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Q6W4X9 (MUC6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-6

Short name=MUC-6
Alternative name(s):
Gastric mucin-6
Gene names
Name:MUC6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2439 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Ref.10 Ref.11 Ref.12

Subunit structure

Multimer; disulfide-linked. Ref.8

Subcellular location

Secreted.

Tissue specificity

Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13

Developmental stage

Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation. Ref.10 Ref.11

Induction

Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors. Ref.14

Post-translational modification

O-glycosylated. Ref.12

Polymorphism

The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 TIL (trypsin inhibitory-like) domain.

Contains 3 VWFD domains.

Sequence caution

The sequence AK092533 differs from that shown. Reason: Erroneous termination at position 2357. Translated as Glu.

The sequence BAC04860.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 24392417Mucin-6
PRO_0000259496

Regions

Domain44 – 246203VWFD 1
Domain302 – 35756TIL
Domain396 – 608213VWFD 2
Domain867 – 1075209VWFD 3
Repeat1561 – 17381781; truncated
Repeat1785 – 19531692
Domain2349 – 243890CTCK
Region1607 – 1953347Approximate repeats
Compositional bias1241 – 1664424Pro-rich
Compositional bias1246 – 23441099Thr-rich
Compositional bias2069 – 2275207Ser-rich

Amino acid modifications

Glycosylation2681N-linked (GlcNAc...) Potential
Glycosylation4861N-linked (GlcNAc...) Potential
Glycosylation6591N-linked (GlcNAc...) Potential
Glycosylation9751N-linked (GlcNAc...) Potential
Glycosylation11791N-linked (GlcNAc...) Potential
Disulfide bond67 ↔ 75 By similarity
Disulfide bond2349 ↔ 2396 By similarity
Disulfide bond2363 ↔ 2410 By similarity
Disulfide bond2372 ↔ 2430 By similarity
Disulfide bond2376 ↔ 2432 By similarity
Disulfide bond? ↔ 2437 By similarity

Natural variations

Natural variant15781P → S.
Corresponds to variant rs10736904 [ dbSNP | Ensembl ].
VAR_059542
Natural variant17941P → T. Ref.5
Corresponds to variant rs35549382 [ dbSNP | Ensembl ].
VAR_061488

Experimental info

Sequence conflict811T → S in AAQ82434. Ref.2
Sequence conflict2311I → G in AAQ82434. Ref.2
Sequence conflict2711C → Y in AAQ82434. Ref.2
Sequence conflict289 – 2913RRW → AL in AAQ82434. Ref.2
Sequence conflict322 – 3232PQ → SE in AAQ82434. Ref.2
Sequence conflict3411V → D in AAQ82434. Ref.2
Sequence conflict5691A → D in AAQ82434. Ref.2
Sequence conflict6141F → I in AAQ82434. Ref.2
Sequence conflict6191V → M in AAQ82434. Ref.2
Sequence conflict7571P → L in AAQ82434. Ref.2
Sequence conflict8181D → Y in AAQ82434. Ref.2
Sequence conflict9031D → Y in AAQ82434. Ref.2
Sequence conflict14721T → S in AAQ82434. Ref.2
Sequence conflict15441T → S in AAQ82434. Ref.2
Sequence conflict15581V → M in AAQ82434. Ref.2
Sequence conflict1806 – 18072TT → SS in AAA35866. Ref.5
Sequence conflict18151V → M in AAA35866. Ref.5
Sequence conflict18331H → E in AAA35866. Ref.5
Sequence conflict18421S → P in AAA35866. Ref.5
Sequence conflict18571I → T in AAA35866. Ref.5
Sequence conflict18611T → A in AAA35866. Ref.5
Sequence conflict18721M → T in AAA35866. Ref.5
Sequence conflict1880 – 18856PTTIKA → LTTLMN in AAA35866. Ref.5
Sequence conflict18951M → V in AAA35866. Ref.5
Sequence conflict1905 – 19062SP → AA in AAA35866. Ref.5
Sequence conflict1919 – 19202PY → HS in AAA35866. Ref.5
Sequence conflict19341S → A in AAA35866. Ref.5
Sequence conflict1937 – 195115NITPK…TRTPV → KITTNPTSIGSSTPM in AAA35866. Ref.5
Sequence conflict19401P → F in BAC04860. Ref.6
Sequence conflict19581S → T in AAA35866. Ref.5
Sequence conflict19631P → T in AAA35866. Ref.5
Sequence conflict19721P → S in AAA35866. Ref.5
Sequence conflict20911S → SSWS in AAC51370. Ref.8
Sequence conflict21291S → F in BAC04860. Ref.6
Sequence conflict2190 – 21923ASV → GSG in AAC51370. Ref.8
Sequence conflict22721R → G in AAC51370. Ref.8
Sequence conflict23181F → S in AAC51370. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q6W4X9 [UniParc].

