Q6W5P9 (Q6W5P9_9ACTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
FscB EMBL AAQ82565.1

Gene names

Name:

fscB EMBL AAQ82565.1

Organism

Streptomyces sp. FR-008 EMBL AAQ82565.1

Taxonomic identifier

206662 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	5541 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6W5P9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E901D0BE12B0E932	FASTA	5,541	576,548
	10 20 30 40 50 60 MSNEDRLRAY LKRAVTDLQE ARQQLSDAEN RDREPVAVVA MACRYPGGVR TPQDLWELAR 70 80 90 100 110 120 DGVDAISAFP ANRGWDLDHL FHPDPAHHGT TYTREGGFLH DAGEFDPAFF GISPREALAM 130 140 150 160 170 180 DPQQRLLLET SWEALERAGI LPDTLAGSTT GVFVGTGHGD YDGASRGRQK EVAGHLLTGN 190 200 210 220 230 240 TVAVASGRLS YTYGFEGPAV TVDTACSSSL VALHLAVRSL RQGECSLALA GGATVMSTPK 250 260 270 280 290 300 MFTEFSRQQG LAADGRCKPF AAGADGTAWS EGVGLILLER LSDAQRNGHE ILAVIRGSAI 310 320 330 340 350 360 NQDGASNGLT APNGPSQQRL IRQALIDAGL TSGEVDVVEA HGTGTTLGDP IEAQALLNTY 370 380 390 400 410 420 GQDRGDAHPL LLGSLKSNTG HTQAASGVAG VIKMVQAMRH GTLPKSLHVD APTPHADWAT 430 440 450 460 470 480 GGVELLTEST TWPETGRPRR AAVSSFGVSG TNAHLILEQA PEDQTPRAEE PGTEPSADDS 490 500 510 520 530 540 ADTVRSWMVS GKSRAAVGEQ AARLAASVRA SDASVLDVAH ALVSSRVAMD RRAVVVGSDR 550 560 570 580 590 600 EELLAGLDAL AAGEPSVRVV EGTAGEGAGD VAFVFPGQGS QWVGMAVELL GSSPVFAGRV 610 620 630 640 650 660 AECAAALEPF TEWSLLDVLN GVEGAASLER VDVVQPVLWA VMVSLAEVWR AQGVEPGAVI 670 680 690 700 710 720 GHSQGEIAAA VVAGGLSLED GARVVALRSR ALRALSGLGG MVSVARNVDE VRGLLAGWEG 730 740 750 760 770 780 RISVAAVNGP SSVVVSGDAE ALDEFVAACD ASGVRARRVA VDYASHSAHV ERIEEELAGL 790 800 810 820 830 840 LAPVAPRSCD VPFYSTLSGG VIDTAGLDAG YWYRNLRGTV EFEAGTRALL ADGFRVFVEV 850 860 870 880 890 900 SAHPVVATGV QETIEDASVQ AGVVGTLRRD EGGLERFALS LGEAWALGAE VDWETHYAGT 910 920 930 940 950 960 RPRHVDLPTY PFRRDWYWLT PAESAAAAAT GDPADGDFWS AVESGDLTRL SSVLEVTGDD 970 980 990 1000 1010 1020 VEAFGTLLPA LASWRRRRTL RSTLDTWRHR VTWTALTGAD DAVPAGRWPA LVPAGHADDP 1030 1040 1050 1060 1070 1080 WVHAVLGALT GRGLRVERHD LTGDEDTAAL TALLTGTGDT EPDGAEGIAG VLSLLALDER 1090 1100 1110 1120 1130 1140 PHPDHPAVPR GLATAKELLH ALSGTEASVW ALTRGAVAVD SRDRLTSPVQ AETWGFGRAV 1150 1160 1170 1180 1190 1200 ALELPDAWGG LADLPADPDA RSLARLATLL GGPEDQIAVR SSGAYARRLA RMPLPEPARV 1210 1220 1230 1240 1250 1260 TDVDAELAVR AADDDGIGGW GDHDTVLITG