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Protein
Submitted name:

Histocompatibility 2, M region locus 2

Gene

H2-M2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Submitted name:
Histocompatibility 2, M region locus 2Imported
Submitted name:
MHC class Ib antigenImported
Gene namesi
Name:H2-M2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95914 H2-M2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501509857625 – 304Sequence analysisAdd BLAST280

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000016283

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016427

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini213 – 301Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000118960
HOVERGENiHBG016709
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6W9J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSAFFTLL FTLYLLLGAS LALAQTFKGS HSLRYFDIAV SRPGLEETHY
60 70 80 90 100
MTVGYVDDTE FVHFDNEAEN PRFEPRVPWM EQMGQKYWDD QTRIAKAAEQ
110 120 130 140 150
QIRVYFQKLR DYYNQSQNSS HTIQRMTGCY IGPDGHLLHA YRQFGYDGQD
160 170 180 190 200
YLTLNEDLST WTAADAAAEI TRREWEATNV AEFWRVYLEG PCMVWLFKYL
210 220 230 240 250
TVGNETLLRT EPPKAYVTHH PRPEGDVTLR CWALGFYPSD IIMIWQRDGE
260 270 280 290 300
DQTQDMDVIE TRPAGDGTFQ KWVAVVVPSG KEQNYTCHVA HEGLPEPLTL

RWSK
Length:304
Mass (Da):35,296
Last modified:July 5, 2004 - v1
Checksum:i677ABE37DADD795A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974427 Genomic DNA No translation available.
AY302217 mRNA Translation: AAQ81308.1
RefSeqiNP_032230.1, NM_008204.2
UniGeneiMm.329041

Genome annotation databases

EnsembliENSMUST00000016427; ENSMUSP00000016427; ENSMUSG00000016283
GeneIDi14990
UCSCiuc008cmz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ6W9J6_MOUSE
AccessioniPrimary (citable) accession number: Q6W9J6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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