ID   MUC6_HUMAN              Reviewed;        2439 AA.
AC   Q6W4X9; O15329; Q14394; Q2TUQ5; Q4L207; Q8N8I1; Q8NAK1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 3.
DT   27-MAR-2024, entry version 143.
DE   RecName: Full=Mucin-6;
DE            Short=MUC-6;
DE   AltName: Full=Gastric mucin-6;
DE   Flags: Precursor;
GN   Name=MUC6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-1570.
RX   PubMed=15081123; DOI=10.1016/j.ygeno.2003.11.003;
RA   Rousseau K., Byrne C., Kim Y.S., Gum J.R. Jr., Swallow D.M., Toribara N.W.;
RT   "The complete genomic organization of the human MUC6 and MUC2 mucin
RT   genes.";
RL   Genomics 83:936-939(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.
RA   van Seuningen I.;
RT   "Muc6 mucin exon1-exon3.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-116.
RA   van Seuningen I., Desseyn J.-L.;
RT   "Promotor characterization of the human MUC6.";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1785-1998, AND VARIANT THR-1794.
RC   TISSUE=Stomach;
RX   PubMed=7680650; DOI=10.1016/s0021-9258(18)53402-5;
RA   Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W.,
RA   Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.;
RT   "Human gastric mucin. Identification of a unique species by expression
RT   cloning.";
RL   J. Biol. Chem. 268:5879-5885(1993).
RN   [6]
RP   SEQUENCE REVISION TO 1954-1998.
RA   Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W.,
RA   Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1843-2439.
RC   TISSUE=Prostate;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 2022-2439, AND SUBUNIT.
RX   PubMed=9195947; DOI=10.1074/jbc.272.26.16398;
RA   Toribara N.W., Ho S.B., Gum E., Gum J.R. Jr., Lau P., Kim Y.S.;
RT   "The carboxyl-terminal sequence of the human secretory mucin, MUC6.
RT   Analysis of the primary amino acid sequence.";
RL   J. Biol. Chem. 272:16398-16403(1997).
RN   [9]
RP   TISSUE SPECIFICITY, AND POLYMORPHISM.
RX   PubMed=9422745; DOI=10.1074/jbc.273.2.881;
RA   Debailleul V., Laine A., Huet G., Mathon P., d'Hooghe M.C., Aubert J.-P.,
RA   Porchet N.;
RT   "Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable
RT   and extremely large mRNAs and exhibit a variable length polymorphism. An
RT   improved method to analyze large mRNAs.";
RL   J. Biol. Chem. 273:881-890(1998).
RN   [10]
RP   TISSUE SPECIFICITY, FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=10209489;
RX   DOI=10.1002/(sici)1096-9896(199812)186:4<398::aid-path192>3.0.co;2-x;
RA   Bartman A.E., Buisine M.-P., Aubert J.-P., Niehans G.A., Toribara N.W.,
RA   Kim Y.S., Kelly E.J., Crabtree J.E., Ho S.B.;
RT   "The MUC6 secretory mucin gene is expressed in a wide variety of epithelial
RT   tissues.";
RL   J. Pathol. 186:398-405(1998).
RN   [11]
RP   FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=10330458; DOI=10.1177/002215549904700611;
RA   Reid C.J., Harris A.;
RT   "Expression of the MUC 6 mucin gene in development of the human kidney and
RT   male genital ducts.";
RL   J. Histochem. Cytochem. 47:817-822(1999).
RN   [12]
RP   FUNCTION, TISSUE SPECIFICITY, AND GLYCOSYLATION.
RX   PubMed=11988092; DOI=10.1042/bj3640191;
RA   Nordman H., Davies J.R., Lindell G., de Bolos C., Real F., Carlstedt I.;
RT   "Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size,
RT   glycosylation and tissue distribution.";
RL   Biochem. J. 364:191-200(2002).
RN   [13]
RP   TISSUE SPECIFICITY.
RX   PubMed=15280409; DOI=10.1136/jcp.2003.015487;
RA   Xia H.H.-X., Yang Y., Lam S.K., Wong W.M., Leung S.Y., Yuen S.T., Elia G.,
RA   Wright N.A., Wong B.C.-Y.;
RT   "Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in
RT   Helicobacter pylori infected gastric antrum, incisura, and body and its
RT   association with antralisation.";
RL   J. Clin. Pathol. 57:861-866(2004).
RN   [14]
RP   INDUCTION.
