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Q6W4X9

- MUC6_HUMAN

UniProt

Q6W4X9 - MUC6_HUMAN

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Protein

Mucin-6

Gene
MUC6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.3 Publications

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. maintenance of gastrointestinal epithelium Source: UniProtKB
  3. O-glycan processing Source: Reactome
  4. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-6
Short name:
MUC-6
Alternative name(s):
Gastric mucin-6
Gene namesi
Name:MUC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7517. MUC6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 24392417Mucin-6PRO_0000259496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 2437 By similarity
Disulfide bondi67 ↔ 75 By similarity
Glycosylationi268 – 2681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi486 – 4861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi659 – 6591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi975 – 9751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1179 – 11791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2349 ↔ 2396 By similarity
Disulfide bondi2363 ↔ 2410 By similarity
Disulfide bondi2372 ↔ 2430 By similarity
Disulfide bondi2376 ↔ 2432 By similarity

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6W4X9.
PRIDEiQ6W4X9.

PTM databases

PhosphoSiteiQ6W4X9.

Expressioni

Tissue specificityi

Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.5 Publications

Developmental stagei

Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.2 Publications

Inductioni

Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.1 Publication

Gene expression databases

ArrayExpressiQ6W4X9.
BgeeiQ6W4X9.
CleanExiHS_MUC6.
GenevestigatoriQ6W4X9.

Organism-specific databases

HPAiCAB002165.

Interactioni

Subunit structurei

Multimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000406861.

Structurei

3D structure databases

ProteinModelPortaliQ6W4X9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 246203VWFD 1Add
BLAST
Domaini302 – 35756TILAdd
BLAST
Domaini396 – 608213VWFD 2Add
BLAST
Domaini867 – 1075209VWFD 3Add
BLAST
Repeati1561 – 17381781; truncatedAdd
BLAST
Repeati1785 – 19531692Add
BLAST
Domaini2349 – 243890CTCKAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1607 – 1953347Approximate repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1241 – 1664424Pro-richAdd
BLAST
Compositional biasi1246 – 23441099Thr-richAdd
BLAST
Compositional biasi2069 – 2275207Ser-richAdd
BLAST

Sequence similaritiesi

Contains 3 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG081998.
InParanoidiQ6W4X9.
OMAiHTPLTSH.
OrthoDBiEOG73V6J9.
PhylomeDBiQ6W4X9.
TreeFamiTF300299.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTiSM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6W4X9-1 [UniParc]FASTAAdd to Basket

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MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA     50
GHFSTFDHHV YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE 100
LGASVVTVSE AIISVKDIGV ISLPYTSNGL QITPFGQSVR LVAKQLELEL 150
EVVWGPDSHL MVLVERKYMG QMCGLCGNFD GKVTNEFVSE EGKFLEPHKF 200
AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA PECSVSKEPF 250
VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG 300
QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT 350
CVPVTQCPCV LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE 400
GGSFVTTFDA RPYRFHGTCT YILLQSPQLP EDGALMAVYD KSGVSHSETS 450
LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL PYKTRNITVF RQTSTHLQMA 500
TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT TDDFTTSMGI 550
AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT 600
VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL 650
WGWRSSVDNC TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG 700
CNCPDGTYLN QKGECVRKAQ CPCILEGYKF ILAEQSTVIN GITCHCINGR 750
LSCPQRPQMF LASCQAPKTF KSCSQSSENK FGAACAPTCQ MLATGVACVP 800
TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA ELHTDCRTCS 850
CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG 900
VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE 950
PHVQLGVTPG ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG 1000
LCGNFNGNMK DDFETRSRYV ASSELELVNS WKESPLCGDV SFVTDPCSLN 1050
AFRRSWAERK CSVINSQTFA TCHSKVYHLP YYEACVRDAC GCDSGGDCEC 1100
LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD GHGEYQYTQE 1150
ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT 1200
TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT 1250
QTPLLPATLT SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT 1300
VTQATTRATA STASPATTST AQSTTRTTMT LPTPATSGTS PTLPKSTNQE 1350
LPGTTATQTT GPRPTPASTT GPTTPQPGQP TRPTATETTQ TRTTTEYTTP 1400
QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE TTLPTHVPPF 1450
STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP 1500
PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT 1550
STRTRTPVAH TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT 1600
TYPTPSHPQT TLPTHVPPFS TSLVTPSTHT VITPTHAQMA TSASIHSMPT 1650
GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ ALSSLNTAKT STSLHSHTSS 1700
THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF STAKTSTSLH 1750
SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH 1800
SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP 1850
STHTVIIPTH TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS 1900
GTSQSPSSFS TAKTSTSLPY HTSSTHHPEV TPTSTTNITP KHTSTGTRTP 1950
VAHTTSASSS RLPTPFTTHS PPTGSSPFSS TGPMTATSFQ TTTTYPTPSH 2000
PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS TPTGTVPPPT 2050
TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS 2100
RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS 2150
SPQTSSPSVG TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS 2200
SPAASTTIRA TLPHTISSPF TLSALLPIST VTVSPTPSSH LASSTIAFPS 2250
TPRTTASTHT APAFSSQSTT SRSTSLTTRV PTSGFVSLTS GVTGIPTSPV 2300
TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT PTPTSPGVCS 2350
VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH 2400
SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD 2439
Length:2,439
Mass (Da):257,051
Last modified:May 3, 2011 - v3
Checksum:i4A1A7E6A7C30F895
GO

