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Q6W4X9

- MUC6_HUMAN

UniProt

Q6W4X9 - MUC6_HUMAN

Protein

Mucin-6

Gene

MUC6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 3 (03 May 2011)
      Previous versions | rss
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    Functioni

    May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.3 Publications

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. maintenance of gastrointestinal epithelium Source: UniProtKB
    3. O-glycan processing Source: Reactome
    4. post-translational protein modification Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Protein family/group databases

    MEROPSiI08.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-6
    Short name:
    MUC-6
    Alternative name(s):
    Gastric mucin-6
    Gene namesi
    Name:MUC6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7517. MUC6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. Golgi lumen Source: Reactome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 24392417Mucin-6PRO_0000259496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 2437By similarity
    Disulfide bondi67 ↔ 75By similarity
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi975 – 9751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1179 – 11791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2349 ↔ 2396By similarity
    Disulfide bondi2363 ↔ 2410By similarity
    Disulfide bondi2372 ↔ 2430By similarity
    Disulfide bondi2376 ↔ 2432By similarity

    Post-translational modificationi

    O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6W4X9.
    PRIDEiQ6W4X9.

    PTM databases

    PhosphoSiteiQ6W4X9.

    Expressioni

    Tissue specificityi

    Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.5 Publications

    Developmental stagei

    Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.2 Publications

    Inductioni

    Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.1 Publication

    Gene expression databases

    ArrayExpressiQ6W4X9.
    BgeeiQ6W4X9.
    CleanExiHS_MUC6.
    GenevestigatoriQ6W4X9.

    Organism-specific databases

    HPAiCAB002165.

    Interactioni

    Subunit structurei

    Multimer; disulfide-linked.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000406861.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6W4X9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 246203VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 35756TILAdd
    BLAST
    Domaini396 – 608213VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini867 – 1075209VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati1561 – 17381781; truncatedAdd
    BLAST
    Repeati1785 – 19531692Add
    BLAST
    Domaini2349 – 243890CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1607 – 1953347Approximate repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1241 – 1664424Pro-richAdd
    BLAST
    Compositional biasi1246 – 23441099Thr-richAdd
    BLAST
    Compositional biasi2069 – 2275207Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG081998.
    InParanoidiQ6W4X9.
    OMAiHTPLTSH.
    OrthoDBiEOG73V6J9.
    PhylomeDBiQ6W4X9.
    TreeFamiTF300299.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 3 hits.
    PF01826. TIL. 3 hits.
    PF00094. VWD. 3 hits.
    [Graphical view]
    SMARTiSM00832. C8. 3 hits.
    SM00041. CT. 1 hit.
    SM00216. VWD. 3 hits.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 3 hits.
    PROSITEiPS01225. CTCK_2. 1 hit.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6W4X9-1 [UniParc]FASTAAdd to Basket

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    MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA     50
    GHFSTFDHHV YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE 100
    LGASVVTVSE AIISVKDIGV ISLPYTSNGL QITPFGQSVR LVAKQLELEL 150
    EVVWGPDSHL MVLVERKYMG QMCGLCGNFD GKVTNEFVSE EGKFLEPHKF 200
    AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA PECSVSKEPF 250
    VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG 300
    QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT 350
    CVPVTQCPCV LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE 400
    GGSFVTTFDA RPYRFHGTCT YILLQSPQLP EDGALMAVYD KSGVSHSETS 450
    LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL PYKTRNITVF RQTSTHLQMA 500
    TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT TDDFTTSMGI 550
    AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT 600
    VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL 650
    WGWRSSVDNC TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG 700
    CNCPDGTYLN QKGECVRKAQ CPCILEGYKF ILAEQSTVIN GITCHCINGR 750
    LSCPQRPQMF LASCQAPKTF KSCSQSSENK FGAACAPTCQ MLATGVACVP 800
    TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA ELHTDCRTCS 850
    CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG 900
    VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE 950
    PHVQLGVTPG ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG 1000
    LCGNFNGNMK DDFETRSRYV ASSELELVNS WKESPLCGDV SFVTDPCSLN 1050
    AFRRSWAERK CSVINSQTFA TCHSKVYHLP YYEACVRDAC GCDSGGDCEC 1100
    LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD GHGEYQYTQE 1150
    ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT 1200
    TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT 1250
    QTPLLPATLT SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT 1300
    VTQATTRATA STASPATTST AQSTTRTTMT LPTPATSGTS PTLPKSTNQE 1350
    LPGTTATQTT GPRPTPASTT GPTTPQPGQP TRPTATETTQ TRTTTEYTTP 1400
    QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE TTLPTHVPPF 1450
    STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP 1500
    PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT 1550
    STRTRTPVAH TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT 1600
    TYPTPSHPQT TLPTHVPPFS TSLVTPSTHT VITPTHAQMA TSASIHSMPT 1650
    GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ ALSSLNTAKT STSLHSHTSS 1700
    THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF STAKTSTSLH 1750
    SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH 1800
    SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP 1850
    STHTVIIPTH TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS 1900
    GTSQSPSSFS TAKTSTSLPY HTSSTHHPEV TPTSTTNITP KHTSTGTRTP 1950
    VAHTTSASSS RLPTPFTTHS PPTGSSPFSS TGPMTATSFQ TTTTYPTPSH 2000
    PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS TPTGTVPPPT 2050
    TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS 2100
    RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS 2150
    SPQTSSPSVG TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS 2200
    SPAASTTIRA TLPHTISSPF TLSALLPIST VTVSPTPSSH LASSTIAFPS 2250
    TPRTTASTHT APAFSSQSTT SRSTSLTTRV PTSGFVSLTS GVTGIPTSPV 2300
    TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT PTPTSPGVCS 2350
    VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH 2400
    SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD 2439
    Length:2,439
    Mass (Da):257,051
    Last modified:May 3, 2011 - v3
    Checksum:i4A1A7E6A7C30F895
    GO