RX   PubMed=15979574; DOI=10.1016/j.bbrc.2005.06.037;
RA   Sakai H., Jinawath A., Yamaoka S., Yuasa Y.;
RT   "Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors.";
RL   Biochem. Biophys. Res. Commun. 333:1254-1260(2005).
CC   -!- FUNCTION: May provide a mechanism for modulation of the composition of
CC       the protective mucus layer related to acid secretion or the presence of
CC       bacteria and noxious agents in the lumen. Plays an important role in
CC       the cytoprotection of epithelial surfaces and are used as tumor markers
CC       in a variety of cancers. May play a role in epithelial organogenesis.
CC       {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458,
CC       ECO:0000269|PubMed:11988092}.
CC   -!- SUBUNIT: Multimer; disulfide-linked. {ECO:0000269|PubMed:9195947}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the regenerative zone of gastric
CC       antrum, gastric body mucosa and gastric incisura mucosa. Expressed in
CC       the deeper mucous glands of gastric antrum. Overexpressed in
CC       Helicobacter pylori infected gastric epithelium. Highly expressed in
CC       duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic
CC       centroacinar cells and ducts, and periductal glands of the common bile
CC       duct. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458,
CC       ECO:0000269|PubMed:11988092, ECO:0000269|PubMed:15280409,
CC       ECO:0000269|PubMed:9422745}.
CC   -!- DEVELOPMENTAL STAGE: Early expressed in fetal development and was
CC       observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in
CC       gastric glands at 20 weeks of gestation. Expressed transiently in the
CC       nephrogenic zone of the kidney in the early mid-trimester of
CC       development. Detected in the epithelium of ureteric buds at 13 weeks
CC       and at lower levels from 17 to 23 weeks of gestation.
CC       {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458}.
CC   -!- INDUCTION: Up-regulated by NFKB1. Repressed by mithramycin A which is
CC       an inhibitor of binding of transcription factors.
CC       {ECO:0000269|PubMed:15979574}.
CC   -!- PTM: O-glycosylated. {ECO:0000269|PubMed:11988092}.
CC   -!- POLYMORPHISM: The number of repeats is highly polymorphic and varies
CC       among different alleles. These repeats are very similar but not
CC       identical.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK092533; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC04860.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Mucin database;
CC       URL="http://www.medkem.gu.se/mucinbiology/databases/";
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="https://atlasgeneticsoncology.org/gene/44115/MUC6";
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DR   EMBL; AC139749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY312160; AAQ82434.1; -; mRNA.
DR   EMBL; AY458429; AAS13634.1; -; mRNA.
DR   EMBL; AY500284; AAS76674.1; -; Genomic_DNA.
DR   EMBL; L07517; AAA35866.2; -; mRNA.
DR   EMBL; AK092533; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK096772; BAC04860.1; ALT_INIT; mRNA.
DR   EMBL; U97698; AAC51370.1; -; mRNA.
DR   CCDS; CCDS44513.1; -.
DR   PIR; A46629; A46629.
DR   RefSeq; NP_005952.2; NM_005961.2.
DR   AlphaFoldDB; Q6W4X9; -.
DR   SMR; Q6W4X9; -.
DR   BioGRID; 110675; 4.
DR   STRING; 9606.ENSP00000406861; -.
DR   MEROPS; I08.952; -.
DR   MEROPS; I08.955; -.
DR   GlyConnect; 1521; 5 N-Linked glycans (3 sites).
DR   GlyCosmos; Q6W4X9; 8 sites, 7 glycans.
DR   GlyGen; Q6W4X9; 8 sites, 7 N-linked glycans (6 sites).
DR   iPTMnet; Q6W4X9; -.
DR   PhosphoSitePlus; Q6W4X9; -.
DR   BioMuta; MUC6; -.
DR   DMDM; 332278200; -.
DR   jPOST; Q6W4X9; -.
DR   MassIVE; Q6W4X9; -.
DR   PaxDb; 9606-ENSP00000406861; -.
DR   PeptideAtlas; Q6W4X9; -.
DR   ProteomicsDB; 67744; -.
DR   Antibodypedia; 22789; 408 antibodies from 23 providers.
DR   DNASU; 4588; -.
DR   Ensembl; ENST00000421673.7; ENSP00000406861.2; ENSG00000184956.16.
DR   GeneID; 4588; -.
DR   KEGG; hsa:4588; -.
DR   MANE-Select; ENST00000421673.7; ENSP00000406861.2; NM_005961.3; NP_005952.2.
