Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

1-Cys peroxiredoxin PER1

Gene

PER1

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Seems to contribute to the inhibition of germination during stress (By similarity).By similarity

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.By similarity

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Cysteine sulfenic acid (-SOH) intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei4381. Ta1CysPrx.

Names & Taxonomyi

Protein namesi
Recommended name:
1-Cys peroxiredoxin PER1 (EC:1.11.1.15)
Alternative name(s):
Rehydrin homolog
Thioredoxin peroxidase
Gene namesi
Name:PER1
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Protein family/group databases

Allergomei6327. Tri a 32.
9499. Tri a 32.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002851041 – 2181-Cys peroxiredoxin PER1Add BLAST218

Proteomic databases

PRIDEiQ6W8Q2.

Expressioni

Gene expression databases

GenevisibleiQ6W8Q2. TA.

Structurei

3D structure databases

ProteinModelPortaliQ6W8Q2.
SMRiQ6W8Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 164ThioredoxinPROSITE-ProRule annotationAdd BLAST161

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi194 – 217Bipartite nuclear localization signalSequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx6 subfamily.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

OMAiMSAGRNF.
OrthoDBiEOG09360KY6.

Family and domain databases

InterProiView protein in InterPro
IPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR036249. Thioredoxin-like_sf.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6W8Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLTIGDTV PNLELDSTHG KIRIHDYVGN GYVILFSHPG DFTPVCTTEL
60 70 80 90 100
AAMANYAKEF EKRGVKLLGI SCDDVQSHKE WTKDIEAYKP GSKVTYPIMA
110 120 130 140 150
DPDRSAIKQL NMVDPDEKDA EGQLPSRTLH IVGPDKKVKL SFLYPSCTGR
160 170 180 190 200
NMDEVVRAVD SLLTAAKHKV ATPANWNPGE CVVIAPGVSD DEAKKMFPQG
210
FETADLPSKK GYLRFTKV
Length:218
Mass (Da):23,965
Last modified:July 5, 2004 - v1
Checksum:i8C98E8F32CC98A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY304482 mRNA. Translation: AAQ74769.1.
UniGeneiTa.67690.

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_2BS_TGACv1_145997_AA0452270.1; TRIAE_CS42_2BS_TGACv1_145997_AA0452270.1; TRIAE_CS42_2BS_TGACv1_145997_AA0452270.
GrameneiTRIAE_CS42_2BS_TGACv1_145997_AA0452270.1; TRIAE_CS42_2BS_TGACv1_145997_AA0452270.1; TRIAE_CS42_2BS_TGACv1_145997_AA0452270.

Similar proteinsi

Entry informationi

Entry nameiREHY_WHEAT
AccessioniPrimary (citable) accession number: Q6W8Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families