Q6W4X9 (MUC6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mucin-6
Short name=MUC-6

Alternative name(s):
Gastric mucin-6

Gene names

Name:

MUC6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Ref.10 Ref.11 Ref.12
Subunit structure	Multimer; disulfide-linked. Ref.8
Subcellular location	Secreted.
Tissue specificity	Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13
Developmental stage	Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation. Ref.10 Ref.11
Induction	Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors. Ref.14
Post-translational modification	O-glycosylated. Ref.12
Polymorphism	The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.
Sequence similarities	Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 TIL (trypsin inhibitory-like) domain. Contains 3 VWFD domains.
Sequence caution	The sequence AK092533 differs from that shown. Reason: Erroneous termination at position 2357. Translated as Glu. The sequence BAC04860.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	O-glycan processing Traceable author statement. Source: Reactome maintenance of gastrointestinal epithelium Non-traceable author statement Ref.5. Source: UniProtKB post-translational protein modification Traceable author statement. Source: Reactome
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome extracellular region Non-traceable author statement. Source: UniProtKB
Molecular_function	extracellular matrix structural constituent Non-traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 2439	2417	Mucin-6		PRO_0000259496
Regions
	Domain	44 – 246	203	VWFD 1
	Domain	302 – 357	56	TIL
	Domain	396 – 608	213	VWFD 2
	Domain	867 – 1075	209	VWFD 3
	Repeat	1561 – 1738	178	1; truncated
	Repeat	1785 – 1953	169	2
	Domain	2349 – 2438	90	CTCK
	Region	1607 – 1953	347	Approximate repeats
	Compositional bias	1241 – 1664	424	Pro-rich
	Compositional bias	1246 – 2344	1099	Thr-rich
	Compositional bias	2069 – 2275	207	Ser-rich
Amino acid modifications
	Glycosylation	268	1	N-linked (GlcNAc...) Potential
	Glycosylation	486	1	N-linked (GlcNAc...) Potential
	Glycosylation	659	1	N-linked (GlcNAc...) Potential
	Glycosylation	975	1	N-linked (GlcNAc...) Potential
	Glycosylation	1179	1	N-linked (GlcNAc...) Potential
	Disulfide bond	67 ↔ 75		By similarity
	Disulfide bond	2349 ↔ 2396		By similarity
	Disulfide bond	2363 ↔ 2410		By similarity
	Disulfide bond	2372 ↔ 2430		By similarity
	Disulfide bond	2376 ↔ 2432		By similarity
	Disulfide bond	? ↔ 2437		By similarity
Natural variations
	Natural variant	1578	1	P → S. Corresponds to variant rs10736904 [ dbSNP | Ensembl ].		VAR_059542
	Natural variant	1794	1	P → T. Ref.5 Corresponds to variant rs35549382 [ dbSNP | Ensembl ].		VAR_061488
Experimental info
	Sequence conflict	81	1	T → S in AAQ82434. Ref.2
	Sequence conflict	231	1	I → G in AAQ82434. Ref.2
	Sequence conflict	271	1	C → Y in AAQ82434. Ref.2
	Sequence conflict	289 – 291	3	RRW → AL in AAQ82434. Ref.2
	Sequence conflict	322 – 323	2	PQ → SE in AAQ82434. Ref.2
	Sequence conflict	341	1	V → D in AAQ82434. Ref.2
	Sequence conflict	569	1	A → D in AAQ82434. Ref.2
	Sequence conflict	614	1	F → I in AAQ82434. Ref.2
	Sequence conflict	619	1	V → M in AAQ82434. Ref.2
	Sequence conflict	757	1	P → L in AAQ82434. Ref.2
	Sequence conflict	818	1	D → Y in AAQ82434. Ref.2
	Sequence conflict	903	1	D → Y in AAQ82434. Ref.2
	Sequence conflict	1472	1	T → S in AAQ82434. Ref.2
	Sequence conflict	1544	1	T → S in AAQ82434. Ref.2
	Sequence conflict	1558	1	V → M in AAQ82434. Ref.2
	Sequence conflict	1806 – 1807	2	TT → SS in AAA35866. Ref.5
	Sequence conflict	1815	1	V → M in AAA35866. Ref.5
	Sequence conflict	1833	1	H → E in AAA35866. Ref.5
	Sequence conflict	1842	1	S → P in AAA35866. Ref.5
	Sequence conflict	1857	1	I → T in AAA35866. Ref.5
	Sequence conflict	1861	1	T → A in AAA35866. Ref.5
	Sequence conflict	1872	1	M → T in AAA35866. Ref.5
	Sequence conflict	1880 – 1885	6	PTTIKA → LTTLMN in AAA35866. Ref.5
	Sequence conflict	1895	1	M → V in AAA35866. Ref.5
	Sequence conflict	1905 – 1906	2	SP → AA in AAA35866. Ref.5
	Sequence conflict	1919 – 1920	2	PY → HS in AAA35866. Ref.5
	Sequence conflict	1934	1	S → A in AAA35866. Ref.5
	Sequence conflict	1937 – 1951	15	NITPK…TRTPV → KITTNPTSIGSSTPM in AAA35866. Ref.5
	Sequence conflict	1940	1	P → F in BAC04860. Ref.6
	Sequence conflict	1958	1	S → T in AAA35866. Ref.5
	Sequence conflict	1963	1	P → T in AAA35866. Ref.5
	Sequence conflict	1972	1	P → S in AAA35866. Ref.5
	Sequence conflict	2091	1	S → SSWS in AAC51370. Ref.8
	Sequence conflict	2129	1	S → F in BAC04860. Ref.6
	Sequence conflict	2190 – 2192	3	ASV → GSG in AAC51370. Ref.8
	Sequence conflict	2272	1	R → G in AAC51370. Ref.8
	Sequence conflict	2318	1	F → S in AAC51370. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Q6W4X9 [UniParc]. Last modified May 3, 2011. Version 3. Checksum: 4A1A7E6A7C30F895	FASTA	2,439	257,051
	10 20 30 40 50 60 MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA GHFSTFDHHV 70 80 90 100 110 120 YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE LGASVVTVSE AIISVKDIGV 130 140 150 160 170 180 ISLPYTSNGL QITPFGQSVR LVAKQLELEL EVVWGPDSHL MVLVERKYMG QMCGLCGNFD 190 200 210 220 230 240 GKVTNEFVSE EGKFLEPHKF AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA 250 260 270 280 290 300 PECSVSKEPF VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG 310 320 330 340 350 360 QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT CVPVTQCPCV 370 380 390 400 410 420 LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE GGSFVTTFDA RPYRFHGTCT 430 440 450 460 470 480 YILLQSPQLP EDGALMAVYD KSGVSHSETS LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL 490 500 510 520 530 540 PYKTRNITVF RQTSTHLQMA TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT 550 560 570 580 590 600 TDDFTTSMGI AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT 610 620 630 640 650 660 VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL WGWRSSVDNC 670 680 690 700 710 720 TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG CNCPDGTYLN QKGECVRKAQ 730 740 750 760 770 780 CPCILEGYKF ILAEQSTVIN GITCHCINGR LSCPQRPQMF LASCQAPKTF KSCSQSSENK 790 800 810 820 830 840 FGAACAPTCQ MLATGVACVP TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA 850 860 870 880 890 900 ELHTDCRTCS CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG 910 920 930 940 950 960 VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE PHVQLGVTPG 970 980 990 1000 1010 1020 ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG LCGNFNGNMK DDFETRSRYV 1030 1040 1050 1060 1070 1080 ASSELELVNS WKESPLCGDV SFVTDPCSLN AFRRSWAERK CSVINSQTFA TCHSKVYHLP 1090 1100 1110 1120 1130 1140 YYEACVRDAC GCDSGGDCEC LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD 1150 1160 1170 1180 1190 1200 GHGEYQYTQE ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT 1210 1220 1230 1240 1250 1260 TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT QTPLLPATLT 1270 1280 1290 1300 1310 1320 SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT VTQATTRATA STASPATTST 1330 1340 1350 1360 1370 1380 AQSTTRTTMT LPTPATSGTS PTLPKSTNQE LPGTTATQTT GPRPTPASTT GPTTPQPGQP 1390 1400 1410 1420 1430 1440 TRPTATETTQ TRTTTEYTTP QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE 1450 1460 1470 1480 1490 1500 TTLPTHVPPF STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP 1510 1520 1530 1540 1550 1560 PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT STRTRTPVAH 1570 1580 1590 1600 1610 1620 TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT TYPTPSHPQT TLPTHVPPFS 1630 1640 1650 1660 1670 1680 TSLVTPSTHT VITPTHAQMA TSASIHSMPT GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ 1690 1700 1710 1720 1730 1740 ALSSLNTAKT STSLHSHTSS THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF 1750 1760 1770 1780 1790 1800 STAKTSTSLH SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH 1810 1820 1830 1840 1850 1860 SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP STHTVIIPTH 1870 1880 1890 1900 1910 1920 TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS GTSQSPSSFS TAKTSTSLPY 1930 1940 1950 1960 1970 1980 HTSSTHHPEV TPTSTTNITP KHTSTGTRTP VAHTTSASSS RLPTPFTTHS PPTGSSPFSS 1990 2000 2010 2020 2030 2040 TGPMTATSFQ TTTTYPTPSH PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS 2050 2060 2070 2080 2090 2100 TPTGTVPPPT TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS 2110 2120 2130 2140 2150 2160 RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS SPQTSSPSVG 2170 2180 2190 2200 2210 2220 TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS SPAASTTIRA TLPHTISSPF 2230 2240 2250 2260 2270 2280 TLSALLPIST VTVSPTPSSH LASSTIAFPS TPRTTASTHT APAFSSQSTT SRSTSLTTRV 2290 2300 2310 2320 2330 2340 PTSGFVSLTS GVTGIPTSPV TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT 2350 2360 2370 2380 2390 2400 PTPTSPGVCS VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH 2410 2420 2430 SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The complete genomic organization of the human MUC6 and MUC2 mucin genes." Rousseau K., Byrne C., Kim Y.S., Gum J.R. Jr., Swallow D.M., Toribara N.W. Genomics 83:936-939(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1570.
[3]	"Muc6 mucin exon1-exon3." van Seuningen I. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.
[4]	"Promotor characterization of the human MUC6." van Seuningen I., Desseyn J.-L. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-116.
[5]	"Human gastric mucin. Identification of a unique species by expression cloning." Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S. J. Biol. Chem. 268:5879-5885(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1785-1998, VARIANT THR-1794. Tissue: Stomach.
[6]	Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 1954-1998.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1843-2439. Tissue: Prostate.
[8]	"The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence." Toribara N.W., Ho S.B., Gum E., Gum J.R. Jr., Lau P., Kim Y.S. J. Biol. Chem. 272:16398-16403(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2022-2439, SUBUNIT.
[9]	"Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs." Debailleul V., Laine A., Huet G., Mathon P., d'Hooghe M.C., Aubert J.-P., Porchet N. J. Biol. Chem. 273:881-890(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, POLYMORPHISM.
[10]	"The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues." Bartman A.E., Buisine M.-P., Aubert J.-P., Niehans G.A., Toribara N.W., Kim Y.S., Kelly E.J., Crabtree J.E., Ho S.B. J. Pathol. 186:398-405(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION, DEVELOPMENTAL STAGE.
[11]	"Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts." Reid C.J., Harris A. J. Histochem. Cytochem. 47:817-822(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[12]	"Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution." Nordman H., Davies J.R., Lindell G., de Bolos C., Real F., Carlstedt I. Biochem. J. 364:191-200(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION.
[13]	"Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation." Xia H.H.-X., Yang Y., Lam S.K., Wong W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A., Wong B.C.-Y. J. Clin. Pathol. 57:861-866(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[14]	"Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors." Sakai H., Jinawath A., Yamaoka S., Yuasa Y. Biochem. Biophys. Res. Commun. 333:1254-1260(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Web resources

