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Protein

Cell cycle checkpoint control protein RAD9B

Gene

RAD9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-176187. Activation of ATR in response to replication stress.
R-HSA-5685938. HDR through Single Strand Annealing (SSA).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-69473. G2/M DNA damage checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle checkpoint control protein RAD9B
Alternative name(s):
DNA repair exonuclease rad9 homolog B
Short name:
hRAD9B
Gene namesi
Name:RAD9B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:21700. RAD9B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi144715.
OpenTargetsiENSG00000151164.
PharmGKBiPA134889252.

Polymorphism and mutation databases

BioMutaiRAD9B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002266981 – 426Cell cycle checkpoint control protein RAD9BAdd BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei359PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6WBX8.
PeptideAtlasiQ6WBX8.
PRIDEiQ6WBX8.

PTM databases

iPTMnetiQ6WBX8.
PhosphoSitePlusiQ6WBX8.

Expressioni

Tissue specificityi

Expressed in testis and skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000151164.
CleanExiHS_RAD9B.
ExpressionAtlasiQ6WBX8. baseline and differential.
GenevisibleiQ6WBX8. HS.

Organism-specific databases

HPAiHPA040643.

Interactioni

Subunit structurei

Interacts with HUS1, HUS1B, RAD1, RAD9A and RAD17.2 Publications

Protein-protein interaction databases

BioGridi126872. 4 interactors.
STRINGi9606.ENSP00000376440.

Structurei

3D structure databases

ProteinModelPortaliQ6WBX8.
SMRiQ6WBX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rad9 family.Curated

Phylogenomic databases

eggNOGiKOG2810. Eukaryota.
ENOG410XYYN. LUCA.
GeneTreeiENSGT00390000005767.
HOGENOMiHOG000059650.
HOVERGENiHBG058989.
InParanoidiQ6WBX8.
KOiK10995.
PhylomeDBiQ6WBX8.

Family and domain databases

InterProiIPR026584. Rad9.
IPR007268. Rad9/Ddc1.
[Graphical view]
PANTHERiPTHR15237. PTHR15237. 1 hit.
PfamiPF04139. Rad9. 1 hit.
[Graphical view]
PIRSFiPIRSF009303. Cell_cycle_RAD9. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 5 (identifier: Q6WBX8-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKCVMSGSQ VKVFGKAVQA LSRISDEFWL DPSKKGLALR CVNSSRSAYG
60 70 80 90 100
CVLFSPVFFQ HYQWSALVKM SENELDTTLH LKCKLGMKSI LPIFRCLNSL
110 120 130 140 150
ERNIEKCRIF TRSDKCKVVI QFFYRHGIKR THNICFQESQ PLQVIFDKNV
160 170 180 190 200
CTNTLMIQPR LLADAIVLFT SSQEEVTLAV TPLNFCLKSS NEESMDLSNA
210 220 230 240 250
VHSEMFVGSD EFDFFQIGMD TEITFCFKEL KGILTFSEAT HAPISIYFDF
260 270 280 290 300
PGKPLALSID DMLVEANFIL ATLADEQSRA SSPQSLCLSQ KRKRSDLIEK
310 320 330 340 350
KAGKNVTGQA LECISKKAAP RRLYPKETLT NISALENCGS PAMKRVDGDV
360 370 380 390 400
SEVSESSVSN TEEVPGSLCL RKFSCMFFGA VSSDQQEHFN HPFDSLARAS
410 420
DSEEDMNNVC CRKEFNGSDA KYFCII
Note: No experimental confirmation available.
Length:426
Mass (Da):47,832
Last modified:November 28, 2006 - v2
Checksum:i876E5F8E8F259A03
GO
Isoform 1 (identifier: Q6WBX8-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     409-426: VCCRKEFNGSDAKYFCII → GSFSIF

Show »
Length:414
Mass (Da):46,392
Checksum:i428278122FCEE61E
GO
Isoform 2 (identifier: Q6WBX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.
     409-426: VCCRKEFNGSDAKYFCII → GSFSIF

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):38,678
Checksum:i5A8F8CD2F4FEA579
GO
Isoform 3 (identifier: Q6WBX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.
     409-426: VCCRKEFNGSDAKYFCII → GSFSIF

