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Protein

Gap junction beta-1 protein

Gene

GJB1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-1 protein
Alternative name(s):
Connexin-32
Short name:
Cx32
Gene namesi
Name:GJB1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Topological domaini96 – 130CytoplasmicSequence analysisAdd BLAST35
Transmembranei131 – 153HelicalSequence analysisAdd BLAST23
Topological domaini154 – 191ExtracellularSequence analysisAdd BLAST38
Transmembranei192 – 214HelicalSequence analysisAdd BLAST23
Topological domaini215 – 283CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578481 – 283Gap junction beta-1 proteinAdd BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei266PhosphoserineBy similarity1
Modified residuei277PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6WGK6.
PRIDEiQ6WGK6.

Expressioni

Gene expression databases

BgeeiENSECAG00000002107.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000001510.

Structurei

3D structure databases

SMRiQ6WGK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8. Eukaryota.
ENOG410Y7VN. LUCA.
GeneTreeiENSGT00900000140773.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ6WGK6.
KOiK07620.
OMAiYLVVRAC.
OrthoDBiEOG091G0FKH.
TreeFamiTF329606.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR002267. Connexin32.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01138. CONNEXINB1.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6WGK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWTGLYTLL SGVNRHSTAI GRVWLSVIFI FRIMVLVVAA ESVWGDEKSS
60 70 80 90 100
FICNTLQPGC NSVCYDHFFP ISHVRLWSLQ LILVSTPALL VAMHVAHQQH
110 120 130 140 150
IEKKMLRLEG HGDPIHLEEV KRHKVHISGT LWWTYVISVV FRLLFEAAFM
160 170 180 190 200
YVFYLLYPGY AMVRLVKCDA YPCPNTVDCF VSRPTEKTVF TVFMLAASGI
210 220 230 240 250
CIILNVAEVV YLIVRACARR AQRRSNPPSR KGSGFGHRLS PEYKQNEINK
260 270 280
LLSEQDGSLK DILRRSPGTG AGLAEKSDRC SAC
Length:283
Mass (Da):31,963
Last modified:July 5, 2004 - v1
Checksum:i2E6ED9FE307ADF42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286490 mRNA. Translation: AAQ20110.1.
RefSeqiNP_001075360.1. NM_001081891.1.
XP_005614276.1. XM_005614219.2.
XP_005614278.1. XM_005614221.2.
XP_014584421.1. XM_014728935.1.
UniGeneiEca.12778.

Genome annotation databases

EnsembliENSECAT00000002133; ENSECAP00000001510; ENSECAG00000002107.
GeneIDi100034021.
KEGGiecb:100034021.

Similar proteinsi

Entry informationi

Entry nameiCXB1_HORSE
AccessioniPrimary (citable) accession number: Q6WGK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families