GTGALGAHVA RSLAASGARH LVLTSRRGPG 1270 1280 1290 1300 1310 1320 SPGAVGLVAE LEELGARVTV ADCDVADRDQ LARLLDSLPA GLPLTGVVHA AGVLDDGVLD 1330 1340 1350 1360 1370 1380 ALTLDRFEAV LRPKTLGTAH LHELTRDHDV TLFVLFSSIV GVLGNAGQAN YAAANAYLDA 1390 1400 1410 1420 1430 1440 VAEQRRAEGL PVTSVAWGPW ADAGMATADV LADRMSHDGL APMDPVTAVA ALRAAVAEGV 1450 1460 1470 1480 1490 1500 PHATVLDVDW RAYGTAMTAA RPSPLVGDLP EVRRALEAAA ATAPDTHALR DRLRGLAPAE 1510 1520 1530 1540 1550 1560 QDRLLTDLVR AEVATALRHS SPEAVDVNRA FKDLGFDSLT AVEVRNRITA ATDVKLPTTL 1570 1580 1590 1600 1610 1620 LFDYPNTTAV VAHLRTLLLG DERPVAAPVV VSAGVTDEPM AVVAMACRFP GGVTTPEELW 1630 1640 1650 1660 1670 1680 HLMAAEVDAV STPPEDRGWD LDALYDPDPE RHGTTYSREG GFIQDVAGFD PVFFGISPRE 1690 1700 1710 1720 1730 1740 ALAMDPQQRL LLETSWETFE RAGIDPGTLR NSATGVFVGS ITTDYQVRLG GAAAQEQLAG 1750 1760 1770 1780 1790 1800 HLMTGNASSI ASGRLSYTYG FEGPAVTMDT GCSSSMVALH LALQSLRTGE CTMALAGGVT 1810 1820 1830 1840 1850 1860 VMSTPEPYVE FSRQRGLAAD GRCKAFAEGA DGMGFAEGVG LVLLERLSDA RRNGHPVLAV 1870 1880 1890 1900 1910 1920 VRGSALNQDG ASNGLTAPNG PSQQRVIRQA LANAGLAPGE VDVVEAHGTG TPLGDPIEAQ 1930 1940 1950 1960 1970 1980 AILATYGQDR DPARPLLLGS LKSNIGHTQA AAGVAGMMKM ILAMRQGTLP KSLHITRPTS 1990 2000 2010 2020 2030 2040 VVDWSSGAVR LVTESTPWPE TGRPRRAGVS SFGISGTNGH LILEEAPAPE PAEDEPADPF 2050 2060 2070 2080 2090 2100 TEPSADDSAD TVRSWMVSGK SRAAVGEQAA RLAASVRTSD ASVLDVAHAL VSSRVAMDRR 2110 2120 2130 2140 2150 2160 AVVVGRDGEE LLAGLDALAA GEPSPRLVEG SVGDGSGKVA FVFPGQGSQW VGMAVELLGS 2170 2180 2190 2200 2210 2220 SPVFAGRVAE CAAALEPFTE WSLLDVLNGV EGAASLERVD VVQPVLWAVM VSLAEVWRAQ 2230 2240 2250 2260 2270 2280 GVEPGAVIGH SQGEIAAAVV AGGLSLEDGA RVVALRSRAL RALSGLGGMV SVARNVDEVR 2290 2300 2310 2320 2330 2340 GLLAGWEGRI SVAAVNGPSS VVVSGDAEAL DEFVAACDAS GVRARRVAVD YASHSAHVER 2350 2360 2370 2380 2390 2400 IEEELAGLLA PVAPRSCDVP FYSTLSGGVI DTAGLDAGYW YRNLRGTVEF EAGTRALLAD 2410 2420 2430 2440 2450 2460 GFRVFVEVSA HPVVATGVQE TIEDASVQAG VVGTLRRDEG GLERFALSLG EAWALGAEVD 2470 2480 2490 2500 2510 2520 WETHYAGTRP RHVDLPTYAF QRQHYWPRFA ELGGDVSSAG LDSPDHPLLG ASVELAGGDG 2530 2540 2550 2560 2570 2580 LVATARWSLR THPWLADHAV SGTVIVPGTA LVESVIRAGD VLGCGRIEEL ALQAPVVLQE 2590 2600 2610 2620 2630 2640 RGEAQVQIGV GEPDASGRRP VTVHTRTTGP DGATEDLWTL RAQGTLTEPG APAVDRPEEF 2650 2660 2670 2680 2690 2700 TSWPPPGATA VAAEGFYELL