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Protein
Submitted name:

DIA3

Gene

Diaph2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
DIA3Imported
Submitted name:
Protein diaphanous homolog 2Imported
Gene namesi
Name:Diaph2Imported
Synonyms:Diap2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1858500. Diaph2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000034480.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 467GBD/FH3 (Rho GTPase-binding/formin homology 3)InterPro annotationAdd BLAST367
Domaini629 – 1029FH2 (formin homology 2)InterPro annotationAdd BLAST401
Domaini1052 – 1082DAD (diaphanous autoregulatory)InterPro annotationAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili384 – 411Sequence analysisAdd BLAST28
Coiled coili514 – 541Sequence analysisAdd BLAST28
Coiled coili1013 – 1050Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1924. Eukaryota.
ENOG410Y29H. LUCA.
GeneTreeiENSGT00760000118986.
HOGENOMiHOG000293231.
HOVERGENiHBG051357.
KOiK05741.
TreeFamiTF315383.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR014767. DAD_dom.
IPR027644. DIAPH2.
IPR010465. Drf_DAD.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR014768. GBD/FH3_dom.
IPR010473. GTPase-bd.
[Graphical view]
PANTHERiPTHR23213:SF174. PTHR23213:SF174. 2 hits.
PfamiPF06345. Drf_DAD. 1 hit.
PF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM01139. Drf_FH3. 1 hit.
SM01140. Drf_GBD. 1 hit.
SM00498. FH2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51231. DAD. 1 hit.
PS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6W4W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELGAAASG AGGGGGGGEE HGGGRSNKRG AGNRAANEEE TRNKPKLNIQ
60 70 80 90 100
IKTLADDVRD RITSFRKSAT KREKPVIQHS IDYQTAVVEI PPALIVHDDR
110 120 130 140 150
SLILSEKEVL DLFEKMMEDM NLNEEKKAPL RKKDFSIKRE MVVQYISATS
160 170 180 190 200
KSGGLKNSKH EFTLSSQEYV HELRSGISDE KLLNCLESLR VSLTSHPVSW
210 220 230 240 250
VNNFGYEGLG VLLDVLEKLL DKKQQENIDK KNQYKVIQCL KAFMNNKFGL
260 270 280 290 300
QRILGDERSL LLLARAIDPK QQNMMTEIVK ILSAICIVGE ENILDKLLGG
310 320 330 340 350
ITAAAELNNR ERFSPIVEGL ENNEALHLQV ACMQFINALV TSPYDLDFRI
360 370 380 390 400
HLRNEFLRCG LKAMLPTLKE IENEGLDIQL RVFEENKEDD LSELSHRLND
410 420 430 440 450
IRAEMDDINE VYHLLYNMLK DTAAEPYLLS ILQHFLLIRN DYYIRPQYYK
460 470 480 490 500
IIEECVSQIV LHCSGMDPDF KYRQRIDFDF THLLDACVNK AKVEENEQKA
510 520 530 540 550
MEFSKKFDEE FTARQEAQAE LQKRDEKIKE LETEIQQLRG QGVPSAIPGP
560 570 580 590 600
PPPPPLPGAG PCPPPPPPPP PPPPLPGVVP PPPPPLPGMP GIPPPPPPPL
610 620 630 640 650
SGVPPPPPPP GGVFPLLSGP IELPYGMKQK KLYKPDIPMK RINWSKIEPK
660 670 680 690 700
ELSENCVWLK LKEEKYENAD LFAKLALTFP SQMKGQRNTE AAEENRSGPP
710 720 730 740 750
KKKVKELRIL DTKTAQNLSI FLGSYRMPYE EIKNIILEVN EEMLSEALIQ
760 770 780 790 800
NLVKYLPDQN ALRELAQLKS EYDDLCEPEQ FGVVMSTVKM LRPRLTSILF
810 820 830 840 850
KLTFEEHVNN IKPSIIAVTL ACEELKKSES FKRLLELILL VGNYMNSGSR
860 870 880 890 900
NAQSLGFKIN FLCKIKDTKS ADQKSTLLHF LAEICDEKYR DILKFPDELE
910 920 930 940 950
HVESAGKVSA QILKSNLVAM EQSILHLEKN IKNFPPAESH HDKFVEKMMS
960 970 980 990 1000
FTQNAREQYD KLSTMHSNML KLYESLGEYF IFDPNTVNME EFFGDLNTFR
1010 1020 1030 1040 1050
TLFLEALKEN HKRKEMEEKS RRAKLAKEKA EQEKLERQKK KKQLIDINKE
1060 1070 1080 1090 1100
GDETGVMDNL LEALQSGAAF RDRRKRIPRN PDNRRPPLER SRSRHNGAMS

SK
Length:1,102
Mass (Da):125,385
Last modified:July 5, 2004 - v1
Checksum:iF869BE9811D07A07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683856 Genomic DNA. No translation available.
AL683857 Genomic DNA. No translation available.
AL732443 Genomic DNA. No translation available.
AL807775 Genomic DNA. No translation available.
AL954869 Genomic DNA. No translation available.
BX813314 Genomic DNA. No translation available.
AY312280 mRNA. Translation: AAQ82539.1.
RefSeqiNP_766081.1. NM_172493.2.
UniGeneiMm.10763.

Genome annotation databases

EnsembliENSMUST00000037854; ENSMUSP00000039334; ENSMUSG00000034480.
GeneIDi54004.
KEGGimmu:54004.
UCSCiuc009uet.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683856 Genomic DNA. No translation available.
AL683857 Genomic DNA. No translation available.
AL732443 Genomic DNA. No translation available.
AL807775 Genomic DNA. No translation available.
AL954869 Genomic DNA. No translation available.
BX813314 Genomic DNA. No translation available.
AY312280 mRNA. Translation: AAQ82539.1.
RefSeqiNP_766081.1. NM_172493.2.
UniGeneiMm.10763.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039334.

Protocols and materials databases

DNASUi54004.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037854; ENSMUSP00000039334; ENSMUSG00000034480.
GeneIDi54004.
KEGGimmu:54004.
UCSCiuc009uet.2. mouse.

Organism-specific databases

CTDi1730.
MGIiMGI:1858500. Diaph2.

Phylogenomic databases

eggNOGiKOG1924. Eukaryota.
ENOG410Y29H. LUCA.
GeneTreeiENSGT00760000118986.
HOGENOMiHOG000293231.
HOVERGENiHBG051357.
KOiK05741.
TreeFamiTF315383.

Miscellaneous databases

ChiTaRSiDiap2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034480.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR014767. DAD_dom.
IPR027644. DIAPH2.
IPR010465. Drf_DAD.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR014768. GBD/FH3_dom.
IPR010473. GTPase-bd.
[Graphical view]
PANTHERiPTHR23213:SF174. PTHR23213:SF174. 2 hits.
PfamiPF06345. Drf_DAD. 1 hit.
PF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM01139. Drf_FH3. 1 hit.
SM01140. Drf_GBD. 1 hit.
SM00498. FH2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51231. DAD. 1 hit.
PS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6W4W7_MOUSE
AccessioniPrimary (citable) accession number: Q6W4W7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.