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Q6WB83 (LLDD_ALCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase [cytochrome]

EC=1.1.2.3
Gene names
Name:lldD
OrganismAlcaligenes faecalis
Taxonomic identifier511 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAlcaligenes

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP-Rule MF_01559

Cofactor

FMN By similarity. HAMAP-Rule MF_01559

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
   LigandFlavoprotein
FMN
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processlactate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379L-lactate dehydrogenase [cytochrome] HAMAP-Rule MF_01559
PRO_0000206330

Regions

Domain1 – 379379FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
Q6WB83 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9975D092C4DDF2F9

FASTA37941,414
        10         20         30         40         50         60 
MIISSSTDYR RAAQKRLPPF LFHYIDGGAY AEHTLRRNVD DLAEVALRQR VLKDMSQLDT 

        70         80         90        100        110        120 
SIDLFGEKLS MPVALSPVGL TGMYARRGEV QAARAADARG IPFTMSSVSV CPIEEVAPRL 

       130        140        150        160        170        180 
SRPMWFQLYV LKDRGFMRNA LERAQAAGCS TLVFTVDMPV PGARYRDAHS GMSGPNAALR 

       190        200        210        220        230        240 
RYAQAVMHPR WAWDVGLLGR PHDLGNISRY LGKPTGLEDY MGYLGANFDP SISWKDLEWI 

       250        260        270        280        290        300 
REFWKGPMLI KGILDPDDAR DAVRFGADGI IVSNHGGRQL DGVLSSARAL PAIADAVKGQ 

       310        320        330        340        350        360 
IKILADSGIR SGLDVVRMIA LGADAAMLGR AYIYALAAAG QSGVDHLLGL IEKEIRVAMT 

       370 
LTSVSSISQI TSELLVREP 

« Hide

References

[1]"Genes for arsenite oxidation from Alcaligenes faecalis."
Silver S., Phung L.T., Malo B.J.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CCUG 2071 / LMG 3368 / NCIB 8687.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY297781 Genomic DNA. Translation: AAQ19817.1.

3D structure databases

ProteinModelPortalQ6WB83.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01559. L_lact_dehydr.
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view]
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLLDD_ALCFA
AccessionPrimary (citable) accession number: Q6WB83
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families