AGRGYEFGPV FQGVRATWSR GEDLYAEVVL PEQVRGDAGR 2710 2720 2730 2740 2750 2760 FGIHPALLDA ALHAAHLAPG SAGRTVVPFT WSGVCLHAAG ATALRVRVSP AGQDAISVQL 2770 2780 2790 2800 2810 2820 TDPTGAPVAT IDALAVREIA PDTLDPSARA ARDWLFRLDW TPVTPPAAVP AATGWAVLGT 2830 2840 2850 2860 2870 2880 PADPVTAPDG SGTTLPAFAT PGALAEHTEA NGHRPDAVLL FAGAAASGTA AAPDAEPGVP 2890 2900 2910 2920 2930 2940 DAVLDDVLAT VQSWLADETT EGVPLVVVTR GAVPTGPADP AHDLPGAAVW GLVRSAQSQH 2950 2960 2970 2980 2990 3000 PGRLVLVDLD IHDDSWLALP AALAAGEPQL ALRQGAAYAP RLVRPRTSDA LTVPEGTGNW 3010 3020 3030 3040 3050 3060 RLDIPEKGSV DRLDLVAAPG TAEEPAAGEV VIEVRAAGLN FRDVLNTLGM YPGPAVLLGA 3070 3080 3090 3100 3110 3120 EAAGVVTAVG EGVTGFAPGD RVMGLVSGGF APRAVADARM LAPVPDGWTW AQAASVPVAF 3130 3140 3150 3160 3170 3180 LTAYYGLRDL AHLDAGESVL VHAAAGGVGM AAAQLARHWG AEVYGTAGDH KRTLLRADGW 3190 3200 3210 3220 3230 3240 DDAHLASSRT LAFEDRFRTT SGGRGVDVVL NSLAGDYIDA SLRLLAPGGR LVDMGKTDVR 3250 3260 3270 3280 3290 3300 DPGQVLRDHP AAALYQAYEL REAGEDRIQE MFRDLSELFA SGALRPLPTV TWDVRHAREA 3310 3320 3330 3340 3350 3360 FRHMAQAKHY GKIVLTLPRA WDPEGTVLVT GGAGVLGGIL ARHLVTRHGM RHLVLTGRRG 3370 3380 3390 3400 3410 3420 PDTPGAGELA AELRELGAEV TLAACDAADA DALAAVLAAV PAEHPLTAVV HAAGVLDDGV 3430 3440 3450 3460 3470 3480 LESLTPDRLR TVLAPKADAA RHLHRLTRDL DLTDLVLFSA GAGVFGNAGQ ANYAAANTYL 3490 3500 3510 3520 3530 3540 DALAHRRRAD GLPTTSLSWG LWADTSALTG QLDDTDLARV RRSGVLPLSA ADGMVLFDAA 3550 3560 3570 3580 3590 3600 LTEQRPHLVP VRLETGQLRA SGDEVPPLLR SLYRGPVRRT AEAGAATGTD GLRARLAGRS 3610 3620 3630 3640 3650 3660 AEDRLSTLRD LVGAHAAAVL GHDDTEPFHA GRAFRDLGFD SLTAVELRNR LSAATGLRLP 3670 3680 3690 3700 3710 3720 ATLVFDHPTV AALAAHLDGE LSDGTPAALP AAPAPAPAAP GDDDPFAIVG MACRLPGDIH 3730 3740 3750 3760 3770 3780 SPEDLWRLLA DGADAVAPFP DDRGWDLARL YDSVPEGQGS SRTREGGFLH DAADFDADFF 3790 3800 3810 3820 3830 3840 GISPREALAM DPQQRLLLET AWETFERAGI DPRSVRGSRT GVFAGLSSSD YLKRVTHVPD 3850 3860 3870 3880 3890 3900 EIAGYVNNGN ANSIVSGRVS YTLGLEGPAV TVDTACSSSL VALHMALQAL RRGECTMALA 3910 3920 3930 3940 3950 3960 GGVTVMSSPE IIVDFSRQRG LAADGRCKPF AEAADGTGFS EGVGLILVER LSDARRNGHQ 3970 3980 3990 4000 4010 4020 VLAVVRGSAV NQDGASNGLS APNGPAQQRV IRQALADAGV GAAEVDVVEA HGTGTRLGDP 4030 4040 4050 4060 4070 4080 IEAQALLATY GRDRDGGHPL FLGSVKSNLG HTQAAAGVAG VMKMVLALRH RLLPESLHID 4090 4100 4110 4120 4130 4140 APTPHVDWAD