    Sequence cautioni

    The sequence BAC04860.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AK092533 differs from that shown. Reason: Erroneous termination at position 2357. Translated as Glu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811T → S in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti231 – 2311I → G in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti271 – 2711C → Y in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti289 – 2913RRW → AL in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti322 – 3232PQ → SE in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti341 – 3411V → D in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti569 – 5691A → D in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti614 – 6141F → I in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti619 – 6191V → M in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti757 – 7571P → L in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti818 – 8181D → Y in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti903 – 9031D → Y in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti1472 – 14721T → S in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti1544 – 15441T → S in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti1558 – 15581V → M in AAQ82434. (PubMed:15081123)Curated
    Sequence conflicti1806 – 18072TT → SS in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1815 – 18151V → M in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1833 – 18331H → E in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1842 – 18421S → P in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1857 – 18571I → T in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1861 – 18611T → A in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1872 – 18721M → T in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1880 – 18856PTTIKA → LTTLMN in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1895 – 18951M → V in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1905 – 19062SP → AA in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1919 – 19202PY → HS in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1934 – 19341S → A in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1937 – 195115NITPK…TRTPV → KITTNPTSIGSSTPM in AAA35866. (PubMed:7680650)CuratedAdd
    BLAST
    Sequence conflicti1940 – 19401P → F in BAC04860. 1 PublicationCurated
    Sequence conflicti1958 – 19581S → T in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1963 – 19631P → T in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti1972 – 19721P → S in AAA35866. (PubMed:7680650)Curated
    Sequence conflicti2091 – 20911S → SSWS in AAC51370. (PubMed:9195947)Curated
    Sequence conflicti2129 – 21291S → F in BAC04860. 1 PublicationCurated
    Sequence conflicti2190 – 21923ASV → GSG in AAC51370. (PubMed:9195947)Curated
    Sequence conflicti2272 – 22721R → G in AAC51370. (PubMed:9195947)Curated
    Sequence conflicti2318 – 23181F → S in AAC51370. (PubMed:9195947)Curated

    Polymorphismi

    The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1578 – 15781P → S.
    Corresponds to variant rs10736904 [ dbSNP | Ensembl ].
    VAR_059542
    Natural varianti1794 – 17941P → T.1 Publication
    Corresponds to variant rs35549382 [ dbSNP | Ensembl ].
    VAR_061488

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC139749 Genomic DNA. No translation available.
    AY312160 mRNA. Translation: AAQ82434.1.
    AY458429 mRNA. Translation: AAS13634.1.
    AY500284 Genomic DNA. Translation: AAS76674.1.
    L07517 mRNA. Translation: AAA35866.2.
    AK092533 mRNA. No translation available.
    AK096772 mRNA. Translation: BAC04860.1. Different initiation.
    U97698 mRNA. Translation: AAC51370.1.
    CCDSiCCDS44513.1.
    PIRiA46629.
    RefSeqiNP_005952.2. NM_005961.2.
    UniGeneiHs.528432.

    Genome annotation databases

    EnsembliENST00000421673; ENSP00000406861; ENSG00000184956.
    GeneIDi4588.
    KEGGihsa:4588.
    UCSCiuc001lsw.2. human.

