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Protein

C-X-C motif chemokine 3

Gene

Cxcl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion.By similarity1 Publication

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR chemokine receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 3
Alternative name(s):
Dendritic cell inflammatory protein 11 Publication
Gene namesi
Name:Cxcl3Imported
Synonyms:Dcip1Imported, Gm1960Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3037818. Cxcl3.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_500009163632 – 100C-X-C motif chemokine 3By similarityAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 62By similarity
Disulfide bondi38 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6W5C0.
PRIDEiQ6W5C0.

PTM databases

iPTMnetiQ6W5C0.
PhosphoSitePlusiQ6W5C0.

Expressioni

Inductioni

By lipopolysaccharide.1 Publication

Gene expression databases

BgeeiENSMUSG00000029379.
GenevisibleiQ6W5C0. MM.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR chemokine receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031326.

Structurei

3D structure databases

ProteinModelPortaliQ6W5C0.
SMRiQ6W5C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ6W5C0.
KOiK05505.
OMAiEVCLNPQ.
OrthoDBiEOG091G0XS0.
PhylomeDBiQ6W5C0.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6W5C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPTCRLLS AALVLLLLLA TNHQATGAVV ASELRCQCLN TLPRVDFETI
60 70 80 90 100
QSLTVTPPGP HCTQTEVIAT LKDGQEVCLN PQGPRLQIII KKILKSGKSS
Length:100
Mass (Da):10,686
Last modified:July 5, 2004 - v1
Checksum:i292AE7DA28DE525C
GO

Sequence cautioni

The sequence BAE25738 differs from that shown. Reason: Frameshift at position 78.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY311403 mRNA. Translation: AAQ86936.1.
AY311404 Genomic DNA. Translation: AAQ86937.1.
AK144158 mRNA. Translation: BAE25738.1. Frameshift.
AK150314 mRNA. Translation: BAE29460.1.
AK154334 mRNA. Translation: BAE32520.1.
CH466617 Genomic DNA. Translation: EDL05303.1.
BC117014 mRNA. Translation: AAI17015.1.
BC117016 mRNA. Translation: AAI17017.1.
CCDSiCCDS19417.1.
RefSeqiNP_976065.1. NM_203320.3.
UniGeneiMm.244289.

Genome annotation databases

EnsembliENSMUST00000031326; ENSMUSP00000031326; ENSMUSG00000029379.
GeneIDi330122.
KEGGimmu:330122.
UCSCiuc008ybj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY311403 mRNA. Translation: AAQ86936.1.
AY311404 Genomic DNA. Translation: AAQ86937.1.
AK144158 mRNA. Translation: BAE25738.1. Frameshift.
AK150314 mRNA. Translation: BAE29460.1.
AK154334 mRNA. Translation: BAE32520.1.
CH466617 Genomic DNA. Translation: EDL05303.1.
BC117014 mRNA. Translation: AAI17015.1.
BC117016 mRNA. Translation: AAI17017.1.
CCDSiCCDS19417.1.
RefSeqiNP_976065.1. NM_203320.3.
UniGeneiMm.244289.

3D structure databases

ProteinModelPortaliQ6W5C0.
SMRiQ6W5C0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031326.

PTM databases

iPTMnetiQ6W5C0.
PhosphoSitePlusiQ6W5C0.

Proteomic databases

PaxDbiQ6W5C0.
PRIDEiQ6W5C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031326; ENSMUSP00000031326; ENSMUSG00000029379.
GeneIDi330122.
KEGGimmu:330122.
UCSCiuc008ybj.2. mouse.

Organism-specific databases

CTDi2921.
MGIiMGI:3037818. Cxcl3.

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ6W5C0.
KOiK05505.
OMAiEVCLNPQ.
OrthoDBiEOG091G0XS0.
PhylomeDBiQ6W5C0.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ6W5C0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029379.
GenevisibleiQ6W5C0. MM.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL3_MOUSE
AccessioniPrimary (citable) accession number: Q6W5C0
Secondary accession number(s): Q3UNK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.