DR   UCSC; uc001lsw.3; human.
DR   AGR; HGNC:7517; -.
DR   DisGeNET; 4588; -.
DR   GeneCards; MUC6; -.
DR   HGNC; HGNC:7517; MUC6.
DR   HPA; ENSG00000184956; Group enriched (pancreas, stomach).
DR   MalaCards; MUC6; -.
DR   MIM; 158374; gene.
DR   neXtProt; NX_Q6W4X9; -.
DR   OpenTargets; ENSG00000184956; -.
DR   VEuPathDB; HostDB:ENSG00000184956; -.
DR   eggNOG; KOG1216; Eukaryota.
DR   GeneTree; ENSGT00940000161708; -.
DR   HOGENOM; CLU_000076_1_0_1; -.
DR   InParanoid; Q6W4X9; -.
DR   OMA; GSNIEGC; -.
DR   OrthoDB; 5398470at2759; -.
DR   PhylomeDB; Q6W4X9; -.
DR   TreeFam; TF300299; -.
DR   PathwayCommons; Q6W4X9; -.
DR   Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC.
DR   Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS.
DR   Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1.
DR   Reactome; R-HSA-5621480; Dectin-2 family.
DR   Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR   Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR   SignaLink; Q6W4X9; -.
DR   BioGRID-ORCS; 4588; 21 hits in 1138 CRISPR screens.
DR   GeneWiki; MUC6; -.
DR   GenomeRNAi; 4588; -.
DR   Pharos; Q6W4X9; Tbio.
DR   PRO; PR:Q6W4X9; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q6W4X9; Protein.
DR   Bgee; ENSG00000184956; Expressed in body of pancreas and 93 other cell types or tissues.
DR   ExpressionAtlas; Q6W4X9; baseline and differential.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; NAS:UniProtKB.
DR   GO; GO:0030277; P:maintenance of gastrointestinal epithelium; NAS:UniProtKB.
DR   CDD; cd19941; TIL; 3.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR   PANTHER; PTHR11339:SF264; MUCIN-6; 1.
DR   Pfam; PF08742; C8; 3.
DR   Pfam; PF01826; TIL; 3.
DR   Pfam; PF00094; VWD; 3.
DR   SMART; SM00832; C8; 3.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00215; VWC_out; 2.
DR   SMART; SM00216; VWD; 3.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS51233; VWFD; 3.
DR   Genevisible; Q6W4X9; HS.
PE   1: Evidence at protein level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..2439
FT                   /note="Mucin-6"
FT                   /id="PRO_0000259496"
FT   DOMAIN          43..214
FT                   /note="VWFD 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          302..357
FT                   /note="TIL"
FT   DOMAIN          395..579
FT                   /note="VWFD 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          866..1038
FT                   /note="VWFD 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   REPEAT          1561..1738
FT                   /note="1; truncated"
FT   REPEAT          1785..1953
FT                   /note="2"
FT   DOMAIN          2349..2438
FT                   /note="CTCK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   REGION          1202..1455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1471..1626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1607..1953
FT                   /note="Approximate repeats"
FT   REGION          1642..1834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1868..1983
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2033..2077
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2090..2196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2233..2278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2323..2348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1212..1367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1380..1455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1471..1570
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1579..1626
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        486
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        659
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        975
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        45..176
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        67..213
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        397..533
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        419..578
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        868..1002
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        890..1037
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        899..999
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        917..924
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2349..2396
FT                   /evidence="ECO:0000250"
FT   DISULFID        2363..2410
FT                   /evidence="ECO:0000250"
FT   DISULFID        2372..2430
FT                   /evidence="ECO:0000250"
FT   DISULFID        2376..2432
FT                   /evidence="ECO:0000250"
FT   DISULFID        ?..2437
FT                   /evidence="ECO:0000250"
FT   VARIANT         1578
FT                   /note="P -> S (in dbSNP:rs10736904)"
FT                   /id="VAR_059542"
FT   VARIANT         1794
FT                   /note="P -> T (in dbSNP:rs35549382)"
FT                   /evidence="ECO:0000269|PubMed:7680650"
FT                   /id="VAR_061488"
FT   CONFLICT        81
FT                   /note="T -> S (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        231
FT                   /note="I -> G (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        271
FT                   /note="C -> Y (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        289..291
FT                   /note="RRW -> AL (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        322..323
FT                   /note="PQ -> SE (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        341
FT                   /note="V -> D (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        569
FT                   /note="A -> D (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        614
FT                   /note="F -> I (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        619
FT                   /note="V -> M (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        757
FT                   /note="P -> L (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        818