Sequence cautioni

The sequence BAC04860.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AK092533 differs from that shown. Reason: Erroneous termination at position 2357. Translated as Glu.

Polymorphismi

The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1578 – 15781P → S.
Corresponds to variant rs10736904 [ dbSNP | Ensembl ].
VAR_059542
Natural varianti1794 – 17941P → T.1 Publication
Corresponds to variant rs35549382 [ dbSNP | Ensembl ].
VAR_061488

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811T → S in AAQ82434. 1 Publication
Sequence conflicti231 – 2311I → G in AAQ82434. 1 Publication
Sequence conflicti271 – 2711C → Y in AAQ82434. 1 Publication
Sequence conflicti289 – 2913RRW → AL in AAQ82434. 1 Publication
Sequence conflicti322 – 3232PQ → SE in AAQ82434. 1 Publication
Sequence conflicti341 – 3411V → D in AAQ82434. 1 Publication
Sequence conflicti569 – 5691A → D in AAQ82434. 1 Publication
Sequence conflicti614 – 6141F → I in AAQ82434. 1 Publication
Sequence conflicti619 – 6191V → M in AAQ82434. 1 Publication
Sequence conflicti757 – 7571P → L in AAQ82434. 1 Publication
Sequence conflicti818 – 8181D → Y in AAQ82434. 1 Publication
Sequence conflicti903 – 9031D → Y in AAQ82434. 1 Publication
Sequence conflicti1472 – 14721T → S in AAQ82434. 1 Publication
Sequence conflicti1544 – 15441T → S in AAQ82434. 1 Publication
Sequence conflicti1558 – 15581V → M in AAQ82434. 1 Publication
Sequence conflicti1806 – 18072TT → SS in AAA35866. 1 Publication
Sequence conflicti1815 – 18151V → M in AAA35866. 1 Publication
Sequence conflicti1833 – 18331H → E in AAA35866. 1 Publication
Sequence conflicti1842 – 18421S → P in AAA35866. 1 Publication
Sequence conflicti1857 – 18571I → T in AAA35866. 1 Publication
Sequence conflicti1861 – 18611T → A in AAA35866. 1 Publication
Sequence conflicti1872 – 18721M → T in AAA35866. 1 Publication
Sequence conflicti1880 – 18856PTTIKA → LTTLMN in AAA35866. 1 Publication
Sequence conflicti1895 – 18951M → V in AAA35866. 1 Publication
Sequence conflicti1905 – 19062SP → AA in AAA35866. 1 Publication
Sequence conflicti1919 – 19202PY → HS in AAA35866. 1 Publication
Sequence conflicti1934 – 19341S → A in AAA35866. 1 Publication
Sequence conflicti1937 – 195115NITPK…TRTPV → KITTNPTSIGSSTPM in AAA35866. 1 PublicationAdd
BLAST
Sequence conflicti1940 – 19401P → F in BAC04860. 1 Publication
Sequence conflicti1958 – 19581S → T in AAA35866. 1 Publication
Sequence conflicti1963 – 19631P → T in AAA35866. 1 Publication
Sequence conflicti1972 – 19721P → S in AAA35866. 1 Publication
Sequence conflicti2091 – 20911S → SSWS in AAC51370. 1 Publication
Sequence conflicti2129 – 21291S → F in BAC04860. 1 Publication
Sequence conflicti2190 – 21923ASV → GSG in AAC51370. 1 Publication
Sequence conflicti2272 – 22721R → G in AAC51370. 1 Publication
Sequence conflicti2318 – 23181F → S in AAC51370. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC139749 Genomic DNA. No translation available.
AY312160 mRNA. Translation: AAQ82434.1.
AY458429 mRNA. Translation: AAS13634.1.
AY500284 Genomic DNA. Translation: AAS76674.1.
L07517 mRNA. Translation: AAA35866.2.
AK092533 mRNA. No translation available.
AK096772 mRNA. Translation: BAC04860.1. Different initiation.
U97698 mRNA. Translation: AAC51370.1.
CCDSiCCDS44513.1.
PIRiA46629.
RefSeqiNP_005952.2. NM_005961.2.
UniGeneiHs.528432.

