Q6W5P4 (NPSR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide S receptor

Alternative name(s):
G-protein coupled receptor 154
G-protein coupled receptor PGR14
G-protein coupled receptor for asthma susceptibility

Gene names

Name:	NPSR1
Synonyms:	GPR154, GPRA, PGR14

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases. Ref.2 Ref.8
Subcellular location	Isoform 1: Cell membrane; Multi-pass membrane protein Ref.2. Isoform 3: Cell membrane; Multi-pass membrane protein Ref.2. Isoform 4: Cell membrane; Multi-pass membrane protein Ref.2. Isoform 2: Cytoplasm Ref.2. Isoform 5: Cytoplasm Ref.2. Isoform 6: Cytoplasm Ref.2. Isoform 7: Cytoplasm Ref.2. Isoform 9: Cytoplasm Ref.2.
Tissue specificity	Ubiquitous. Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients. Ref.1 Ref.2
Involvement in disease	Defects in NPSR1 are a cause of asthma-related traits type 2 (ASRT2) [MIM:608584]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Ref.1 Ref.9 Ref.10
Miscellaneous	Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Asthma
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: HPA
Molecular function	vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6W5P4-1)

Also known as: Isoform A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6W5P4-2)

Also known as: Isoform F;

The sequence of this isoform differs from the canonical sequence as follows:
     94-159: Missing.

Isoform 3 (identifier: Q6W5P4-3)

Also known as: Isoform G;

The sequence of this isoform differs from the canonical sequence as follows:
     343-371: EQRSQDSRMTFRERTERHEMQILSKPEFI → ANSSVYLLAC...GFQNDVPGEN

Isoform 4 (identifier: Q6W5P4-4)

Also known as: Isoform B long form;

The sequence of this isoform differs from the canonical sequence as follows:
     343-371: EQRSQDSRMTFRERTERHEMQILSKPEFI → VIRLRQLQEAALMLCPQRENWKGTWPGVPSWALPR

Isoform 5 (identifier: Q6W5P4-5)

Also known as: Isoform B short form;

The sequence of this isoform differs from the canonical sequence as follows:
     93-103: Missing.
     343-371: EQRSQDSRMTFRERTERHEMQILSKPEFI → VIRLRQLQEAALMLCPQRENWKGTWPGVPSWALPR

Isoform 6 (identifier: Q6W5P4-6)

Also known as: Isoform D;

The sequence of this isoform differs from the canonical sequence as follows:
     94-158: DSFTGLVNIL...AIVYPMKFLQ → GCAALRLYLR...HIWEEDTVQR
     159-371: Missing.

Isoform 7 (identifier: Q6W5P4-7)

Also known as: Isoform E;

The sequence of this isoform differs from the canonical sequence as follows:
     129-136: VVLLYAST → KSKPGSSL
     137-371: Missing.

Isoform 8 (identifier: Q6W5P4-8)

The sequence of this isoform differs from the canonical sequence as follows:
     130-143: VLLYASTYVLVSLS → MVMKLFHIQKMNME
     144-371: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: Q6W5P4-9)

Also known as: Isoform C;

