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Protein

C-X-C motif chemokine 3

Gene

Cxcl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion.By similarity1 Publication

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 3
Alternative name(s):
Dendritic cell inflammatory protein 11 Publication
Gene namesi
Name:Cxcl3Imported
Synonyms:Dcip1Imported, Gm1960Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3037818. Cxcl3.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131By similarityAdd
BLAST
Chaini32 – 10069C-X-C motif chemokine 3By similarityPRO_5000091636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 62By similarity
Disulfide bondi38 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6W5C0.
PRIDEiQ6W5C0.

PTM databases

iPTMnetiQ6W5C0.
PhosphoSiteiQ6W5C0.

Expressioni

Inductioni

By lipopolysaccharide.1 Publication

Gene expression databases

BgeeiQ6W5C0.
GenevisibleiQ6W5C0. MM.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031326.

Structurei

3D structure databases

ProteinModelPortaliQ6W5C0.
SMRiQ6W5C0. Positions 28-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ6W5C0.
KOiK05505.
OMAiEVCLNPQ.
OrthoDBiEOG7NSB57.
PhylomeDBiQ6W5C0.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6W5C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPTCRLLS AALVLLLLLA TNHQATGAVV ASELRCQCLN TLPRVDFETI
60 70 80 90 100
QSLTVTPPGP HCTQTEVIAT LKDGQEVCLN PQGPRLQIII KKILKSGKSS
Length:100
Mass (Da):10,686
Last modified:July 5, 2004 - v1
Checksum:i292AE7DA28DE525C
GO

Sequence cautioni

The sequence BAE25738.1 differs from that shown. Reason: Frameshift at position 78. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY311403 mRNA. Translation: AAQ86936.1.
AY311404 Genomic DNA. Translation: AAQ86937.1.
AK144158 mRNA. Translation: BAE25738.1. Frameshift.
AK150314 mRNA. Translation: BAE29460.1.
AK154334 mRNA. Translation: BAE32520.1.
CH466617 Genomic DNA. Translation: EDL05303.1.
BC117014 mRNA. Translation: AAI17015.1.
BC117016 mRNA. Translation: AAI17017.1.
CCDSiCCDS19417.1.
RefSeqiNP_976065.1. NM_203320.3.
UniGeneiMm.244289.

Genome annotation databases

EnsembliENSMUST00000031326; ENSMUSP00000031326; ENSMUSG00000029379.
GeneIDi330122.
KEGGimmu:330122.
UCSCiuc008ybj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY311403 mRNA. Translation: AAQ86936.1.
AY311404 Genomic DNA. Translation: AAQ86937.1.
AK144158 mRNA. Translation: BAE25738.1. Frameshift.
AK150314 mRNA. Translation: BAE29460.1.
AK154334 mRNA. Translation: BAE32520.1.
CH466617 Genomic DNA. Translation: EDL05303.1.
BC117014 mRNA. Translation: AAI17015.1.
BC117016 mRNA. Translation: AAI17017.1.
CCDSiCCDS19417.1.
RefSeqiNP_976065.1. NM_203320.3.
UniGeneiMm.244289.

3D structure databases

ProteinModelPortaliQ6W5C0.
SMRiQ6W5C0. Positions 28-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031326.

PTM databases

iPTMnetiQ6W5C0.
PhosphoSiteiQ6W5C0.

Proteomic databases

PaxDbiQ6W5C0.
PRIDEiQ6W5C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031326; ENSMUSP00000031326; ENSMUSG00000029379.
GeneIDi330122.
KEGGimmu:330122.
UCSCiuc008ybj.2. mouse.

Organism-specific databases

CTDi2921.
MGIiMGI:3037818. Cxcl3.

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ6W5C0.
KOiK05505.
OMAiEVCLNPQ.
OrthoDBiEOG7NSB57.
PhylomeDBiQ6W5C0.
TreeFamiTF333433.

Miscellaneous databases

PROiQ6W5C0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6W5C0.
GenevisibleiQ6W5C0. MM.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals."
    Nolan K.F., Strong V., Soler D., Fairchild P.J., Cobbold S.P., Croxton R., Gonzalo J.-A., Rubio A., Wells M., Waldmann H.
    J. Immunol. 172:2201-2209(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION.
    Strain: 129/Sv X 129SvCpImported and CBA/CaImported.
    Tissue: Dendritic cellImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and NODImported.
    Tissue: Bone marrow macrophageImported and Dendritic cellImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCXCL3_MOUSE
AccessioniPrimary (citable) accession number: Q6W5C0
Secondary accession number(s): Q3UNK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.