Reviewed, UniProtKB/Swiss-Prot Q6W5G4 (LPPR2_RAT)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphatase-related protein type 2
    EC=3.1.3.4
Alternative name(s):
    Plasticity-related gene 4 protein
      Short name=PRG-4

Gene names

Name:	Lppr2
Synonyms:	Prg4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Lipid phosphate phosphatase-related protein type 2		PRO_0000317540
Regions
	Transmembrane	12 – 32	21	Potential
	Transmembrane	72 – 92	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	210 – 230	21	Potential
	Transmembrane	239 – 259	21	Potential
	Transmembrane	266 – 286	21	Potential
Amino acid modifications
	Glycosylation	165	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6W5G4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: DE2F7F0F0F8215FD	FASTA	343	36,936
	10 20 30 40 50 60 MAGGRPHLKR SFSIIPCFVF VESVLLGIVV LLAYRLEFTD TFPVHTQGFF CYDSAYAKPY 70 80 90 100 110 120 PGPEAASRAP PALIYALVTA GPTLTILLGE LARAFFPAPP SSSPVSGEST IVSGACCRFS 130 140 150 160 170 180 PPLRRLVRFL GVYSFGLFTT TIFANAGQVV TGNPTPHFLS VCRPNYTALG CPPPSPDRPG 190 200 210 220 230 240 PDRFVTDQSA CAGSPSLVAA ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL 250 260 270 280 290 300 CLALLCPAFL VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPHSGRRLSP 310 320 330 340 WEDLSQAPTM DSPLEKNPRP AGRIRHRHGS PHPSRRTVPA VAT

References

[1]	"Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family." Savaskan N.E., Brauer A.U., Nitsch R. Eur. J. Neurosci. 19:212-220(2004) [PubMed: 14750979] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY310911 mRNA. Translation: AAQ76703.1.
IPI	IPI00421445.
RefSeq	NP_001005881.1.
UniGene	Rn.162976
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000012164. Rattus norvegicus. [Contig view]
GeneID	300443.
KEGG	rno:300443.
Organism-specific databases
RGD	1597171. Lppr2.
Phylogenomic databases
HOVERGEN	Q6W5G4.
Enzyme and pathway databases
BRENDA	3.1.3.4. 248.
Gene expression databases
ArrayExpress	Q6W5G4.
Family and domain databases
InterPro	IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	646894.

Entry information

Entry name

LPPR2_RAT

Accession

Primary (citable) accession number: Q6W5G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	February 10, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)