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Protein

Putative cancer susceptibility gene HEPN1 protein

Gene

HEPN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cancer susceptibility gene HEPN1 protein
Gene namesi
Name:HEPN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:34400. HEPN1.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390850.

Polymorphism and mutation databases

BioMutaiHEPN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Putative cancer susceptibility gene HEPN1 proteinPRO_0000317106Add
BLAST

Proteomic databases

PaxDbiQ6WQI6.
PRIDEiQ6WQI6.

Expressioni

Tissue specificityi

Expressed in liver. Expression is either down-regulated or lost in hepatocellular carcinomas (HCC).1 Publication

Gene expression databases

BgeeiQ6WQI6.
CleanExiHS_HEPN1.

Organism-specific databases

HPAiHPA063054.

Structurei

3D structure databases

ProteinModelPortaliQ6WQI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IUU6. Eukaryota.
ENOG4110PUM. LUCA.
GeneTreeiENSGT00510000055197.
HOGENOMiHOG000112888.
InParanoidiQ6WQI6.
OMAiWHGHVLA.
OrthoDBiEOG7034KJ.
PhylomeDBiQ6WQI6.

Sequencei

Sequence statusi: Complete.

Q6WQI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNWGLGIAP WVDGESELEF RRLGMQGPLE ALRRREWNTQ RASFSFSFLI
60 70 80
ALSPHTVDYC HSYELFNRRW HGHVLATQRP SLFILMLV
Length:88
Mass (Da):10,305
Last modified:February 5, 2008 - v2
Checksum:i86B4FBE3F21C6EE0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371W → R.1 Publication
Corresponds to variant rs3802904 [ dbSNP | Ensembl ].
VAR_051027

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275431 mRNA. Translation: AAQ19120.1.
BC037810 mRNA. No translation available.
CCDSiCCDS41729.1.
RefSeqiNP_001032647.2. NM_001037558.2.
UniGeneiHs.159863.

Genome annotation databases

EnsembliENST00000408930; ENSP00000386143; ENSG00000221932.
GeneIDi641654.
KEGGihsa:641654.
UCSCiuc001qbj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275431 mRNA. Translation: AAQ19120.1.
BC037810 mRNA. No translation available.
CCDSiCCDS41729.1.
RefSeqiNP_001032647.2. NM_001037558.2.
UniGeneiHs.159863.

3D structure databases

ProteinModelPortaliQ6WQI6.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiHEPN1.

Proteomic databases

PaxDbiQ6WQI6.
PRIDEiQ6WQI6.

Protocols and materials databases

DNASUi641654.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408930; ENSP00000386143; ENSG00000221932.
GeneIDi641654.
KEGGihsa:641654.
UCSCiuc001qbj.2. human.

Organism-specific databases

CTDi641654.
GeneCardsiHEPN1.
HGNCiHGNC:34400. HEPN1.
HPAiHPA063054.
MIMi611641. gene.
neXtProtiNX_Q6WQI6.
PharmGKBiPA162390850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUU6. Eukaryota.
ENOG4110PUM. LUCA.
GeneTreeiENSGT00510000055197.
HOGENOMiHOG000112888.
InParanoidiQ6WQI6.
OMAiWHGHVLA.
OrthoDBiEOG7034KJ.
PhylomeDBiQ6WQI6.

Miscellaneous databases

GenomeRNAii641654.
SOURCEiSearch...

Gene expression databases

BgeeiQ6WQI6.
CleanExiHS_HEPN1.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells."
    Moh M.C., Lee L.H., Yang X., Shen S.
    J. Hepatol. 39:580-586(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ARG-37.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hypothalamus.

Entry informationi

Entry nameiHEPN1_HUMAN
AccessioniPrimary (citable) accession number: Q6WQI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 8, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Product of a dubious CDS prediction. Encoded by the 3'-UTR of HEPACAM.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.