Mucin database

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC139749 Genomic DNA. No translation available. AY312160 mRNA. Translation: AAQ82434.1. AY458429 mRNA. Translation: AAS13634.1. AY500284 Genomic DNA. Translation: AAS76674.1. L07517 mRNA. Translation: AAA35866.2. AK092533 mRNA. No translation available. AK096772 mRNA. Translation: BAC04860.1. Different initiation. U97698 mRNA. Translation: AAC51370.1.
IPI	IPI00941125.
PIR	A46629.
RefSeq	NP_005952.2. NM_005961.2.
UniGene	Hs.528432.
3D structure databases
HSSP	HSSP built from PDB template 1CCV based on UniProtKB P56682.
ProteinModelPortal	Q6W4X9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000406861.
Protein family/group databases
MEROPS	I08.952.
PTM databases
PhosphoSite	Q6W4X9.
Polymorphism databases
DMDM	117949606.
Proteomic databases
PaxDb	Q6W4X9.
PRIDE	Q6W4X9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000421673; ENSP00000406861; ENSG00000184956.
GeneID	4588.
KEGG	hsa:4588.
UCSC	uc001lsw.2. human.
Organism-specific databases
CTD	4588.
GeneCards	GC11M001002.
H-InvDB	HIX0023085.
HGNC	HGNC:7517. MUC6.
HPA	CAB002165.
MIM	158374. gene.
neXtProt	NX_Q6W4X9.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOVERGEN	HBG081998.
InParanoid	Q6W4X9.
OMA	HTPLTSH.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q6W4X9.
Bgee	Q6W4X9.
CleanEx	HS_MUC6.
Genevestigator	Q6W4X9.
GermOnline	ENSG00000184956. Homo sapiens.
Family and domain databases
InterPro	IPR006207. Cys_knot_C. IPR002919. TIL_dom. IPR014853. Unchr_dom_Cys-rich. IPR001846. VWF_type-D. [Graphical view]
Pfam	PF08742. C8. 3 hits. PF01826. TIL. 3 hits. PF00094. VWD. 3 hits. [Graphical view]
SMART	SM00832. C8. 3 hits. SM00041. CT. 1 hit. SM00216. VWD. 3 hits. [Graphical view]
SUPFAM	SSF57567. Cysrich_TIL. 3 hits.
PROSITE	PS01225. CTCK_2. 1 hit. PS51233. VWFD. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4588.
NextBio	17636.
SOURCE	Search...

Entry information

Entry name

MUC6_HUMAN

Accession

Primary (citable) accession number: Q6W4X9
Secondary accession number(s): O15329 , Q14394, Q2TUQ5, Q4L207, Q8N8I1, Q8NAK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 3, 2011
Last modified:	April 3, 2013
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.