Last modified May 3, 2011. Version 3.
Checksum: 4A1A7E6A7C30F895

FASTA2,439257,051
        10         20         30         40         50         60 
MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA GHFSTFDHHV 

        70         80         90        100        110        120 
YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE LGASVVTVSE AIISVKDIGV 

       130        140        150        160        170        180 
ISLPYTSNGL QITPFGQSVR LVAKQLELEL EVVWGPDSHL MVLVERKYMG QMCGLCGNFD 

       190        200        210        220        230        240 
GKVTNEFVSE EGKFLEPHKF AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA 

       250        260        270        280        290        300 
PECSVSKEPF VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG 

       310        320        330        340        350        360 
QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT CVPVTQCPCV 

       370        380        390        400        410        420 
LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE GGSFVTTFDA RPYRFHGTCT 

       430        440        450        460        470        480 
YILLQSPQLP EDGALMAVYD KSGVSHSETS LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL 

       490        500        510        520        530        540 
PYKTRNITVF RQTSTHLQMA TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT 

       550        560        570        580        590        600 
TDDFTTSMGI AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT 

       610        620        630        640        650        660 
VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL WGWRSSVDNC 

       670        680        690        700        710        720 
TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG CNCPDGTYLN QKGECVRKAQ 

       730        740        750        760        770        780 
CPCILEGYKF ILAEQSTVIN GITCHCINGR LSCPQRPQMF LASCQAPKTF KSCSQSSENK 

       790        800        810        820        830        840 
FGAACAPTCQ MLATGVACVP TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA 

       850        860        870        880        890        900 
ELHTDCRTCS CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG 

       910        920        930        940        950        960 
VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE PHVQLGVTPG 

       970        980        990       1000       1010       1020 
ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG LCGNFNGNMK DDFETRSRYV 

      1030       1040       1050       1060       1070       1080 
ASSELELVNS WKESPLCGDV SFVTDPCSLN AFRRSWAERK CSVINSQTFA TCHSKVYHLP 

      1090       1100       1110       1120       1130       1140 
YYEACVRDAC GCDSGGDCEC LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD 

      1150       1160       1170       1180       1190       1200 
GHGEYQYTQE ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT 

      1210       1220       1230       1240       1250       1260 
TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT QTPLLPATLT 

      1270       1280       1290       1300       1310       1320 
SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT VTQATTRATA STASPATTST 

      1330       1340       1350       1360       1370       1380 
AQSTTRTTMT LPTPATSGTS PTLPKSTNQE LPGTTATQTT GPRPTPASTT GPTTPQPGQP 

      1390       1400       1410       1420       1430       1440 
TRPTATETTQ TRTTTEYTTP QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE 

      1450       1460       1470       1480       1490       1500 
TTLPTHVPPF STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP 

      1510       1520       1530       1540       1550       1560 
PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT STRTRTPVAH 

      1570       1580       1590       1600       1610       1620 
TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT TYPTPSHPQT TLPTHVPPFS 

      1630       1640       1650       1660       1670       1680 
TSLVTPSTHT VITPTHAQMA TSASIHSMPT GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ 

      1690       1700       1710       1720       1730       1740 
ALSSLNTAKT STSLHSHTSS THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF 

      1750       1760       1770       1780       1790       1800 
STAKTSTSLH SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH 

      1810       1820       1830       1840       1850       1860 
SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP STHTVIIPTH 

      1870       1880       1890       1900       1910       1920 
TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS GTSQSPSSFS TAKTSTSLPY 

      1930       1940       1950       1960       1970       1980 
HTSSTHHPEV TPTSTTNITP KHTSTGTRTP VAHTTSASSS RLPTPFTTHS PPTGSSPFSS 

      1990       2000       2010       2020       2030       2040 
TGPMTATSFQ TTTTYPTPSH PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS 

      2050       2060       2070       2080       2090       2100 
TPTGTVPPPT TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS 

      2110       2120       2130       2140       2150       2160 
RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS SPQTSSPSVG 

      2170       2180       2190       2200       2210       2220 
TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS SPAASTTIRA TLPHTISSPF 

      2230       2240       2250       2260       2270       2280 
TLSALLPIST VTVSPTPSSH LASSTIAFPS TPRTTASTHT APAFSSQSTT SRSTSLTTRV 