FT                   /note="D -> Y (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        903
FT                   /note="D -> Y (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1472
FT                   /note="T -> S (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1544
FT                   /note="T -> S (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1558
FT                   /note="V -> M (in Ref. 2; AAQ82434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1806..1807
FT                   /note="TT -> SS (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1815
FT                   /note="V -> M (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1833
FT                   /note="H -> E (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1842
FT                   /note="S -> P (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1857
FT                   /note="I -> T (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1861
FT                   /note="T -> A (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1872
FT                   /note="M -> T (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1880..1885
FT                   /note="PTTIKA -> LTTLMN (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1895
FT                   /note="M -> V (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1905..1906
FT                   /note="SP -> AA (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1919..1920
FT                   /note="PY -> HS (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1934
FT                   /note="S -> A (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1937..1951
FT                   /note="NITPKHTSTGTRTPV -> KITTNPTSIGSSTPM (in Ref. 5;
FT                   AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1940
FT                   /note="P -> F (in Ref. 6; BAC04860)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1958
FT                   /note="S -> T (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1963
FT                   /note="P -> T (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1972
FT                   /note="P -> S (in Ref. 5; AAA35866)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2091
FT                   /note="S -> SSWS (in Ref. 8; AAC51370)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2129
FT                   /note="S -> F (in Ref. 6; BAC04860)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2190..2192
FT                   /note="ASV -> GSG (in Ref. 8; AAC51370)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2272
FT                   /note="R -> G (in Ref. 8; AAC51370)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2318
FT                   /note="F -> S (in Ref. 8; AAC51370)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2439 AA;  257051 MW;  4A1A7E6A7C30F895 CRC64;
     MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA GHFSTFDHHV
     YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE LGASVVTVSE AIISVKDIGV
     ISLPYTSNGL QITPFGQSVR LVAKQLELEL EVVWGPDSHL MVLVERKYMG QMCGLCGNFD
     GKVTNEFVSE EGKFLEPHKF AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA
     PECSVSKEPF VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG
     QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT CVPVTQCPCV
     LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE GGSFVTTFDA RPYRFHGTCT
     YILLQSPQLP EDGALMAVYD KSGVSHSETS LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL
     PYKTRNITVF RQTSTHLQMA TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT
     TDDFTTSMGI AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT
     VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL WGWRSSVDNC
     TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG CNCPDGTYLN QKGECVRKAQ
     CPCILEGYKF ILAEQSTVIN GITCHCINGR LSCPQRPQMF LASCQAPKTF KSCSQSSENK
     FGAACAPTCQ MLATGVACVP TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA
     ELHTDCRTCS CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG
     VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE PHVQLGVTPG
     ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG LCGNFNGNMK DDFETRSRYV
     ASSELELVNS WKESPLCGDV SFVTDPCSLN AFRRSWAERK CSVINSQTFA TCHSKVYHLP
     YYEACVRDAC GCDSGGDCEC LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD
     GHGEYQYTQE ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT
     TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT QTPLLPATLT
     SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT VTQATTRATA STASPATTST
     AQSTTRTTMT LPTPATSGTS PTLPKSTNQE LPGTTATQTT GPRPTPASTT GPTTPQPGQP
     TRPTATETTQ TRTTTEYTTP QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE
     TTLPTHVPPF STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP
     PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT STRTRTPVAH
     TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT TYPTPSHPQT TLPTHVPPFS
     TSLVTPSTHT VITPTHAQMA TSASIHSMPT GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ
     ALSSLNTAKT STSLHSHTSS THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF
     STAKTSTSLH SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH
     SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP STHTVIIPTH
     TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS GTSQSPSSFS TAKTSTSLPY
     HTSSTHHPEV TPTSTTNITP KHTSTGTRTP VAHTTSASSS RLPTPFTTHS PPTGSSPFSS
     TGPMTATSFQ TTTTYPTPSH PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS
     TPTGTVPPPT TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS
     RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS SPQTSSPSVG
     TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS SPAASTTIRA TLPHTISSPF
     TLSALLPIST VTVSPTPSSH LASSTIAFPS TPRTTASTHT APAFSSQSTT SRSTSLTTRV
     PTSGFVSLTS GVTGIPTSPV TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT
     PTPTSPGVCS VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH
     SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD
//