    Polymorphism databases

    DMDMi332278200.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Mucin database
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC139749 Genomic DNA. No translation available.
    AY312160 mRNA. Translation: AAQ82434.1 .
    AY458429 mRNA. Translation: AAS13634.1 .
    AY500284 Genomic DNA. Translation: AAS76674.1 .
    L07517 mRNA. Translation: AAA35866.2 .
    AK092533 mRNA. No translation available.
    AK096772 mRNA. Translation: BAC04860.1 . Different initiation.
    U97698 mRNA. Translation: AAC51370.1 .
    CCDSi CCDS44513.1.
    PIRi A46629.
    RefSeqi NP_005952.2. NM_005961.2.
    UniGenei Hs.528432.

    3D structure databases

    ProteinModelPortali Q6W4X9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000406861.

    Protein family/group databases

    MEROPSi I08.952.

    PTM databases

    PhosphoSitei Q6W4X9.

    Polymorphism databases

    DMDMi 332278200.

    Proteomic databases

    PaxDbi Q6W4X9.
    PRIDEi Q6W4X9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000421673 ; ENSP00000406861 ; ENSG00000184956 .
    GeneIDi 4588.
    KEGGi hsa:4588.
    UCSCi uc001lsw.2. human.

    Organism-specific databases

    CTDi 4588.
    GeneCardsi GC11M001002.
    H-InvDB HIX0023085.
    HGNCi HGNC:7517. MUC6.
    HPAi CAB002165.
    MIMi 158374. gene.
    neXtProti NX_Q6W4X9.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG081998.
    InParanoidi Q6W4X9.
    OMAi HTPLTSH.
    OrthoDBi EOG73V6J9.
    PhylomeDBi Q6W4X9.
    TreeFami TF300299.

    Enzyme and pathway databases

    Reactomei REACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    GeneWikii MUC6.
    GenomeRNAii 4588.
    NextBioi 17636.
    PROi Q6W4X9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6W4X9.
    Bgeei Q6W4X9.
    CleanExi HS_MUC6.
    Genevestigatori Q6W4X9.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 3 hits.
    PF01826. TIL. 3 hits.
    PF00094. VWD. 3 hits.
    [Graphical view ]
    SMARTi SM00832. C8. 3 hits.
    SM00041. CT. 1 hit.
    SM00216. VWD. 3 hits.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 3 hits.
    PROSITEi PS01225. CTCK_2. 1 hit.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The complete genomic organization of the human MUC6 and MUC2 mucin genes."
      Rousseau K., Byrne C., Kim Y.S., Gum J.R. Jr., Swallow D.M., Toribara N.W.
      Genomics 83:936-939(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1570.
    3. "Muc6 mucin exon1-exon3."
      van Seuningen I.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.
    4. "Promotor characterization of the human MUC6."
      van Seuningen I., Desseyn J.-L.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-116.
    5. "Human gastric mucin. Identification of a unique species by expression cloning."
      Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.
      J. Biol. Chem. 268:5879-5885(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1785-1998, VARIANT THR-1794.
      Tissue: Stomach.
    6. Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 1954-1998.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1843-2439.
      Tissue: Prostate.
    8. "The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence."
      Toribara N.W., Ho S.B., Gum E., Gum J.R. Jr., Lau P., Kim Y.S.
      J. Biol. Chem. 272:16398-16403(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2022-2439, SUBUNIT.
    9. "Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs."
      Debailleul V., Laine A., Huet G., Mathon P., d'Hooghe M.C., Aubert J.-P., Porchet N.
      J. Biol. Chem. 273:881-890(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, POLYMORPHISM.
    10. "The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues."
      Bartman A.E., Buisine M.-P., Aubert J.-P., Niehans G.A., Toribara N.W., Kim Y.S., Kelly E.J., Crabtree J.E., Ho S.B.
      J. Pathol. 186:398-405(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION, DEVELOPMENTAL STAGE.
    11. "Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts."
      Reid C.J., Harris A.
      J. Histochem. Cytochem. 47:817-822(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    12. "Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution."
      Nordman H., Davies J.R., Lindell G., de Bolos C., Real F., Carlstedt I.
      Biochem. J. 364:191-200(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION.
    13. "Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation."
      Xia H.H.-X., Yang Y., Lam S.K., Wong W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A., Wong B.C.-Y.
      J. Clin. Pathol. 57:861-866(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    14. "Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors."
      Sakai H., Jinawath A., Yamaoka S., Yuasa Y.
      Biochem. Biophys. Res. Commun. 333:1254-1260(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiMUC6_HUMAN
    AccessioniPrimary (citable) accession number: Q6W4X9
    Secondary accession number(s): O15329
    , Q14394, Q2TUQ5, Q4L207, Q8N8I1, Q8NAK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 87 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3