The sequence of this isoform differs from the canonical sequence as follows:
     94-94: D → V
     95-371: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Neuropeptide S receptor		PRO_0000069639
Regions
	Topological domain	1 – 52	52	Extracellular Potential
	Transmembrane	53 – 73	21	Helical; Name=1; Potential
	Topological domain	74 – 82	9	Cytoplasmic Potential
	Transmembrane	83 – 103	21	Helical; Name=2; Potential
	Topological domain	104 – 123	20	Extracellular Potential
	Transmembrane	124 – 144	21	Helical; Name=3; Potential
	Topological domain	145 – 164	20	Cytoplasmic Potential
	Transmembrane	165 – 185	21	Helical; Name=4; Potential
	Topological domain	186 – 212	27	Extracellular Potential
	Transmembrane	213 – 233	21	Helical; Name=5; Potential
	Topological domain	234 – 275	42	Cytoplasmic Potential
	Transmembrane	276 – 296	21	Helical; Name=6; Potential
	Topological domain	297 – 312	16	Extracellular Potential
	Transmembrane	313 – 333	21	Helical; Name=7; Potential
	Topological domain	334 – 371	38	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Disulfide bond	121 ↔ 197		By similarity
Natural variations
	Alternative sequence	93 – 103	11	Missing in isoform 5.		VSP_016078
	Alternative sequence	94 – 159	66	Missing in isoform 2.		VSP_016079
	Alternative sequence	94 – 158	65	DSFTG…MKFLQ → GCAALRLYLRPGVPQHRQIP CHRLPHEVPSRRKASQGPHC DRLEPVFSVLHSHPDHIWEE DTVQR in isoform 6.		VSP_016080
	Alternative sequence	94	1	D → V in isoform 9.		VSP_016081
	Alternative sequence	95 – 371	277	Missing in isoform 9.		VSP_016082
	Alternative sequence	129 – 136	8	VVLLYAST → KSKPGSSL in isoform 7.		VSP_016083
	Alternative sequence	130 – 143	14	VLLYA…LVSLS → MVMKLFHIQKMNME in isoform 8.		VSP_016084
	Alternative sequence	137 – 371	235	Missing in isoform 7.		VSP_016085
	Alternative sequence	144 – 371	228	Missing in isoform 8.		VSP_016086
	Alternative sequence	159 – 371	213	Missing in isoform 6.		VSP_016087
	Alternative sequence	343 – 371	29	EQRSQ…KPEFI → ANSSVYLLACDVSVLWALVL TSEKESCESWRRKGAKITGF QNDVPGEN in isoform 3.		VSP_016088
	Alternative sequence	343 – 371	29	EQRSQ…KPEFI → VIRLRQLQEAALMLCPQREN WKGTWPGVPSWALPR in isoform 4 and isoform 5.		VSP_016089
	Natural variant	107	1	N → I. Ref.1 Ref.3 Ref.4 Ref.5 Corresponds to variant rs324981 [ dbSNP | Ensembl ].		VAR_023757
	Natural variant	122	1	R → Q. Ref.5 Corresponds to variant rs35436513 [ dbSNP | Ensembl ].		VAR_025103
	Natural variant	143	1	S → G. Ref.5 Corresponds to variant rs325465 [ dbSNP | Ensembl ].		VAR_025104
	Natural variant	197	1	C → F. Ref.5 Corresponds to variant rs34705969 [ dbSNP | Ensembl ].		VAR_025105
	Natural variant	212	1	T → I. Ref.5 Corresponds to variant rs35537374 [ dbSNP | Ensembl ].		VAR_025106
	Natural variant	241	1	S → R. Ref.5 Corresponds to variant rs727162 [ dbSNP | Ensembl ].		VAR_023758
	Natural variant	315	1	I → T. Ref.5 Corresponds to variant rs10270766 [ dbSNP | Ensembl ].		VAR_025107
	Natural variant	344	1	Q → R. Ref.5 Corresponds to variant rs6972158 [ dbSNP | Ensembl ].		VAR_023759

