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Protein

Desmoglein-4

Gene

Dsg4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-4
Gene namesi
Name:Dsg4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi735015. Dsg4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 633ExtracellularSequence analysisAdd BLAST584
Transmembranei634 – 654HelicalSequence analysisAdd BLAST21
Topological domaini655 – 1040CytoplasmicSequence analysisAdd BLAST386

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Dsg4 are the cause of an autosomal recessive phenotype lanceolate hair (lah). Lah rats pups develop only a few short hairs on the head and neck which form a lance head at the tip and disappear within one month. Hair regrows again a few days later, following a 29-day cycle of external growth and loss. Almost complete pelage hair loss occurs by 18 month.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000385924 – 49Sequence analysisAdd BLAST26
ChainiPRO_000000386050 – 1040Desmoglein-4Add BLAST991

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ6W3B0.
PRIDEiQ6W3B0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031941.

Structurei

3D structure databases

ProteinModelPortaliQ6W3B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 157Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini158 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini270 – 385Cadherin 3PROSITE-ProRule annotationAdd BLAST116
Domaini389 – 497Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Repeati883 – 909Desmoglein repeat 1Add BLAST27
Repeati910 – 940Desmoglein repeat 2Add BLAST31

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiQ6W3B0.
KOiK07599.
OMAiPFTFCVV.
OrthoDBiEOG091G011Q.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 2 hits.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6W3B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWLLFRNIC LLILFMVVLG VNSEFIVEVK ELDIENGTTT WQTVRRQKRE
60 70 80 90 100
WIKFAAACRE GEDNSKRNPI ARIRSDCEVS QRITYRISGA GIDRPPYGVF
110 120 130 140 150
TINPRTGEIN ITSVVDREIT PLFLIHCRAL NSRGEDLERP LELRVKVMDV
160 170 180 190 200
NDNPPVFTQN VYTANIEENS DANALVVKLS ATDADEDNHL NSKIAYKIIS
210 220 230 240 250
QEPAGAPMFM VNRYTGEVRT MSNFLDREQH SMYNLLVRGS DRDGATDGLS
260 270 280 290 300
SECDCRIKIL DVNDNFPILE KTSYSASIEE NCLSSELIRL QAIDLDEEGT
310 320 330 340 350
DNWLAQYSIL SGNDGNWFEI QTDPKTNEGI LKLVKMLDYE QEPNIYLSIG
360 370 380 390 400
VRNQAEFHHS VASQFQMHST PVRIQVINVR EGPTFRPSSM TFSLRGGMRG
410 420 430 440 450
DSLMNYVLGT YTAIDMDTGS PATNVRYVIG HDAGSWLKVD SRTGEIQFSR
460 470 480 490 500
EFDTKSKYIT DGMYAAEILA IDDGSGRTAT GTICIEVPDA NDYCPVIYAE
510 520 530 540 550
SRSVCTHASS VRIYVNDHSF GAPFTFCVVD ESPDTADIWD IRSINGTSAI
560 570 580 590 600
LMTEQTLSPG PYQIPILVKD SHNRACELPQ TVLLDACLCD DYHVCLHSST
610 620 630 640 650
TGIYTGDTIW VTDDMGTVTD DGLRQSNVGL GPAGIGMIIL GLLLLFLSPL
660 670 680 690 700
LLLMCCCKRR QPEGLGTRFA PVPEGGEGVM QPWRIEGAHP EDRDVSNICV
710 720 730 740 750
PMTASNTQDR IDSSEIYTNT YAGGGTVEGG VSGVELNTGV GTAAGIAAGG
760 770 780 790 800
ATGTLRKRSS TIGTLREYQD TGMNMAFLDS YFSEKAYAYA DEDEGRPAND
810 820 830 840 850
CLLIYDHEGT GSPVGSIGCC SWIVDDLDES YMETLDPKFR TLAEICLDTE
860 870 880 890 900
IEPFPSHQAC IPISTDLPLL GPNYFVNESS GMTLSEAEFQ AEMAAASEPM
910 920 930 940 950
IHGDIIVTET YTATDPCVQP TTIVFDSQLP PNVVVTETVM APVYDVQGNI
960 970 980 990 1000
CVPAEIANTH NVYYAERVVA SPGVPDMGNG NIGDTCIGPV MSGGILVGPE
1010 1020 1030 1040
IQVTQMMSPD IHISQTTRST SPMTSQHRVT RYSNIHYSRQ
Length:1,040
Mass (Da):114,367
Last modified:July 19, 2004 - v1
Checksum:iB543E3A1B2968677
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti228E → V in lah. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY314982 mRNA. Translation: AAQ88398.1.
RefSeqiNP_955784.1. NM_199490.1.
UniGeneiRn.122657.

Genome annotation databases

EnsembliENSRNOT00000038450; ENSRNOP00000031941; ENSRNOG00000022364.
GeneIDi291754.
KEGGirno:291754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY314982 mRNA. Translation: AAQ88398.1.
RefSeqiNP_955784.1. NM_199490.1.
UniGeneiRn.122657.

3D structure databases

ProteinModelPortaliQ6W3B0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031941.

Proteomic databases

PaxDbiQ6W3B0.
PRIDEiQ6W3B0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038450; ENSRNOP00000031941; ENSRNOG00000022364.
GeneIDi291754.
KEGGirno:291754.

Organism-specific databases

CTDi147409.
RGDi735015. Dsg4.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiQ6W3B0.
KOiK07599.
OMAiPFTFCVV.
OrthoDBiEOG091G011Q.

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6W3B0.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 2 hits.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSG4_RAT
AccessioniPrimary (citable) accession number: Q6W3B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.