVAQA DDSGYRTKRY TLFHNGTLYF NNVGMAEEGD YICSAQNTLG
2110 2120 2130 2140 2150
KDEMKVHLTV LTAIPRIRQS YKTTMRLRAG ETAVLDCEVT GEPKPNVFWL
2160 2170 2180 2190 2200
LPSNNVISFS NDRFTFHANR TLSIHKVKPL DSGDYVCVAQ NPSGDDTKTY
2210 2220 2230 2240 2250
KLDIVSKPPL INGLYANKTV IKATAIRHSK KYFDCRADGI PSSQVTWIMP
2260 2270 2280 2290 2300
GNIFLPAPYF GSRVTVHPNG TLEMRNIRLS DSADFTCVVR SEGGESVLVV
2310 2320 2330 2340 2350
QLEVLEMLRR PTFRNPFNEK VIAQAGKPVA LNCSVDGNPP PEITWILPDG
2360 2370 2380 2390 2400
TQFANRPHNS PYLMAGNGSL ILYKATRNKS GKYRCAARNK VGYIEKLILL
2410 2420 2430 2440 2450
EIGQKPVILT YEPGMVKSVS GEPLSLHCVS DGIPKPNVKW TTPGGHVIDR
2460 2470 2480 2490 2500
PQVDGKYILH ENGTLVIKAT TAHDQGNYIC RAQNSVGQAV ISVSVMVVAY
2510 2520 2530 2540 2550
PPRIINYLPR NMLRRTGEAM QLHCVALGIP KPKVTWETPR HSLLSKATAR
2560 2570 2580 2590
KPHRSEMLHP QGTLVIQNLQ TSDSGVYKCR AQNLLGTDYA TTYIQVL
Length:2,597
Mass (Da):284,743
Last modified:July 5, 2004 - v1
Checksum:iC6A284BBFCE2C5D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273816 mRNA. Translation: AAQ16157.1.
RefSeqiNP_942063.1. NM_198768.2.
UniGeneiRn.205647.

Genome annotation databases

GeneIDi310448.
KEGGirno:310448.
UCSCiRGD:735030. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273816 mRNA. Translation: AAQ16157.1.
RefSeqiNP_942063.1. NM_198768.2.
UniGeneiRn.205647.

3D structure databases

ProteinModelPortaliQ6WRH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018629.

PTM databases

iPTMnetiQ6WRH9.
PhosphoSiteiQ6WRH9.

Proteomic databases

PaxDbiQ6WRH9.
PRIDEiQ6WRH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi310448.
KEGGirno:310448.
UCSCiRGD:735030. rat.

Organism-specific databases

CTDi285313.
RGDi735030. Igsf10.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
ENOG4111N04. LUCA.
HOGENOMiHOG000113014.
HOVERGENiHBG107995.
InParanoidiQ6WRH9.
PhylomeDBiQ6WRH9.

Miscellaneous databases

PROiQ6WRH9.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 8 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 12 hits.
SM00408. IGc2. 12 hits.
SM00406. IGv. 5 hits.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "CMF608 -- a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells."
    Segev O., Samach A., Faerman A., Kalinski H., Beiman M., Gelfand A., Turam H., Boguslavsky S., Moshayov A., Gottlieb H., Kazanov E., Nevo Z., Robinson D., Skaliter R., Einat P., Binderman I., Feinstein E.
    Bone 34:246-260(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Strain: Sprague-Dawley.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2577, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIGS10_RAT
AccessioniPrimary (citable) accession number: Q6WRH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.