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Protein

Interleukin-4 receptor subunit alpha

Gene

IL4R

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4 receptor subunit alpha
Short name:
IL-4 receptor subunit alpha
Short name:
IL-4R subunit alpha
Short name:
IL-4R-alpha
Short name:
IL-4RA
Alternative name(s):
CD_antigen: CD124
Gene namesi
Name:IL4R
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 231ExtracellularSequence analysisAdd BLAST206
Transmembranei232 – 255HelicalSequence analysisAdd BLAST24
Topological domaini256 – 809CytoplasmicSequence analysisAdd BLAST554

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001088626 – 809Interleukin-4 receptor subunit alphaAdd BLAST784

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 44By similarity
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi74 ↔ 86By similarity
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Modified residuei163PhosphoserineBy similarity1
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Modified residuei488PhosphotyrosineBy similarity1

Post-translational modificationi

On IL4 binding, phosphorylated on tyrosine residues in the cytoplasmic domain.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6WG24.
PRIDEiQ6WG24.

Interactioni

Subunit structurei

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity).By similarity

Protein-protein interaction databases

STRINGi9796.ENSECAP00000019165.

Structurei

3D structure databases

ProteinModelPortaliQ6WG24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 222Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi211 – 215WSXWS motif5
Motifi261 – 269Box 1 motif9
Motifi695 – 700ITIM motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 377Poly-Glu9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGBQ. Eukaryota.
ENOG41124QC. LUCA.
HOGENOMiHOG000090263.
HOVERGENiHBG052116.
InParanoidiQ6WG24.
KOiK05071.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015319. IL-4_rcpt-alpha_N.
[Graphical view]
PfamiPF09238. IL4Ra_N. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6WG24-1) [UniParc]FASTAAdd to basket
Also known as: Membrane form

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCLCPGLTL PVSCLILVWA AGSGSVKVLR LTACFSDYIS ASTCEWKMDR
60 70 80 90 100
PTNCSAQLRL SYQLNDEFSD NLTCIPENRE DEVCVCRMLM DNIVSEDVYE
110 120 130 140 150
LDLWAGNQLL WNSSFKPSRH VKPRAPQNLT VHAISHTWLL TWSNPYPLKN
160 170 180 190 200
HLWSELTYLV NISKEDDPTD FKIYNVTYMD PTLRVTASTL KSRATYSARV
210 220 230 240 250
KARAQNYNST WSEWSPSTTW HNYYEQPLEQ RLPLGVSISC VVILAICLSC
260 270 280 290 300
YFSIIKIKKE WWDQIPNPAH SPLVAIVLQD SQVSLWGKQS RGQEPAKCPR
310 320 330 340 350
WKTCLTKLLP CLLEHGLQKE EDSSKTVRNG PFQSPGKSAW HTVEVNHTIL
360 370 380 390 400
RPEIISVVPC VELCEAQVES EEEEVEEDRG SFCPSPESSG SGFQEGREGV
410 420 430 440 450
AARLTESLFL GLLGAENGAL GESCLLPPLG SAHMPWARIS SAGPQEAASQ
460 470 480 490 500
GEEQPLNPES NPLATLTQSP GSLAFTEAPA VVADNPAYRS FSNSLSQPRG
510 520 530 540 550
PGELDSDPQL AEHLGQVDPS IPSAPQPSEP PTALQPEPET WEQMLRQSVL
560 570 580 590 600
QQGAAPAPAS APTGGYREFA QVVKQGGGAA GSGPSGEAGY KAFSSLLAGS
610 620 630 640 650
AVCPGQSGVE ASSGEGGYRP YESPDPGAPA PVPVPLFTFG LDVEPPHSPQ
660 670 680 690 700
NSLLPGGSPE LPGPEPTVKG EDPRKPLLSA QQATDSLRDD LGSGIVYSAL
710 720 730 740 750
TCHLCGHLKQ CHGQEEHGEA HTVASPCCGC CCGDRSSPPV SPVRALDPPP
760 770 780 790 800
GGVPLEAGLS LASLGSLGLS EERKPSLFFQ PAPGNAQSSS QTPLTVAMLS

TGPTCTSAS
Length:809
Mass (Da):86,735
Last modified:July 19, 2004 - v2
Checksum:i55CFBA1358375DA0
GO
Isoform 2 (identifier: Q6WG24-2) [UniParc]FASTAAdd to basket
Also known as: Soluble form

The sequence of this isoform differs from the canonical sequence as follows:
     223-224: YY → SP
     225-809: Missing.

Show »
Length:224
Mass (Da):25,581
Checksum:i36EA10358490A17A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti464A → V.1 Publication1
Natural varianti554A → S.1 Publication1
Natural varianti559A → T.1 Publication1
Natural varianti572V → A.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011114223 – 224YY → SP in isoform 2. 1 Publication2
Alternative sequenceiVSP_011115225 – 809Missing in isoform 2. 1 PublicationAdd BLAST585

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081138 mRNA. Translation: AAL87462.1.
AY289616 mRNA. Translation: AAQ56236.1.
RefSeqiNP_001075243.1. NM_001081774.2. [Q6WG24-1]
UniGeneiEca.21654.
Eca.492.

Genome annotation databases

GeneIDi791252.
KEGGiecb:791252.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081138 mRNA. Translation: AAL87462.1.
AY289616 mRNA. Translation: AAQ56236.1.
RefSeqiNP_001075243.1. NM_001081774.2. [Q6WG24-1]
UniGeneiEca.21654.
Eca.492.

3D structure databases

ProteinModelPortaliQ6WG24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000019165.

Proteomic databases

PaxDbiQ6WG24.
PRIDEiQ6WG24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi791252.
KEGGiecb:791252.

Organism-specific databases

CTDi3566.

Phylogenomic databases

eggNOGiENOG410IGBQ. Eukaryota.
ENOG41124QC. LUCA.
HOGENOMiHOG000090263.
HOVERGENiHBG052116.
InParanoidiQ6WG24.
KOiK05071.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015319. IL-4_rcpt-alpha_N.
[Graphical view]
PfamiPF09238. IL4Ra_N. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL4RA_HORSE
AccessioniPrimary (citable) accession number: Q6WG24
Secondary accession number(s): Q8MIR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.