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Q6W4X9

- MUC6_HUMAN

UniProt

Q6W4X9 - MUC6_HUMAN

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Protein

Mucin-6

Gene

MUC6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.3 Publications

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. maintenance of gastrointestinal epithelium Source: UniProtKB
  3. O-glycan processing Source: Reactome
  4. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-6
Short name:
MUC-6
Alternative name(s):
Gastric mucin-6
Gene namesi
Name:MUC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7517. MUC6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 24392417Mucin-6PRO_0000259496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 2437By similarity
Disulfide bondi67 ↔ 75By similarity
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi975 – 9751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1179 – 11791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2349 ↔ 2396By similarity
Disulfide bondi2363 ↔ 2410By similarity
Disulfide bondi2372 ↔ 2430By similarity
Disulfide bondi2376 ↔ 2432By similarity

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6W4X9.
PRIDEiQ6W4X9.

PTM databases

PhosphoSiteiQ6W4X9.

Expressioni

Tissue specificityi

Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.5 Publications

Developmental stagei

Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.2 Publications

Inductioni

Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.1 Publication

Gene expression databases

BgeeiQ6W4X9.
CleanExiHS_MUC6.
ExpressionAtlasiQ6W4X9. baseline.
GenevestigatoriQ6W4X9.

Organism-specific databases

HPAiCAB002165.

Interactioni

Subunit structurei

Multimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000406861.

Structurei

3D structure databases

ProteinModelPortaliQ6W4X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 246203VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini302 – 35756TILAdd
BLAST
Domaini396 – 608213VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini867 – 1075209VWFD 3PROSITE-ProRule annotationAdd
BLAST
Repeati1561 – 17381781; truncatedAdd
BLAST
Repeati1785 – 19531692Add
BLAST
Domaini2349 – 243890CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1607 – 1953347Approximate repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1241 – 1664424Pro-richAdd
BLAST
Compositional biasi1246 – 23441099Thr-richAdd
BLAST
Compositional biasi2069 – 2275207Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 3 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118896.
HOVERGENiHBG081998.
InParanoidiQ6W4X9.
OMAiHTPLTSH.
OrthoDBiEOG73V6J9.
PhylomeDBiQ6W4X9.
TreeFamiTF300299.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTiSM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6W4X9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA
60 70 80 90 100
GHFSTFDHHV YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE
110 120 130 140 150
LGASVVTVSE AIISVKDIGV ISLPYTSNGL QITPFGQSVR LVAKQLELEL
160 170 180 190 200
EVVWGPDSHL MVLVERKYMG QMCGLCGNFD GKVTNEFVSE EGKFLEPHKF
210 220 230 240 250
AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA PECSVSKEPF
260 270 280 290 300
VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG
310 320 330 340 350
QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT
360 370 380 390 400
CVPVTQCPCV LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE
410 420 430 440 450
GGSFVTTFDA RPYRFHGTCT YILLQSPQLP EDGALMAVYD KSGVSHSETS
460 470 480 490 500
LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL PYKTRNITVF RQTSTHLQMA
510 520 530 540 550
TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT TDDFTTSMGI
560 570 580 590 600
AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT
610 620 630 640 650
VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL
660 670 680 690 700
WGWRSSVDNC TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG
710 720 730 740 750
CNCPDGTYLN QKGECVRKAQ CPCILEGYKF ILAEQSTVIN GITCHCINGR
760 770 780 790 800
LSCPQRPQMF LASCQAPKTF KSCSQSSENK FGAACAPTCQ MLATGVACVP
810 820 830 840 850
TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA ELHTDCRTCS
860 870 880 890 900
CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG
910 920 930 940 950
VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE
960 970 980 990 1000
PHVQLGVTPG ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG
1010 1020 1030 1040 1050
LCGNFNGNMK DDFETRSRYV ASSELELVNS WKESPLCGDV SFVTDPCSLN
1060 1070 1080 1090 1100
AFRRSWAERK CSVINSQTFA TCHSKVYHLP YYEACVRDAC GCDSGGDCEC
1110 1120 1130 1140 1150
LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD GHGEYQYTQE
1160 1170 1180 1190 1200
ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT
1210 1220 1230 1240 1250
TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT
1260 1270 1280 1290 1300
QTPLLPATLT SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT
1310 1320 1330 1340 1350
VTQATTRATA STASPATTST AQSTTRTTMT LPTPATSGTS PTLPKSTNQE
1360 1370 1380 1390 1400
LPGTTATQTT GPRPTPASTT GPTTPQPGQP TRPTATETTQ TRTTTEYTTP
1410 1420 1430 1440 1450
QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE TTLPTHVPPF
1460 1470 1480 1490 1500
STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP
1510 1520 1530 1540 1550
PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT
1560 1570 1580 1590 1600
STRTRTPVAH TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT
1610 1620 1630 1640 1650
TYPTPSHPQT TLPTHVPPFS TSLVTPSTHT VITPTHAQMA TSASIHSMPT
1660 1670 1680 1690 1700
GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ ALSSLNTAKT STSLHSHTSS
1710 1720 1730 1740 1750
THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF STAKTSTSLH
1760 1770 1780 1790 1800
SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH
1810 1820 1830 1840 1850
SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP
1860 1870 1880 1890 1900
STHTVIIPTH TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS
1910 1920 1930 1940 1950
GTSQSPSSFS TAKTSTSLPY HTSSTHHPEV TPTSTTNITP KHTSTGTRTP
1960 1970 1980 1990 2000
VAHTTSASSS RLPTPFTTHS PPTGSSPFSS TGPMTATSFQ TTTTYPTPSH
2010 2020 2030 2040 2050
PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS TPTGTVPPPT
2060 2070 2080 2090 2100
TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS
2110 2120 2130 2140 2150
RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS
2160 2170 2180 2190 2200
SPQTSSPSVG TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS
2210 2220 2230 2240 2250
SPAASTTIRA TLPHTISSPF TLSALLPIST VTVSPTPSSH LASSTIAFPS
2260 2270 2280 2290 2300
TPRTTASTHT APAFSSQSTT SRSTSLTTRV PTSGFVSLTS GVTGIPTSPV
2310 2320 2330 2340 2350
TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT PTPTSPGVCS
2360 2370 2380 2390 2400
VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH
2410 2420 2430
SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD
Length:2,439
Mass (Da):257,051
Last modified:May 3, 2011 - v3
Checksum:i4A1A7E6A7C30F895
GO

Sequence cautioni

The sequence AK092533 differs from that shown. Reason: Erroneous termination at position 2357. Translated as Glu.Curated
The sequence BAC04860.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811T → S in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti231 – 2311I → G in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti271 – 2711C → Y in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti289 – 2913RRW → AL in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti322 – 3232PQ → SE in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti341 – 3411V → D in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti569 – 5691A → D in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti614 – 6141F → I in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti619 – 6191V → M in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti757 – 7571P → L in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti818 – 8181D → Y in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti903 – 9031D → Y in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti1472 – 14721T → S in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti1544 – 15441T → S in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti1558 – 15581V → M in AAQ82434. (PubMed:15081123)Curated
Sequence conflicti1806 – 18072TT → SS in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1815 – 18151V → M in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1833 – 18331H → E in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1842 – 18421S → P in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1857 – 18571I → T in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1861 – 18611T → A in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1872 – 18721M → T in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1880 – 18856PTTIKA → LTTLMN in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1895 – 18951M → V in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1905 – 19062SP → AA in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1919 – 19202PY → HS in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1934 – 19341S → A in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1937 – 195115NITPK…TRTPV → KITTNPTSIGSSTPM in AAA35866. (PubMed:7680650)CuratedAdd
BLAST
Sequence conflicti1940 – 19401P → F in BAC04860. 1 PublicationCurated
Sequence conflicti1958 – 19581S → T in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1963 – 19631P → T in AAA35866. (PubMed:7680650)Curated
Sequence conflicti1972 – 19721P → S in AAA35866. (PubMed:7680650)Curated
Sequence conflicti2091 – 20911S → SSWS in AAC51370. (PubMed:9195947)Curated
Sequence conflicti2129 – 21291S → F in BAC04860. 1 PublicationCurated
Sequence conflicti2190 – 21923ASV → GSG in AAC51370. (PubMed:9195947)Curated
Sequence conflicti2272 – 22721R → G in AAC51370. (PubMed:9195947)Curated
Sequence conflicti2318 – 23181F → S in AAC51370. (PubMed:9195947)Curated

Polymorphismi

The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1578 – 15781P → S.
Corresponds to variant rs10736904 [ dbSNP | Ensembl ].
VAR_059542
Natural varianti1794 – 17941P → T.1 Publication
Corresponds to variant rs35549382 [ dbSNP | Ensembl ].
VAR_061488

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139749 Genomic DNA. No translation available.
AY312160 mRNA. Translation: AAQ82434.1.
AY458429 mRNA. Translation: AAS13634.1.
AY500284 Genomic DNA. Translation: AAS76674.1.
L07517 mRNA. Translation: AAA35866.2.
AK092533 mRNA. No translation available.
AK096772 mRNA. Translation: BAC04860.1. Different initiation.
U97698 mRNA. Translation: AAC51370.1.
CCDSiCCDS44513.1.
PIRiA46629.
RefSeqiNP_005952.2. NM_005961.2.
UniGeneiHs.528432.