SGVRLLTEAT AWPEAGASRP RRAAVSSFGI SGHQRPRHPG GGPPPPPART 4150 4160 4170 4180 4190 4200 AASRSPPAPD AAETRPAPLP WVLSARSEAA LRGQAKALLT HLDAHPGTDP ADIAHTLVTR 4210 4220 4230 4240 4250 4260 RAQLEKRAVV VGSATGDFRA GLAALAEGSP AAHVVTGGRG AGRDRRTVLV FPGQGSQWAG 4270 4280 4290 4300 4310 4320 MGAELLDASP AFADRVAACE EALAPYVDWS LTAVLRQEEG APALDRVDVV QPVTWAVMVA 4330 4340 4350 4360 4370 4380 LAEVWRAHGL RPAAVLGHSQ GEIAAAAVAG ALSLADAARI VAVRSRAIAR ELSGHGGMVA 4390 4400 4410 4420 4430 4440 VTAPHDEVTA LLADLPGVCV AAVNGPSSVV VSGDTGGLDT LLAACEEQGV RARRVPVDYA 4450 4460 4470 4480 4490 4500 SHSAHVDRLA ESLPAALDGI EPRDGDIPFF STVTADWHPG TGLGAAYWHR NLRGTVRLEE 4510 4520 4530 4540 4550 4560 SLRALVEQGH DVFVECGPHP VLTVGIEDTV AALGADAVAL GSLRRDDGGP ARVLTALAAA 4570 4580 4590 4600 4610 4620 HVEGVPVDWR PAVSHGTAVD LPTYAFQRRR YWLDAGTPQG DPAGLDSVVR LADGGAVLSG 4630 4640 4650 4660 4670 4680 SLSLTTQPWL DAHRTHGAAV VPTTALLDWA VRAGDETGLP VVAALDEHSP LVVPEEGHVE 4690 4700 4710 4720 4730 4740 IQLTVSAADT DSRPFSVHSR LHAADAGEPA TPWTRNATGD LTDRPTTTPQ ASGTWPPADA 4750 4760 4770 4780 4790 4800 VAADPAPVRA LAEDRGLDLA APFDTVRSLW RAGTDVLAEV ALPDAAHADA ARFRLHPALL 4810 4820 4830 4840 4850 4860 QTPLALAATT EEATAPVLPA AWRDVTVHAT GASRLRVRLT PGDDATWSVE ARDAAGDLVL 4870 4880 4890 4900 4910 4920 TGTAVTRSAG PDRLPATAGP DAPHRVAWLP WTDTTSSATP EPHGPWAVIG APGRLTAALE 4930 4940 4950 4960 4970 4980 RSGATVQLHP DLAALTTALD NDEAAPPALV VAFHGHDSGE DPTKAAHTSA ARALTLSTAW 4990 5000 5010 5020 5030 5040 LREPRLADAR LLLVTEGAVA TGPDDTVPGL ADATAWGLLR SAQTEHPGRF LLADLDPAPG 5050 5060 5070 5080 5090 5100 DTDEDSAADA LIAAAAAAAR TGEHQFAVRA GTVTVPRLVP AGHPEGAPAP AATAPWGEGT 5110 5120 5130 5140 5150 5160 GAGTVLITGG TGTLGALVAR HLVTRHGVRH LLLTSRRGPG APGAAALREE LAALGAEAEI 5170 5180 5190 5200 5210 5220 VACDVADREQ LAGVLDAVPA EHPLTAVVHT AGVLDDGTLD GLTADRVAHV LRPKADAAWH 5230 5240 5250 5260 5270 5280 LHELTRDTKL TAFVMFSSYA GVAGGPGQAN YAAANAFLDA LAQHRRASGL PAHSLAWGLW 5290 5300 5310 5320 5330 5340 EDRSDLTGAL DTTGLARLER SGIRPLTAGQ GLALLDASTA LDTAHLVPVR LDTRTLRADE 5350 5360 5370 5380 5390 5400 VPPLLRALAR PAVRRAADSG PGAATGAPAD LRERLAGLSG PQQRALLHRT VLGHLAAVLG 5410 5420 5430 5440 5450 5460 HASAASLDAD RGFLDLGMSS LTAVELRNRL NADTGLSLPT TLIFDHPDPA ALVRHLQTEL 5470 5480 5490 5500 5510 5520 GTGAGEPDQA VFAELAALEA AVGGAALDDQ DRARLAQRLK ALGWKLDATS QDADEPDDDS 5530 5540 DLDTTTDDEM FDLIDNELGL A