Genome annotation databases

EnsembliENST00000421673; ENSP00000406861; ENSG00000184956.
GeneIDi4588.
KEGGihsa:4588.
UCSCiuc001lsw.2. human.

Polymorphism databases

DMDMi332278200.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC139749 Genomic DNA. No translation available.
AY312160 mRNA. Translation: AAQ82434.1 .
AY458429 mRNA. Translation: AAS13634.1 .
AY500284 Genomic DNA. Translation: AAS76674.1 .
L07517 mRNA. Translation: AAA35866.2 .
AK092533 mRNA. No translation available.
AK096772 mRNA. Translation: BAC04860.1 . Different initiation.
U97698 mRNA. Translation: AAC51370.1 .
CCDSi CCDS44513.1.
PIRi A46629.
RefSeqi NP_005952.2. NM_005961.2.
UniGenei Hs.528432.

3D structure databases

ProteinModelPortali Q6W4X9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000406861.

Protein family/group databases

MEROPSi I08.952.

PTM databases

PhosphoSitei Q6W4X9.

Polymorphism databases

DMDMi 332278200.

Proteomic databases

PaxDbi Q6W4X9.
PRIDEi Q6W4X9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421673 ; ENSP00000406861 ; ENSG00000184956 .
GeneIDi 4588.
KEGGi hsa:4588.
UCSCi uc001lsw.2. human.

Organism-specific databases

CTDi 4588.
GeneCardsi GC11M001002.
H-InvDB HIX0023085.
HGNCi HGNC:7517. MUC6.
HPAi CAB002165.
MIMi 158374. gene.
neXtProti NX_Q6W4X9.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG081998.
InParanoidi Q6W4X9.
OMAi HTPLTSH.
OrthoDBi EOG73V6J9.
PhylomeDBi Q6W4X9.
TreeFami TF300299.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

GeneWikii MUC6.
GenomeRNAii 4588.
NextBioi 17636.
PROi Q6W4X9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6W4X9.
Bgeei Q6W4X9.
CleanExi HS_MUC6.
Genevestigatori Q6W4X9.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 3 hits.
[Graphical view ]
SMARTi SM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The complete genomic organization of the human MUC6 and MUC2 mucin genes."
    Rousseau K., Byrne C., Kim Y.S., Gum J.R. Jr., Swallow D.M., Toribara N.W.
    Genomics 83:936-939(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1570.
  3. "Muc6 mucin exon1-exon3."
    van Seuningen I.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.
  4. "Promotor characterization of the human MUC6."
    van Seuningen I., Desseyn J.-L.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-116.
  5. "Human gastric mucin. Identification of a unique species by expression cloning."
    Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.
    J. Biol. Chem. 268:5879-5885(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1785-1998, VARIANT THR-1794.
    Tissue: Stomach.
  6. Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 1954-1998.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1843-2439.
    Tissue: Prostate.
  8. "The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence."
    Toribara N.W., Ho S.B., Gum E., Gum J.R. Jr., Lau P., Kim Y.S.
    J. Biol. Chem. 272:16398-16403(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2022-2439, SUBUNIT.
  9. "Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs."
    Debailleul V., Laine A., Huet G., Mathon P., d'Hooghe M.C., Aubert J.-P., Porchet N.
    J. Biol. Chem. 273:881-890(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, POLYMORPHISM.
  10. "The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues."
    Bartman A.E., Buisine M.-P., Aubert J.-P., Niehans G.A., Toribara N.W., Kim Y.S., Kelly E.J., Crabtree J.E., Ho S.B.
    J. Pathol. 186:398-405(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION, DEVELOPMENTAL STAGE.
  11. "Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts."
    Reid C.J., Harris A.
    J. Histochem. Cytochem. 47:817-822(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  12. "Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution."
    Nordman H., Davies J.R., Lindell G., de Bolos C., Real F., Carlstedt I.
    Biochem. J. 364:191-200(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION.
  13. "Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation."
    Xia H.H.-X., Yang Y., Lam S.K., Wong W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A., Wong B.C.-Y.
    J. Clin. Pathol. 57:861-866(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  14. "Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors."
    Sakai H., Jinawath A., Yamaoka S., Yuasa Y.
    Biochem. Biophys. Res. Commun. 333:1254-1260(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiMUC6_HUMAN
AccessioniPrimary (citable) accession number: Q6W4X9
Secondary accession number(s): O15329
, Q14394, Q2TUQ5, Q4L207, Q8N8I1, Q8NAK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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