Show »
Length:259
Mass (Da):28,518
Checksum:i35242F6E863F52C3
GO
Isoform 4 (identifier: Q6WBX8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,958
Checksum:i6AEDB10323DE4959
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226C → Y in BAC05138 (PubMed:14702039).Curated1
Sequence conflicti401D → G in BAB71704 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0174441 – 155Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST155
Alternative sequenceiVSP_0174451 – 69Missing in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_017446409 – 426VCCRK…YFCII → GSFSIF in isoform 1, isoform 2 and isoform 3. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY297459 mRNA. Translation: AAQ62859.1.
AK058176 mRNA. Translation: BAB71704.1.
AK097665 mRNA. Translation: BAC05138.1.
AK124109 mRNA. Translation: BAC85774.1.
AC002350 Genomic DNA. No translation available.
BC047645 mRNA. Translation: AAH47645.1.
BC068031 mRNA. Translation: AAH68031.2.
CCDSiCCDS73527.1. [Q6WBX8-2]
RefSeqiNP_001273460.1. NM_001286531.1. [Q6WBX8-2]
NP_001273461.1. NM_001286532.1. [Q6WBX8-2]
NP_001273462.1. NM_001286533.1. [Q6WBX8-3]
NP_001273463.1. NM_001286534.1. [Q6WBX8-3]
NP_001273464.1. NM_001286535.1.
NP_001273465.1. NM_001286536.1.
NP_689655.3. NM_152442.3.
XP_011536276.1. XM_011537974.2. [Q6WBX8-2]
XP_016874367.1. XM_017018878.1. [Q6WBX8-2]
XP_016874371.1. XM_017018882.1. [Q6WBX8-3]
UniGeneiHs.97794.

Genome annotation databases

EnsembliENST00000409246; ENSP00000387329; ENSG00000151164. [Q6WBX8-2]
ENST00000409425; ENSP00000386629; ENSG00000151164. [Q6WBX8-2]
GeneIDi144715.
KEGGihsa:144715.
UCSCiuc001tre.6. human. [Q6WBX8-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY297459 mRNA. Translation: AAQ62859.1.
AK058176 mRNA. Translation: BAB71704.1.
AK097665 mRNA. Translation: BAC05138.1.
AK124109 mRNA. Translation: BAC85774.1.
AC002350 Genomic DNA. No translation available.
BC047645 mRNA. Translation: AAH47645.1.
BC068031 mRNA. Translation: AAH68031.2.
CCDSiCCDS73527.1. [Q6WBX8-2]
RefSeqiNP_001273460.1. NM_001286531.1. [Q6WBX8-2]
NP_001273461.1. NM_001286532.1. [Q6WBX8-2]
NP_001273462.1. NM_001286533.1. [Q6WBX8-3]
NP_001273463.1. NM_001286534.1. [Q6WBX8-3]
NP_001273464.1. NM_001286535.1.
NP_001273465.1. NM_001286536.1.
NP_689655.3. NM_152442.3.
XP_011536276.1. XM_011537974.2. [Q6WBX8-2]
XP_016874367.1. XM_017018878.1. [Q6WBX8-2]
XP_016874371.1. XM_017018882.1. [Q6WBX8-3]
UniGeneiHs.97794.

3D structure databases

ProteinModelPortaliQ6WBX8.
SMRiQ6WBX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126872. 4 interactors.
STRINGi9606.ENSP00000376440.

PTM databases

iPTMnetiQ6WBX8.
PhosphoSitePlusiQ6WBX8.

Polymorphism and mutation databases

BioMutaiRAD9B.

Proteomic databases

PaxDbiQ6WBX8.
PeptideAtlasiQ6WBX8.
PRIDEiQ6WBX8.

Protocols and materials databases

DNASUi144715.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409246; ENSP00000387329; ENSG00000151164. [Q6WBX8-2]
ENST00000409425; ENSP00000386629; ENSG00000151164. [Q6WBX8-2]
GeneIDi144715.
KEGGihsa:144715.
UCSCiuc001tre.6. human. [Q6WBX8-5]

Organism-specific databases

CTDi144715.
DisGeNETi144715.
GeneCardsiRAD9B.
HGNCiHGNC:21700. RAD9B.
HPAiHPA040643.
MIMi608368. gene.
neXtProtiNX_Q6WBX8.
OpenTargetsiENSG00000151164.
PharmGKBiPA134889252.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2810. Eukaryota.
ENOG410XYYN. LUCA.
GeneTreeiENSGT00390000005767.
HOGENOMiHOG000059650.
HOVERGENiHBG058989.
InParanoidiQ6WBX8.
KOiK10995.
PhylomeDBiQ6WBX8.

Enzyme and pathway databases

ReactomeiR-HSA-176187. Activation of ATR in response to replication stress.
R-HSA-5685938. HDR through Single Strand Annealing (SSA).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-69473. G2/M DNA damage checkpoint.

Miscellaneous databases

ChiTaRSiRAD9B. human.
GenomeRNAii144715.
PROiQ6WBX8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151164.
CleanExiHS_RAD9B.
ExpressionAtlasiQ6WBX8. baseline and differential.
GenevisibleiQ6WBX8. HS.

Family and domain databases

InterProiIPR026584. Rad9.
IPR007268. Rad9/Ddc1.
[Graphical view]
PANTHERiPTHR15237. PTHR15237. 1 hit.
PfamiPF04139. Rad9. 1 hit.
[Graphical view]
PIRSFiPIRSF009303. Cell_cycle_RAD9. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRAD9B_HUMAN
AccessioniPrimary (citable) accession number: Q6WBX8
Secondary accession number(s): Q5U5K0
, Q6NVJ1, Q6ZVT7, Q8N7T9, Q96LI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 28, 2006
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.