Genome annotation databases

EnsembliENST00000421673; ENSP00000406861; ENSG00000184956.
GeneIDi4588.
KEGGihsa:4588.
UCSCiuc001lsw.2. human.

Polymorphism databases

DMDMi332278200.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139749 Genomic DNA. No translation available.
AY312160 mRNA. Translation: AAQ82434.1 .
AY458429 mRNA. Translation: AAS13634.1 .
AY500284 Genomic DNA. Translation: AAS76674.1 .
L07517 mRNA. Translation: AAA35866.2 .
AK092533 mRNA. No translation available.
AK096772 mRNA. Translation: BAC04860.1 . Different initiation.
U97698 mRNA. Translation: AAC51370.1 .
CCDSi CCDS44513.1.
PIRi A46629.
RefSeqi NP_005952.2. NM_005961.2.
UniGenei Hs.528432.

3D structure databases

ProteinModelPortali Q6W4X9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000406861.

Protein family/group databases

MEROPSi I08.952.

PTM databases

PhosphoSitei Q6W4X9.

Polymorphism databases

DMDMi 332278200.

Proteomic databases

PaxDbi Q6W4X9.
PRIDEi Q6W4X9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421673 ; ENSP00000406861 ; ENSG00000184956 .
GeneIDi 4588.
KEGGi hsa:4588.
UCSCi uc001lsw.2. human.

Organism-specific databases

CTDi 4588.
GeneCardsi GC11M001002.
H-InvDB HIX0023085.
HGNCi HGNC:7517. MUC6.
HPAi CAB002165.
MIMi 158374. gene.
neXtProti NX_Q6W4X9.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118896.
HOVERGENi HBG081998.
InParanoidi Q6W4X9.
OMAi HTPLTSH.
OrthoDBi EOG73V6J9.
PhylomeDBi Q6W4X9.
TreeFami TF300299.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

GeneWikii MUC6.
GenomeRNAii 4588.
NextBioi 17636.
PROi Q6W4X9.
SOURCEi Search...

Gene expression databases

Bgeei Q6W4X9.
CleanExi HS_MUC6.
ExpressionAtlasi Q6W4X9. baseline.
Genevestigatori Q6W4X9.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 3 hits.
[Graphical view ]
SMARTi SM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The complete genomic organization of the human MUC6 and MUC2 mucin genes."
    Rousseau K., Byrne C., Kim Y.S., Gum J.R. Jr., Swallow D.M., Toribara N.W.
    Genomics 83:936-939(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1570.
  3. "Muc6 mucin exon1-exon3."
    van Seuningen I.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.
  4. "Promotor characterization of the human MUC6."
    van Seuningen I., Desseyn J.-L.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-116.
  5. "Human gastric mucin. Identification of a unique species by expression cloning."
    Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.
    J. Biol. Chem. 268:5879-5885(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1785-1998, VARIANT THR-1794.
    Tissue: Stomach.
  6. Toribara N.W., Roberton A.M., Ho S.B., Kuo W.-L., Gum E., Hicks J.W., Gum J.R. Jr., Byrd J.C., Siddiki B., Kim Y.S.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 1954-1998.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1843-2439.
    Tissue: Prostate.
  8. "The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence."
    Toribara N.W., Ho S.B., Gum E., Gum J.R. Jr., Lau P., Kim Y.S.
    J. Biol. Chem. 272:16398-16403(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2022-2439, SUBUNIT.
  9. "Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs."
    Debailleul V., Laine A., Huet G., Mathon P., d'Hooghe M.C., Aubert J.-P., Porchet N.
    J. Biol. Chem. 273:881-890(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, POLYMORPHISM.
  10. "The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues."
    Bartman A.E., Buisine M.-P., Aubert J.-P., Niehans G.A., Toribara N.W., Kim Y.S., Kelly E.J., Crabtree J.E., Ho S.B.
    J. Pathol. 186:398-405(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION, DEVELOPMENTAL STAGE.
  11. "Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts."
    Reid C.J., Harris A.
    J. Histochem. Cytochem. 47:817-822(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  12. "Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution."
    Nordman H., Davies J.R., Lindell G., de Bolos C., Real F., Carlstedt I.
    Biochem. J. 364:191-200(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION.
  13. "Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation."
    Xia H.H.-X., Yang Y., Lam S.K., Wong W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A., Wong B.C.-Y.
    J. Clin. Pathol. 57:861-866(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  14. "Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors."
    Sakai H., Jinawath A., Yamaoka S., Yuasa Y.
    Biochem. Biophys. Res. Commun. 333:1254-1260(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiMUC6_HUMAN
AccessioniPrimary (citable) accession number: Q6W4X9
Secondary accession number(s): O15329
, Q14394, Q2TUQ5, Q4L207, Q8N8I1, Q8NAK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3