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Protein

Rab11 family-interacting protein 1

Gene

RAB11FIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 1
Short name:
Rab11-FIP1
Alternative name(s):
Rab-coupling protein
Gene namesi
Name:RAB11FIP1
Synonyms:RCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30265. RAB11FIP1.

Subcellular locationi

Isoform 2 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1254Y → F: Does not abolish the interaction with RAB11A, homooligomerization and subcellular location. Reduces the interaction with RAB4A. 1 Publication1
Mutagenesisi1255I → E: Abolishes the interaction with RAB11A and RAB4A, homooligomerization and subcellular location. 1 Publication1
Mutagenesisi1256D → N: Does not abolish the interaction with RAB11A, homooligomerization and subcellular location. Reduces the interaction with RAB4A. 1 Publication1

Organism-specific databases

DisGeNETi80223.
OpenTargetsiENSG00000156675.
PharmGKBiPA134937501.

Polymorphism and mutation databases

BioMutaiRAB11FIP1.
DMDMi519668675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973041 – 1283Rab11 family-interacting protein 1Add BLAST1283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei382PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Modified residuei1135PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6WKZ4.
PaxDbiQ6WKZ4.
PeptideAtlasiQ6WKZ4.
PRIDEiQ6WKZ4.

PTM databases

iPTMnetiQ6WKZ4.
PhosphoSitePlusiQ6WKZ4.

Expressioni

Tissue specificityi

Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000156675.
CleanExiHS_RAB11FIP1.
ExpressionAtlasiQ6WKZ4. baseline and differential.
GenevisibleiQ6WKZ4. HS.

Organism-specific databases

HPAiCAB017037.
HPA023904.
HPA024010.
HPA025960.

Interactioni

Subunit structurei

Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123189. 27 interactors.
IntActiQ6WKZ4. 16 interactors.
STRINGi9606.ENSP00000331342.

Structurei

Secondary structure

11283
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1233 – 1265Combined sources33
Helixi1267 – 1270Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0GX-ray2.50C1216-1283[»]
ProteinModelPortaliQ6WKZ4.
SMRiQ6WKZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 108C2PROSITE-ProRule annotationAdd BLAST104
Domaini1211 – 1273FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1219 – 1283Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recyclingAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi209 – 218Poly-Lys10
Compositional biasi556 – 609Ser-richAdd BLAST54

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 FIP-RBD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGQZ. Eukaryota.
ENOG410Z6B0. LUCA.
GeneTreeiENSGT00530000063203.
HOGENOMiHOG000234700.
InParanoidiQ6WKZ4.
KOiK12484.
OMAiGTGSAKH.
OrthoDBiEOG091G09IV.
PhylomeDBiQ6WKZ4.
TreeFamiTF326172.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR019018. Rab-bd_FIP-RBD.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF09457. RBD-FIP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51511. FIP_RBD. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6WKZ4-4) [UniParc]FASTAAdd to basket
Also known as: Rab11-FIP 1B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLMVSAGRG LGAVWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE
60 70 80 90 100
KYATSVSERS LGAPVWREEA TFELPSLLSS GPAAAATLQL TVLHRALLGL
110 120 130 140 150
DKFLGRAEVD LRDLHRDQGR RKTQWYKLKS KPGKKDKERG EIEVDIQFMR
160 170 180 190 200
NNMTASMFDL SMKDKSRNPF GKLKDKIKGK NKDSGSDTAS AIIPSTTPSV
210 220 230 240 250
DSDDESVVKD KKKKSKIKTL LSKSNLQKTP LSQSMSVLPT SKPEKVLLRP
260 270 280 290 300
GDFQSQWDED DNEDESSSAS DVMSHKRTAS TDLKQLNQVN FTLPKKEGLS
310 320 330 340 350
FLGGLRSKND VLSRSNVCIN GNHVYLEQPE AKGEIKDSSP SSSPSPKGFR
360 370 380 390 400
KKHLFSSTEN LAAGSWKEPA EGGGLSSDRQ LSESSTKDSL KSMTLPSYRP
410 420 430 440 450
APLVSGDLRE NMAPANSEAT KEAKESKKPE SRRSSLLSLM TGKKDVAKGS
460 470 480 490 500
EGENPLTVPG REKEGMLMGV KPGEDASGPA EDLVRRSEKD TAAVVSRQGS
510 520 530 540 550
SLNLFEDVQI TEPEAEPESK SEPRPPISSP RAPQTRAVKP RLEVSPEAQP
560 570 580 590 600
TARLPSPTDS PSSLPPLPSS SGQASVPSEL GHGADTQSSE SPSVFSSLSS
610 620 630 640 650
PIAAPISTST PIESWPLVDR GQAKSEGPPL LPKAELQTES LTPVPNSGSS
660 670 680 690 700
ALGSLFKQPS FPANKGTEDS LMGRTRETGT EKNTSSLELE ESLPEQPETG
710 720 730 740 750
RQEEELPRFP CKKQDYSPSS GEAQEVPFAL SLSSDGAVSP VGELAAGGDR
760 770 780 790 800
DLESQAGSLV ESKARDAAEE VAPPLPMGAS VPSIDSMMRK LEEMGLNLRK
810 820 830 840 850
DQKKTKKRVS FSEQLFTEEA VAGAALLVEG HSSCPQELNP AWSVAGNASD
860 870 880 890 900
GEPPESPHAE DSERESVTTP GPATCGAPAS PADHLLLPSQ EESFSEVPMS
910 920 930 940 950
EASSAKDTPL FRMEGEDALV TQYQSKASDH EGLLSDPLSD LQLVSDFKSP
960 970 980 990 1000
IMADLNLSLP SIPEVASDDE RIDQVEDDGD QVEDDGETAK SSTLDIGALS
1010 1020 1030 1040 1050
LGLVVPCPER GKGPSGEADR LVLGEGLCDF RLQAPQASVT APSEQTTEFG
1060 1070 1080 1090 1100
IHKPHLGKSS SLDKQLPGPS GGEEEKPMGN GSPSPPPGTS LDNPVPSPSP
1110 1120 1130 1140 1150
SEIFPVTHSF PSSAHSDTHH TSTAESQKKA TAEGSAGRVE NFGKRKPLLQ
1160 1170 1180 1190 1200
AWVSPSETHP VSAQPGAGTG SAKHRLHPVK PMNAMATKVA NCSLGTATII
1210 1220 1230 1240 1250
SENLNNEVMM KKYSPSDPAF AYAQLTHDEL IQLVLKQKET ISKKEFQVRE
1260 1270 1280
LEDYIDNLLV RVMEETPNIL RIPTQVGKKA GKM
Length:1,283
Mass (Da):137,167
Last modified:June 26, 2013 - v3
Checksum:i19DF0C848435780B
GO
Isoform 2 (identifier: Q6WKZ4-3) [UniParc]FASTAAdd to basket
Also known as: Rab11-FIP 1C