References

[1]	"Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex." Chen S., Huang X., Zhou X., Bai L., He J., Jeong K.J., Lee S.Y., Deng Z. Chem. Biol. 10:1065-1076(2003) [PubMed: 14652074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Chen S., Huang X., Zhou X., He J., Bai L., Jeong K.J., Lee S.Y., Deng Z. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY310323 Genomic DNA. Translation: AAQ82565.1.
3D structure databases
ProteinModelPortal	Q6W5P9.
SMR	Q6W5P9. Positions 4-920, 1487-1575, 1597-2487, 3701-4594.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR000794. Beta-ketoacyl_synthase. IPR011032. GroES-like. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR006163. Phsphopanteth-bd. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020807. PKS_dehydratase. IPR020843. PKS_ER. IPR013968. PKS_KR. IPR020806. PKS_PP-bd. IPR015083. Polyketide_synth_docking. IPR006162. PPantetheine_attach_site. IPR002364. Quin_OxRdtase/zeta-crystal_CS. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 6 hits. G3DSA:1.10.1200.10. ACP_like. 3 hits. G3DSA:3.40.50.720. NAD(P)-bd. 4 hits. G3DSA:3.40.47.10. Thiolase-like_subgr. 6 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00698. Acyl_transf_1. 3 hits. PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. PF08990. Docking. 1 hit. PF00109. ketoacyl-synt. 3 hits. PF02801. Ketoacyl-synt_C. 3 hits. PF08659. KR. 3 hits. PF00550. PP-binding. 3 hits. [Graphical view]
SMART	SM00827. PKS_AT. 3 hits. SM00826. PKS_DH. 2 hits. SM00829. PKS_ER. 1 hit. SM00822. PKS_KR. 3 hits. SM00825. PKS_KS. 3 hits. SM00823. PKS_PP. 3 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 3 hits. SSF52151. Acyl_Trfase/lysoPlipase. 3 hits. SSF50129. GroES_like. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 3 hits. SSF101173. Polyketide_synth_docking. 1 hit. SSF53901. Thiolase-like. 3 hits.
PROSITE	PS50075. ACP_DOMAIN. 3 hits. PS00606. B_KETOACYL_SYNTHASE. 3 hits. PS00012. PHOSPHOPANTETHEINE. 3 hits. PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6W5P9_9ACTO

Accession

Primary (citable) accession number: Q6W5P9

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)