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Isoform A) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EA084B381562353D	FASTA	371	42,687
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 100 110 120 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV NILTDINWRF TGDFTAPDLV 130 140 150 160 170 180 CRVVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGE KQARVLIVIA WSLSFLFSIP 190 200 210 220 230 240 TLIIFGKRTL SNGEVQCWAL WPDDSYWTPY MTIVAFLVYF IPLTIISIMY GIVIRTIWIK 250 260 270 280 290 300 SKTYETVISN CSDGKLCSSY NRGLISKAKI KAIKYSIIII LAFICCWSPY FLFDILDNFN 310 320 330 340 350 360 LLPDTQERFY ASVIIQNLPA LNSAINPLIY CVFSSSISFP CREQRSQDSR MTFRERTERH 370 EMQILSKPEF I
	Isoform 2 (Isoform F) [UniParc]. Checksum: 665844DF66FDDC89	FASTA	305	35,116
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 100 110 120 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITEKQARVL IVIAWSLSFL FSIPTLIIFG 130 140 150 160 170 180 KRTLSNGEVQ CWALWPDDSY WTPYMTIVAF LVYFIPLTII SIMYGIVIRT IWIKSKTYET 190 200 210 220 230 240 VISNCSDGKL CSSYNRGLIS KAKIKAIKYS IIIILAFICC WSPYFLFDIL DNFNLLPDTQ 250 260 270 280 290 300 ERFYASVIIQ NLPALNSAIN PLIYCVFSSS ISFPCREQRS QDSRMTFRER TERHEMQILS KPEFI
	Isoform 3 (Isoform G) [UniParc]. Checksum: 42FACA8D36EBAB1D	FASTA	390	44,294
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 100 110 120 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV NILTDINWRF TGDFTAPDLV 130 140 150 160 170 180 CRVVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGE KQARVLIVIA WSLSFLFSIP 190 200 210 220 230 240 TLIIFGKRTL SNGEVQCWAL WPDDSYWTPY MTIVAFLVYF IPLTIISIMY GIVIRTIWIK 250 260 270 280 290 300 SKTYETVISN CSDGKLCSSY NRGLISKAKI KAIKYSIIII LAFICCWSPY FLFDILDNFN 310 320 330 340 350 360 LLPDTQERFY ASVIIQNLPA LNSAINPLIY CVFSSSISFP CRANSSVYLL ACDVSVLWAL 370 380 390 VLTSEKESCE SWRRKGAKIT GFQNDVPGEN
	Isoform 4 (Isoform B long form) [UniParc]. Checksum: 310B778C70C104B9	FASTA	377	43,123
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 100 110 120 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV NILTDINWRF TGDFTAPDLV 130 140 150 160 170 180 CRVVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGE KQARVLIVIA WSLSFLFSIP 190 200 210 220 230 240 TLIIFGKRTL SNGEVQCWAL WPDDSYWTPY MTIVAFLVYF IPLTIISIMY GIVIRTIWIK 250 260 270 280 290 300 SKTYETVISN CSDGKLCSSY NRGLISKAKI KAIKYSIIII LAFICCWSPY FLFDILDNFN 310 320 330 340 350 360 LLPDTQERFY ASVIIQNLPA LNSAINPLIY CVFSSSISFP CRVIRLRQLQ EAALMLCPQR 370 ENWKGTWPGV PSWALPR
	Isoform 5 (Isoform B short form) [UniParc]. Checksum: 523DDC610B719DF0	FASTA	366	41,961
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 100 110 120 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDINWRFT GDFTAPDLVC RVVRYLQVVL 130 140 150 160 170 180 LYASTYVLVS LSIDRYHAIV YPMKFLQGEK QARVLIVIAW SLSFLFSIPT LIIFGKRTLS 190 200 210 220 230 240 NGEVQCWALW PDDSYWTPYM TIVAFLVYFI PLTIISIMYG IVIRTIWIKS KTYETVISNC 250 260 270 280 290 300 SDGKLCSSYN RGLISKAKIK AIKYSIIIIL AFICCWSPYF LFDILDNFNL LPDTQERFYA 310 320 330 340 350 360 SVIIQNLPAL NSAINPLIYC VFSSSISFPC RVIRLRQLQE AALMLCPQRE NWKGTWPGVP SWALPR
	Isoform 6 (Isoform D) [UniParc]. Checksum: 3D69DADA95C6F873	FASTA	158	18,043
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 100 110 120 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITGCAALRL YLRPGVPQHR QIPCHRLPHE 130 140 150 VPSRRKASQG PHCDRLEPVF SVLHSHPDHI WEEDTVQR
	Isoform 7 (Isoform E) [UniParc]. Checksum: 19AA8C544568D426	FASTA	136	15,327
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 100 110 120 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV NILTDINWRF TGDFTAPDLV 130 CRVVRYLQKS KPGSSL
	Isoform 8 [UniParc]. Checksum: 2F3C09CB873FDFA6	FASTA	143	16,403
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 100 110 120 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV NILTDINWRF TGDFTAPDLV 130 140 CRVVRYLQVM VMKLFHIQKM NME
	Isoform 9 (Isoform C) [UniParc]. Checksum: 324E80DBCA39A3E8	FASTA	94	10,612
	10 20 30 40 50 60 MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF 70 80 90 VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a common susceptibility locus for asthma-related traits." Laitinen T., Polvi A., Rydman P., Vendelin J., Pulkkinen V., Salmikangas P., Maekelae S., Rehn M., Pirskanen A., Rautanen A., Zucchelli M., Gullsten H., Leino M., Alenius H., Petaeys T., Haahtela T., Laitinen A., Laprise C. , Hudson T.J., Laitinen L.A., Kere J. Science 304:300-304(2004) [PubMed: 15073379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), VARIANT ILE-107, INVOLVEMENT IN ASRT2, TISSUE SPECIFICITY.
[2]	"Characterization of GPRA, a novel G protein-coupled receptor related to asthma." Vendelin J., Pulkkinen V., Rehn M., Pirskanen A., Raisanen-Sokolowski A., Laitinen A., Laitinen L.A., Kere J., Laitinen T. Am. J. Respir. Cell Mol. Biol. 33:262-270(2005) [PubMed: 15947423] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5; 6; 7 AND 9), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	"Human neuropeptide S receptor isoforms A and G: nucleotide and deduced amino acid sequence." Uebele V.N. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), VARIANT ILE-107.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8), VARIANT ILE-107.
[5]	SeattleSNPs variation discovery resource Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-107; GLN-122; GLY-143; PHE-197; ILE-212; ARG-241; THR-315 AND ARG-344.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[8]	"Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects." Xu Y.-L., Reinscheid R.K., Huitron-Resendiz S., Clark S.D., Wang Z., Lin S.H., Brucher F.A., Zeng J., Ly N.K., Henriksen S.J., de Lecea L., Civelli O. Neuron 43:487-497(2004) [PubMed: 15312648] [Abstract] Cited for: FUNCTION.
[9]	"Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma." Melen E., Bruce S., Doekes G., Kabesch M., Laitinen T., Lauener R., Lindgren C.M., Riedler J., Scheynius A., van Hage-Hamsten M., Kere J., Pershagen G., Wickman M., Nyberg F. Am. J. Respir. Crit. Care Med. 171:1089-1095(2005) [PubMed: 15710598] [Abstract] Cited for: INVOLVEMENT IN ASRT2.
[10]	"G-protein-coupled receptor polymorphisms are associated with asthma in a large German population." Kormann M.S., Carr D., Klopp N., Illig T., Leupold W., Fritzsch C., Weiland S.K., von Mutius E., Kabesch M. Am. J. Respir. Crit. Care Med. 171:1358-1362(2005) [PubMed: 15764725] [Abstract] Cited for: INVOLVEMENT IN ASRT2.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY310326 mRNA. Translation: AAQ76966.1. AY310327 mRNA. Translation: AAQ76967.1. AY310328 mRNA. Translation: AAQ76968.1. AY310329 mRNA. Translation: AAQ76969.1. AY310330 mRNA. Translation: AAQ76970.1. AY310331 mRNA. Translation: AAQ76971.1. AY310332 mRNA. Translation: AAQ76972.1. AY956446 mRNA. Translation: AAX63744.1. AY956447 mRNA. Translation: AAX63745.1. AY956448 mRNA. Translation: AAX63746.1. AK172847 mRNA. Translation: BAD18811.1. DQ272236 Genomic DNA. Translation: ABB72550.1. CH471073 Genomic DNA. Translation: EAW94036.1. BC132693 mRNA. Translation: AAI32694.1. BC132695 mRNA. Translation: AAI32696.1.
IPI	IPI00410389. IPI00418373. IPI00428568. IPI00428571. IPI00441882. IPI00556142. IPI00654752. IPI00654855. IPI00654899.
RefSeq	NP_997055.1. NM_207172.1. NP_997056.1. NM_207173.1.
UniGene	Hs.652373.
3D structure databases
ProteinModelPortal	Q6W5P4.
SMR	Q6W5P4. Positions 47-348.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6W5P4.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q6W5P4.
Polymorphism databases
DMDM	74758626.
Proteomic databases
PRIDE	Q6W5P4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360581; ENSP00000353788; ENSG00000187258.
GeneID	387129.
KEGG	hsa:387129.
UCSC	uc003teg.1. human. uc003teh.1. human. uc003tei.1. human. uc010kwv.1. human. uc010kww.1. human.
Organism-specific databases
CTD	387129.
GeneCards	GC07P034664.
HGNC	HGNC:23631. NPSR1.
HPA	HPA007489.
MIM	608584. phenotype. 608595. gene.
neXtProt	NX_Q6W5P4.
PharmGKB	PA134951416.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074198.
HOVERGEN	HBG106615.
OMA	GEKQARV.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q6W5P4.
Genevestigator	Q6W5P4.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001817. Vasoprsn_rcpt. [Graphical view]
KO	K08376.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00896. VASOPRESSINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB01159. Halothane.
NextBio	101236.
SOURCE	Search...

Entry information

Entry name

NPSR1_HUMAN

Accession

Primary (citable) accession number: Q6W5P4
Secondary accession number(s): A2RTZ4 , Q2XP58, Q56H76, Q56H77, Q56H78, Q6JSL4, Q6JSL5, Q6JSL6, Q6JSL7, Q6JSL8, Q6W5P3, Q6ZMB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.