The sequence of this isoform differs from the canonical sequence as follows:
     541-1174: Missing.

Show »
Length:649
Mass (Da):70,983
Checksum:iC291028B31112E01
GO
Isoform 3 (identifier: Q6WKZ4-1) [UniParc]FASTAAdd to basket
Also known as: Rab11-FIP 1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-671: Missing.

Show »
Length:612
Mass (Da):65,217
Checksum:i310263344F395FD4
GO
Isoform 4 (identifier: Q6WKZ4-2) [UniParc]FASTAAdd to basket
Also known as: Rab11-FIP 1H, No Rab11-binding protein 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     541-1174: Missing.
     1212-1221: KYSPSDPAFA → VCPLRSWCVR
     1222-1283: Missing.

Show »
Length:439
Mass (Da):47,704
Checksum:i9A54EC6C78C3C3F3
GO
Isoform 5 (identifier: Q6WKZ4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-142: RDQGRRKTQWYKLKSKPGKKDKERGEI → SSLGKSFFKTLKKRAWAIFLRLCLKKN
     143-1283: Missing.

Show »
Length:142
Mass (Da):15,304
Checksum:i6C070166F8160FDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330 – 332EAK → QPT in AAM09571 (PubMed:11786538).Curated3
Sequence conflicti353H → T in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti377S → T in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti380 – 381QL → DV in AAM09571 (PubMed:11786538).Curated2
Sequence conflicti397S → T in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti404V → I in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti411N → K in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti455P → L in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti482D → G in AAQ18788 (PubMed:16920206).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069365622Q → K.2 PublicationsCorresponds to variant rs7341564dbSNPEnsembl.1
Natural variantiVAR_059714651A → V.1 PublicationCorresponds to variant rs12541651dbSNPEnsembl.1
Natural variantiVAR_056977768A → V.Corresponds to variant rs16887092dbSNPEnsembl.1
Natural variantiVAR_0224471185M → T.3 PublicationsCorresponds to variant rs7817179dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0137261 – 671Missing in isoform 3. 2 PublicationsAdd BLAST671
Alternative sequenceiVSP_0137271 – 148Missing in isoform 4. 1 PublicationAdd BLAST148
Alternative sequenceiVSP_013728116 – 142RDQGR…ERGEI → SSLGKSFFKTLKKRAWAIFL RLCLKKN in isoform 5. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_013729143 – 1283Missing in isoform 5. 1 PublicationAdd BLAST1141
Alternative sequenceiVSP_013730541 – 1174Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST634
Alternative sequenceiVSP_0137311212 – 1221KYSPSDPAFA → VCPLRSWCVR in isoform 4. 1 Publication10
Alternative sequenceiVSP_0137321222 – 1283Missing in isoform 4. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368294 mRNA. Translation: AAM09571.1.
DQ236342 mRNA. Translation: ABB43161.1.
AY280966 mRNA. Translation: AAQ18784.1.
AY280968 mRNA. Translation: AAQ18786.1.
AY280970 mRNA. Translation: AAQ18788.1.
AK026275 mRNA. Translation: BAB15424.1.
AK122583 mRNA. Translation: BAC56924.1.
AK291781 mRNA. Translation: BAF84470.1.
AC130304 Genomic DNA. No translation available.
BC077720 mRNA. Translation: AAH77720.1.
CCDSiCCDS34881.1. [Q6WKZ4-3]
CCDS34882.1. [Q6WKZ4-4]
RefSeqiNP_001002814.2. NM_001002814.2. [Q6WKZ4-4]
NP_079427.4. NM_025151.4. [Q6WKZ4-3]
UniGeneiHs.191179.

Genome annotation databases

EnsembliENST00000287263; ENSP00000287263; ENSG00000156675. [Q6WKZ4-3]
ENST00000330843; ENSP00000331342; ENSG00000156675. [Q6WKZ4-4]
ENST00000524118; ENSP00000430680; ENSG00000156675. [Q6WKZ4-2]
GeneIDi80223.
KEGGihsa:80223.
UCSCiuc003xkm.3. human. [Q6WKZ4-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368294 mRNA. Translation: AAM09571.1.
DQ236342 mRNA. Translation: ABB43161.1.
AY280966 mRNA. Translation: AAQ18784.1.
AY280968 mRNA. Translation: AAQ18786.1.
AY280970 mRNA. Translation: AAQ18788.1.
AK026275 mRNA. Translation: BAB15424.1.
AK122583 mRNA. Translation: BAC56924.1.
AK291781 mRNA. Translation: BAF84470.1.
AC130304 Genomic DNA. No translation available.
BC077720 mRNA. Translation: AAH77720.1.
CCDSiCCDS34881.1. [Q6WKZ4-3]
CCDS34882.1. [Q6WKZ4-4]
RefSeqiNP_001002814.2. NM_001002814.2. [Q6WKZ4-4]
NP_079427.4. NM_025151.4. [Q6WKZ4-3]
UniGeneiHs.191179.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0GX-ray2.50C1216-1283[»]
ProteinModelPortaliQ6WKZ4.
SMRiQ6WKZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123189. 27 interactors.
IntActiQ6WKZ4. 16 interactors.
STRINGi9606.ENSP00000331342.

PTM databases

iPTMnetiQ6WKZ4.
PhosphoSitePlusiQ6WKZ4.

Polymorphism and mutation databases

BioMutaiRAB11FIP1.
DMDMi519668675.

Proteomic databases

EPDiQ6WKZ4.
PaxDbiQ6WKZ4.
PeptideAtlasiQ6WKZ4.
PRIDEiQ6WKZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287263; ENSP00000287263; ENSG00000156675. [Q6WKZ4-3]
ENST00000330843; ENSP00000331342; ENSG00000156675. [Q6WKZ4-4]
ENST00000524118; ENSP00000430680; ENSG00000156675. [Q6WKZ4-2]
GeneIDi80223.
KEGGihsa:80223.
UCSCiuc003xkm.3. human. [Q6WKZ4-4]

Organism-specific databases

CTDi80223.
DisGeNETi80223.
GeneCardsiRAB11FIP1.
HGNCiHGNC:30265. RAB11FIP1.
HPAiCAB017037.
HPA023904.
HPA024010.
HPA025960.
MIMi608737. gene.
neXtProtiNX_Q6WKZ4.
OpenTargetsiENSG00000156675.
PharmGKBiPA134937501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQZ. Eukaryota.
ENOG410Z6B0. LUCA.
GeneTreeiENSGT00530000063203.
HOGENOMiHOG000234700.
InParanoidiQ6WKZ4.
KOiK12484.
OMAiGTGSAKH.
OrthoDBiEOG091G09IV.
PhylomeDBiQ6WKZ4.
TreeFamiTF326172.

Miscellaneous databases

ChiTaRSiRAB11FIP1. human.
GeneWikiiRAB11FIP1.
GenomeRNAii80223.
PROiQ6WKZ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156675.
CleanExiHS_RAB11FIP1.
ExpressionAtlasiQ6WKZ4. baseline and differential.
GenevisibleiQ6WKZ4. HS.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR019018. Rab-bd_FIP-RBD.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF09457. RBD-FIP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51511. FIP_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFIP1_HUMAN
AccessioniPrimary (citable) accession number: Q6WKZ4
Secondary accession number(s): J3KNP0
, Q307T1, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 26, 2013
Last modified: November 2, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.