      2290       2300       2310       2320       2330       2340 
PTSGFVSLTS GVTGIPTSPV TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT 

      2350       2360       2370       2380       2390       2400 
PTPTSPGVCS VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH 

      2410       2420       2430 
SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD 

« Hide

References

« Hide 'large scale' references
[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The complete genomic organization of the human MUC6 and MUC2 mucin genes."
Rousseau K., Byrne C., Kim Y.S., Gum J.R. Jr., Swallow D.M., Toribara N.W.
Genomics 83:936-939(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1570.
[3]"Muc6 mucin exon1-exon3."
van Seuningen I.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.
[4]"Promotor characterization of the human MUC6."
van Seuningen I., Desseyn J.-L.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-116.
[5]"Human gastric mucin. Identification of a unique species by expression cloning."
Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.
J. Biol. Chem. 268:5879-5885(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1785-1998, VARIANT THR-1794.
Tissue: Stomach.
[6]Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 1954-1998.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1843-2439.
Tissue: Prostate.
[8]"The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence."
Toribara N.W., Ho S.B., Gum E., Gum J.R. Jr., Lau P., Kim Y.S.
J. Biol. Chem. 272:16398-16403(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2022-2439, SUBUNIT.
[9]"Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs."
Debailleul V., Laine A., Huet G., Mathon P., d'Hooghe M.C., Aubert J.-P., Porchet N.
J. Biol. Chem. 273:881-890(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, POLYMORPHISM.
[10]"The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues."
Bartman A.E., Buisine M.-P., Aubert J.-P., Niehans G.A., Toribara N.W., Kim Y.S., Kelly E.J., Crabtree J.E., Ho S.B.
J. Pathol. 186:398-405(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION, DEVELOPMENTAL STAGE.
[11]"Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts."
Reid C.J., Harris A.
J. Histochem. Cytochem. 47:817-822(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[12]"Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution."
Nordman H., Davies J.R., Lindell G., de Bolos C., Real F., Carlstedt I.
Biochem. J. 364:191-200(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION.
[13]"Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation."
Xia H.H.-X., Yang Y., Lam S.K., Wong W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A., Wong B.C.-Y.
J. Clin. Pathol. 57:861-866(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[14]"Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors."
Sakai H., Jinawath A., Yamaoka S., Yuasa Y.
Biochem. Biophys. Res. Commun. 333:1254-1260(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC139749 Genomic DNA. No translation available.
AY312160 mRNA. Translation: AAQ82434.1.
AY458429 mRNA. Translation: AAS13634.1.
AY500284 Genomic DNA. Translation: AAS76674.1.
L07517 mRNA. Translation: AAA35866.2.
AK092533 mRNA. No translation available.
AK096772 mRNA. Translation: BAC04860.1. Different initiation.
U97698 mRNA. Translation: AAC51370.1.
PIRA46629.
RefSeqNP_005952.2. NM_005961.2.
UniGeneHs.528432.

3D structure databases

ProteinModelPortalQ6W4X9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000406861.

Protein family/group databases

MEROPSI08.952.

PTM databases

PhosphoSiteQ6W4X9.

Polymorphism databases

DMDM332278200.

Proteomic databases

PaxDbQ6W4X9.
PRIDEQ6W4X9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000421673; ENSP00000406861; ENSG00000184956.
GeneID4588.
KEGGhsa:4588.
UCSCuc001lsw.2. human.

Organism-specific databases

CTD4588.
GeneCardsGC11M001002.
H-InvDBHIX0023085.
HGNCHGNC:7517. MUC6.
HPACAB002165.
MIM158374. gene.
neXtProtNX_Q6W4X9.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOVERGENHBG081998.
InParanoidQ6W4X9.
OMAHTPLTSH.
OrthoDBEOG73V6J9.
TreeFamTF300299.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ6W4X9.
BgeeQ6W4X9.
CleanExHS_MUC6.
GenevestigatorQ6W4X9.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF08742. C8. 3 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTSM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMSSF57567. SSF57567. 3 hits.
PROSITEPS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMUC6.
GenomeRNAi4588.
NextBio17636.
PROQ6W4X9.
SOURCESearch...

Entry information

Entry nameMUC6_HUMAN
AccessionPrimary (citable) accession number: Q6W4X9
Secondary accession number(s): O15329 expand/collapse secondary AC list , Q14394, Q2TUQ5, Q4L207, Q8N8I1, Q8NAK1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 3, 2011
Last modified: April 16, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM